Echinacea

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    Last Updated: October 13, 2024

    Echinacea purpurea is an herb commonly used either in response to or daily for prevention of the common cold. It outperforms placebo unreliably and the amount of benefit derived is similarly unreliable.

    What is Echinacea?

    The term "echinacea" refers to a genera of plants, and a few species in this family including purpurea and angustifolia are desired due to their alkylamide content (seen as the active ingredients). It's often taken as a tincture, but dry capsules are also common.

    What are Echinacea's benefits?

    Overall, echinacea appears to be somewhat effective for fighting off upper respiratory tract infections (mostly studied for the common cold), and when taken consistently as a prophylactic, it has support from research. It has also been studied for its potential ability to accelerate the rate of recovery in sickness, but the current evidence for that is highly ambiguous. There are trials suggesting remarkable recovery rates, and there are trials suggesting no benefits whatsoever. Overall, it doesn't look very potent. Limited research suggests that it can increase the levels of a variety of immune cells, but more research is needed to be confident in this.

    What are Echinacea's drawbacks and downsides?

    Echinacea hasn't demonstrated notably, greater adverse events in trials than placebo, however, as with herbal extracts in general, there may be a risk for drug interactions, particularly for those who take multiple medications.

    What are other names for Echinacea

    Note that Echinacea is also known as:
    • Brauneria purpurea
    • Echinacea intermedia
    • Rudbeckia purpurea
    • Purple coneflower herb
    • Coneflower
    • Red sunflower

    Dosage information

    For dehydrated powders (including encapsulated echinacea) the species of purpuera tends to be used and oral doses are taken upwards of 300mg thrice a day (900mg daily) and 500mg thrice daily (1,500mg daily).

    Tinctures of an ethanolic extract of the aerial parts (leaves and stems) appears to be used in the concentration of 2.5mL thrice a day or up to 10mL daily.

    There is no much evidence as to whether these are the optimal doses, and studies seem to be very hetereogeneous in their benefits due to lack of standardization.

    Research Breakdown

    References

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    3. ^Bahar Kaymakamzade, Rana Karabudak, Aslı Tuncer Kurne, Gülay NurluAcute Disseminated Encephalomyelitis after Oral Therapy with Herbal Extracts: A Case ReportBalkan Med J.(2016 May)
    4. ^Liatsos G, Elefsiniotis I, Todorova R, Moulakakis ASevere thrombotic thrombocytopenic purpura (TTP) induced or exacerbated by the immunostimulatory herb Echinacea.Am J Hematol.(2006 Mar)
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    9. ^Penzak SR, Robertson SM, Hunt JD, Chairez C, Malati CY, Alfaro RM, Stevenson JM, Kovacs JAEchinacea purpurea significantly induces cytochrome P450 3A activity but does not alter lopinavir-ritonavir exposure in healthy subjects.Pharmacotherapy.(2010 Aug)
    10. ^Mohi Iqbal Mohammed Abdul, Xuemin Jiang, Kenneth M Williams, Richard O Day, Basil D Roufogalis, Winston S Liauw, Hongmei Xu, Anita Matthias, Reginald P Lehmann, Andrew J McLachlanPharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjectsBr J Clin Pharmacol.(2010 May)
    11. ^Torstein Schrøder Hansen, Odd Georg NilsenEchinacea purpurea and P-glycoprotein drug transport in Caco-2 cellsPhytother Res.(2009 Jan)
    12. ^Christine M Gilroy, John F Steiner, Tim Byers, Howard Shapiro, William GeorgianEchinacea and truth in labelingArch Intern Med.(2003 Mar 24)
    13. ^Krochmal R, Hardy M, Bowerman S, Lu QY, Wang HJ, Elashoff R, Heber DPhytochemical Assays of Commercial Botanical Dietary Supplements.Evid Based Complement Alternat Med.(2004 Dec)
    14. ^M Gallo, M Sarkar, W Au, K Pietrzak, B Comas, M Smith, T V Jaeger, A Einarson, G KorenPregnancy outcome following gestational exposure to echinacea: a prospective controlled studyArch Intern Med.(2000 Nov 13)