Alzheimer’s Disease

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    Morgan Pfiffner

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    Marina Shkayeva, Igor Deoli
    Last Updated: October 17, 2023

    Alzheimer’s disease is a neurodegenerative disorder that impairs cognitive function, especially memory formation. It is the most common type of dementia.

    97 references on this page
    29,573 participants in 32 trials and 9 meta-analyses

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    Examine Database: Alzheimer’s Disease

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    Examine Database References

    1. Alzheimer's Disease Symptoms - Jingya Jia, Jing Hu, Xiaoxu Huo, Rujuan Miao, Yanping Zhang, Fei MaEffects of vitamin D supplementation on cognitive function and blood Aβ-related biomarkers in older adults with Alzheimer's disease: a randomised, double-blind, placebo-controlled trialJ Neurol Neurosurg Psychiatry.(2019 Dec)
    2. Alzheimer's Disease Symptoms - I-Chen Li, Han-Hsin Chang, Chuan-Han Lin, Wan-Ping Chen, Tsung-Han Lu, Li-Ya Lee, Yu-Wen Chen, Yen-Po Chen, Chin-Chu Chen, David Pei-Cheng LinPrevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled StudyFront Aging Neurosci.(2020 Jun 3)
    3. Alzheimer's Disease Symptoms - Soon-Tae Lee, Kon Chu, Ji-Young Sim, Jae-Hyeok Heo, Manho KimPanax ginseng enhances cognitive performance in Alzheimer diseaseAlzheimer Dis Assoc Disord.(Jul-Sep 2008)
    4. Alzheimer's Disease Symptoms - Jae-Hyeok Heo, Soon-Tae Lee, Min Jung Oh, Hyun-Jung Park, Ji-Young Shim, Kon Chu, Manho KimImprovement of cognitive deficit in Alzheimer's disease patients by long term treatment with korean red ginsengJ Ginseng Res.(2011 Nov)
    5. Alzheimer's Disease Symptoms - Jae-Hyeok Heo, Soon-Tae Lee, Kon Chu, Min Jung Oh, Hyun-Jung Park, Ji-Young Shim, Manho KimHeat-processed ginseng enhances the cognitive function in patients with moderately severe Alzheimer's diseaseNutr Neurosci.(2012 Nov)
    6. Alzheimer's Disease Symptoms - Lee, Soon-Tae., Chu, Kon., Kim, Jeong-Min., Park, Hyun-Jeong., Kim, Man-Ho Cognitive improvement by ginseng in Alzheimer's diseaseJournal of Ginseng Research.()
    7. Cognitive Decline - Heo JH, Lee ST, Chu K, Oh MJ, Park HJ, Shim JY, Kim MAn open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer's diseaseEur J Neurol.(2008 Aug)
    8. Alzheimer's Disease Symptoms - Dysken MW, Sano M, Asthana S, Vertrees JE, Pallaki M, Llorente M, Love S, Schellenberg GD, McCarten JR, Malphurs J, Prieto S, Chen P, Loreck DJ, Trapp G, Bakshi RS, Mintzer JE, Heidebrink JL, Vidal-Cardona A, Arroyo LM, Cruz AR, Zachariah S, Kowall NW, Chopra MP, Craft S, Thielke S, Turvey CL, Woodman C, Monnell KA, Gordon K, Tomaska J, Segal Y, Peduzzi PN, Guarino PDEffect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trialJAMA.(2014 Jan 1)
    9. Alzheimer's Disease Symptoms - Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, Woodbury P, Growdon J, Cotman CW, Pfeiffer E, Schneider LS, Thal LJA controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative StudyN Engl J Med.(1997 Apr 24)
    10. Cognition - Farina N, Llewellyn D, Isaac MGEKN, Tabet NVitamin E for Alzheimer's dementia and mild cognitive impairment.Cochrane Database Syst Rev.(2017 Apr 18)
    11. Alzheimer's Disease Risk - Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, Galasko D, Jin S, Kaye J, Levey A, Pfeiffer E, Sano M, van Dyck CH, Thal LJ, Alzheimer's Disease Cooperative Study GroupVitamin E and donepezil for the treatment of mild cognitive impairmentN Engl J Med.(2005 Jun 9)
    12. Alzheimer's Disease Risk - Wang W, Li J, Zhang H, Wang X, Zhang XEffects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis.Nutr Neurosci.(2021 Jan)
    13. Alzheimer's Disease Symptoms - Quinn JF, Raman R, Thomas RG, Yurko-Mauro K, Nelson EB, Van Dyck C, Galvin JE, Emond J, Jack CR Jr, Weiner M, Shinto L, Aisen PSDocosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trialJAMA.(2010 Nov 3)
    14. Alzheimer's Disease Symptoms - Green RC, Goldstein FC, Auchus AP, Presley R, Clark WS, Van Tuyl L, Green J, Hersch SM, Karp HRTreatment trial of oxiracetam in Alzheimer's diseaseArch Neurol.(1992 Nov)
    15. Alzheimer's Disease Symptoms - Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi ASaffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trialJ Clin Pharm Ther.(2010 Oct)
    16. Alzheimer's Disease Symptoms - Mehdi Farokhnia, Mehdi Shafiee Sabet, Negar Iranpour, Amirhossein Gougol, Habibeh Yekehtaz, Roozbeh Alimardani, Farzaneh Farsad, Maryam Kamalipour, Shahin AkhondzadehComparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trialHum Psychopharmacol.(2014 Jul)
    17. Alzheimer's Disease Symptoms - Akhondzadeh S, Shafiee Sabet M, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SS, Yousefi MH, Alimardani R, Jamshidi A, Rezazadeh SA, Yousefi A, Zare F, Moradi A, Vossoughi AA 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's diseasePsychopharmacology (Berl).(2010 Jan)
    18. Alzheimer's Disease Symptoms - Sudesh Prabhakar, Venugopalan Y Vishnu, Manish Modi, Manju Mohanty, Anchal Sharma, Bikas Medhi, B R Mittal, Niranjan Khandelwal, Manoj K Goyal, Vivek Lal, Rajesh Singla, Avinash Kansal, Ajit AvasthiEfficacy of Bacopa Monnieri (Brahmi) and Donepezil in Alzheimer's Disease and Mild Cognitive Impairment: A Randomized Double-Blind Parallel Phase 2b StudyAnn Indian Acad Neurol.(Nov-Dec 2020)
    19. Alzheimer's Disease Symptoms - Herrschaft H, Nacu A, Likhachev S, Sholomov I, Hoerr R, Schlaefke SGinkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mgJ Psychiatr Res.(2012 Jun)
    20. Alzheimer's Disease Symptoms - Ihl R, Tribanek M, Bachinskaya N, GOTADAY Study GroupEfficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761® in Alzheimer's disease and vascular dementia: results from a randomised controlled trialPharmacopsychiatry.(2012 Mar)
    21. Cognitive Decline - Yancheva S, Ihl R, Nikolova G, Panayotov P, Schlaefke S, Hoerr R, GINDON Study GroupGinkgo biloba extract EGb 761(R), donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: a randomised, double-blind, exploratory trialAging Ment Health.(2009 Mar)
    22. Cognitive Decline - Vellas B, Coley N, Ousset PJ, Berrut G, Dartigues JF, Dubois B, Grandjean H, Pasquier F, Piette F, Robert P, Touchon J, Garnier P, Mathiex-Fortunet H, Andrieu S, GuidAge Study GroupLong-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trialLancet Neurol.(2012 Oct)
    23. Alzheimer's Disease Symptoms - Barak Y, Levine J, Glasman A, Elizur A, Belmaker RHInositol treatment of Alzheimer's disease: a double blind, cross-over placebo controlled trialProg Neuropsychopharmacol Biol Psychiatry.(1996 May)
    24. Alzheimer's Disease Symptoms - Salloway S, Sperling R, Keren R, Porsteinsson AP, van Dyck CH, Tariot PN, Gilman S, Arnold D, Abushakra S, Hernandez C, Crans G, Liang E, Quinn G, Bairu M, Pastrak A, Cedarbaum JM, ELND005-AD201 InvestigatorsA phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer diseaseNeurology.(2011 Sep 27)
    25. Alzheimer's Disease Symptoms - De Jesus Moreno Moreno MCognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trialClin Ther.(2003 Jan)
    26. Cognitive Decline - Engel RR, Satzger W, Günther W, Kathmann N, Bove D, Gerke S, Münch U, Hippius HDouble-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer typeEur Neuropsychopharmacol.(1992 Jun)
    27. Cognitive Decline - Crook T, Petrie W, Wells C, Massari DCEffects of phosphatidylserine in Alzheimer's diseasePsychopharmacol Bull.(1992)
    28. Cognitive Decline - Klinkhammer P, Szelies B, Heiss W.D.Effect of Phosphatidylserine on Cerebral Glucose Metabolism in Alzheimer's DiseaseDementia and Geriatric Cognitive Disorders.()
    29. Cognitive Decline - Dubois B, Zaim M, Touchon J, Vellas B, Robert P, Murphy MF, Pujadas-Navinés F, Rainer M, Soininen H, Riordan HJ, Kanony-Truc CEffect of six months of treatment with V0191 in patients with suspected prodromal Alzheimer's diseaseJ Alzheimers Dis.(2012)
    30. Cognitive Decline - Baum L, Lam CW, Cheung SK, Kwok T, Lui V, Tsoh J, Lam L, Leung V, Hui E, Ng C, Woo J, Chiu HF, Goggins WB, Zee BC, Cheng KF, Fong CY, Wong A, Mok H, Chow MS, Ho PC, Ip SP, Ho CS, Yu XW, Lai CY, Chan MH, Szeto S, Chan IH, Mok VSix-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer diseaseJ Clin Psychopharmacol.(2008 Feb)
    31. Cognitive Decline - Croisile B, Trillet M, Fondarai J, Laurent B, Mauguière F, Billardon MLong-term and high-dose piracetam treatment of Alzheimer's diseaseNeurology.(1993 Feb)
    32. Cognition - Konstantinos I Avgerinos, Josephine M Egan, Mark P Mattson, Dimitrios KapogiannisMedium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studiesAgeing Res Rev.(2020 Mar)
    33. Cognition - Carolina B Castro, Cintia B Dias, Heidi Hillebrandt, Hamid R Sohrabi, Pratishtha Chatterjee, Tejal M Shah, Stephanie J Fuller, Manohar L Garg, Ralph N MartinsMedium-chain fatty acids for the prevention or treatment of Alzheimer's disease: a systematic review and meta-analysisNutr Rev.(2023 Jan 12)
    34. Cognition - Meer N, Fischer TMedium-Chain Triglycerides (MCTs) for the Symptomatic Treatment of Dementia-Related Diseases: A Systematic Review.J Nutr Metab.(2024)
    35. Cognition - Chiu S, Gericke N, Farina-Woodbury M, Badmaev V, Raheb H, Terpstra K, Antongiorgi J, Bureau Y, Cernovsky Z, Hou J, Sanchez V, Williams M, Copen J, Husni M, Goble LProof-of-Concept Randomized Controlled Study of Cognition Effects of the Proprietary Extract Sceletium tortuosum (Zembrin) Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects: Implications for Alzheimer's DementiaEvid Based Complement Alternat Med.(2014)
    36. Cognition - Kalamara TV, Dodos K, Georgakopoulou VE, Fotakopoulos G, Spandidos DA, Kapoukranidou DCognitive efficacy of omega‑3 fatty acids in Alzheimer's disease: A systematic review and meta‑analysis.Biomed Rep.(2025 Apr)
    37. Dementia Symptoms - Lott IT, Doran E, Nguyen VQ, Tournay A, Head E, Gillen DLDown syndrome and dementia: a randomized, controlled trial of antioxidant supplementationAm J Med Genet A.(2011 Aug)
    38. C-Reactive Protein (CRP) - Armita Mahdavi Gorabi, Saeed Aslani, Danyal Imani, Bahman Razi, Thozhukat Sathyapalan, Amirhossein SahebkarEffect of resveratrol on C-reactive protein: An updated meta-analysis of randomized controlled trialsPhytother Res.(2021 Dec)
    39. Weight - Mousavi SM, Milajerdi A, Sheikhi A, Kord-Varkaneh H, Feinle-Bisset C, Larijani B, Esmaillzadeh AResveratrol supplementation significantly influences obesity measures: a systematic review and dose-response meta-analysis of randomized controlled trials.Obes Rev.(2019-Mar)
    40. Body Mass Index (BMI) - Ko J, Park SEffects of aerobic exercise on beta-amyloid, insulin resistance, and blood markers in obese middle-aged women.Phys Act Nutr.(2024 Dec)
    41. Depression Symptoms - Seok JW, Kim JDLight Therapy for Older People with Depressive Symptoms: Systematic Review and Meta-Analysis.J Clin Med.(2024 Nov 20)