Examine Database: Probiotics

The conditions below have no primary outcomes

Health Condition/Goal	Health Outcome	Grade	Evidence
Autism Spectrum Disorder	1 primary outcome	B	8 Studies
Hair Loss	1 primary outcome		2 Studies
Nonalcoholic Fatty Liver Disease	3 primary outcomes		4 Studies
Obesity	1 primary outcome		7 Studies
Chemotherapy Side-Effects	1 primary outcome		12 Studies
Cystic Fibrosis	2 primary outcomes		10 Studies
Overweight	2 primary outcomes		8 Studies
Weight Loss & Maintenance	2 primary outcomes		8 Studies
Asthma	1 primary outcome		2 Studies
Depression	1 primary outcome		5 Studies
Eczema	1 primary outcome		2 Studies
Migraine Headache	3 primary outcomes		13 Studies
Irritable Bowel Syndrome	2 primary outcomes		70 Studies
Osteoarthritis	2 primary outcomes		7 Studies
Psoriasis	1 primary outcome		5 Studies
Type 2 Diabetes	3 primary outcomes		72 Studies
Bacterial Vaginosis	1 primary outcome		14 Studies
Body Composition	1 primary outcome		1 Study
Metabolic Syndrome	1 primary outcome		6 Studies
Mild Cognitive Impairment	2 primary outcomes		12 Studies
Prediabetes	2 primary outcomes		14 Studies
Preeclampsia	1 primary outcome		11 Studies
Gingivitis	1 primary outcome		24 Studies
Food Allergy	1 primary outcome		3 Studies
Periodontitis	1 primary outcome		24 Studies
Radiation Therapy Side-Effects	1 primary outcome		12 Studies
H. Pylori Infection	0 outcomes	-	2 Studies
Stress	0 outcomes		2 Studies
Alzheimer’s Disease	0 outcomes		1 Study
Insomnia	0 outcomes		1 Study
Colorectal Cancer	0 outcomes		1 Study
Head And Neck Cancer	0 outcomes		1 Study
Hormone Health	0 outcomes		1 Study
Metabolic Health	0 outcomes		1 Study
Pregnancy And Delivery Health	0 outcomes		1 Study
Schizophrenia	0 outcomes		1 Study
Vaginal Health	0 outcomes		1 Study
Acute Gastroenteritis	0 outcomes		1 Study
Malnutrition	0 outcomes		1 Study
Diabetic Retinopathy	0 outcomes		1 Study

Autism Spectrum Disorder

1 primary outcome

8 Studies

Hair Loss

1 primary outcome

2 Studies

Nonalcoholic Fatty Liver Disease

3 primary outcomes

4 Studies

Obesity

1 primary outcome

7 Studies

Chemotherapy Side-Effects

1 primary outcome

12 Studies

Cystic Fibrosis

2 primary outcomes

10 Studies

Overweight

2 primary outcomes

8 Studies

Weight Loss & Maintenance

2 primary outcomes

8 Studies

Asthma

1 primary outcome

2 Studies

Depression

1 primary outcome

5 Studies

Eczema

1 primary outcome

2 Studies

Migraine Headache

3 primary outcomes

13 Studies

Irritable Bowel Syndrome

2 primary outcomes

70 Studies

Osteoarthritis

2 primary outcomes

7 Studies

Psoriasis

1 primary outcome

5 Studies

Type 2 Diabetes

3 primary outcomes

72 Studies

Bacterial Vaginosis

1 primary outcome

14 Studies

Body Composition

1 primary outcome

1 Study

Metabolic Syndrome

1 primary outcome

6 Studies

Mild Cognitive Impairment

2 primary outcomes

12 Studies

Prediabetes

2 primary outcomes

14 Studies

Preeclampsia

1 primary outcome

11 Studies

Gingivitis

1 primary outcome

24 Studies

Food Allergy

1 primary outcome

3 Studies

Periodontitis

1 primary outcome

24 Studies

Radiation Therapy Side-Effects

1 primary outcome

12 Studies

H. Pylori Infection

0 outcomes

2 Studies

Stress

0 outcomes

2 Studies

Alzheimer’s Disease

0 outcomes

1 Study

Insomnia

0 outcomes

1 Study

Colorectal Cancer

0 outcomes

1 Study

Head And Neck Cancer

0 outcomes

1 Study

Hormone Health

0 outcomes

1 Study

Metabolic Health

0 outcomes

1 Study

Pregnancy And Delivery Health

0 outcomes

1 Study

Schizophrenia

0 outcomes

1 Study

Vaginal Health

0 outcomes

1 Study

Acute Gastroenteritis

0 outcomes

1 Study

Malnutrition

0 outcomes

1 Study

Diabetic Retinopathy

0 outcomes

1 Study

Autism Spectrum Disorder

Hair Loss

Nonalcoholic Fatty Liver Disease

Obesity

Chemotherapy Side-Effects

Cystic Fibrosis

Overweight

Weight Loss & Maintenance

Irritable Bowel Syndrome

Mild Cognitive Impairment

Radiation Therapy Side-Effects

The conditions below have no primary outcomes

Pregnancy And Delivery Health

Schizophrenia

Vaginal Health

Acute Gastroenteritis

Malnutrition

Diabetic Retinopathy

Research FeedRead all studies

Can probiotics reduce acute diarrhea in children?

In this meta-analysis of 10 randomized controlled trials in 1,125 children (aged less than 1 month to 6 years) in China, adding Saccharomyces boulardii to standard care improved acute gastroenteritis.

The effect of Lactobacillus plantarum GKM3 on gastrointestinal health in people with overweight and obesity

Probiotic lozenges can improve clinical outcomes in adults with stage 3 or 4 periodontitis

Multistrain probiotics did not improve cardiovascular disease risk factors in adults with obesity and hypertension

Probiotics for mucositis symptoms in people undergoing chemotherapy for head and neck cancer

Update History

One meta-analysis added
minor

Research written by

Daryl Nault

Reviewed by

Nick Milazzo

Examine Database References

Fecal Calprotectin - Coffey MJ, Garg M, Homaira N, Jaffe A, Ooi CYProbiotics for people with cystic fibrosis.Cochrane Database Syst Rev.(2020-Jan-22)
Lung Function - Cruz Mosquera FE, Perlaza CL, Naranjo Rojas A, Murillo Rios S, Carrero Gallego A, Fischersworring SI, Rodríguez JS, Liscano YEffectiveness of Probiotics, Prebiotics, and Symbiotic Supplementation in Cystic Fibrosis Patients: A Systematic Review and Meta-Analysis of Clinical Trials.Medicina (Kaunas).(2025 Mar 12)
Gestational Diabetes Risk - Li X, Zhang L, He Y, Zhang D, Zhang SProbiotics for the prevention of gestational diabetes mellitus: A meta-analysis of randomized controlled trials.Biomol Biomed.(2024 Apr 20)
Insulin Resistance - Farajipour H, Matin HR, Asemi Z, Sadr S, Tajabadi-Ebrahimi M, Sharifi N, Banikazemi Z, Taghizadeh M, Mirzaei HThe effects of probiotics supplements on metabolic indices and clinical signs in patients with diabetic retinopathy, a randomized double blind clinical trial.J Diabetes Metab Disord.(2024 Jun)
Hair Regrowth - Mori-Ichioka A, Sunada Y, Koikeda T, Matsuda H, Matsuo SEffect of applying Lactiplantibacillus plantarum subsp. plantarum N793 to the scalps of men and women with thinning hair: a randomized, double-blind, placebo-controlled, parallel-group study.Biosci Microbiota Food Health.(2024)
Hair Regrowth - García-Navarro A, Vasallo-Morillas MI, Navarro-Belmonte R, Vilanova C, Torrent D, Kilasoniya A, Moles-Ugeda I, Gallego-Herrera E, Ramírez-Boscá ARandomized Clinical Trial to Evaluate the Effect of Probiotic Intake on Androgenic Alopecia.Nutrients.(2024 Aug 30)
Sleep Quality - .(2024-05-30)
Cognition - Casertano M, Dekker M, Valentino V, De Filippis F, Fogliano V, Ercolini DGaba-producing lactobacilli boost cognitive reactivity to negative mood without improving cognitive performance: A human Double-Blind Placebo-Controlled Cross-Over study.Brain Behav Immun.(2024 Nov)
Total cholesterol - Mozaffari S, Aliari M, Emamgholipour S, Hosseini H, Amirkiasar PR, Zare M, Katsiki N, Panahi G, Sahebkar AThe effect of probiotic consumption on lipid profile, glycemic index, inflammatory markers, and liver function in NAFLD patients: A systematic review and meta-analysis of randomized controlled trials.J Diabetes Complications.(2024 Jun 6)
Total cholesterol - Song Y, Liu S, Zhang L, Zhao W, Qin Y, Liu MThe effect of gut microbiome-targeted therapies in nonalcoholic fatty liver disease: a systematic review and network meta-analysis.Front Nutr.(2025 Jan 5)
Mucositis Symptoms - Lin P, Zhuang J, Lai J, Cui J, Jiang D, Huang JEfficacy of probiotics in the treatment of oral mucositis in head and neck cancer patients: A systematic review and meta-analysis.Microb Pathog.(2024 Jul 4)
Irritable Bowel Syndrome Symptoms - Wu Y, Li Y, Zheng Q, Li LThe Efficacy of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.Nutrients.(2024 Jul 2)
Mucositis Symptoms - Zhu Z, Pan W, Ming X, Wu J, Zhang X, Miao J, Cui WThe effect of probiotics on severe oral mucositis in cancer patients undergoing chemotherapy and/or radiotherapy: A meta-analysis.J Stomatol Oral Maxillofac Surg.(2024 Aug 24)
Diarrhea Symptoms - Siritientong T, Thet D, Leelakanok N, Areepium NOral probiotic supplementation to alleviate diarrhea induced by fluoropyrimidines or irinotecan-based chemotherapy: A systematic review and meta-analysis.Complement Ther Med.(2025 May)
Autism Symptoms - Kotowska M, Kołodziej M, Szajewska H, Łukasik JThe impact of probiotics on core autism symptoms - A systematic review and meta-analysis of randomized clinical trials.Clin Nutr ESPEN.(2024 Aug 20)
Autism Symptoms - Lin CH, Zeng T, Lu CW, Li DY, Liu YY, Li BM, Chen SQ, Deng YHEfficacy and safety of Bacteroides fragilis BF839 for pediatric autism spectrum disorder: a randomized clinical trial.Front Nutr.(2024)
Autism Symptoms - Soleimanpour S, Abavisani M, Khoshrou A, Sahebkar AProbiotics for autism spectrum disorder: An updated systematic review and meta-analysis of effects on symptoms.J Psychiatr Res.(2024 Sep 11)
Psoriasis Symptoms - Zhu Y, Xu F, Chen H, Zheng QThe efficacy and safety of probiotics in the adjuvant treatment of psoriasis: a systematic review and meta-analysis of randomized controlled trials.Front Med (Lausanne).(2024 Sep 4)
Testosterone - Ljunggren L, Butler E, Axelsson J, Åström M, Ohlsson LEffects of probiotic supplementation on testosterone levels in healthy ageing men: A 12-week double-blind, placebo-controlled randomized clinical trial.Contemp Clin Trials Commun.(2024 Jun)
Weight - Paiandeh M, Maghalian M, Mohammad-Alizadeh-Charandabi S, Mirghafourvand MThe effect of probiotic, prebiotic, and synbiotic supplements on anthropometric measures and respiratory infections in malnourished children: a systematic review and meta-analysis of randomized controlled trials.BMC Pediatr.(2024 Nov 6)
Body Fat - Shin SM, Park JS, Kim SB, Cho YH, Seo H, Lee HSA 12-Week, Single-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Design Clinical Trial for the Evaluation of the Efficacy and Safety of Lactiplantibacillus plantarum SKO-001 in Reducing Body Fat.Nutrients.(2024 Apr 11)
Weight - Guo M, Li J, Zhang L, Chen C, Wei Y, Shen ZAEffects of oral supplementation of probiotics on body weight and visceral fat in obese patients: a meta-analysis and systematic review.Sci Rep.(2025 Feb 21)
All-Cause Mortality - McDougall A, Nguyen R, Nguyen PY, Allen C, Cheang S, Makama M, Mills K, Hastie R, Ammerdorffer A, Gulmezoglu AM, Vogel JPThe effects of probiotics administration during pregnancy on preeclampsia and associated maternal, fetal, and newborn outcomes: a systematic review and meta-analysis.Am J Obstet Gynecol MFM.(2024 Mar 4)
Blood glucose - Hejazi N, Ghalandari H, Rahmanian R, Haghpanah F, Makhtoomi M, Asadi A, Askarpour MEffects of probiotics supplementation on glycemic profile in adults with type 2 diabetes mellitus: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials.Clin Nutr ESPEN.(2024 Sep 28)
Depression Symptoms - Chen L, Zhou J, Xu T, Xu L, Yu CThe Effect of Probiotics on Obesity with Comorbid Depression: A Systematic Review and Meta-Analysis.Br J Hosp Med (Lond).(2024 Sep 30)
Asthma Symptoms - Balan D, Baral T, Manu MK, Mohapatra AK, Miraj SSEfficacy of probiotics as adjuvant therapy in bronchial asthma: a systematic review and meta-analysis.Allergy Asthma Clin Immunol.(2024 Nov 19)
Helicobacter Pylori Infection Signs - Li M, Xie YEfficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis.Front Cell Infect Microbiol.(2025)
Helicobacter Pylori Infection Signs - Tanashat M, Abuelazm M, Abouzid M, Al-Ajlouni YA, Ramadan A, Alsalah S, Sharaf A, Ayman D, Elharti H, Zhana S, Altobaishat O, Abdelazeem B, Jaber FEfficacy of probiotics regimens for Helicobacter pylori eradication: A systematic review, pairwise, and network meta-analysis of randomized controlled trials.Clin Nutr ESPEN.(2025 Dec 3)
C-Reactive Protein (CRP) - Romero-Ferreiro V, García-Fernández L, Biscaia JM, Romero C, González-Soltero R, De la Fuente M, Álvarez-Mon MA, Wynn R, Rodriguez-Jimenez REffect of probiotics on C-reactive protein levels in schizophrenia: Evidence from a systematic review and meta-analysis.Complement Ther Med.(2025 May)
HbA1c - Japar KV, Hariyanto TI, Hamzah DV, Prasetya IB, Suastika KProbiotics Supplementation for Improving Glucolipid Parameters in Individuals with Prediabetes: A Systematic Review and Meta-Analysis of Randomized Trials.Probiotics Antimicrob Proteins.(2025 Jan 14)
Eczema Symptoms - Tan-Lim CSC, Esteban-Ipac NARSystematic review and meta-analysis on probiotics as treatment for food allergies among pediatric patients: A 2024 update.Pediatr Allergy Immunol.(2025 Jan 13)
Vaginal Infection Risk - Yefet E, Suleiman A, Colodner R, Battino S, Wattad M, Kuzmin O, Nachum ZEfficacy of Oral Probiotic Supplementation in Preventing Vulvovaginal Infections During Pregnancy: A Randomized and Placebo-Controlled Clinical Trial.Nutrients.(2024 Dec 22)
Dental Health Metrics - Benavides-Reyes C, Cabello I, Magán-Fernández A, Rodríguez-Barranco M, Usta SN, Mesa FClinical effects of probiotics on the treatment of gingivitis and periodontitis: a systematic review and meta-analysis.BMC Oral Health.(2025 Apr 4)
Diarrhea Symptoms - Yang R, Liu W, Cai S, Feng X, Chen Y, Cheng X, Ma J, Ma W, Tian Z, Yang WEvaluation of the efficacy of probiotics in the chemoradiotherapy of colorectal cancer: a meta-analysis of Randomized Controlled Trials.BMC Gastroenterol.(2025 Apr 29)
Osteoarthritis Symptoms - Tian M, Zhu Y, Lu S, Qin Y, Li X, Wang T, Guo Y, Shi H, Qin DClinical efficacy of probiotic supplementation in the treatment of knee osteoarthritis: a meta-analysis.Front Microbiol.(2025)
Cognition - Tripathi S, Kaushik M, Dwivedi R, Tiwari P, Tripathi M, Dada RThe effect of probiotics on select cognitive domains in mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis.J Alzheimers Dis Rep.(2024)
Migraine Frequency - Talandashti MK, Shahinfar H, Delgarm P, Jazayeri SEffects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials.Neurol Sci.(2024 Oct 15)
Bacterial Vaginosis Symptoms - Rongdan Chen, Rong Li, Wei Qing, Yingxuan Zhang, Zuyi Zhou, Yi Hou, Yiya Shi, Hongwei Zhou, Muxuan ChenProbiotics are a good choice for the treatment of bacterial vaginosis: a meta-analysis of randomized controlled trialReprod Health.(2022 Jun 13)
Diarrhea Symptoms - McFarland LV, Li TEfficacy and safety of Saccharomyces boulardii CNCM I-745 for the treatment of pediatric acute diarrhea in China: a systematic review and meta-analysis.Front Cell Infect Microbiol.(2025)

Probiotics

Examine Database: Probiotics

Research FeedRead all studies

Update History

One meta-analysis addedminor

Examine Database References

Examine Database References

Research FeedRead all studies

Examine Database: Probiotics

One meta-analysis added
minor