Sex Hormone Binding Globulin

    Last Updated: October 13, 2024

    Sex Hormone Binding Globulin (SHBG) is a globulin that is able to bind to and sequester steroid hormones such as estrogen, testosterone, and DHT. Its elevations are associated with less activity of the steroid hormones.

    10,175 participants in 33 trials

    Examine Database: Sex Hormone Binding Globulin

    Research FeedRead all studies

    Examine Database References

    1. Red Clover Extract - Baber RJ, Templeman C, Morton T, Kelly GE, West LRandomized placebo-controlled trial of an isoflavone supplement and menopausal symptoms in womenClimacteric.(1999 Jun)
    2. L-Carnitine - Salvatore Benvenga, Antonino Amato, Menotti Calvani, Francesco TrimarchiEffects of carnitine on thyroid hormone actionAnn N Y Acad Sci.(2004 Nov)
    3. Vitamin D - Armin Zittermann, Jana B Ernst, Sylvana Prokop, Uwe Fuchs, Jens Dreier, Joachim Kuhn, Cornelius Knabbe, Heiner K Berthold, Ioanna Gouni-Berthold, Jan F Gummert, Jochen Börgermann, Stefan PilzVitamin D supplementation does not prevent the testosterone decline in males with advanced heart failure: the EVITA trialEur J Nutr.(2019 Mar)
    4. Red Clover Extract - Vrieling A, Rookus MA, Kampman E, Bonfrer JM, Bosma A, Cats A, van Doorn J, Korse CM, Witteman BJ, van Leeuwen FE, van't Veer LJ, Voskuil DWNo effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancerCancer Epidemiol Biomarkers Prev.(2008 Oct)
    5. Maca - Brooks NA, Wilcox G, Walker KZ, Ashton JF, Cox MB, Stojanovska LBeneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen contentMenopause.(2008 Nov-Dec)
    6. Coenzyme Q10 - Izadi A, Ebrahimi S, Shirazi S, Taghizadeh S, Parizad M, Farzadi L, Gargari BPHormonal and Metabolic Effects of Coenzyme Q10 and/or Vitamin E in Patients With Polycystic Ovary SyndromeJ Clin Endocrinol Metab.(2019 Feb 1)
    7. Red Clover Extract - Hidalgo LA, Chedraui PA, Morocho N, Ross S, San Miguel GThe effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled studyGynecol Endocrinol.(2005 Nov)
    8. Fish Oil - Vargas ML, Almario RU, Buchan W, Kim K, Karakas SEMetabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndromeMetabolism.(2011 Dec)
    9. DHEA - Alessandro D Genazzani, Massimo Stomati, Francesca Bernardi, Matteo Pieri, Lucio Rovati, Andrea R GenazzaniLong-term low-dose dehydroepiandrosterone oral supplementation in early and late postmenopausal women modulates endocrine parameters and synthesis of neuroactive steroidsFertil Steril.(2003 Dec)
    10. Licorice - Helga Agusta Sigurjonsdottir, Magnus Axelson, Gudmundur Johannsson, Karin Manhem, Ernst Nystrom, Sven WallerstedtLiquorice in moderate doses does not affect sex steroid hormones of biological importance although the effect differs between the gendersHorm Res.(2006)
    11. Tongkat Ali - Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske ERandomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in MenEvid Based Complement Alternat Med.(2012)
    12. Vitamin D - Soma Saha, Ravinder Goswami, Lakshmy Ramakrishnan, Sreenivas Vishnubhatla, Samrina Mahtab, Parmita Kar, Sunita Srinivasan, Namrata Singh, Upinderpal SinghVitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: Randomized control trialClin Endocrinol (Oxf).(2018 Feb)
    13. Red Clover Extract - Lee CC, Bloem CJ, Kasa-Vubu JZ, Liang LJEffect of oral phytoestrogen on androgenicity and insulin sensitivity in postmenopausal womenDiabetes Obes Metab.(2012 Apr)
    14. Vitamin D - Elisabeth Lerchbaum, Christian Trummer, Verena Theiler-Schwetz, Martina Kollmann, Monika Wölfler, Annemieke C Heijboer, Stefan Pilz, Barbara Obermayer-PietschEffects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trialEur J Nutr.(2019 Dec)
    15. Chromium - Lydic ML, McNurlan M, Bembo S, Mitchell L, Komaroff E, Gelato MChromium picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndromeFertil Steril.(2006 Jul)
    16. Tribulus Terrestris - Kamenov Z, Fileva S, Kalinov K, Jannini EAEvaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trialMaturitas.(2017 May)
    17. DHEA - Stomati M, Monteleone P, Casarosa E, Quirici B, Puccetti S, Bernardi F, Genazzani AD, Rovati L, Luisi M, Genazzani ARSix-month oral dehydroepiandrosterone supplementation in early and late postmenopauseGynecol Endocrinol.(2000 Oct)
    18. DHEA - Dayal M, Sammel MD, Zhao J, Hummel AC, Vandenbourne K, Barnhart KTSupplementation with DHEA: effect on muscle size, strength, quality of life, and lipidsJ Womens Health (Larchmt).(2005 Jun)
    19. DHEA - Kenny AM, Boxer RS, Kleppinger A, Brindisi J, Feinn R, Burleson JADehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older womenJ Am Geriatr Soc.(2010 Sep)
    20. Vitamin D - Michelle S Rockwell, Madlyn I Frisard, Janet W Rankin, Jennifer S Zabinsky, Ryan P Mcmillan, Wen You, Kevin P Davy, Matthew W HulverEffects of Seasonal Vitamin D3 Supplementation on Strength, Power, and Body Composition in College SwimmersInt J Sport Nutr Exerc Metab.(2020 Feb 4)
    21. Red Clover Extract - Imhof M, Gocan A, Reithmayr F, Lipovac M, Schimitzek C, Chedraui P, Huber JEffects of a red clover extract (MF11RCE) on endometrium and sex hormones in postmenopausal womenMaturitas.(2006 Aug 20)
    22. Red Clover Extract - Knight DC, Howes JB, Eden JAThe effect of Promensil, an isoflavone extract, on menopausal symptomsClimacteric.(1999 Jun)
    23. Magnesium - Farsinejad-Marj M, Azadbakht L, Mardanian F, Saneei P, Esmaillzadeh AClinical and Metabolic Responses to Magnesium Supplementation in Women with Polycystic Ovary Syndrome.Biol Trace Elem Res.(2020-Aug)
    24. Tongkat Ali - Chan KQ, Stewart C, Chester N, Hamzah SH, Yusof AThe effect of Eurycoma Longifolia on the regulation of reproductive hormones in young males.Andrologia.(2021-May)
    25. Tongkat Ali - Sasikala M Chinnappan, Annie George, Pragya Pandey, Govinda Narke, Yogendra Kumar ChoudharyEffect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicentre studyFood Nutr Res.(2021 May 19)
    26. Tongkat Ali - Henkel RR, Wang R, Bassett SH, Chen T, Liu N, Zhu Y, Tambi MITongkat Ali as a potential herbal supplement for physically active male and female seniors--a pilot study.Phytother Res.(2014-Apr)
    27. Berberine - Xie L, Zhang D, Ma H, He H, Xia Q, Shen W, Chang H, Deng Y, Wu Q, Cong J, Wang CC, Wu XThe Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials.Evid Based Complement Alternat Med.(2019)
    28. N-Acetylcysteine - Zahra Shahveghar Asl, Karim Parastouei, Eslam EskandariThe effects of N-acetylcysteine on ovulation and sex hormones profile in women with polycystic ovary syndrome: a systematic review and meta-analysisBr J Nutr.(2023 Jan 4)
    29. Red Clover Extract - Katharine E Reed, Juliana Camargo, Jill Hamilton-Reeves, Mindy Kurzer, Mark MessinaNeither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studiesReprod Toxicol.(2021 Mar)
    30. DHEA - Marina L, Sojat AS, Maseroli E, Spaggiari G, Pandurevic S, Santi DHormonal profile of menopausal women receiving androgen replacement therapy: a meta-analysis.J Endocrinol Invest.(2020-Jun)
    31. Resveratrol - Ali Fadlalmola H, Elhusein AM, Al-Sayaghi KM, Albadrani MS, Swamy DV, Mamanao DM, El-Amin EI, Ibrahim SE, Abbas SMEfficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.Pan Afr Med J.(2023)
    32. Flaxseed - Musazadeh V, Nazari A, Natami M, Hajhashemy Z, Kazemi KS, Torabi F, Moridpour AH, Vajdi M, Askari GThe effect of flaxseed supplementation on sex hormone profile in adults: a systematic review and meta-analysis.Front Nutr.(2023)
    33. Probiotics - Ljunggren L, Butler E, Axelsson J, Åström M, Ohlsson LEffects of probiotic supplementation on testosterone levels in healthy ageing men: A 12-week double-blind, placebo-controlled randomized clinical trial.Contemp Clin Trials Commun.(2024 Jun)