Examine Database: Probiotics

Health Condition/Goal	Health Outcome	Evidence
Alzheimer’s Disease	3 outcomes	3 Studies
Autism Spectrum Disorder	1 outcome	8 Studies
Depression	6 outcomes	2 Studies
Asthma	5 outcomes	11 Studies
Hair Loss	2 outcomes	2 Studies
Insomnia	5 outcomes	3 Studies
Nonalcoholic Fatty Liver Disease	13 outcomes	4 Studies
Obesity	6 outcomes	7 Studies
Chemotherapy Side Effects	7 outcomes	12 Studies
Cognitive Improvement	2 outcomes	1 Study
Cystic Fibrosis	4 outcomes	10 Studies
H. Pylori Infection	8 outcomes	2 Studies
Metabolic Health	15 outcomes	2 Studies
Overweight	11 outcomes	8 Studies
Stress	2 outcomes	2 Studies
Weight Loss & Maintenance	11 outcomes	8 Studies
Acute Gastroenteritis	3 outcomes	2 Studies
Anxiety Disorders (Other)	3 outcomes	38 Studies
Common Cold	1 outcome	5 Studies
Coronary Artery Disease	5 outcomes	1 Study
Eczema	2 outcomes	2 Studies
Migraine Headache	3 outcomes	6 Studies
Irritable Bowel Syndrome	4 outcomes	70 Studies
Menopause	2 outcomes	4 Studies
Osteoarthritis	4 outcomes	7 Studies
Psoriasis	4 outcomes	5 Studies
Type 2 Diabetes	4 outcomes	72 Studies
Bacterial Vaginosis	1 outcome	14 Studies
Body Composition	8 outcomes	1 Study
Bone Health	1 outcome	5 Studies
General Cardiovascular Health	10 outcomes	26 Studies
Colorectal Cancer	2 outcomes	1 Study
Head And Neck Cancer	1 outcome	1 Study
Hormone Health	10 outcomes	1 Study
Immune Health	1 outcome	1 Study
Metabolic Syndrome	5 outcomes	6 Studies
Mild Cognitive Impairment	3 outcomes	12 Studies
Prediabetes	10 outcomes	14 Studies
Preeclampsia	2 outcomes	11 Studies
Pregnancy And Delivery Health	1 outcome	1 Study
Schizophrenia	1 outcome	1 Study
Sleep Health	3 outcomes	1 Study
Vaginal Health	1 outcome	1 Study
Gingivitis	1 outcome	24 Studies
Food Allergy	2 outcomes	3 Studies
Periodontitis	1 outcome	24 Studies
Malnutrition	3 outcomes	1 Study
Radiation Therapy Side-Effects	1 outcome	12 Studies
Diabetic Retinopathy	10 outcomes	1 Study

Alzheimer’s Disease

3 outcomes

Autism Spectrum Disorder

1 outcome

6 outcomes

5 outcomes

2 outcomes

5 outcomes

Nonalcoholic Fatty Liver Disease

13 outcomes

Obesity

6 outcomes

Chemotherapy Side Effects

7 outcomes

Cognitive Improvement

2 outcomes

4 outcomes

8 outcomes

15 outcomes

11 outcomes

2 outcomes

Weight Loss & Maintenance

11 outcomes

Acute Gastroenteritis

3 outcomes

Anxiety Disorders (Other)

3 outcomes

Common Cold

1 outcome

Coronary Artery Disease

5 outcomes

Eczema

2 outcomes

Migraine Headache

3 outcomes

Irritable Bowel Syndrome

4 outcomes

2 outcomes

4 outcomes

4 outcomes

4 outcomes

1 outcome

8 outcomes

1 outcome

General Cardiovascular Health

10 outcomes

2 outcomes

1 outcome

10 outcomes

1 outcome

5 outcomes

Mild Cognitive Impairment

3 outcomes

Prediabetes

10 outcomes

Preeclampsia

2 outcomes

Pregnancy And Delivery Health

1 outcome

1 outcome

3 outcomes

1 outcome

1 outcome

2 outcomes

1 outcome

3 outcomes

Radiation Therapy Side-Effects

1 outcome

Diabetic Retinopathy

10 outcomes

Alzheimer’s Disease

Autism Spectrum Disorder

Nonalcoholic Fatty Liver Disease

Obesity

Chemotherapy Side Effects

Cognitive Improvement

Weight Loss & Maintenance

Acute Gastroenteritis

Anxiety Disorders (Other)

Common Cold

Coronary Artery Disease

Eczema

Migraine Headache

Irritable Bowel Syndrome

General Cardiovascular Health

Mild Cognitive Impairment

Prediabetes

Preeclampsia

Pregnancy And Delivery Health

Radiation Therapy Side-Effects

Diabetic Retinopathy

Research FeedRead all studies

Probiotics may improve cognition in adults with neurological or psychiatric disordersNew

In this meta-analysis of 6 randomized controlled trials in 386 men and women (most with neurological or psychiatric disorders), supplementation with probiotics moderately improved cognition.

Pomegranate extract and probiotics may ease unpleasant gut symptoms

Bifidobacterium alters gut bacteria in adults

A synbiotic vs. antioxidants for improving sperm quality

Can probiotics replace bismuth for H. pylori treatment?

Update History

Examine Database update
minor

One meta-analysis added
minor

Research written by

Daryl Nault

Reviewed by

Nick Milazzo

Examine Database References

Fecal Calprotectin - Coffey MJ, Garg M, Homaira N, Jaffe A, Ooi CYProbiotics for people with cystic fibrosis.Cochrane Database Syst Rev.(2020-Jan-22)
Lung Function - Cruz Mosquera FE, Perlaza CL, Naranjo Rojas A, Murillo Rios S, Carrero Gallego A, Fischersworring SI, Rodríguez JS, Liscano YEffectiveness of Probiotics, Prebiotics, and Symbiotic Supplementation in Cystic Fibrosis Patients: A Systematic Review and Meta-Analysis of Clinical Trials.Medicina (Kaunas).(2025 Mar 12)
Gestational Diabetes Risk - Li X, Zhang L, He Y, Zhang D, Zhang SProbiotics for the prevention of gestational diabetes mellitus: A meta-analysis of randomized controlled trials.Biomol Biomed.(2024 Apr 20)
Insulin Resistance - Farajipour H, Matin HR, Asemi Z, Sadr S, Tajabadi-Ebrahimi M, Sharifi N, Banikazemi Z, Taghizadeh M, Mirzaei HThe effects of probiotics supplements on metabolic indices and clinical signs in patients with diabetic retinopathy, a randomized double blind clinical trial.J Diabetes Metab Disord.(2024 Jun)
Hair Regrowth - Mori-Ichioka A, Sunada Y, Koikeda T, Matsuda H, Matsuo SEffect of applying Lactiplantibacillus plantarum subsp. plantarum N793 to the scalps of men and women with thinning hair: a randomized, double-blind, placebo-controlled, parallel-group study.Biosci Microbiota Food Health.(2024)
Hair Regrowth - García-Navarro A, Vasallo-Morillas MI, Navarro-Belmonte R, Vilanova C, Torrent D, Kilasoniya A, Moles-Ugeda I, Gallego-Herrera E, Ramírez-Boscá ARandomized Clinical Trial to Evaluate the Effect of Probiotic Intake on Androgenic Alopecia.Nutrients.(2024 Aug 30)
Sleep Quality - Liu Y, Yu Y, Lu S, Tan K, Jiang P, Liu P, Peng QImpact of probiotics on sleep quality and mood states in patients with insomnia: a systematic review and meta-analysis.Front Microbiol.(2025)
Sleep Quality - .(2024-05-30)
Cognition - Casertano M, Dekker M, Valentino V, De Filippis F, Fogliano V, Ercolini DGaba-producing lactobacilli boost cognitive reactivity to negative mood without improving cognitive performance: A human Double-Blind Placebo-Controlled Cross-Over study.Brain Behav Immun.(2024 Nov)
Total cholesterol - Mozaffari S, Aliari M, Emamgholipour S, Hosseini H, Amirkiasar PR, Zare M, Katsiki N, Panahi G, Sahebkar AThe effect of probiotic consumption on lipid profile, glycemic index, inflammatory markers, and liver function in NAFLD patients: A systematic review and meta-analysis of randomized controlled trials.J Diabetes Complications.(2024 Jun 6)
Total cholesterol - Song Y, Liu S, Zhang L, Zhao W, Qin Y, Liu MThe effect of gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review and network meta-analysis.Front Nutr.(2025 Jan 5)
Mucositis Symptoms - Lin P, Zhuang J, Lai J, Cui J, Jiang D, Huang JEfficacy of probiotics in the treatment of oral mucositis in head and neck cancer patients: A systematic review and meta-analysis.Microb Pathog.(2024 Jul 4)
Irritable Bowel Syndrome Symptoms - Wu Y, Li Y, Zheng Q, Li LThe Efficacy of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.Nutrients.(2024 Jul 2)
Mucositis Symptoms - Zhu Z, Pan W, Ming X, Wu J, Zhang X, Miao J, Cui WThe effect of probiotics on severe oral mucositis in cancer patients undergoing chemotherapy and/or radiotherapy: A meta-analysis.J Stomatol Oral Maxillofac Surg.(2024 Aug 24)
Diarrhea Symptoms - Siritientong T, Thet D, Leelakanok N, Areepium NOral probiotic supplementation to alleviate diarrhea induced by fluoropyrimidines or irinotecan-based chemotherapy: A systematic review and meta-analysis.Complement Ther Med.(2025 May)
Autism Symptoms - Kotowska M, Kołodziej M, Szajewska H, Łukasik JThe impact of probiotics on core autism symptoms - A systematic review and meta-analysis of randomized clinical trials.Clin Nutr ESPEN.(2024 Aug 20)
Autism Symptoms - Lin CH, Zeng T, Lu CW, Li DY, Liu YY, Li BM, Chen SQ, Deng YHEfficacy and safety of Bacteroides fragilis BF839 for pediatric autism spectrum disorder: a randomized clinical trial.Front Nutr.(2024)
Autism Symptoms - Soleimanpour S, Abavisani M, Khoshrou A, Sahebkar AProbiotics for autism spectrum disorder: An updated systematic review and meta-analysis of effects on symptoms.J Psychiatr Res.(2024 Sep 11)
Psoriasis Symptoms - Zhu Y, Xu F, Chen H, Zheng QThe efficacy and safety of probiotics in the adjuvant treatment of psoriasis: a systematic review and meta-analysis of randomized controlled trials.Front Med (Lausanne).(2024 Sep 4)
Testosterone - Ljunggren L, Butler E, Axelsson J, Åström M, Ohlsson LEffects of probiotic supplementation on testosterone levels in healthy ageing men: A 12-week double-blind, placebo-controlled randomized clinical trial.Contemp Clin Trials Commun.(2024 Jun)
HbA1c - Liu R, Wong GThe effects of probiotic supplementation on cardiometabolic health in patients with prediabetes: a systematic review, meta-analysis, and GRADE assessment.Front Nutr.(2025)
Weight - Paiandeh M, Maghalian M, Mohammad-Alizadeh-Charandabi S, Mirghafourvand MThe effect of probiotic, prebiotic, and synbiotic supplements on anthropometric measures and respiratory infections in malnourished children: a systematic review and meta-analysis of randomized controlled trials.BMC Pediatr.(2024 Nov 6)
Body Fat - Shin SM, Park JS, Kim SB, Cho YH, Seo H, Lee HSA 12-Week, Single-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Design Clinical Trial for the Evaluation of the Efficacy and Safety of Lactiplantibacillus plantarum SKO-001 in Reducing Body Fat.Nutrients.(2024 Apr 11)
Weight - Guo M, Li J, Zhang L, Chen C, Wei Y, Shen ZAEffects of oral supplementation of probiotics on body weight and visceral fat in obese patients: a meta-analysis and systematic review.Sci Rep.(2025 Feb 21)
All-Cause Mortality - McDougall A, Nguyen R, Nguyen PY, Allen C, Cheang S, Makama M, Mills K, Hastie R, Ammerdorffer A, Gulmezoglu AM, Vogel JPThe effects of probiotics administration during pregnancy on preeclampsia and associated maternal, fetal, and newborn outcomes: a systematic review and meta-analysis.Am J Obstet Gynecol MFM.(2024 Mar 4)
Blood glucose - Hejazi N, Ghalandari H, Rahmanian R, Haghpanah F, Makhtoomi M, Asadi A, Askarpour MEffects of probiotics supplementation on glycemic profile in adults with type 2 diabetes mellitus: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials.Clin Nutr ESPEN.(2024 Sep 28)
Depression Symptoms - Chen L, Zhou J, Xu T, Xu L, Yu CThe Effect of Probiotics on Obesity with Comorbid Depression: A Systematic Review and Meta-Analysis.Br J Hosp Med (Lond).(2024 Sep 30)
Depression Symptoms - Zhang J, Zhu L, Meng Q, Wang Z, Zhu HThe efficacy of probiotics, prebiotics, and synbiotics on anxiety, depression, and sleep: a systematic review and meta-analysis of randomized controlled trials.BMC Psychiatry.(2025 Nov 27)
Asthma Symptoms - Sun J, Zhu M, Liu Y, Zhang DA network meta-analysis of probiotics in the treatment of childhood asthma.Front Pediatr.(2025)
Asthma Symptoms - Balan D, Baral T, Manu MK, Mohapatra AK, Miraj SSEfficacy of probiotics as adjuvant therapy in bronchial asthma: a systematic review and meta-analysis.Allergy Asthma Clin Immunol.(2024 Nov 19)
Helicobacter Pylori Infection Signs - Li M, Xie YEfficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis.Front Cell Infect Microbiol.(2025)
Helicobacter Pylori Infection Signs - Tanashat M, Abuelazm M, Abouzid M, Al-Ajlouni YA, Ramadan A, Alsalah S, Sharaf A, Ayman D, Elharti H, Zhana S, Altobaishat O, Abdelazeem B, Jaber FEfficacy of probiotics regimens for Helicobacter pylori eradication: A systematic review, pairwise, and network meta-analysis of randomized controlled trials.Clin Nutr ESPEN.(2025 Dec 3)
C-Reactive Protein (CRP) - Romero-Ferreiro V, García-Fernández L, Biscaia JM, Romero C, González-Soltero R, De la Fuente M, Álvarez-Mon MA, Wynn R, Rodriguez-Jimenez REffect of probiotics on C-reactive protein levels in schizophrenia: Evidence from a systematic review and meta-analysis.Complement Ther Med.(2025 May)
HbA1c - Japar KV, Hariyanto TI, Hamzah DV, Prasetya IB, Suastika KProbiotics Supplementation for Improving Glucolipid Parameters in Individuals with Prediabetes: A Systematic Review and Meta-Analysis of Randomized Trials.Probiotics Antimicrob Proteins.(2025 Jan 14)
Eczema Symptoms - Tan-Lim CSC, Esteban-Ipac NARSystematic review and meta-analysis on probiotics as treatment for food allergies among pediatric patients: A 2024 update.Pediatr Allergy Immunol.(2025 Jan 13)
Vaginal Infection Risk - Yefet E, Suleiman A, Colodner R, Battino S, Wattad M, Kuzmin O, Nachum ZEfficacy of Oral Probiotic Supplementation in Preventing Vulvovaginal Infections During Pregnancy: A Randomized and Placebo-Controlled Clinical Trial.Nutrients.(2024 Dec 22)
Dental Health Metrics - Benavides-Reyes C, Cabello I, Magán-Fernández A, Rodríguez-Barranco M, Usta SN, Mesa FClinical effects of probiotics on the treatment of gingivitis and periodontitis: a systematic review and meta-analysis.BMC Oral Health.(2025 Apr 4)
Diarrhea Symptoms - Yang R, Liu W, Cai S, Feng X, Chen Y, Cheng X, Ma J, Ma W, Tian Z, Yang WEvaluation of the efficacy of probiotics in the chemoradiotherapy of colorectal cancer: a meta-analysis of Randomized Controlled Trials.BMC Gastroenterol.(2025 Apr 29)
Osteoarthritis Symptoms - Tian M, Zhu Y, Lu S, Qin Y, Li X, Wang T, Guo Y, Shi H, Qin DClinical efficacy of probiotic supplementation in the treatment of knee osteoarthritis: a meta-analysis.Front Microbiol.(2025)
Cognition - Tripathi S, Kaushik M, Dwivedi R, Tiwari P, Tripathi M, Dada RThe effect of probiotics on select cognitive domains in mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis.J Alzheimers Dis Rep.(2024)
Cognition - Liu W, Guo J, Dong Y, Li J, Wang YEfficacy of probiotic supplementation in influencing cognitive function in Alzheimer's disease: A systematic review and meta-analysis.J Food Sci.(2025 Jul)
Cognition - Peng TR, Lin HH, Tseng TL, Wu TWEffectiveness of probiotic supplements on cognitive function in mild cognitive impairment and Alzheimer's disease: A meta-analysis of randomized controlled trials.Gen Hosp Psychiatry.(2025 Nov-Dec)
Migraine Frequency - Talandashti MK, Shahinfar H, Delgarm P, Jazayeri SEffects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials.Neurol Sci.(2024 Oct 15)
Bacterial Vaginosis Symptoms - Rongdan Chen, Rong Li, Wei Qing, Yingxuan Zhang, Zuyi Zhou, Yi Hou, Yiya Shi, Hongwei Zhou, Muxuan ChenProbiotics are a good choice for the treatment of bacterial vaginosis: a meta-analysis of randomized controlled trialReprod Health.(2022 Jun 13)
Diarrhea Symptoms - McFarland LV, Li TEfficacy and safety of Saccharomyces boulardii CNCM I-745 for the treatment of pediatric acute diarrhea in China: a systematic review and meta-analysis.Front Cell Infect Microbiol.(2025)
Diarrhea Symptoms - Alsabri M, Rath S, Abo-Elnour DE, Shaban NS, Aziz MM, Aboali AA, Dafallah MA, Gamboa LLEfficacy of probiotics in reducing the duration and severity of acute gastroenteritis in children: A meta-analysis of randomized controlled trials.J Pediatr Gastroenterol Nutr.(2025 Oct)
Menopausal Symptoms - Andrews RAF, Lacey A, Roach H, Tomlinson R, Kidd EJ, Bache KInvestigating the effects of probiotics during the menopause transition: A systematic review & meta-analysis.Clin Nutr ESPEN.(2025 Jul 8)
Bone Mineral Density - J N H, G G, Mahadevan S, R IEffects of probiotic supplements on bone mineral density and bone turnover markers in postmenopausal women: A systematic review.Clin Nutr ESPEN.(2025 Oct)
Serum BDNF - Hashemi R, Raouf MMHM, Salih TS, Feyzpour M, Eskandarioun M, Nezamabadipour N, Gandomkar HImpact of probiotic supplementation on serum levels of brain-derived neurotrophic factor: GRADE-based dose-response meta-analysis.BMC Nutr.(2025 Aug 11)
Cognition - Calzada-Gonzales N, Moreno-Colina I, Chu-Fuentes L, Andrade-Girón D, Tito-Chura HE, Quispe-Vicuña C, Torres-Balarezo PI, Bautista-Pariona A, Barboza JJEfficacy and safety of probiotic supplements on cognitive function: a systematic review and meta-analysis of randomized clinical trials.BMC Complement Med Ther.(2025 Nov 25)
C-Reactive Protein (CRP) - Chiou YY, Chiu TY, Chen MJProbiotic Supplementation and Inflammatory Status in Coronary Artery Disease: A Systematic Review and Meta-Analysis.Microorganisms.(2025 Oct 4)
Common Cold Symptoms - Kato Y, Kobayashi K, Kuramochi Y, Miyata T, Ushida Y, Hayamizu KLactococcus lactis strain Plasma activates plasmacytoid dendritic cells and mitigates common cold-like symptoms in healthy adults: a meta-analysis of individual participant data.Front Immunol.(2025)

Probiotics

Examine Database: Probiotics

Research FeedRead all studies

Update History

Examine Database updateminor

Examine Database updateminor

Examine Database updateminor

Examine Database updateminor

Examine Database updateminor

Examine Database updateminor

One meta-analysis addedminor

Examine Database References

Examine Database: Probiotics

Research FeedRead all studies

Examine Database References

Examine Database update
minor

Examine Database update
minor

Examine Database update
minor

Examine Database update
minor

Examine Database update
minor

Examine Database update
minor

One meta-analysis added
minor