Nicotinamide Mononucleotide

    Written by:
    Bill Willis, Nick Milazzo

    Fact-checked

    by:

    Marina Shkayeva, Natalka Roshak
    Last Updated: May 17, 2024

    Nicotinamide mononucleotide (NMN) is a form of vitamin B3 taken to boost levels of NAD+ and for its purported anti-aging effects. Although NMN was formerly available as a supplement, classification of NMN in the U.S. as an investigational drug has reduced its availability to consumers in the U.S.[2]

    31 references on this page
    1,246 participants in 6 trials and 3 meta-analyses

    Overview

    Dosage information

    NMN has been taken by mouth in doses of 250–1200 milligrams daily for 4–12 weeks. Higher doses of 2000 milligrams daily have been taken by mouth for 2 weeks.[1]

    Examine Database: Nicotinamide Mononucleotide

    Frequently asked questions

    Update History

    FAQ on the current legal status of NMN added, where we break down the convoluted path from legal dietary supplement to being pulled from the shelves of most retailers in the U.S.

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    Examine Database References

    1. Walking Ability - Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar VThe efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.Geroscience.(2023-Feb)
    2. Insulin Resistance - Huang HA Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults.Front Aging.(2022)
    3. Pulse Wave Velocity - Katayoshi T, Uehata S, Nakashima N, Nakajo T, Kitajima N, Kageyama M, Tsuji-Naito KNicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial.Sci Rep.(2023-Feb-16)
    4. Anaerobic Capacity - Bagen Liao, Yunlong Zhao, Dan Wang, Xiaowen Zhang, Xuanming Hao, Min HuNicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind studyJ Int Soc Sports Nutr.(2021 Jul 8)
    5. Insulin Resistance - Mihoko Yoshino, Jun Yoshino, Brandon D Kayser, Gary J Patti, Michael P Franczyk, Kathryn F Mills, Miriam Sindelar, Terri Pietka, Bruce W Patterson, Shin-Ichiro Imai, Samuel KleinNicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic womenScience.(2021 Jun 11)
    6. Serum NAD+ Levels - Zhang J, Poon ET, Wong SHEfficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials.Crit Rev Food Sci Nutr.(2024 Aug 8)
    7. Muscle Mass - Prokopidis K, Moriarty F, Bahat G, McLean J, Church DD, Patel HPThe Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.J Cachexia Sarcopenia Muscle.(2025 Jun)