Breast Cancer

    Written by:
    Marina Shkayeva

    Fact-checked

    by:

    Zia Poonja, Nick Milazzo
    Last Updated: October 13, 2024

    Breast cancer is the second most common cancer in women, after skin cancer. It affects men very rarely. It is most treatable when caught early, therefore it is important to do regular breast exams and regular physician visits.

    9 references on this page
    13,466 participants in 18 trials and 5 meta-analyses

    Overview

    Examine Database: Breast Cancer

    Research FeedRead all studies

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    Examine Database References

    1. Breast Cancer Risk - Schernhammer ES, Berrino F, Krogh V, Secreto G, Micheli A, Venturelli E, Grioni S, Sempos CT, Cavalleri A, Schünemann HJ, Strano S, Muti PUrinary 6-Sulphatoxymelatonin levels and risk of breast cancer in premenopausal women: the ORDET cohortCancer Epidemiol Biomarkers Prev.(2010 Mar)
    2. Estrogen - Schernhammer ES, Giobbie-Hurder A, Gantman K, Savoie J, Scheib R, Parker LM, Chen WYA randomized controlled trial of oral melatonin supplementation and breast cancer biomarkersCancer Causes Control.(2012 Apr)
    3. Breast Cancer Risk - Crew KD, Gammon MD, Steck SE, Hershman DL, Cremers S, Dworakowski E, Shane E, Terry MB, Desai M, Teitelbaum SL, Neugut AI, Santella RMAssociation between plasma 25-hydroxyvitamin D and breast cancer riskCancer Prev Res (Phila).(2009 Jun)
    4. Breast Cancer Risk - Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FCVitamin D and prevention of breast cancer: pooled analysisJ Steroid Biochem Mol Biol.(2007 Mar)
    5. Aromatase-Inhibitor Related Joint Pain - Qamar J Khan, Pavan S Reddy, Bruce F Kimler, Priyanka Sharma, Susan E Baxa, Anne P O'Dea, Jennifer R Klemp, Carol J FabianEffect of vitamin D supplementation on serum 25-hydroxy vitamin D levels, joint pain, and fatigue in women starting adjuvant letrozole treatment for breast cancerBreast Cancer Res Treat.(2010 Jan)
    6. DNA methylation - Zhu W, Qin W, Zhang K, Rottinghaus GE, Chen YC, Kliethermes B, Sauter ERTrans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancerNutr Cancer.(2012 Apr)
    7. Menopausal Symptoms - Atkinson C, Warren RM, Sala E, Dowsett M, Dunning AM, Healey CS, Runswick S, Day NE, Bingham SARed-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial ISRCTN42940165Breast Cancer Res.(2004)
    8. Menopausal Symptoms - Matthias Rostock, Julia Fischer, Andreas Mumm, Ute Stammwitz, Reinhard Saller, Hans Helge BartschBlack cohosh (Cimicifuga racemosa) in tamoxifen-treated breast cancer patients with climacteric complaints - a prospective observational studyGynecol Endocrinol.(2011 Oct)
    9. Menopausal Symptoms - Jacobson JS, Troxel AB, Evans J, Klaus L, Vahdat L, Kinne D, Lo KM, Moore A, Rosenman PJ, Kaufman EL, Neugut AI, Grann VRRandomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancerJ Clin Oncol.(2001 May 15)
    10. Breast Density - E Lundström, A L Hirschberg, G SöderqvistDigitized assessment of mammographic breast density--effects of continuous combined hormone therapy, tibolone and black cohosh compared to placeboMaturitas.(2011 Dec)
    11. Estrogen - Ikuko Kijima, Sheryl Phung, Gene Hur, Sum-Ling Kwok, Shiuan ChenGrape seed extract is an aromatase inhibitor and a suppressor of aromatase expressionCancer Res.(2006 Jun 1)
    12. Depression Symptoms - Sue Gessler, Michael King, Alessandra Lemma, Julie Barber, Louise Jones, Susan Dunning, Val Madden, Stephen Pilling, Rachael Hunter, Peter Fonagy, Karen Summerville, Nicola MacDonald, Adeola Olaitan, Anne LanceleyStepped approach to improving sexual function after gynaecological cancer: the SAFFRON feasibility RCTHealth Technol Assess.(2019 Feb)
    13. Depression Symptoms - Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang XSpore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical TrialEvid Based Complement Alternat Med.(2012)
    14. Depression Symptoms - Lin G, Yang L, Wang Y, Lin R, Huang B, Sheng X, Wu X, Cao ZThe Efficacy of Laughter Therapy on Psychological Symptoms in People With Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Studies.Psychooncology.(2024 Oct 20)
    15. Depression Symptoms - Liu W, Gao F, Ma N, Zhang H, Chui PL, Che CCEffects of CBT-based interventions on health outcomes in breast cancer patients: a systematic review and Meta-analysis.Breast Cancer.(2025 Jul)
    16. Anxiety Symptoms - Henderson VP, Clemow L, Massion AO, Hurley TG, Druker S, Hébert JRThe effects of mindfulness-based stress reduction on psychosocial outcomes and quality of life in early-stage breast cancer patients: a randomized trialBreast Cancer Res Treat.(2012 Jan)
    17. Natural Killer Cell Activity - Torkelson CJ, Sweet E, Martzen MR, Sasagawa M, Wenner CA, Gay J, Putiri A, Standish LJPhase 1 Clinical Trial of Trametes versicolor in Women with Breast CancerISRN Oncol.(2012)
    18. Fatigue Symptoms - Li Y, Zhang J, Hu D, Gao L, Huang TWhich specific modes of exercise training are most effective for breast related cancer fatigue? Network meta-analysis.Front Oncol.(2025)
    19. IGF-1 - Amanollahi A, Khazdouz M, Malekahmadi M, Klement RJ, Lee D, Khodabakhshi AEffect of Ketogenic Diets on Cardio-Metabolic Outcomes in Cancer Patients: A Systematic Review and Meta-Analysis of Controlled Clinical Trials.Nutr Cancer.(2023)
    20. Weight - Marzieh Taftian, Sara Beigrezaei, Vahid Arabi, Amin Salehi-AbargoueiThe Effect of Ketogenic Diet on Weight Loss in Adult Patients with Cancer: A Systematic Review and Meta-Analysis of Controlled Clinical TrialsNutr Cancer.(2022 Feb 7)
    21. Dermatitis Risk - Sharp L, Finnilä K, Johansson H, Abrahamsson M, Hatschek T, Bergenmar MNo differences between Calendula cream and aqueous cream in the prevention of acute radiation skin reactions--results from a randomised blinded trial.Eur J Oncol Nurs.(2013-Aug)
    22. Dermatitis Risk - Pommier P, Gomez F, Sunyach MP, D'Hombres A, Carrie C, Montbarbon XPhase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer.J Clin Oncol.(2004-Apr-15)
    23. Dermatitis Risk - De Angelis C, Di Stadio A, Vitale S, Saccone G, Angelis MC, Zizolfi B, Di Spiezio Sardo AUse of calendula ointment after episiotomy: a randomized clinical trial.J Matern Fetal Neonatal Med.(2022-May)