Peripheral Arterial Disease

    Written by:
    Thomas Solomon

    Fact-checked

    by:

    Morgan Pfiffner, Shyam Jayaraman
    Last Updated: October 13, 2024

    Peripheral arterial disease is a condition characterized by a narrowing of the arteries that carry blood away from the heart to other parts of the body. It is usually caused by atherosclerosis. The legs and feet are most commonly affected, resulting in reduced blood flow to these areas.

    39 references on this page
    1,870 participants in 16 trials and 1 meta-analysis

    Overview

    Examine Database: Peripheral Arterial Disease

    Frequently asked questions

    Examine Database References

    1. Intermittent Claudication Symptoms - Castaño G, Más Ferreiro R, Fernández L, Gámez R, Illnait J, Fernández CA long-term study of policosanol in the treatment of intermittent claudicationAngiology.(2001 Feb)
    2. Intermittent Claudication Symptoms - Wilson AM, Harada R, Nair N, Balasubramanian N, Cooke JPL-arginine supplementation in peripheral arterial disease: no benefit and possible harmCirculation.(2007 Jul 10)
    3. Nitric Oxide - Jabłecka A, Bogdański P, Balcer N, Cieślewicz A, Skołuda A, Musialik KThe effect of oral L-arginine supplementation on fasting glucose, HbA1c, nitric oxide and total antioxidant status in diabetic patients with atherosclerotic peripheral arterial disease of lower extremitiesEur Rev Med Pharmacol Sci.(2012 Mar)
    4. Intermittent Claudication Symptoms - William R Hiatt, Mark A Creager, Antonino Amato, Eric P BrassEffect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery diseaseJ Cardiopulm Rehabil Prev.(Mar-Apr 2011)
    5. Walking Ability - G Brevetti, S Perna, C Sabbà, A Rossini, V Scotto di Uccio, E Berardi, L GodiSuperiority of L-propionylcarnitine vs L-carnitine in improving walking capacity in patients with peripheral vascular disease: an acute, intravenous, double-blind, cross-over studyEur Heart J.(1992 Feb)
    6. Walking Ability - G A Barker, S Green, C D Askew, A A Green, P J WalkerEffect of propionyl-L-carnitine on exercise performance in peripheral arterial diseaseMed Sci Sports Exerc.(2001 Sep)
    7. Walking Ability - G Brevetti, M Chiariello, G Ferulano, A Policicchio, E Nevola, A Rossini, T Attisano, G Ambrosio, N Siliprandi, C AngeliniIncreases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over studyCirculation.(1988 Apr)
    8. Blood Flow - C Corsi, M Pollastri, E Marrapodi, D Leanza, S Giordano, S D'IddioL-propionylcarnitine effect on postexercise and postischemic hyperemia in patients affected by peripheral vascular diseaseAngiology.(1995 Aug)
    9. Intermittent Claudication Symptoms - Bauer U6-Month double-blind randomised clinical trial of Ginkgo biloba extract versus placebo in two parallel groups in patients suffering from peripheral arterial insufficiencyArzneimittelforschung.(1984)
    10. Intermittent Claudication Symptoms - Gardner CD, Taylor-Piliae RE, Kiazand A, Nicholus J, Rigby AJ, Farquhar JWEffect of Ginkgo biloba (EGb 761) on treadmill walking time among adults with peripheral artery disease: a randomized clinical trialJ Cardiopulm Rehabil Prev.(2008 Jul-Aug)
    11. Intermittent Claudication Symptoms - Mouren X, Caillard P, Schwartz FStudy of the antiischemic action of EGb 761 in the treatment of peripheral arterial occlusive disease by TcPo2 determinationAngiology.(1994 Jun)
    12. Intermittent Claudication Symptoms - Vincent HK, Bourguignon CM, Vincent KR, Taylor AGEffects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot studyJ Altern Complement Med.(2007 Jun)
    13. Peripheral Vascular Disease Symptoms - Kiesewetter H, Jung F, Jung EM, Blume J, Mrowietz C, Birk A, Koscielny J, Wenzel EEffects of garlic coated tablets in peripheral arterial occlusive diseaseClin Investig.(1993 May)
    14. Peripheral Vascular Disease Symptoms - Hammer A, Koppensteiner R, Steiner S, Niessner A, Goliasch G, Gschwandtner M, Hoke MDark chocolate and vascular function in patients with peripheral artery disease: a randomized, controlled cross-over trialClin Hemorheol Microcirc.(2015)
    15. Peripheral Vascular Disease Symptoms - Loffredo L, Perri L, Catasca E, Pignatelli P, Brancorsini M, Nocella C, De Falco E, Bartimoccia S, Frati G, Carnevale R, Violi FDark chocolate acutely improves walking autonomy in patients with peripheral artery diseaseJ Am Heart Assoc.(2014 Jul 2)
    16. C-Reactive Protein (CRP) - Mackay I, Ford I, Thies F, Fielding S, Bachoo P, Brittenden JEffect of Omega-3 fatty acid supplementation on markers of platelet and endothelial function in patients with peripheral arterial diseaseAtherosclerosis.(2012 Jan 13)
    17. Endothelial Function - Mohammadipoor N, Shafiee F, Rostami A, Kahrizi MS, Soleimanpour H, Ghodsi M, Ansari MJ, Bokov DO, Jannat B, Mosharkesh E, Pour Abbasi MSResveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials.Phytother Res.(2022-Sep)