Hesperidin

    Written by:
    Giulia Guerrini

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    by:

    Nick Milazzo
    Last Updated: October 5, 2023

    Hesperidin, found abundantly in orange peels and various citrus fruits, exhibits promising potential in reducing risk factors associated with cardiovascular disease, such as triglycerides and total cholesterol. Additionally, it appears to some have anti-inflammatory properties. While other potential benefits of hesperidin exist, further clinical studies are required to fully understand its range of effects.

    41 references on this page
    2,650 participants in 8 trials and 5 meta-analyses

    Overview

    Dosage information

    Most studies tend to use 500 mg or more of supplemental hesperidin, and use the standard form of hesperidin if taking it as a daily preventative.[1]

    For the prevention of muscle soreness associated with delayed onset muscle soreness (DOMS), a daily dosage of 500 mg of hesperidin methyl chalcone (HMC) for 3 days prior to intensive anaerobic exercise has shown positive outcomes. HMC concentration typically peaks 1–2 hours after oral administration.[2]

    When it comes to food products, the amount of hesperidin contained in orange juice or other citrus peels (e.g., tangerine peel) may vary depending on multiple factors. As a result, establishing a recommended quantity of specific foods containing hesperidin to achieve effects similar to those obtained with oral supplements is challenging. For instance, one study analyzing the composition of citrus juices found hesperidin concentrations ranging from 20–60 mg/100 ml in orange juice, 8–46 mg/100 ml in tangerine juice, 4–41 mg/100 ml in lemon juice, and 2–17 mg/100 ml in grapefruit juice.[3] Sun-dried tangerine peels, used in traditional Chinese medicine, appear to confer such a substantial dose of hesperidin that additional supplementation may not be required. These peels may be made more palatable by blending them into a shake.[4]

    Examine Database: Hesperidin

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    Examine Database References

    1. Blood Flow - Hiroko Takumi, Hiroyasu Nakamura, Terumi Simizu, Ryoko Harada, Takashi Kometani, Tomonori Nadamoto, Rie Mukai, Kaeko Murota, Yoshichika Kawai, Junji TeraoBioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolitesFood Funct.(2012 Apr)
    2. Blood glucose - Morand C, Dubray C, Milenkovic D, Lioger D, Martin JF, Scalbert A, Mazur AHesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteersAm J Clin Nutr.(2011 Jan)
    3. Blood glucose - Khorasanian AS, Fateh ST, Gholami F, Rasaei N, Gerami H, Khayyatzadeh SS, Shiraseb F, Asbaghi OThe effects of hesperidin supplementation on cardiovascular risk factors in adults: a systematic review and dose-response meta-analysis.Front Nutr.(2023)
    4. Low-density lipoprotein (LDL) - Miwa Y, Mitsuzumi H, Sunayama T, Yamada M, Okada K, Kubota M, Chaen H, Mishima Y, Kibata MGlucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein metabolic abnormalityJ Nutr Sci Vitaminol (Tokyo).(2005 Dec)
    5. Low-density lipoprotein (LDL) - Miwa Y, Yamada M, Sunayama T, Mitsuzumi H, Tsuzaki Y, Chaen H, Mishima Y, Kibata MEffects of glucosyl hesperidin on serum lipids in hyperlipidemic subjects: preferential reduction in elevated serum triglyceride levelJ Nutr Sci Vitaminol (Tokyo).(2004 Jun)
    6. Low-density lipoprotein (LDL) - Demonty I, Lin Y, Zebregs YE, Vermeer MA, van der Knaap HC, Jäkel M, Trautwein EAThe citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and womenJ Nutr.(2010 Sep)
    7. C-Reactive Protein (CRP) - Lorzadeh E, Ramezani-Jolfaie N, Mohammadi M, Khoshbakht Y, Salehi-Abargouei AThe effect of hesperidin supplementation on inflammatory markers in human adults: A systematic review and meta-analysis of randomized controlled clinical trials.Chem Biol Interact.(2019-Jul-01)
    8. Blood glucose - Shams-Rad S, Mohammadi M, Ramezani-Jolfaie N, Zarei S, Mohsenpour M, Salehi-Abargouei AHesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials.Br J Clin Pharmacol.(2020-Jan)
    9. Total cholesterol - Rizza S, Muniyappa R, Iantorno M, Kim JA, Chen H, Pullikotil P, Senese N, Tesauro M, Lauro D, Cardillo C, Quon MJCitrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndromeJ Clin Endocrinol Metab.(2011 May)
    10. Total cholesterol - Mohammadi M, Ramezani-Jolfaie N, Lorzadeh E, Khoshbakht Y, Salehi-Abargouei AHesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trialsPhytother Res.(2019 Mar)
    11. Rheumatoid Arthritis Symptoms - Kometani T, Fukuda T, Kakuma T, Kawaguchi K, Tamura W, Kumazawa Y, Nagata KEffects of alpha-glucosylhesperidin, a bioactive food material, on collagen-induced arthritis in mice and rheumatoid arthritis in humansImmunopharmacol Immunotoxicol.(2008)
    12. Neutrophil Count - Perche O, Vergnaud-Gauduchon J, Morand C, Dubray C, Mazur A, Vasson MPOrange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humansClin Nutr.(2013 Mar 26)