Omega-3 Fatty Acids is most often used for Cardiovascular Health. The Examine Database covers Alzheimer’s Disease, Anxiety, and 6 other conditions and goals.

Omega-3 Fatty Acids

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•Last Updated: September 26, 2023

Omega-3 fatty acids are essential polyunsaturated fatty acids. That means humans must consume them through their diet from sources like fish, seafood, walnuts, and flaxseeds. Omega-3s have anti-inflammatory properties and are crucial for brain development and cardiovascular health.

This page overlaps with our Fish Oil page, and the two will be merged in the coming months.

Omega-3 Fatty Acids is most often used for Cardiovascular Health. The Examine Database covers Alzheimer’s Disease, Anxiety, and 6 other conditions and goals.

4 references on this page

55,169 participants in 1 trial and 10 meta-analyses

Examine Evidence Grades

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Last Updated:September 26, 2023

4 references on this page

55,169 participants in 1 trial and 10 meta-analyses

Examine Evidence Grades

Examine Database: Omega-3 Fatty Acids

Show Conditions

Alzheimer’s Disease

1 Outcome

1 Study

1 Outcome

1 Study

1 Outcome

1 Study

Type 2 Diabetes

6 Outcomes

1 Study

Cardiovascular Disease

4 Outcomes

1 Study

Cystic Fibrosis

3 Outcomes

1 Study

2 Outcomes

1 Study

Uremic Pruritus

1 Outcome

1 Study

Alzheimer’s Disease

Type 2 Diabetes

Cardiovascular Disease

Cystic Fibrosis

Uremic Pruritus

Research FeedRead all studies

Can omega-3 fatty acids improve cognition in people with Alzheimer’s disease?

In this meta-analysis of 5 randomized controlled trials, supplementation with omega-3 fatty acids did not improve cognitive function in 702 older adults (ages 64 to 85) with Alzheimer’s disease.

Can fatty acids reduce migraine severity?

Are higher omega-3 levels in the blood linked to a lower risk of cardiovascular mortality?

The effect of omega−3s on heart arrhythmias in people with acute coronary syndrome

Omega-3 fatty acids for heart failure: What’s the best protocol?

Update History

A few new studies added
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References

Examine Database References

Lung Function - Watson H, Stackhouse COmega-3 fatty acid supplementation for cystic fibrosis.Cochrane Database Syst Rev.(2020-Apr-10)
Interleukin 6 - Ibrahim Mohialdeen Gubari MEffect of omega-3 fatty acid supplementation on markers of inflammation and endothelial function in patients with chronic heart disease: A systematic review and meta-analysis.Cell Mol Biol (Noisy-le-grand).(2024 Jun 30)
Anxiety Symptoms - Bafkar N, Zeraattalab-Motlagh S, Jayedi A, Shab-Bidar SEfficacy and safety of omega-3 fatty acids supplementation for anxiety symptoms: a systematic review and dose-response meta-analysis of randomized controlled trials.BMC Psychiatry.(2024 Jun 18)
Itching - Alqahtani S, Bakhamees BH, Almalki FM, Alshaer AB, Altaymani AF, Alazmi MM, Almutlaq KA, Albalawi AM, Alfaqih AA, Abdullah R, Alnashri AH, Ebrahim AM, Alghofaili JEfficacy and Safety of Omega-3 Fatty Acids in Ameliorating Pruritus in Adult Patients With Chronic Kidney Disease: A Meta-Analysis of Randomized Controlled Trials.Cureus.(2024 Aug)
Total Antioxidant Capacity (TAC) - Muzammil K, Khaleel AQ, Merza MS, Kyada A, Ariffin IA, Verma S, Kaur H, Hasaanzadeh SThe effects of ω-3 fatty acids on inflammatory and oxidative stress markers in patients with Type 2 diabetes mellitus: A systematic review and meta-analysis of controlled trials.Prostaglandins Other Lipid Mediat.(2024 Sep 5)
Cardiovascular Disease Mortality - Dwiputra B, Ambari AM, Desandri DR, Purwowiyoto BS, Radi B, Pandhita BAW, Fatrin S, Santoso AThe Effect of Omega-3 Supplementation on Heart Failure Outcome: A Meta-Analysis of Randomized Clinical Trial.J Lipid Atheroscler.(2024 May)
Cognitive Function - Kalamara TV, Dodos K, Georgakopoulou VE, Fotakopoulos G, Spandidos DA, Kapoukranidou DCognitive efficacy of omega‑3 fatty acids in Alzheimer's disease: A systematic review and meta‑analysis.Biomed Rep.(2025 Apr)
Depression Symptoms - Christos F Kelaiditis, E Leigh Gibson, Simon C DyallEffects of long-chain omega-3 polyunsaturated fatty acids on reducing anxiety and/or depression in adults; A systematic review and meta-analysis of randomised controlled trialsProstaglandins Leukot Essent Fatty Acids.(2023 Apr 2)