Overview
What is NMN?
What are NMN’s main benefits?
What are NMN’s main drawbacks?
How does NMN work?
What is the legal status of NMN in the U.S.?
Dosage information
NMN has been taken by mouth in doses of 250–1200 milligrams daily for 4–12 weeks. Higher doses of 2000 milligrams daily have been taken by mouth for 2 weeks.[1]
Safety InformationNew
Examine Database: Nicotinamide Mononucleotide
Research FeedRead all studies
In this systematic review and meta-analysis of 10 randomized controlled trials, supplementation with nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) generally did not improve measures of muscle strength or physical function in older adults.
Frequently asked questions
Can NMN be obtained through dietary sources?
Can I take NADH supplements to increase my NAD+ levels?
Why haven’t the results of human NMN trials to date been as impressive as the results of animal studies?
Could NMN supplementation have potential drawbacks in people with neurological conditions?
Can NMN promote chronic inflammation?
Update History
Safety Information added
FAQ on the current legal status of NMN added, where we break down the convoluted path from legal dietary supplement to being pulled from the shelves of most retailers in the U.S.
Research written by
Reviewed by
FAQs on the potential for NMN interactions with chronic inflammation and SASP (senescence-associated secretory phenotype) added
Error in "potential mechanisms of drawbacks" FAQ
Research written by
FAQ and database update
References
Examine Database References
- Walking Ability - Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar VThe efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.Geroscience.(2023-Feb)
- Insulin Resistance - Huang HA Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults.Front Aging.(2022)
- Pulse Wave Velocity - Katayoshi T, Uehata S, Nakashima N, Nakajo T, Kitajima N, Kageyama M, Tsuji-Naito KNicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial.Sci Rep.(2023-Feb-16)
- Anaerobic Capacity - Bagen Liao, Yunlong Zhao, Dan Wang, Xiaowen Zhang, Xuanming Hao, Min HuNicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind studyJ Int Soc Sports Nutr.(2021 Jul 8)
- Insulin Resistance - Mihoko Yoshino, Jun Yoshino, Brandon D Kayser, Gary J Patti, Michael P Franczyk, Kathryn F Mills, Miriam Sindelar, Terri Pietka, Bruce W Patterson, Shin-Ichiro Imai, Samuel KleinNicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic womenScience.(2021 Jun 11)
- Serum NAD+ Levels - Zhang J, Poon ET, Wong SHEfficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials.Crit Rev Food Sci Nutr.(2024 Aug 8)
- Muscle Mass - Prokopidis K, Moriarty F, Bahat G, McLean J, Church DD, Patel HPThe Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.J Cachexia Sarcopenia Muscle.(2025 Jun)