Osteocalcin

•Last Updated: October 13, 2024

Osteocalcin is secreted by osteoblasts (bone-producing cells), and is often used as a marker of bone formation. Additionally, it acts as a hormone, and can promote the release of insulin, adiponectin, and testosterone.

1,103 participants in 6 trials

Examine Evidence Grades

Last Updated:October 13, 2024

1,103 participants in 6 trials

Examine Evidence Grades

Examine Database: Osteocalcin

B

Participants: 733

Moderate Decrease

C

Participants: 46

Small Increase

D

Participants: 22

No effect

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Red Clover Extract

Participants: 252

Participants: 50

Intervention	Grade	Effect	Detail
Vitamin K	B
Magnesium	C
Vitamin C	D
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Red Clover Extract
L-Carnitine

Research FeedRead all studies

Can probiotics improve femoral bone health in postmenopausal women?

In this 48-week randomized controlled trial in 61 postmenopausal women, probiotics had no meaningful effects on femoral neck bone mineral density, fracture risk, or bone turnover biomarkers.

Finding the threshold for low energy availability in men

A walnut-enriched diet does not improve bone health in older adults

Eggshell powder + vitamin D may prevent bone loss in Korean postmenopausal women

Weight-bearing aerobic exercise may improve calcium balance in healthy young women

Examine Database References

Magnesium - Doyle L, Flynn A, Cashman KThe effect of magnesium supplementation on biochemical markers of bone metabolism or blood pressure in healthy young adult femalesEur J Clin Nutr.(1999 Apr)
Red Clover Extract - Schult TM, Ensrud KE, Blackwell T, Ettinger B, Wallace R, Tice JAEffect of isoflavones on lipids and bone turnover markers in menopausal womenMaturitas.(2004 Jul 15)
Vitamin C - Pirbudak L, Balat O, Cekmen M, Ugur MG, Aygün S, Oner UEffect of ascorbic acid on surgical stress response in gynecologic surgeryInt J Clin Pract.(2004 Oct)
L-Carnitine - Salvatore Benvenga, Antonino Amato, Menotti Calvani, Francesco TrimarchiEffects of carnitine on thyroid hormone actionAnn N Y Acad Sci.(2004 Nov)
Magnesium - Aydin H, Deyneli O, Yavuz D, Gözü H, Mutlu N, Kaygusuz I, Akalin SShort-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic womenBiol Trace Elem Res.(2010 Feb)
Vitamin K - Geng C, Huang L, Pu L, Feng YEffects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials.Front Nutr.(2022)