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DNA Damage

DNA damage refers to oxidative changes to DNA, which can be measured in the urine or in white blood cells. Reductions in DNA damage from antioxidant supplements are thought to reduce the risk of cancer development and mutations.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect dna damage
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Blueberry Notable Very High See all 4 studies
DNA damage appears to be acutely decreased following consumption of blueberries or its extracts (375mg anthocyanins or more) and tends to be in the range of a 20% reduction.
grade-b Vitamin E - High See all 3 studies
While most evidence suggests no influence on DNA damage, it is possible based on some studies that when vitamin E turns prooxidative that it may damage DNA.
grade-c Olive leaf extract Notable - See study
The one study to measure DNA damage (via 8-oxo-dGF as a biomarker) noted up to 50% reductions in mitochondrial and urine measurements; a fairly significant reduction.
grade-c Creatine  
grade-c Curcumin  
grade-c Eleutherococcus senticosus  
grade-c Panax ginseng  
grade-c Watercress  
grade-c Chlorella  
grade-c Citrulline  
grade-c Conjugated Linoleic Acid  
grade-c Fish Oil  
grade-c Ganoderma lucidum  
grade-c Glutathione  
grade-c Sea Buckthorn  
grade-c Vitamin C  
grade-d Garlic  
grade-d Melissa officinalis  
grade-d Chromium  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.