Olive Leaf Extract

Last Updated: September 28 2022

Olive leaf extract comes from the leaves of olive plants, and is distinct from olive oil; the leaf extract contains phenolics such as oleuropein, and appears to have highly protective effects against LDL oxidation and may also benefit glucose metabolism and skin health.

Olive Leaf Extract is most often used for

Summary

Olive leaf extract is a supplement derived from the leaves of the plant that bears olive (a fruit from which the cooking oil is derived from) and contains the main bioactives of hydroxytyrosol/tyrosol and oleuropein/ligstroside.

Olive phenolics in general, which are present in high levels in olive leaf supplements, appear to potently protect against the oxidation of LDL cholesterol. This is attributed to the effects of hydroxytyrosol, and appears to be active at a low enough dose to apply to olive product (e.g., extra virgin olive oil) consumption. Olive leaf may also influence levels of blood lipids in a beneficial manner (lower LDL-C, lower triglycerides, higher HDL-C) although these changes are rather small and inconsistent. Olive leaf extract shows some promise in lowering blood pressure in people with high blood pressure.

Olive leaf extract may have beneficial effects on glycemic control, although research is limited. The mechanisms of olive leaf on glucose metabolism could be related to effects on pancreatic function and/or inhibition of carbohydrate (e.g., sucrose) metabolism in the intestines.

Although olive leaf has been implicated in fat burning through various mechanisms (increased thyroid hormones and adrenaline have been shown in animal studies), clinical trials have failed to show a fat burning effect with olive leaf supplement use. The reason for this is not known, but may be related to a decrease in levels of the receptor that adrenaline works through which may attenuate the effects.

What else is Olive Leaf Extract known as?
Note that Olive Leaf Extract is also known as:
  • Olive polyphenols
Olive Leaf Extract should not be confused with:
  • Olive oil (the fatty acids from the fruits)
  • Oleuropein (main bioactive)
Dosage information

Supplemental olive leaf is taken in the 500-1000 mg range daily, although supplements with even as low as 10 mg (as seen in olive oil products) may confer good protection against LDL oxidation. At least for LDL oxidation, olive food products may suffice rather than supplementation.

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      References
      2.^Susalit E, Agus N, Effendi I, Tjandrawinata RR, Nofiarny D, Perrinjaquet-Moccetti T, Verbruggen MOlive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with CaptoprilPhytomedicine.(2011 Feb 15)
      9.^de Bock M, Derraik JG, Brennan CM, Biggs JB, Morgan PE, Hodgkinson SC, Hofman PL, Cutfield WSOlive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover TrialPLoS One.(2013)
      10.^Hansen K, Adsersen A, Christensen SB, Jensen SR, Nyman U, Smitt UWIsolation of an angiotensin converting enzyme (ACE) inhibitor from Olea europaea and Olea lanceaPhytomedicine.(1996 Mar)
      11.^Perrinjaquet-Moccetti T, Busjahn A, Schmidlin C, Schmidt A, Bradl B, Aydogan CFood supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twinsPhytother Res.(2008 Sep)
      15.^Sánchez-González M, Lozano-Mena G, Juan ME, García-Granados A, Planas JMAssessment of the safety of maslinic acid, a bioactive compound from Olea europaea LMol Nutr Food Res.(2013 Feb)
      16.^Alqahtani A, Hamid K, Kam A, Wong KH, Abdelhak Z, Razmovski-Naumovski V, Chan K, Li KM, Groundwater PW, Li GQThe pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complicationsCurr Med Chem.(2013 Mar 1)
      17.^Quirantes-Piné R, Lozano-Sánchez J, Herrero M, Ibáñez E, Segura-Carretero A, Fernández-Gutiérrez AHPLC-ESI-QTOF-MS as a Powerful Analytical Tool for Characterising Phenolic Compounds in Olive-leaf ExtractsPhytochem Anal.(2012 Sep 15)
      19.^Venditti A, Serrilli AM, Rizza L, Frasca G, Cardile V, Bonina FP, Bianco AAromadendrine, a new component of the flavonoid pattern of Olea europaea L. and its anti-inflammatory activityNat Prod Res.(2013 Mar)
      21.^Gandul-Rojas B, Cepero MR, Mínguez-Mosquera MIChlorophyll and carotenoid patterns in olive fruits, Olea europaea Cv. arbequinaJ Agric Food Chem.(1999 Jun)
      22.^Ryan D, Robards K, Prenzler P, Jardine D, Herlt T, Antolovich MLiquid chromatography with electrospray ionisation mass spectrometric detection of phenolic compounds from Olea europaeaJ Chromatogr A.(1999 Sep 10)
      24.^Franconi F, Coinu R, Carta S, Urgeghe PP, Ieri F, Mulinacci N, Romani AAntioxidant effect of two virgin olive oils depends on the concentration and composition of minor polar compoundsJ Agric Food Chem.(2006 Apr 19)
      25.^Brenes M, García A, García P, Garrido AAcid hydrolysis of secoiridoid aglycons during storage of virgin olive oilJ Agric Food Chem.(2001 Nov)
      28.^Owen RW, Mier W, Giacosa A, Hull WE, Spiegelhalder B, Bartsch HIdentification of lignans as major components in the phenolic fraction of olive oilClin Chem.(2000 Jul)
      29.^Japón-Luján R, Luque-Rodríguez JM, Luque de Castro MDDynamic ultrasound-assisted extraction of oleuropein and related biophenols from olive leavesJ Chromatogr A.(2006 Mar 3)
      31.^Tuck KL, Hayball PJMajor phenolic compounds in olive oil: metabolism and health effectsJ Nutr Biochem.(2002 Nov)
      32.^Agati G, Pinelli P, Cortés Ebner S, Romani A, Cartelat A, Cerovic ZGNondestructive evaluation of anthocyanins in olive (Olea europaea) fruits by in situ chlorophyll fluorescence spectroscopyJ Agric Food Chem.(2005 Mar 9)
      33.^Panzanaro S, Nutricati E, Miceli A, De Bellis LBiochemical characterization of a lipase from olive fruit (Olea europaea L.)Plant Physiol Biochem.(2010 Sep)
      34.^Yanik H, Turktas M, Dundar E, Hernandez P, Dorado G, Unver TGenome-wide identification of alternate bearing-associated microRNAs (miRNAs) in olive (Olea europaea L.)BMC Plant Biol.(2013 Jan 15)
      35.^Svobodova M1, Andreadou I, Skaltsounis AL, Kopecky J, Flachs POleuropein as an inhibitor of peroxisome proliferator-activated receptor gammaGenes Nutr.(2014 Jan)
      36.^Manna C, Galletti P, Maisto G, Cucciolla V, D'Angelo S, Zappia VTransport mechanism and metabolism of olive oil hydroxytyrosol in Caco-2 cellsFEBS Lett.(2000 Mar 31)
      37.^Visioli F, Galli C, Bornet F, Mattei A, Patelli R, Galli G, Caruso DOlive oil phenolics are dose-dependently absorbed in humansFEBS Lett.(2000 Feb 25)
      38.^Vissers MN, Zock PL, Roodenburg AJ, Leenen R, Katan MBOlive oil phenols are absorbed in humansJ Nutr.(2002 Mar)
      39.^Corona G, Tzounis X, Assunta Dessì M, Deiana M, Debnam ES, Visioli F, Spencer JPThe fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformationFree Radic Res.(2006 Jun)
      41.^Ciafardini G, Marsilio V, Lanza B, Pozzi NHydrolysis of Oleuropein by Lactobacillus plantarum Strains Associated with Olive FermentationAppl Environ Microbiol.(1994 Nov)
      42.^Pinto J, Paiva-Martins F, Corona G, Debnam ES, Jose Oruna-Concha M, Vauzour D, Gordon MH, Spencer JPAbsorption and metabolism of olive oil secoiridoids in the small intestineBr J Nutr.(2011 Jun)
      43.^Tan HW, Tuck KL, Stupans I, Hayball PJSimultaneous determination of oleuropein and hydroxytyrosol in rat plasma using liquid chromatography with fluorescence detectionJ Chromatogr B Analyt Technol Biomed Life Sci.(2003 Feb 25)
      44.^Del Boccio P, Di Deo A, De Curtis A, Celli N, Iacoviello L, Rotilio DLiquid chromatography-tandem mass spectrometry analysis of oleuropein and its metabolite hydroxytyrosol in rat plasma and urine after oral administrationJ Chromatogr B Analyt Technol Biomed Life Sci.(2003 Feb 25)
      45.^De Nicoló S, Tarani L, Ceccanti M, Maldini M, Natella F, Vania A, Chaldakov GN, Fiore MEffects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brainNutrition.(2013 Apr)
      46.^Ibi M, Katsuyama M, Fan C, Iwata K, Nishinaka T, Yokoyama T, Yabe-Nishimura CNOX1/NADPH oxidase negatively regulates nerve growth factor-induced neurite outgrowthFree Radic Biol Med.(2006 May 15)
      47.^Gundimeda U, McNeill TH, Schiffman JE, Hinton DR, Gopalakrishna RGreen tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen speciesJ Neurosci Res.(2010 Dec)
      48.^Pasban-Aliabadi H, Esmaeili-Mahani S, Sheibani V, Abbasnejad M, Mehdizadeh A, Yaghoobi MMInhibition of 6-hydroxydopamine-induced PC12 cell apoptosis by olive (Olea europaea L.) leaf extract is performed by its main component oleuropeinRejuvenation Res.(2013 Feb 9)
      49.^Kaeidi A, Esmaeili-Mahani S, Sheibani V, Abbasnejad M, Rasoulian B, Hajializadeh Z, Afrazi SOlive (Olea europaea L.) leaf extract attenuates early diabetic neuropathic pain through prevention of high glucose-induced apoptosis: in vitro and in vivo studiesJ Ethnopharmacol.(2011 Jun 14)
      50.^Khayyal MT, el-Ghazaly MA, Abdallah DM, Nassar NN, Okpanyi SN, Kreuter MHBlood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in ratsArzneimittelforschung.(2002)
      51.^Lasserre B, Kaiser R, Pham Huu Chanh, Ifansyah N, Gleye J, Moulis CEffects on rats of aqueous extracts of plants used in folk medicine as antihypertensive agentsNaturwissenschaften.(1983 Feb)
      52.^Gimeno E, de la Torre-Carbot K, Lamuela-Raventós RM, Castellote AI, Fitó M, de la Torre R, Covas MI, López-Sabater MCChanges in the phenolic content of low density lipoprotein after olive oil consumption in men. A randomized crossover controlled trialBr J Nutr.(2007 Dec)
      53.^Covas MI, Nyyssönen K, Poulsen HE, Kaikkonen J, Zunft HJ, Kiesewetter H, Gaddi A, de la Torre R, Mursu J, Bäumler H, Nascetti S, Salonen JT, Fitó M, Virtanen J, Marrugat J; EUROLIVE Study GroupThe effect of polyphenols in olive oil on heart disease risk factors: a randomized trialAnn Intern Med.(2006 Sep 5)
      54.^Marrugat J, Covas MI, Fitó M, Schröder H, Miró-Casas E, Gimeno E, López-Sabater MC, de la Torre R, Farré M; SOLOS InvestigatorsEffects of differing phenolic content in dietary olive oils on lipids and LDL oxidation--a randomized controlled trialEur J Nutr.(2004 Jun)
      56.^Lapointe A, Couillard C, Lemieux SEffects of dietary factors on oxidation of low-density lipoprotein particlesJ Nutr Biochem.(2006 Oct)
      57.^Raederstorff DAntioxidant activity of olive polyphenols in humans: a reviewInt J Vitam Nutr Res.(2009 May)
      58.^Covas MI, de la Torre K, Farré-Albaladejo M, Kaikkonen J, Fitó M, López-Sabater C, Pujadas-Bastardes MA, Joglar J, Weinbrenner T, Lamuela-Raventós RM, de la Torre RPostprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humansFree Radic Biol Med.(2006 Feb 15)
      59.^Fitó M, Cladellas M, de la Torre R, Martí J, Alcántara M, Pujadas-Bastardes M, Marrugat J, Bruguera J, López-Sabater MC, Vila J, Covas MI; members of the SOLOS InvestigatorsAntioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trialAtherosclerosis.(2005 Jul)
      60.^Weinbrenner T, Fitó M, de la Torre R, Saez GT, Rijken P, Tormos C, Coolen S, Albaladejo MF, Abanades S, Schroder H, Marrugat J, Covas MIOlive oils high in phenolic compounds modulate oxidative/antioxidative status in menJ Nutr.(2004 Sep)
      61.^Visioli F, Galli CAntiatherogenic components of olive oilCurr Atheroscler Rep.(2001 Jan)
      62.^Carluccio MA, Siculella L, Ancora MA, Massaro M, Scoditti E, Storelli C, Visioli F, Distante A, De Caterina ROlive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicalsArterioscler Thromb Vasc Biol.(2003 Apr 1)
      63.^Castañer O, Covas MI, Khymenets O, Nyyssonen K, Konstantinidou V, Zunft HF, de la Torre R, Muñoz-Aguayo D, Vila J, Fitó MProtection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humansAm J Clin Nutr.(2012 May)
      64.^Sato H, Genet C, Strehle A, Thomas C, Lobstein A, Wagner A, Mioskowski C, Auwerx J, Saladin RAnti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaeaBiochem Biophys Res Commun.(2007 Nov 3)
      66.^Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx JBile acids induce energy expenditure by promoting intracellular thyroid hormone activationNature.(2006 Jan 26)
      67.^Baxter JD, Webb PMetabolism: bile acids heat things upNature.(2006 Jan 26)
      68.^Al-Qarawi AA, Al-Damegh MA, ElMougy SAEffect of freeze dried extract of Olea europaea on the pituitary-thyroid axis in ratsPhytother Res.(2002 May)
      69.^Oi-Kano Y, Kawada T, Watanabe T, Koyama F, Watanabe K, Senbongi R, Iwai KExtra virgin olive oil increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in ratsJ Nutr Biochem.(2007 Oct)
      71.^Heinze JE, Hale AH, Carl PLSpecificity of the antiviral agent calcium elenolateAntimicrob Agents Chemother.(1975 Oct)
      72.^Renis HEIn vitro antiviral activity of calcium elenolateAntimicrob Agents Chemother (Bethesda).(1969)
      74.^Sudjana AN1, D'Orazio C, Ryan V, Rasool N, Ng J, Islam N, Riley TV, Hammer KAAntimicrobial activity of commercial Olea europaea (olive) leaf extractInt J Antimicrob Agents.(2009 May)
      75.^Markin D1, Duek L, Berdicevsky IIn vitro antimicrobial activity of olive leavesMycoses.(2003 Apr)
      77.^Soret MGAntiviral activity of calcium elenolate on parainfluenza infection of hamstersAntimicrob Agents Chemother (Bethesda).(1969)
      79.^Micol V1, Caturla N, Pérez-Fons L, Más V, Pérez L, Estepa AThe olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV)Antiviral Res.(2005 Jun)
      80.^Lee-Huang S1, Zhang L, Huang PL, Chang YT, Huang PLAnti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatmentBiochem Biophys Res Commun.(2003 Aug 8)
      81.^Manna C, Della Ragione F, Cucciolla V, Borriello A, D'Angelo S, Galletti P, Zappia VBiological effects of hydroxytyrosol, a polyphenol from olive oil endowed with antioxidant activityAdv Exp Med Biol.(1999)
      83.^Blekas G, Vassilakis C, Harizanis C, Tsimidou M, Boskou DGBiophenols in table olivesJ Agric Food Chem.(2002 Jun 19)
      84.^Kim JS, Kwon CS, Son KHInhibition of alpha-glucosidase and amylase by luteolin, a flavonoidBiosci Biotechnol Biochem.(2000 Nov)
      85.^Wainstein J, Ganz T, Boaz M, Bar Dayan Y, Dolev E, Kerem Z, Madar ZOlive leaf extract as a hypoglycemic agent in both human diabetic subjects and in ratsJ Med Food.(2012 Jul)
      86.^Cvjetićanin T, Miljković D, Stojanović I, Dekanski D, Stosić-Grujicić SDried leaf extract of Olea europaea ameliorates islet-directed autoimmunity in miceBr J Nutr.(2010 May)
      87.^El-Amin M, Virk P, Abdel-Rahman M, Elobeid, Almarhoon ZM, Hassan ZK, Omer SA, Merghani NM, Daghestani MH, Al-Olayan EMAnti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic ratsPak J Pharm Sci.(2013 Mar)
      88.^Eidi A, Eidi M, Darzi RAntidiabetic effect of Olea europaea L. in normal and diabetic ratsPhytother Res.(2009 Mar)
      89.^Neves JM, Matos C, Moutinho C, Queiroz G, Gomes LREthnopharmacological notes about ancient uses of medicinal plants in Trás-os-Montes (northern of Portugal)J Ethnopharmacol.(2009 Jul 15)
      92.^Perugini P, Vettor M, Rona C, Troisi L, Villanova L, Genta I, Conti B, Pavanetto FEfficacy of oleuropein against UVB irradiation: preliminary evaluationInt J Cosmet Sci.(2008 Apr)
      96.^Tunca B, Tezcan G, Cecener G, Egeli U, Ak S, Malyer H, Tumen G, Bilir AOlea europaea leaf extract alters microRNA expression in human glioblastoma cellsJ Cancer Res Clin Oncol.(2012 Nov)
      97.^Abaza L, Talorete TP, Yamada P, Kurita Y, Zarrouk M, Isoda HInduction of growth inhibition and differentiation of human leukemia HL-60 cells by a Tunisian gerboui olive leaf extractBiosci Biotechnol Biochem.(2007 May)
      98.^Fares R, Bazzi S, Baydoun SE, Abdel-Massih RMThe antioxidant and anti-proliferative activity of the Lebanese Olea europaea extractPlant Foods Hum Nutr.(2011 Mar)
      100.^Mijatovic SA, Timotijevic GS, Miljkovic DM, Radovic JM, Maksimovic-Ivanic DD, Dekanski DP, Stosic-Grujicic SDMultiple antimelanoma potential of dry olive leaf extractInt J Cancer.(2011 Apr 15)
      102.^Florido Lopez JF, Quiralte Enriquez J, Arias de Saavedra Alías JM, Saenz de San Pedro B, Martin Casañez EAn allergen from Olea europaea pollen (Ole e 7) is associated with plant-derived food anaphylaxisAllergy.(2002)
      103.^Pastorello EA, Pravettoni V, Farioli L, Ispano M, Fortunato D, Monza M, Giuffrida MG, Rivolta F, Scibola E, Ansaloni R, Incorvaia C, Conti A, Ortolani CClinical role of a lipid transfer protein that acts as a new apple-specific allergenJ Allergy Clin Immunol.(1999 Nov)
      104.^Marazuela EG, Hajek R, Villalba M, Barber D, Breiteneder H, Rodríguez R, Batanero EA non-allergenic Ole e 1-like protein from birch pollen as a tool to design hypoallergenic vaccine candidatesMol Immunol.(2012 Feb)
      105.^Fritsch R, Bohle B, Vollmann U, Wiedermann U, Jahn-Schmid B, Krebitz M, Breiteneder H, Kraft D, Ebner CBet v 1, the major birch pollen allergen, and Mal d 1, the major apple allergen, cross-react at the level of allergen-specific T helper cellsJ Allergy Clin Immunol.(1998 Oct)
      107.^Mauro M, Russello M, Incorvaia C, Gazzola G, Frati F, Moingeon P, Passalacqua GBirch-apple syndrome treated with birch pollen immunotherapyInt Arch Allergy Immunol.(2011)