Polycystic Ovary Syndrome (PCOS)

    Last Updated: October 13, 2024

    Polycystic ovary syndrome (PCOS) is a hormone disorder that is common among women of reproductive age. PCOS is often caused by high androgen levels and frequently involves infertility, cysts on the ovaries, and metabolic abnormalities.

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    Examine Database: Polycystic Ovary Syndrome (PCOS)

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    Examine Database References

    1. Blood glucose - Donà G, Sabbadin C, Fiore C, Bragadin M, Giorgino FL, Ragazzi E, Clari G, Bordin L, Armanini DInositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndromeEur J Endocrinol.(2012 Apr)
    2. Blood glucose - Miñambres I, Cuixart G, Gonçalves A, Corcoy REffects of inositol on glucose homeostasis: Systematic review and meta-analysis of randomized controlled trialsClin Nutr.(2019 Jun)
    3. Blood glucose - Costantino D, Minozzi G, Minozzi E, Guaraldi CMetabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trialEur Rev Med Pharmacol Sci.(2009 Mar-Apr)
    4. Blood glucose - M Nordio, E ProiettiThe combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation aloneEur Rev Med Pharmacol Sci.(2012 May)
    5. Blood glucose - Gerli S, Mignosa M, Di Renzo GCEffects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trialEur Rev Med Pharmacol Sci.(2003 Nov-Dec)
    6. Blood glucose - Alessandro D Genazzani, Alessia Prati, Susanna Santagni, Federica Ricchieri, Elisa Chierchia, Erica Rattighieri, Annalisa Campedelli, Tommaso Simoncini, Paolo G ArtiniDifferential insulin response to myo-inositol administration in obese polycystic ovary syndrome patientsGynecol Endocrinol.(2012 Dec)
    7. Blood glucose - Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Várbíró S, Horváth EMInositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.Reprod Biol Endocrinol.(2023-Jan-26)
    8. PCOS Symptoms - Papaleo E, Unfer V, Baillargeon JP, Fusi F, Occhi F, De Santis LMyo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trialFertil Steril.(2009 May)
    9. PCOS Symptoms - Raffone E, Rizzo P, Benedetto VInsulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS womenGynecol Endocrinol.(2010 Apr)
    10. PCOS Symptoms - Unfer V, Carlomagno G, Rizzo P, Raffone E, Roseff SMyo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trialEur Rev Med Pharmacol Sci.(2011 Apr)
    11. PCOS Symptoms - Ciotta L, Stracquadanio M, Pagano I, Carbonaro A, Palumbo M, Gulino FEffects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trialEur Rev Med Pharmacol Sci.(2011 May)
    12. PCOS Symptoms - Enrico Papaleo, Vittorio Unfer, Jean-Patrice Baillargeon, Lucia De Santis, Francesco Fusi, Claudio Brigante, Guido Marelli, Ilaria Cino, Anna Redaelli, Augusto FerrariMyo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation inductionGynecol Endocrinol.(2007 Dec)
    13. PCOS Symptoms - Genazzani AD, Lanzoni C, Ricchieri F, Jasonni VMMyo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndromeGynecol Endocrinol.(2008 Mar)
    14. PCOS Symptoms - Iuorno MJ, Jakubowicz DJ, Baillargeon JP, Dillon P, Gunn RD, Allan G, Nestler JEEffects of d-chiro-inositol in lean women with the polycystic ovary syndromeEndocr Pract.(2002 Nov-Dec)
    15. PCOS Symptoms - Zacchè MM, Caputo L, Filippis S, Zacchè G, Dindelli M, Ferrari AEfficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndromeGynecol Endocrinol.(2009 Aug)
    16. Gestational Diabetes Risk - D'Anna R, Di Benedetto V, Rizzo P, Raffone E, Interdonato ML, Corrado F, Di Benedetto AMyo-inositol may prevent gestational diabetes in PCOS womenGynecol Endocrinol.(2012 Jun)
    17. Pregnancy Complications - Showell MG, Mackenzie-Proctor R, Jordan V, Hodgson R, Farquhar CInositol for subfertile women with polycystic ovary syndrome.Cochrane Database Syst Rev.(2018-12-20)
    18. Blood glucose - Izadi A, Ebrahimi S, Shirazi S, Taghizadeh S, Parizad M, Farzadi L, Gargari BPHormonal and Metabolic Effects of Coenzyme Q10 and/or Vitamin E in Patients With Polycystic Ovary SyndromeJ Clin Endocrinol Metab.(2019 Feb 1)
    19. High-density lipoprotein (HDL) - Tianqing Zhang, Qi He, Hao Xiu, ZiZhu Zhang, Yao Liu, Zhenrong Chen, Hengjing HuEfficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysisReprod Sci.(2022 Aug 8)
    20. Blood glucose - Vargas ML, Almario RU, Buchan W, Kim K, Karakas SEMetabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndromeMetabolism.(2011 Dec)
    21. Blood glucose - Zhou J, Zuo W, Tan Y, Wang X, Zhu M, Zhang HEffects of n-3 polyunsaturated fatty acid on metabolic status in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials.J Ovarian Res.(2023-Mar-17)
    22. Blood glucose - Mansooreh Samimi, Mehri Jamilian, Faraneh Afshar Ebrahimi, Maryam Rahimi, Banafsheh Tajbakhsh, Zatollah AsemiOral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trialClin Endocrinol (Oxf).(2016 Jun)
    23. Oxidative Stress Biomarkers - Hamidreza Jamilian, Mehri Jamilian, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Maryam Rahimi, Fereshteh Bahmani, Sama Aghababayan, Mobina Kouhi, Sedighe Shahabbaspour, Zatollah AsemiOral carnitine supplementation influences mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trialGynecol Endocrinol.(2017 Jun)
    24. Insulin - Gong Y, Jiang T, He H, Wang Y, Wu GL, Shi Y, Cai Q, Xiong CL, Shen R, Li JEffects of carnitine on glucose and lipid metabolic profiles and fertility outcomes in women with polycystic ovary syndrome: A systematic review and meta-analysis.Clin Endocrinol (Oxf).(2023-May)
    25. C-Reactive Protein (CRP) - Hamid Reza Talari, Zeinab Jafari Azad, Yaser Hamidian, Mansooreh Samimi, Hamid Reza Gilasi, Faraneh Ebrahimi Afshar, Vahidreza Ostadmohammadi, Zatollah AsemiEffects of Carnitine Administration on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome: A Randomized, Double-blind, Placebo-controlled TrialInt J Prev Med.(2019 Jun 7)
    26. Body Mass Index (BMI) - Mohd Falihin Mohd Shukri, Mohd Noor Norhayati, Salziyan Badrin, Azidah Abdul KadirEffects of L-carnitine supplementation for women with polycystic ovary syndrome: a systematic review and meta-analysisPeerJ.(2022 Sep 16)
    27. Blood glucose - Tang XL, Sun Z, Gong LChromium supplementation in women with polycystic ovary syndrome: Systematic review and meta-analysisJ Obstet Gynaecol Res.(2018 Jan)
    28. Oxidative Stress Biomarkers - Jamilian M, Bahmani F, Siavashani MA, Mazloomi M, Asemi Z, Esmaillzadeh AThe Effects of Chromium Supplementation on Endocrine Profiles, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled TrialBiol Trace Elem Res.(2016 Jul)
    29. Oxidative Stress Biomarkers - Morvaridzadeh M, Estêvão MD, Qorbani M, Heydari H, Hosseini AS, Fazelian S, Belančić A, Persad E, Rezamand G, Heshmati JThe effect of chromium intake on oxidative stress parameters: A systematic review and meta-analysis.J Trace Elem Med Biol.(2022-Jan)
    30. Glycemic Control - Jamilian M, Asemi ZChromium Supplementation and the Effects on Metabolic Status in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled TrialAnn Nutr Metab.(2015)
    31. Glycemic Control - Lydic ML, McNurlan M, Bembo S, Mitchell L, Komaroff E, Gelato MChromium picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndromeFertil Steril.(2006 Jul)
    32. C-Reactive Protein (CRP) - Zhang X, Cui L, Chen B, Xiong Q, Zhan Y, Ye J, Yin QEffect of chromium supplementation on hs-CRP, TNF-α and IL-6 as risk factor for cardiovascular diseases: A meta-analysis of randomized-controlled trials.Complement Ther Clin Pract.(2021-Feb)
    33. Blood glucose - Farsinejad-Marj M, Azadbakht L, Mardanian F, Saneei P, Esmaillzadeh AClinical and Metabolic Responses to Magnesium Supplementation in Women with Polycystic Ovary Syndrome.Biol Trace Elem Res.(2020-Aug)
    34. Blood glucose - Abu-Zaid A, Alzayed MM, Albahrani SJ, Almaqhawi A, Al Shaikh MA, Baradwan S, Almudiheem NA, Abuzaid M, Adly HM, Saleh SAK, Alomar ODoes Magnesium Affect Sex Hormones and Cardiometabolic Risk Factors in Patients with PCOS? Findings from a Systematic Review and Meta-Analysis.Medicina (Kaunas).(2025 Feb 6)
    35. Oxidative Stress Biomarkers - Reihaneh Mousavi, Mohammad Alizadeh, Mohammad Asghari Jafarabadi, Lida Heidari, Roshan Nikbakht, Hossein Babaahmadi Rezaei, Majid KarandishEffects of Melatonin and/or Magnesium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled TrialBiol Trace Elem Res.(2021 May 19)
    36. Insulin - Mohammad Alizadeh, Majid Karandish, Mohammad Asghari Jafarabadi, Lida Heidari, Roshan Nikbakht, Hossein Babaahmadi Rezaei, Reihaneh MousaviMetabolic and hormonal effects of melatonin and/or magnesium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trialNutr Metab (Lond).(2021 Jun 6)
    37. Acne Symptoms - Jaripur M, Ghasemi-Tehrani H, Askari G, Gholizadeh-Moghaddam M, Clark CCT, Rouhani MHThe effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial.Reprod Biol Endocrinol.(2022-Aug-02)
    38. Blood glucose - Xie L, Zhang D, Ma H, He H, Xia Q, Shen W, Chang H, Deng Y, Wu Q, Cong J, Wang CC, Wu XThe Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials.Evid Based Complement Alternat Med.(2019)
    39. Blood glucose - Zamani M, Zarei M, Nikbaf-Shandiz M, Hosseini S, Shiraseb F, Asbaghi OThe effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis.Front Nutr.(2022)
    40. High-density lipoprotein (HDL) - Blais JE, Huang X, Zhao JVOverall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.Drugs.(2023-Apr)
    41. Blood glucose - Liu J, Su H, Jin X, Wang L, Huang JThe effects of N-acetylcysteine supplement on metabolic parameters in women with polycystic ovary syndrome: a systematic review and meta-analysis.Front Nutr.(2023)
    42. Fertility - Devi N, Boya C, Chhabra M, Bansal DN-acetyl-cysteine as adjuvant therapy in female infertility: a systematic review and meta-analysis.J Basic Clin Physiol Pharmacol.(2020-Nov-19)
    43. Follicle-Stimulating Hormone - Zahra Shahveghar Asl, Karim Parastouei, Eslam EskandariThe effects of N-acetylcysteine on ovulation and sex hormones profile in women with polycystic ovary syndrome: a systematic review and meta-analysisBr J Nutr.(2023 Jan 4)
    44. Blood glucose - Heshmati J, Sepidarkish M, Morvaridzadeh M, Farsi F, Tripathi N, Razavi M, Rezaeinejad MThe effect of cinnamon supplementation on glycemic control in women with polycystic ovary syndrome: A systematic review and meta-analysis.J Food Biochem.(2021 Jan)
    45. Blood glucose - Yu M, Chen S, Liu X, Dong H, Wang DCThe impact of vitamin D supplementation on glycemic control and lipid metabolism in polycystic ovary syndrome: a systematic review of randomized controlled trials.BMC Endocr Disord.(2025 Apr 21)
    46. Oxidative Stress Biomarkers - Wei Y, Zhang X, Meng Y, Wang Q, Xu H, Chen LThe Effects of Resistant Starch on Biomarkers of Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.Nutr Cancer.(2022)
    47. Insulin - Yin S, Zhu F, Zhou Q, Chen M, Wang X, Chen QLack of Efficacy of Pomegranate Supplementation on Insulin Resistance and Sensitivity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Phytother Res.(2024 Nov 5)
    48. Insulin - Nasiri M, Monazzami A, Alavimilani S, Asemi ZModulation of hormonal, metabolic, inflammatory and oxidative stress biomarkers in women with polycystic ovary syndrome following combined (resistant and endurance) training: a randomized controlled trail.BMC Endocr Disord.(2025 Jan 2)
    49. Weight - Hu R, Zhang L, Zhu J, Zhao S, Yin L, Hu JWeight loss effects of non-pharmacological interventions in women with polycystic ovary syndrome: a systematic review and network meta-analysis.PeerJ.(2025)
    50. Weight - Mousavi SM, Milajerdi A, Sheikhi A, Kord-Varkaneh H, Feinle-Bisset C, Larijani B, Esmaillzadeh AResveratrol supplementation significantly influences obesity measures: a systematic review and dose-response meta-analysis of randomized controlled trials.Obes Rev.(2019-Mar)
    51. High-density lipoprotein (HDL) - Larik MO, Ahmed A, Khan L, Iftekhar MAEffects of resveratrol on polycystic ovarian syndrome: a systematic review and meta-analysis of randomized controlled trials.Endocrine.(2024-Jan)
    52. Total cholesterol - Ali Fadlalmola H, Elhusein AM, Al-Sayaghi KM, Albadrani MS, Swamy DV, Mamanao DM, El-Amin EI, Ibrahim SE, Abbas SMEfficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.Pan Afr Med J.(2023)
    53. TNF-Alpha - Melodi Omraninava, Bahman Razi, Saeed Aslani, Danyal Imani, Tannaz Jamialahmadi, Amirhossein SahebkarEffect of resveratrol on inflammatory cytokines: A meta-analysis of randomized controlled trialsEur J Pharmacol.(2021 Oct 5)
    54. Blood Urea Nitrogen (BUN) - Abdollahi S, Vajdi M, Meshkini F, Vasmehjani AA, Sangsefidi ZS, Clark CCT, Soltani SResveratrol may mildly improve renal function in the general adult population: A systematic review and meta-analysis of randomized controlled clinical trials.Nutr Res.(2023-May)
    55. Endothelial Function - Mohammadipoor N, Shafiee F, Rostami A, Kahrizi MS, Soleimanpour H, Ghodsi M, Ansari MJ, Bokov DO, Jannat B, Mosharkesh E, Pour Abbasi MSResveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials.Phytother Res.(2022-Sep)
    56. Body Mass Index (BMI) - Hooshmandi H, Ghadiri-Anari A, Ranjbar AM, Fallahzadeh H, Hosseinzadeh M, Nadjarzadeh AEffects of licorice extract in combination with a low-calorie diet on obesity indices, glycemic indices, and lipid profiles in overweight/obese women with polycystic ovary syndrome (PCOS): a randomized, double-blind, placebo-controlled trial.J Ovarian Res.(2024 Jul 30)
    57. Depression Symptoms - Varaee H, Darand M, Hassanizadeh S, Hosseinzadeh MEffect of low-carbohydrate diet on depression and anxiety: A systematic review and meta-analysis of controlled trials.J Affect Disord.(2023-Mar-15)