Adiponectin

    Last Updated: October 13, 2024

    Adiponectin is an adipokine (signalling molecule secreted from fat cells, like leptin) which positively influences glucose metabolism and fat loss. Increasing adiponectin levels are thought to result in fat loss and improved health.

    Examine Database: Adiponectin

    B
    Small Increase
    C
    Small Increase
    D
    No effect

    Research FeedRead all studies

    Examine Database References

    1. Vegan Diet - F Eichelmann, L Schwingshackl, V Fedirko, K AleksandrovaEffect of plant-based diets on obesity-related inflammatory profiles: a systematic review and meta-analysis of intervention trialsObes Rev.(2016 Nov)
    2. 16:8 Intermittent Fasting - Tatiana Moro, Grant Tinsley, Antonino Bianco, Giuseppe Marcolin, Quirico Francesco Pacelli, Giuseppe Battaglia, Antonio Palma, Paulo Gentil, Marco Neri, Antonio PaoliEffects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained malesJ Transl Med.(2016 Oct 13)
    3. Coffee - Kempf K, Herder C, Erlund I, Kolb H, Martin S, Carstensen M, Koenig W, Sundvall J, Bidel S, Kuha S, Tuomilehto JEffects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trialAm J Clin Nutr.(2010 Apr)
    4. Curcumin - Campbell MS, Ouyang A, I M K, Charnigo RJ, Westgate PM, Fleenor BSInfluence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: A double-blinded, randomized, controlled trialNutrition.(2019 Jun)
    5. Blueberry - Arpita Basu, Mei Du, Misti J Leyva, Karah Sanchez, Nancy M Betts, Mingyuan Wu, Christopher E Aston, Timothy J LyonsBlueberries decrease cardiovascular risk factors in obese men and women with metabolic syndromeJ Nutr.(2010 Sep)
    6. Rose Hip - Andersson U, Berger K, Högberg A, Landin-Olsson M, Holm CEffects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese personsEur J Clin Nutr.(2012 May)
    7. Astaxanthin - Mashhadi NS, Zakerkish M, Mohammadiasl J, Zarei M, Mohammadshahi M, Haghighizadeh MHAstaxanthin improves glucose metabolism and reduces blood pressure in patients with type 2 diabetes mellitusAsia Pac J Clin Nutr.(2018)
    8. L-Carnitine - Giuseppe Derosa, Pamela Maffioli, Sibilla A T Salvadeo, Ilaria Ferrari, Alessia Gravina, Roberto Mereu, Angela D'Angelo, Ilaria Palumbo, Sabrina Randazzo, Arrigo F G CiceroEffects of combination of sibutramine and L-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patientsMetabolism.(2011 Mar)
    9. Niacin (Vitamin B3) - Fraterrigo G, Fabbrini E, Mittendorfer B, O'Rahilly S, Scherer PE, Patterson BW, Klein SRelationship between Changes in Plasma Adiponectin Concentration and Insulin Sensitivity after Niacin TherapyCardiorenal Med.(2012 Aug)
    10. Conjugated Linoleic Acid - Syvertsen C, Halse J, Høivik HO, Gaullier JM, Nurminiemi M, Kristiansen K, Einerhand A, O'Shea M, Gudmundsen OThe effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obeseInt J Obes (Lond).(2007 Jul)
    11. Fish Oil - M Gorety Jacobo-Cejudo, Roxana Valdés-Ramos, Ana L Guadarrama-López, Rosa-Virgen Pardo-Morales, Beatriz E Martínez-Carrillo, Laurence S HarbigeEffect of n-3 Polyunsaturated Fatty Acid Supplementation on Metabolic and Inflammatory Biomarkers in Type 2 Diabetes Mellitus PatientsNutrients.(2017 Jun 3)
    12. Panax Ginseng (Korean Ginseng) - Meegun Hong, Yoon Hyeong Lee, Seungwoo Kim, Ki Tae Suk, Chang Seok Bang, Jai Hoon Yoon, Gwang Ho Baik, Dong Joon Kim, Myong Jo KimAnti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver diseaseJ Ginseng Res.(2016 Jul)
    13. Ketogenic Diet - Varady KA, Bhutani S, Klempel MC, Phillips SAImprovements in vascular health by a low-fat diet, but not a high-fat diet, are mediated by changes in adipocyte biologyNutr J.(2011 Jan 20)
    14. Fish Oil - Krebs JD, Browning LM, McLean NK, Rothwell JL, Mishra GD, Moore CS, Jebb SAAdditive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic womenInt J Obes (Lond).(2006 Oct)
    15. Curcumin - Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai SCurcumin extract for prevention of type 2 diabetesDiabetes Care.(2012 Nov)
    16. Astaxanthin - Yoshida H, Yanai H, Ito K, Tomono Y, Koikeda T, Tsukahara H, Tada NAdministration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemiaAtherosclerosis.(2010 Apr)
    17. Conjugated Linoleic Acid - Sneddon AA, Tsofliou F, Fyfe CL, Matheson I, Jackson DM, Horgan G, Winzell MS, Wahle KW, Ahren B, Williams LMEffect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectinObesity (Silver Spring).(2008 May)
    18. Inositol - Corrado F, D'Anna R, Di Vieste G, Giordano D, Pintaudi B, Santamaria A, Di Benedetto AThe effect of myoinositol supplementation on insulin resistance in patients with gestational diabetesDiabet Med.(2011 Aug)
    19. Niacin (Vitamin B3) - Westphal S, Borucki K, Taneva E, Makarova R, Luley CExtended-release niacin raises adiponectin and leptinAtherosclerosis.(2007 Aug)
    20. Green Tea Extract - Hsu CH, Tsai TH, Kao YH, Hwang KC, Tseng TY, Chou PEffect of green tea extract on obese women: a randomized, double-blind, placebo-controlled clinical trialClin Nutr.(2008 Jun)
    21. Coenzyme Q10 - Gholami M, Zarei P, Sadeghi Sedeh B, Rafiei F, Khosrowbeygi AEffects of coenzyme Q10 supplementation on serum values of adiponectin, leptin, 8-isoprostane and malondialdehyde in women with type 2 diabetesGynecol Endocrinol.(2018 Dec)
    22. African Mango - Ngondi JL, Etoundi BC, Nyangono CB, Mbofung CM, Oben JEIGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigationLipids Health Dis.(2009 Mar 2)
    23. Ketogenic Diet - Rosenbaum M, Hall KD, Guo J, Ravussin E, Mayer LS, Reitman ML, Smith SR, Walsh BT, Leibel RLGlucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric Ketogenic DietObesity (Silver Spring).(2019 Jun)
    24. OMAD And 20:4 Intermittent Fasting - B D Horne, J B Muhlestein, D L Lappé, H T May, J F Carlquist, O Galenko, K D Brunisholz, J L AndersonRandomized cross-over trial of short-term water-only fasting: metabolic and cardiovascular consequencesNutr Metab Cardiovasc Dis.(2013 Nov)
    25. Fish Oil - Vargas ML, Almario RU, Buchan W, Kim K, Karakas SEMetabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndromeMetabolism.(2011 Dec)
    26. Vitamin C - Gutierrez AD, Duran-Valdez E, Robinson I, de Serna DG, Schade DSDoes short-term vitamin C reduce cardiovascular risk in type 2 diabetes?Endocr Pract.(2013 Sep-Oct)
    27. Chromium - Julie Martin, Zhong Q Wang, Xian H Zhang, Deborah Wachtel, Julia Volaufova, Dwight E Matthews, William T CefaluChromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetesDiabetes Care.(2006 Aug)
    28. L-Carnitine - Ruggenenti P, Cattaneo D, Loriga G, Ledda F, Motterlini N, Gherardi G, Orisio S, Remuzzi GAmeliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapyHypertension.(2009 Sep)
    29. Coenzyme Q10 - Gökbel H, Gergerlioğlu HS, Okudan N, Gül I, Büyükbaş S, Belviranli MEffects of coenzyme Q10 supplementation on plasma adiponectin, interleukin-6, and tumor necrosis factor-alpha levels in menJ Med Food.(2010 Feb)
    30. Curcumin - Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai SReduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trialJ Nutr Biochem.(2014 Feb)
    31. Chromium - Kim CW, Kim BT, Park KH, Kim KM, Lee DJ, Yang SW, Joo NSEffects of short-term chromium supplementation on insulin sensitivity and body composition in overweight children: randomized, double-blind, placebo-controlled studyJ Nutr Biochem.(2011 Nov)
    32. Ketogenic Diet - Boden G, Sargrad K, Homko C, Mozzoli M, Stein TPEffect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetesAnn Intern Med.(2005 Mar 15)
    33. L-Carnitine - Giuseppe Derosa, Pamela Maffioli, Ilaria Ferrari, Angela D'Angelo, Elena Fogari, Ilaria Palumbo, Sabrina Randazzo, Arrigo F G CiceroComparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patientsFundam Clin Pharmacol.(2011 Oct)
    34. Kefir - Z Jenko Pražnikar, S Kenig, T Vardjan, M Černelič Bizjak, A PetelinEffects of kefir or milk supplementation on zonulin in overweight subjectsJ Dairy Sci.(2020 May)
    35. Garlic - Gómez-Arbeláez D, Lahera V, Oubiña P, Valero-Muñoz M, de Las Heras N, Rodríguez Y, García RG, Camacho PA, López-Jaramillo PAged garlic extract improves adiponectin levels in subjects with metabolic syndrome: a double-blind, placebo-controlled, randomized, crossover studyMediators Inflamm.(2013)
    36. Curcumin - Adibian M, Hodaei H, Nikpayam O, Sohrab G, Hekmatdoost A, Hedayati MThe effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trialPhytother Res.(2019 May)
    37. 16:8 Intermittent Fasting - Matthew T Stratton, Grant M Tinsley, Michaela G Alesi, Garrett M Hester, Alex A Olmos, Paul R Serafini, Andrew S Modjeski, Gerald T Mangine, Kelsey King, Shelby N Savage, Austin T Webb, Trisha A VanDusseldorpFour Weeks of Time-Restricted Feeding Combined with Resistance Training Does Not Differentially Influence Measures of Body Composition, Muscle Performance, Resting Energy Expenditure, and Blood BiomarkersNutrients.(2020 Apr 17)
    38. Arginine - Lucotti P, Setola E, Monti LD, Galluccio E, Costa S, Sandoli EP, Fermo I, Rabaiotti G, Gatti R, Piatti PBeneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patientsAm J Physiol Endocrinol Metab.(2006 Nov)
    39. Spirulina - Lee EH, Park JE, Choi YJ, Huh KB, Kim WYA randomized study to establish the effects of spirulina in type 2 diabetes mellitus patientsNutr Res Pract.(2008 Winter)
    40. Vitamin K - Hyung Jin Choi, MD, Juyoun Yu, BS, Hosanna Choi, BS, Jee Hyun An, MD, Sang Wan Kim, MD, PHD, Kyong Soo Park, MD, PHD, Hak C. Jang, MD, PHD, Seong Yeon Kim, MD, PHD and Chan Soo Shin, MD, PHDVitamin K2 Supplementation Improves Insulin Sensitivity via Osteocalcin Metabolism: A Placebo-Controlled Trial2011.()
    41. Melatonin - Gonciarz M, Bielański W, Partyka R, Brzozowski T, Konturek PC, Eszyk J, Celiński K, Reiter RJ, Konturek SJPlasma insulin, leptin, adiponectin, resistin, ghrelin, and melatonin in nonalcoholic steatohepatitis patients treated with melatoninJ Pineal Res.(2012 Jun 13)
    42. Licorice - Bell ZW, Canale RE, Bloomer RJA dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemical markers of health and adiposityLipids Health Dis.(2011 Feb 10)
    43. Conjugated Linoleic Acid - Joseph SV, Jacques H, Plourde M, Mitchell PL, McLeod RS, Jones PJConjugated linoleic acid supplementation for 8 weeks does not affect body composition, lipid profile, or safety biomarkers in overweight, hyperlipidemic menJ Nutr.(2011 Jul)
    44. Black seed - Datau EA, Wardhana, Surachmanto EE, Pandelaki K, Langi JA, FiasEfficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese maleActa Med Indones.(2010 Jul)
    45. Ketogenic Diet - Partsalaki I, Karvela A, Spiliotis BEMetabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescentsJ Pediatr Endocrinol Metab.(2012)
    46. Spirulina - Reyhaneh Yousefi, Azadeh Mottaghi, Atoosa SaidpourSpirulina platensis effectively ameliorates anthropometric measurements and obesity-related metabolic disorders in obese or overweight healthy individuals: A randomized controlled trialComplement Ther Med.(2018 Oct)
    47. OMAD And 20:4 Intermittent Fasting - Carlson O, Martin B, Stote KS, Golden E, Maudsley S, Najjar SS, Ferrucci L, Ingram DK, Longo DL, Rumpler WV, Baer DJ, Egan J, Mattson MPImpact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and womenMetabolism.(2007 Dec)
    48. Cocoa Extract - Muniyappa R, Hall G, Kolodziej TL, Karne RJ, Crandon SK, Quon MJCocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertensionAm J Clin Nutr.(2008 Dec)
    49. Betaine - Abdelmalek MF, Sanderson SO, Angulo P, Soldevila-Pico C, Liu C, Peter J, Keach J, Cave M, Chen T, McClain CJ, Lindor KDBetaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trialHepatology.(2009 Dec)
    50. Tart Cherry Juice - Johnson SA, Navaei N, Pourafshar S, Jaime SJ, Akhavan NS, Alvarez-Alvarado S, Proaño GV, Litwin NS, Clark EA, Foley EM, George KS, Elam ML, Payton ME, Arjmandi BH, Figueroa AEffects of Montmorency Tart Cherry Juice Consumption on Cardiometabolic Biomarkers in Adults with Metabolic Syndrome: A Randomized Controlled Pilot Trial.J Med Food.(2020-Dec)
    51. Curcumin - Akbari M, Lankarani KB, Tabrizi R, Ghayour-Mobarhan M, Peymani P, Ferns G, Ghaderi A, Asemi ZThe Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Front Pharmacol.(2019)
    52. Fish Oil - Zhou J, Zuo W, Tan Y, Wang X, Zhu M, Zhang HEffects of n-3 polyunsaturated fatty acid on metabolic status in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials.J Ovarian Res.(2023-Mar-17)
    53. Mediterranean Diet - Schwingshackl L, Hoffmann GMediterranean dietary pattern, inflammation and endothelial function: a systematic review and meta-analysis of intervention trialsNutr Metab Cardiovasc Dis.(2014 Sep)
    54. Mediterranean Diet - Sánchez-Rosales AI, Guadarrama-López AL, Gaona-Valle LS, Martínez-Carrillo BE, Valdés-Ramos RThe Effect of Dietary Patterns on Inflammatory Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrients.(2022-Oct-31)
    55. Coenzyme Q10 - Shi-Ying Zhang, Kai-Lin Yang, Liu-Ting Zeng, Xiao-He Wu, Hui-Yong HuangEffectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-AnalysisInt J Endocrinol.(2018 Sep 16)
    56. Resveratrol - Mohammadi-Sartang M, Mazloom Z, Sohrabi Z, Sherafatmanesh S, Barati-Boldaji RResveratrol supplementation and plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials.Pharmacol Res.(2017-Mar)
    57. Resveratrol - Sheida Zeraattalab-Motlagh, Ahmad Jayedi, Sakineh Shab-BidarThe effects of resveratrol supplementation in patients with type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease: an umbrella review of meta-analyses of randomized controlled trialsAm J Clin Nutr.(2021 Nov 8)
    58. Resveratrol - Qian Zhou, Yanmei Wang, Xuke Han, Shunlian Fu, Chan Zhu, Qiu ChenEfficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic ReviewFront Physiol.(2022 Mar 31)
    59. Vitamin K - Suksomboon N, Poolsup N, Darli Ko Ko HEffect of vitamin K supplementation on insulin sensitivity: a meta-analysis.Diabetes Metab Syndr Obes.(2017)
    60. Flaxseed - Jalili C, Pezeshki M, Askarpour M, Marx W, Hassani B, Hadi A, Ghaedi EThe effect of flaxseed supplementation on circulating adiponectin and leptin concentration in adults: A systematic review and meta-analysis of randomized controlled trials.Phytother Res.(2020 Jul)
    61. Flaxseed - Abbasi S, Karimi K, Hossein Moridpour A, Musazadeh V, Faghfouri AH, Jozi HCan flaxseed supplementation affect circulating adipokines in adults? An updated systematic review and meta-analysis of randomized controlled trials.Front Nutr.(2023)