Overview
What is yohimbine?
What are yohimbine’s main benefits?
What are yohimbine’s main drawbacks?
How does yohimbine work?
Dosage information
Total daily dosages of 0.2mg/kg bodyweight have been successfully used to increase fat burning without significant implications on cardiovascular parameters like heart rate and blood pressure. This results in a total daily dosage of:
- 14 mg for a 150 lb (68 kg) person
- 18 mg for a 200 lb (91 kg) person
- 22 mg for a 250 lb (113 kg) person
These total daily doses are often divided and taken in two to four doses throughout the day. For example, a 150 lb (68 kg) person could take 7 mg twice daily to reach to total dose of 14 mg.
Supplementation is most effective between meals or during short term fasting.
Caution should be exercised at higher body weight, since the cardiovascular system may not be prepared to handle a stimulatory agent such as yohimbine. When supplementing yohimbine for the first time, always start with a half-dose and assess tolerance before proceeding.
Caution should also be exercised since many supplements containing yohimbine either do not list how much yohimbine is included, or if they do, the actual dose ranges from 25-150% of the dose listed. Since the dosage may be higher than listed, this is extra reason to start with a lower dose.
When pairing yohimbine with other stimulatory agents, half-dose both supplements and work up to the recommended dose cautiously, as two supplements can interact negatively.
Research FeedRead all studies
Frequently asked questions
What are other names for Yohimbine?
Research Breakdown
References
Examine Database References
- Diuresis - Kennedy SH, Gnam W, Ralevski E, Brown GMMelatonin responses to clonidine and yohimbine challengesJ Psychiatry Neurosci.(1995 Jul)
- Heart Rate - Sommer M, Braumann M, Althoff T, Backhaus J, Kordon A, Junghanns K, Ehrenthal D, Bartmann U, Hohagen F, Broocks APsychological and neuroendocrine responses to social stress and to the administration of the alpha-2-receptor antagonist, yohimbine, in highly trained endurance athletes in comparison to untrained healthy controlsPharmacopsychiatry.(2011 Jun)
- Blood Pressure - O G Cameron, J K Zubieta, L Grunhaus, S MinoshimaEffects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humansPsychosom Med.(Jul-Aug 2000)
- Testosterone - Guay AT, Spark RF, Jacobson J, Murray FT, Geisser MEYohimbine treatment of organic erectile dysfunction in a dose-escalation trialInt J Impot Res.(2002 Feb)
- Erections - Ernst E, Pittler MHYohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trialsJ Urol.(1998 Feb)
- Body Fat - Ostojic SMYohimbine: the effects on body composition and exercise performance in soccer playersRes Sports Med.(2006 Oct-Dec)
- Phobia Symptoms - Powers MB, Smits JA, Otto MW, Sanders C, Emmelkamp PMFacilitation of fear extinction in phobic participants with a novel cognitive enhancer: a randomized placebo controlled trial of yohimbine augmentationJ Anxiety Disord.(2009 Apr)
- Cortisol - Umhau JC, Schwandt ML, Usala J, Geyer C, Singley E, George DT, Heilig MPharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosateNeuropsychopharmacology.(2011 May)
- Gastric Emptying Rate - Jonderko K, Kucio CEffect of anti-obesity drugs promoting energy expenditure, yohimbine and ephedrine, on gastric emptying in obese patientsAliment Pharmacol Ther.(1991 Aug)
- Orthostatic Hypotension Symptoms - Shibao C, Okamoto LE, Gamboa A, Yu C, Diedrich A, Raj SR, Robertson D, Biaggioni IComparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failureHypertension.(2010 Nov)
- Phobia Symptoms - Meyerbroeker K, Powers MB, van Stegeren A, Emmelkamp PMDoes yohimbine hydrochloride facilitate fear extinction in virtual reality treatment of fear of flying? A randomized placebo-controlled trialPsychother Psychosom.(2012)