Evidence-based

Sex Hormone Binding Globulin

•Last Updated: October 13, 2024

Sex Hormone Binding Globulin (SHBG) is a globulin that is able to bind to and sequester steroid hormones such as estrogen, testosterone, and DHT. Its elevations are associated with less activity of the steroid hormones.

Last Updated:October 13, 2024

Research Snapshot

5,968 participants in 32 trials

Examine Evidence Grades

BBerberine

C3 outcomes

D14 outcomes

Examine Database: Sex Hormone Binding Globulin

Intervention	Grade	Evidence	Effect
Flaxseed	D	Participants: 629	No effect
Red Clover Extract	D	Participants: 319	No effect
Tongkat Ali	D	Participants: 271	No effect
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Vitamin D		Participants: 449
N-Acetylcysteine		Participants: 414
Flavonoids		Participants: 256
Berberine		Participants: 228
Resveratrol		Participants: 108
Magnesium		Participants: 102
DHEA		Participants: 149
Chromium		Participants: 5
Fish Oil		Participants: 51
Licorice		Participants: 36
Tribulus Terrestris		Participants: 180
Maca		Participants: 16
Coenzyme Q10		Participants: 86
L-Carnitine		Participants: 50
Probiotics		Participants: 47

Flaxseed

No effect

Red Clover Extract

No effect

Tongkat Ali

No effect

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Vitamin D