IGF-1

    Last Updated: October 13, 2024

    Insulin-like growth factor-1 (IGF-1) is an anabolic derivative of growth hormone that is thought to mediate cell growth and muscle protein synthesis. Supplements that increase IGF-1 are thought to promote muscle hypertrophy.

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    2,538 participants in 41 trials

    Examine Database: IGF-1

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    Examine Database References

    1. Red Clover Extract - Vrieling A, Rookus MA, Kampman E, Bonfrer JM, Bosma A, Cats A, van Doorn J, Korse CM, Witteman BJ, van Leeuwen FE, van't Veer LJ, Voskuil DWNo effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancerCancer Epidemiol Biomarkers Prev.(2008 Oct)
    2. Betaine - Apicella JM, Lee EC, Bailey BL, Saenz C, Anderson JM, Craig SA, Kraemer WJ, Volek JS, Maresh CMBetaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exerciseEur J Appl Physiol.(2013 Mar)
    3. Spirulina - Reza Bagheri, Raoof Negaresh, Mohamad S Motevalli, Alexei Wong, Damoon Ashtary-Larky, Mehdi Kargarfard, Amir RashidlamirSpirulina supplementation during gradual weight loss in competitive wrestlersBr J Nutr.(2021 Mar 15)
    4. Zinc - Rodondi A, Ammann P, Ghilardi-Beuret S, Rizzoli RZinc increases the effects of essential amino acids-whey protein supplements in frail elderlyJ Nutr Health Aging.(2009 Jun)
    5. Colostrum - Mero A, Kähkönen J, Nykänen T, Parviainen T, Jokinen I, Takala T, Nikula T, Rasi S, Leppäluoto JIGF-I, IgA, and IgG responses to bovine colostrum supplementation during trainingJ Appl Physiol (1985).(2002 Aug)
    6. Velvet Antler - Sleivert G, Burke V, Palmer C, Walmsley A, Gerrard D, Haines S, Littlejohn RThe effects of deer antler velvet extract or powder supplementation on aerobic power, erythropoiesis, and muscular strength and endurance characteristicsInt J Sport Nutr Exerc Metab.(2003 Sep)
    7. Zinc - Blostein-Fujii A, DiSilvestro RA, Frid D, Katz C, Malarkey WShort-term zinc supplementation in women with non-insulin-dependent diabetes mellitus: effects on plasma 5'-nucleotidase activities, insulin-like growth factor I concentrations, and lipoprotein oxidation rates in vitroAm J Clin Nutr.(1997 Sep)
    8. Ursolic Acid - Bang HS, Seo DY, Chung YM, Oh KM, Park JJ, Arturo F, Jeong SH, Kim N, Han JUrsolic Acid-induced elevation of serum irisin augments muscle strength during resistance training in menKorean J Physiol Pharmacol.(2014 Oct)
    9. DHEA - Igwebuike A, Irving BA, Bigelow ML, Short KR, McConnell JP, Nair KSLack of dehydroepiandrosterone effect on a combined endurance and resistance exercise program in postmenopausal womenJ Clin Endocrinol Metab.(2008 Feb)
    10. Vitamin D - Amirhossein Ramezani Ahmadi, Majid Mohammadshahi, Aliakbar Alizadeh, Kambiz Ahmadi Angali, Alireza JahanshahiEffects of vitamin D3 supplementation for 12 weeks on serum levels of anabolic hormones, anaerobic power, and aerobic performance in active male subjects: A randomized, double-blind, placebo-controlled trialEur J Sport Sci.(2020 Nov)
    11. Whey Protein - Reitelseder S, Agergaard J, Doessing S, Helmark IC, Lund P, Kristensen NB, Frystyk J, Flyvbjerg A, Schjerling P, van Hall G, Kjaer M, Holm LWhey and casein labeled with L-1-13Cleucine and muscle protein synthesis: effect of resistance exercise and protein ingestionAm J Physiol Endocrinol Metab.(2011 Jan)
    12. Colostrum - Coombes JS, Conacher M, Austen SK, Marshall PADose effects of oral bovine colostrum on physical work capacity in cyclistsMed Sci Sports Exerc.(2002 Jul)
    13. Creatine - Volek JS, Ratamess NA, Rubin MR, Gómez AL, French DN, McGuigan MM, Scheett TP, Sharman MJ, Häkkinen K, Kraemer WJThe effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreachingEur J Appl Physiol.(2004 May)
    14. Olive Leaf Extract - de Bock M, Derraik JG, Brennan CM, Biggs JB, Morgan PE, Hodgkinson SC, Hofman PL, Cutfield WSOlive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover TrialPLoS One.(2013)
    15. Creatine - Hoffman J, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout JEffect of creatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletesInt J Sport Nutr Exerc Metab.(2006 Aug)
    16. Melatonin - Schernhammer ES, Giobbie-Hurder A, Gantman K, Savoie J, Scheib R, Parker LM, Chen WYA randomized controlled trial of oral melatonin supplementation and breast cancer biomarkersCancer Causes Control.(2012 Apr)
    17. L-Carnitine - Kraemer WJ, Volek JS, French DN, Rubin MR, Sharman MJ, Gómez AL, Ratamess NA, Newton RU, Jemiolo B, Craig BW, Häkkinen KThe effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recoveryJ Strength Cond Res.(2003 Aug)
    18. DHEA - Alessandro D Genazzani, Massimo Stomati, Francesca Bernardi, Matteo Pieri, Lucio Rovati, Andrea R GenazzaniLong-term low-dose dehydroepiandrosterone oral supplementation in early and late postmenopausal women modulates endocrine parameters and synthesis of neuroactive steroidsFertil Steril.(2003 Dec)
    19. Tongkat Ali - Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske ERandomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in MenEvid Based Complement Alternat Med.(2012)
    20. Vitamin D - Michelle S Rockwell, Madlyn I Frisard, Janet W Rankin, Jennifer S Zabinsky, Ryan P Mcmillan, Wen You, Kevin P Davy, Matthew W HulverEffects of Seasonal Vitamin D3 Supplementation on Strength, Power, and Body Composition in College SwimmersInt J Sport Nutr Exerc Metab.(2020 Feb 4)
    21. Colostrum - Buckley JD, Brinkworth GD, Abbott MJEffect of bovine colostrum on anaerobic exercise performance and plasma insulin-like growth factor IJ Sports Sci.(2003 Jul)
    22. DHEA - Libè R, Barbetta L, Dall'Asta C, Salvaggio F, Gala C, Beck-Peccoz P, Ambrosi BEffects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalismJ Endocrinol Invest.(2004 Sep)
    23. DHEA - Martina V, Benso A, Gigliardi VR, Masha A, Origlia C, Granata R, Ghigo EShort-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjectsClin Endocrinol (Oxf).(2006 Mar)
    24. DHEA - Weiss EP, Shah K, Fontana L, Lambert CP, Holloszy JO, Villareal DTDehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on boneAm J Clin Nutr.(2009 May)
    25. Ketogenic Diet - Urbain P, Strom L, Morawski L, Wehrle A, Deibert P, Bertz HImpact of a 6-week non-energy-restricted ketogenic diet on physical fitness, body composition and biochemical parameters in healthy adultsNutr Metab (Lond).(2017 Feb 20)
    26. Colostrum - A Mero, H Miikkulainen, J Riski, R Pakkanen, J Aalto, T TakalaEffects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during trainingJ Appl Physiol (1985).(1997 Oct)
    27. L-Carnitine - Angelika K Sawicka, Dace Hartmane, Patrycja Lipinska, Ewa Wojtowicz, Wieslawa Lysiak-Szydlowska, Robert A Olekl-Carnitine Supplementation in Older Women. A Pilot Study on Aging Skeletal Muscle Mass and FunctionNutrients.(2018 Feb 23)
    28. Ketogenic Diet - Cohen CW, Fontaine KR, Arend RC, Alvarez RD, Leath CA III, Huh WK, Bevis KS, Kim KH, Straughn JM Jr, Gower BAA Ketogenic Diet Reduces Central Obesity and Serum Insulin in Women with Ovarian or Endometrial CancerJ Nutr.(2018 Aug 1)
    29. Red Clover Extract - Campbell MJ, Woodside JV, Honour JW, Morton MS, Leathem AJEffect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot studyEur J Clin Nutr.(2004 Jan)
    30. Creatine - Burke DG, Candow DG, Chilibeck PD, MacNeil LG, Roy BD, Tarnopolsky MA, Ziegenfuss TEffect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adultsInt J Sport Nutr Exerc Metab.(2008 Aug)
    31. DHEA - Muller M, van den Beld AW, van der Schouw YT, Grobbee DE, Lamberts SWEffects of dehydroepiandrosterone and atamestane supplementation on frailty in elderly menJ Clin Endocrinol Metab.(2006 Oct)
    32. 16:8 Intermittent Fasting - Tatiana Moro, Grant Tinsley, Antonino Bianco, Giuseppe Marcolin, Quirico Francesco Pacelli, Giuseppe Battaglia, Antonio Palma, Paulo Gentil, Marco Neri, Antonio PaoliEffects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained malesJ Transl Med.(2016 Oct 13)
    33. Colostrum - Buckley JD, Abbott MJ, Brinkworth GD, Whyte PBBovine colostrum supplementation during endurance running training improves recovery, but not performanceJ Sci Med Sport.(2002 Jun)
    34. Citrulline - Thibault R, Flet L, Vavasseur F, Lemerle M, Ferchaud-Roucher V, Picot D, Darmaun DOral citrulline does not affect whole body protein metabolism in healthy human volunteers: results of a prospective, randomized, double-blind, cross-over studyClin Nutr.(2011 Dec)
    35. Creatine - Peyrebrune MC, Stokes K, Hall GM, Nevill MEEffect of creatine supplementation on training for competition in elite swimmersMed Sci Sports Exerc.(2005 Dec)
    36. HMB - Portal S, Zadik Z, Rabinowitz J, Pilz-Burstein R, Adler-Portal D, Meckel Y, Cooper DM, Eliakim A, Nemet DThe effect of HMB supplementation on body composition, fitness, hormonal and inflammatory mediators in elite adolescent volleyball players: a prospective randomized, double-blind, placebo-controlled studyEur J Appl Physiol.(2011 Sep)
    37. Red Clover Extract - Vrieling A, Rookus MA, Kampman E, Bonfrer JM, Korse CM, van Doorn J, Lampe JW, Cats A, Witteman BJ, van Leeuwen FE, van't Veer LJ, Voskuil DWIsolated isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer riskJ Nutr.(2007 Feb)
    38. Creatine - Louise Deldicque, Magali Louis, Daniel Theisen, Henri Nielens, Mischaël Dehoux, Jean-Paul Thissen, Michael J Rennie, Marc FrancauxIncreased IGF mRNA in human skeletal muscle after creatine supplementationMed Sci Sports Exerc.(2005 May)
    39. Tongkat Ali - Sasikala M Chinnappan, Annie George, Pragya Pandey, Govinda Narke, Yogendra Kumar ChoudharyEffect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicentre studyFood Nutr Res.(2021 May 19)
    40. DHEA - Lin H, Li L, Wang Q, Wang Y, Wang J, Long XA systematic review and meta-analysis of randomized placebo-controlled trials of DHEA supplementation of bone mineral density in healthy adults.Gynecol Endocrinol.(2019-Nov)
    41. Ketogenic Diet - Amanollahi A, Khazdouz M, Malekahmadi M, Klement RJ, Lee D, Khodabakhshi AEffect of Ketogenic Diets on Cardio-Metabolic Outcomes in Cancer Patients: A Systematic Review and Meta-Analysis of Controlled Clinical Trials.Nutr Cancer.(2023)