Fatigue Symptoms

    Last Updated: October 13, 2024

    Fatigue is a decrease in energy that lowers motivation and mental and physical performance. Some supplements are stimulants; they provide a temporary boost. Others may help by improving sleep (if bad sleep is a cause) or energy metabolism (either directly or by affecting hormones).

    15,687 participants in 150 trials

    Summary

    Fatigue is a reduction in the amount of energy that one is able to expend and goes hand in hand with a lack of motivation. While physical and mental fatigue are often found together, they're distinct as well. This page contains information on both. It's also helpful to distinguish between acute and chronic fatigue. Acute fatigue is normal and derives from doing tiring activities such as exercising, staying up later than usual, or doing mentally demanding work. Chronic fatigue is when, regardless of your activities, you're generally fatigued and lacking motivation. This isn't normal and suggests that something is wrong. The causes of chronic fatigue are numerous and include insomnia/poor sleep quality, stress, anxiety, depression, metabolic abnormalities, severe nutrient deficiencies, use of drugs, and a lack of exercise, among many others.

    Supplements on this page may work through ameliorating the various sleep and mood issues that can lead to fatigue, by being neuroprotective (as much fatigue is due to neural dysfunction) affecting metabolism, hormones, and neurological function, among other roles. For this reason, simply because a supplement can reduce fatigue in some instances doesn't mean that it will work for everyone.

    Examine Database: Fatigue Symptoms

    InterventionGradeEffectDetail
    Rhodiola Rosea
    A
    L-Carnitine
    B
    Panax Ginseng (Korean Ginseng)
    B
    Branched-Chain Amino Acids
    Cannabis
    Coenzyme Q10
    Creatine
    Beta-Alanine
    Ashwagandha
    Low-FODMAP Diet
    L-Tyrosine
    Vitamin D
    Fish Oil
    Citrulline
    Phosphatidylserine
    Glycine
    HMB
    Vitamin B12
    Choline
    Caffeine
    Tribulus Terrestris
    Spirulina
    Reishi
    Colostrum
    Binaural Beats
    Ornithine
    Betaine
    Tart Cherry Juice
    Specific Carbohydrate Diet (SCD)
    Vegan Diet
    Meditation
    Tongkat Ali
    Coleus forskohlii
    Curcumin
    Ginger
    Saffron
    Bacopa Monnieri
    Kefir
    Alanylglutamine
    Soy Protein
    Theanine
    Vitamin C
    Resveratrol
    Quercetin
    Magnesium
    Zinc
    Iron
    Phenylpiracetam
    7-Keto DHEA
    Lavender
    Chaste tree
    Lemon Balm
    Maca
    Cocoa Extract
    Valerian
    Pyruvate
    D-Ribose
    PQQ
    N-Acetylcysteine
    MSM
    16:8 Intermittent Fasting
    Diaphragmatic Breathing
    Honey
    Omega-3 Fatty Acids
    Pea Protein
    Pranayama Breathing
    Progressive Muscle Relaxation
    Sauna
    Yarrow
    Red Light Therapy

    Research FeedRead all studies

    Examine Database References

    1. Panax Ginseng (Korean Ginseng) - Meegun Hong, Yoon Hyeong Lee, Seungwoo Kim, Ki Tae Suk, Chang Seok Bang, Jai Hoon Yoon, Gwang Ho Baik, Dong Joon Kim, Myong Jo KimAnti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver diseaseJ Ginseng Res.(2016 Jul)
    2. Reishi - Tang W, Gao Y, Chen G, Gao H, Dai X, Ye J, Chan E, Huang M, Zhou SA randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurastheniaJ Med Food.(2005 Spring)
    3. Colostrum - Florén CH, Chinenye S, Elfstrand L, Hagman C, Ihse IColoPlus, a new product based on bovine colostrum, alleviates HIV-associated diarrhoeaScand J Gastroenterol.(2006 Jun)
    4. Citrulline - Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJCitrulline/malate promotes aerobic energy production in human exercising muscleBr J Sports Med.(2002 Aug)
    5. PQQ - Masahiko Nakano, Tetsuro Yamamoto, Hisayoshi Okamura, Akira Tsuda, Yasuyuki KowatariEffects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and SleepFunctional Foods in Health and Disease.()
    6. Fish Oil - Fontani G, Corradeschi F, Felici A, Alfatti F, Migliorini S, Lodi LCognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjectsEur J Clin Invest.(2005 Nov)
    7. Zinc - Siahbazi S, Behboudi-Gandevani S, Moghaddam-Banaem L, Montazeri AEffect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trialJ Obstet Gynaecol Res.(2017 May)
    8. Ashwagandha - Adrian L Lopresti, Peter D Drummond, Stephen J SmithA Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight MalesAm J Mens Health.(Mar-Apr 2019)
    9. Rhodiola Rosea - Cropley M, Banks AP, Boyle JThe Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood SymptomsPhytother Res.(2015 Dec)
    10. MSM - Kalman DS, Feldman S, Scheinberg AR, Krieger DR, Bloomer RJInfluence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot studyJ Int Soc Sports Nutr.(2012 Sep 27)
    11. Rhodiola Rosea - Shevtsov VA, Zholus BI, Shervarly VI, Vol'skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman GA randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental workPhytomedicine.(2003 Mar)
    12. Rhodiola Rosea - Ross SMRhodiola rosea (SHR-5), Part I: a proprietary root extract of Rhodiola rosea is found to be effective in the treatment of stress-related fatigueHolist Nurs Pract.(2014 Mar-Apr)
    13. 7-Keto DHEA - Douglas S. Kaiman, Carlon M. Colker, Melissa A. Swain, Georgeann C. Torina, Qiuhu ShiA randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adultsCurrent Therapeutic Research.()
    14. Creatine - Watanabe A, Kato N, Kato TEffects of creatine on mental fatigue and cerebral hemoglobin oxygenationNeurosci Res.(2002 Apr)
    15. Creatine - McMorris T, Harris RC, Swain J, Corbett J, Collard K, Dyson RJ, Dye L, Hodgson C, Draper NEffect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisolPsychopharmacology (Berl).(2006 Mar)
    16. Glycine - Wataru Yamadera, Kentaro Inagawa, Shintaro Chiba, Makoto Bannai, Michio Takahashi, Kazuhiko NakayamaGlycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changesSleep and Biological Rhythms.()
    17. Resveratrol - Kennedy DO, Wightman EL, Reay JL, Lietz G, Okello EJ, Wilde A, Haskell CFEffects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigationAm J Clin Nutr.(2010 Jun)
    18. Creatine - Deminice R, Rosa FT, Franco GS, Jordao AA, de Freitas ECEffects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humansNutrition.(2013 Sep)
    19. L-Tyrosine - Deijen JB, Wientjes CJ, Vullinghs HF, Cloin PA, Langefeld JJTyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training courseBrain Res Bull.(1999 Jan 15)
    20. L-Tyrosine - Harris R Lieberman, Lauren A Thompson, Christina M Caruso, Philip J Niro, Caroline R Mahoney, James P McClung, Gregory R CaronThe catecholamine neurotransmitter precursor tyrosine increases anger during exposure to severe psychological stressPsychopharmacology (Berl).(2015 Mar)
    21. Lemon Balm - Cases J, Ibarra A, Feuillère N, Roller M, Sukkar SGPilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbancesMed J Nutrition Metab.(2011 Dec)
    22. Low-FODMAP Diet - Heidi Maria Staudacher, Miranda C E Lomer, Freda M Farquharson, Petra Louis, Francesca Fava, Elena Franciosi, Matthias Scholz, Kieran M Tuohy, James O Lindsay, Peter M Irving, Kevin WhelanA Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled TrialGastroenterology.(2017 Oct)
    23. Coenzyme Q10 - Gökbel H, Gül I, Belviranl M, Okudan NThe effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary menJ Strength Cond Res.(2010 Jan)
    24. Ashwagandha - Cooley K, Szczurko O, Perri D, Mills EJ, Bernhardt B, Zhou Q, Seely DNaturopathic care for anxiety: a randomized controlled trial ISRCTN78958974PLoS One.(2009 Aug 31)
    25. Rhodiola Rosea - Lekomtseva Y, Zhukova I, Wacker ARhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical TrialComplement Med Res.(2017)
    26. Coenzyme Q10 - Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar FCoenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trialNutr Neurosci.(2016)
    27. Vitamin B12 - Huijts M, van Oostenbrugge RJ, Rouhl RP, Menheere P, Duits AEffects of vitamin B12 supplementation on cognition, depression, and fatigue in patients with lacunar strokeInt Psychogeriatr.(2013 Mar)
    28. Phenylpiracetam - P P Kalinskiĭ, V V Nazarov[Use of phenotropil in the treatment of asthenic syndrome and autonomic disturbances in the acute period of mild cranial brain trauma]Zh Nevrol Psikhiatr Im S S Korsakova.(2007)
    29. Branched-Chain Amino Acids - Portier H, Chatard JC, Filaire E, Jaunet-Devienne MF, Robert A, Guezennec CYEffects of branched-chain amino acids supplementation on physiological and psychological performance during an offshore sailing raceEur J Appl Physiol.(2008 Nov)
    30. Betaine - Hoffman JR, Ratamess NA, Kang J, Gonzalez AM, Beller NA, Craig SAEffect of 15 days of betaine ingestion on concentric and eccentric force outputs during isokinetic exerciseJ Strength Cond Res.(2011 Aug)
    31. Colostrum - Kaducu FO, Okia SA, Upenytho G, Elfstrand L, Florén CHEffect of bovine colostrum-based food supplement in the treatment of HIV-associated diarrhea in Northern Uganda: a randomized controlled trialIndian J Gastroenterol.(2011 Dec)
    32. HMB - Gallagher PM, Carrithers JA, Godard MP, Schulze KE, Trappe SWBeta-hydroxy-beta-methylbutyrate ingestion, Part I: effects on strength and fat free massMed Sci Sports Exerc.(2000 Dec)
    33. Reishi - Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang XSpore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical TrialEvid Based Complement Alternat Med.(2012)
    34. Phosphatidylserine - Kingsley MI, Miller M, Kilduff LP, McEneny J, Benton DEffects of phosphatidylserine on exercise capacity during cycling in active malesMed Sci Sports Exerc.(2006 Jan)
    35. Maca - Gonzales-Arimborgo C, Yupanqui I, Montero E, Alarcón-Yaquetto DE, Zevallos-Concha A, Caballero L, Gasco M, Zhao J, Khan IA, Gonzales GFAcceptability, Safety, and Efficacy of Oral Administration of Extracts of Black or Red Maca (Lepidium meyenii) in Adult Human Subjects: A Randomized, Double-Blind, Placebo-Controlled StudyPharmaceuticals (Basel).(2016 Aug 18)
    36. Branched-Chain Amino Acids - Wiśnik P, Chmura J, Ziemba AW, Mikulski T, Nazar KThe effect of branched chain amino acids on psychomotor performance during treadmill exercise of changing intensity simulating a soccer gameAppl Physiol Nutr Metab.(2011 Dec)
    37. Choline - Spector SA, Jackman MR, Sabounjian LA, Sakkas C, Landers DM, Willis WTEffect of choline supplementation on fatigue in trained cyclistsMed Sci Sports Exerc.(1995 May)
    38. HMB - Hoffman JR, Cooper J, Wendell M, Im J, Kang JEffects of beta-hydroxy beta-methylbutyrate on power performance and indices of muscle damage and stress during high-intensity trainingJ Strength Cond Res.(2004 Nov)
    39. Vitamin D - Majid MS, Ahmad HS, Bizhan H, Hosein HZM, Mohammad AThe effect of vitamin D supplement on the score and quality of sleep in 20-50 year-old people with sleep disorders compared with control groupNutr Neurosci.(2018 Sep)
    40. L-Carnitine - Jun-jie Zhang, Zhi-bing Wu, You-jin Cai, Bin Ke, Ying-juan Huang, Chao-ping Qiu, Yu-bing Yang, Lan-ying Shi, Jian QinL-carnitine ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in patients with metabolic syndrome: a randomized controlled studyNutr J.(2014 Nov 26)
    41. Rhodiola Rosea - Salima Punja, Larissa Shamseer, Karin Olson, Sunita VohraRhodiola Rosea for Mental and Physical Fatigue in Nursing Students: A Randomized Controlled TrialPLoS.()
    42. Branched-Chain Amino Acids - Bigard AX, Lavier P, Ullmann L, Legrand H, Douce P, Guezennec CYBranched-chain amino acid supplementation during repeated prolonged skiing exercises at altitudeInt J Sport Nutr.(1996 Sep)
    43. Vitamin D - Amirhossein Ramezani Ahmadi, Majid Mohammadshahi, Aliakbar Alizadeh, Kambiz Ahmadi Angali, Alireza JahanshahiEffects of vitamin D3 supplementation for 12 weeks on serum levels of anabolic hormones, anaerobic power, and aerobic performance in active male subjects: A randomized, double-blind, placebo-controlled trialEur J Sport Sci.(2020 Nov)
    44. Cannabis - Jody Corey-Bloom, Tanya Wolfson, Anthony Gamst, Shelia Jin, Thomas D Marcotte, Heather Bentley, Ben GouauxSmoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trialCMAJ.(2012 Jul 10)
    45. Cannabis - Anthony N Nicholson, Claire Turner, Barbara M Stone, Philip J RobsonEffect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adultsJ Clin Psychopharmacol.(2004 Jun)
    46. Fish Oil - Behboudi-Gandevani S, Hariri FZ, Moghaddam-Banaem LThe effect of omega 3 fatty acid supplementation on premenstrual syndrome and health-related quality of life: a randomized clinical trialJ Psychosom Obstet Gynaecol.(2018 Dec)
    47. Rhodiola Rosea - Noreen EE, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJThe effects of an acute dose of Rhodiola rosea on endurance exercise performanceJ Strength Cond Res.(2013 Mar)
    48. Beta-Alanine - Sale C, Saunders B, Hudson S, Wise JA, Harris RC, Sunderland CDEffect of β-alanine plus sodium bicarbonate on high-intensity cycling capacityMed Sci Sports Exerc.(2011 Oct)
    49. Beta-Alanine - Stout JR, Cramer JT, Zoeller RF, Torok D, Costa P, Hoffman JR, Harris RC, O'Kroy JEffects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in womenAmino Acids.(2007)
    50. Beta-Alanine - Hoffman JR, Ratamess NA, Faigenbaum AD, Ross R, Kang J, Stout JR, Wise JAShort-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football playersNutr Res.(2008 Jan)
    51. Vegan Diet - Ulka Agarwal, Suruchi Mishra, Jia Xu, Susan Levin, Joseph Gonzales, Neal D BarnardA multicenter randomized controlled trial of a nutrition intervention program in a multiethnic adult population in the corporate setting reduces depression and anxiety and improves quality of life: the GEICO studyAm J Health Promot.(Mar-Apr 2015)
    52. Low-FODMAP Diet - Shanti Eswaran, William D Chey, Kenya Jackson, Sivaram Pillai, Samuel W Chey, Theresa Han-MarkeyA Diet Low in Fermentable Oligo-, Di-, and Monosaccharides and Polyols Improves Quality of Life and Reduces Activity Impairment in Patients With Irritable Bowel Syndrome and DiarrheaClin Gastroenterol Hepatol.(2017 Dec)
    53. Iron - Waldvogel S, Pedrazzini B, Vaucher P, Bize R, Cornuz J, Tissot JD, Favrat BClinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trialBMC Med.(2012 Jan 24)
    54. Spirulina - Sajjad Moradi, Mehdi Zobeiri, Awat Feizi, Cain C T Clark, Mohammad Hassan EntezariThe effects of spirulina (Arthrospira platensis) supplementation on anthropometric indices, blood pressure, sleep quality, mental health, fatigue status and quality of life in patients with ulcerative colitis: A randomised, double-blinded, placebo-controlled trialInt J Clin Pract.(2021 Jun 9)
    55. Creatine - Anomasiri W, Sanguanrungsirikul S, Saichandee PLow dose creatine supplementation enhances sprint phase of 400 meters swimming performanceJ Med Assoc Thai.(2004 Sep)
    56. L-Carnitine - Decombaz J, Deriaz O, Acheson K, Gmuender B, Jequier EEffect of L-carnitine on submaximal exercise metabolism after depletion of muscle glycogenMed Sci Sports Exerc.(1993 Jun)
    57. Binaural Beats - Jeong-Hwan Lim, Hyeri Kim, Chuljin Jeon, Soohyun ChoThe effects on mental fatigue and the cognitive function of mechanical massage and binaural beats (brain massage) provided by massage chairsComplement Ther Clin Pract.(2018 Aug)
    58. Rhodiola Rosea - Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VVA double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimenPhytomedicine.(2000 Apr)
    59. 16:8 Intermittent Fasting - Kelsey Gabel, Kristin K Hoddy, Krista A VaradySafety of 8-h time restricted feeding in adults with obesityAppl Physiol Nutr Metab.(2019 Jan)
    60. Citrulline - Pérez-Guisado J, Jakeman PMCitrulline malate enhances athletic anaerobic performance and relieves muscle sorenessJ Strength Cond Res.(2010 May)
    61. Rhodiola Rosea - Punja S, Shamseer L, Olson K, Vohra SRhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trialPLoS One.(2014 Sep 30)
    62. Branched-Chain Amino Acids - Shimizu M, Miyagawa K, Iwashita S, Noda T, Hamada K, Genno H, Nose HEnergy expenditure during 2-day trail walking in the mountains (2,857 m) and the effects of amino acid supplementation in older men and womenEur J Appl Physiol.(2012 Mar)
    63. Low-FODMAP Diet - Derrick K Ong, Shaylyn B Mitchell, Jacqueline S Barrett, Sue J Shepherd, Peter M Irving, Jessica R Biesiekierski, Stuart Smith, Peter R Gibson, Jane G MuirManipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndromeJ Gastroenterol Hepatol.(2010 Aug)
    64. Creatine - Schneider-Gold C, Beck M, Wessig C, George A, Kele H, Reiners K, Toyka KVCreatine monohydrate in DM2/PROMM: a double-blind placebo-controlled clinical study. Proximal myotonic myopathyNeurology.(2003 Feb 11)
    65. Saffron - Mansoor Shakiba, Ehsan Moazen-Zadeh, Ahmad Ali Noorbala, Morteza Jafarinia, Parisa Divsalar, Ladan Kashani, Nazila Shahmansouri, Abbas Tafakhori, Hannaneh Bayat, Shahin AkhondzadehSaffron ( Crocus sativus) versus duloxetine for treatment of patients with fibromyalgia: A randomized double-blind clinical trialAvicenna J Phytomed.(Nov-Dec 2018)
    66. Pyruvate - Kalman D, Colker CM, Wilets I, Roufs JB, Antonio JThe effects of pyruvate supplementation on body composition in overweight individualsNutrition.(1999 May)
    67. Phosphatidylserine - Parker AG, Gordon J, Thornton A, Byars A, Lubker J, Bartlett M, Byrd M, Oliver J, Simbo S, Rasmussen C, Greenwood M, Kreider RBThe effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exerciseJ Int Soc Sports Nutr.(2011 Oct 21)
    68. Alanylglutamine - Hoffman JR, Williams DR, Emerson NS, Hoffman MW, Wells AJ, McVeigh DM, McCormack WP, Mangine GT, Gonzalez AM, Fragala MSL-alanyl-L-glutamine ingestion maintains performance during a competitive basketball gameJ Int Soc Sports Nutr.(2012 Mar 7)
    69. Coenzyme Q10 - Mario D Cordero, Elísabet Alcocer-Gómez, Manuel de Miguel, Ognjen Culic, Angel M Carrión, José Miguel Alvarez-Suarez, Pedro Bullón, Maurizio Battino, Ana Fernández-Rodríguez, José Antonio Sánchez-AlcazarCan coenzyme q10 improve clinical and molecular parameters in fibromyalgia?Antioxid Redox Signal.(2013 Oct 20)
    70. Specific Carbohydrate Diet (SCD) - James D Lewis, Robert Sandler, Carol Brotherton, Colleen Brensinger, Hongzhe Li, Michael D Kappelman, Scott G Daniel, Kyle Bittinger, Lindsey Albenberg, John F Valentine, John Hanson, David Suskind, Andrea Meyer, Charlene W Compher, Meenakshi Bewtra, Akriti Saxena, Angela Dobes, Benjamin Cohen, Ann D Flynn, Monika Fischer, Sumona Saha, Arun Swaminath, Bruce Yacyshyn, Ellen Scherl, Sara Horst, Jeffrey R Curtis, Kimberly Braly, Lisa Nessel, Maureen McCauley, Liam McKeever, Hans Herfarth, DINE-CD Study GroupA Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults with Crohn's DiseaseGastroenterology.(2021 May 27)
    71. Cannabis - Zajicek JP, Sanders HP, Wright DE, Vickery PJ, Ingram WM, Reilly SM, Nunn AJ, Teare LJ, Fox PJ, Thompson AJCannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow upJ Neurol Neurosurg Psychiatry.(2005 Dec)
    72. L-Carnitine - Malaguarnera M, Gargante MP, Cristaldi E, Colonna V, Messano M, Koverech A, Neri S, Vacante M, Cammalleri L, Motta MAcetyl L-carnitine (ALC) treatment in elderly patients with fatigueArch Gerontol Geriatr.(2008 Mar-Apr)
    73. Caffeine - Paton CD, Lowe T, Irvine ACaffeinated chewing gum increases repeated sprint performance and augments increases in testosterone in competitive cyclistsEur J Appl Physiol.(2010 Dec)
    74. Citrulline - Hickner RC, Tanner CJ, Evans CA, Clark PD, Haddock A, Fortune C, Geddis H, Waugh W, McCammon ML-citrulline reduces time to exhaustion and insulin response to a graded exercise testMed Sci Sports Exerc.(2006 Apr)
    75. Branched-Chain Amino Acids - Blomstrand E, Hassmén P, Ek S, Ekblom B, Newsholme EAInfluence of ingesting a solution of branched-chain amino acids on perceived exertion during exerciseActa Physiol Scand.(1997 Jan)
    76. Binaural Beats - Vera Abeln, Jens Kleinert, Heiko K Strüder, Stefan SchneiderBrainwave entrainment for better sleep and post-sleep state of young elite soccer players - a pilot studyEur J Sport Sci.(2014)
    77. Cocoa Extract - Francis ST, Head K, Morris PG, Macdonald IAThe effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young peopleJ Cardiovasc Pharmacol.(2006)
    78. L-Carnitine - G Cavallini, S Caracciolo, G Vitali, F Modenini, G BiagiottiCarnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male agingUrology.(2004 Apr)
    79. Panax Ginseng (Korean Ginseng) - Tahereh Fathi Najafia, Narjes Bahrib, Hamid Reza Tohidinik, Sahar Feyza, Farnaz Blokia, Safora Savarkar, Shayesteh JahanfarTreatment of cancer-related fatigue with ginseng: A systematic review and meta-analysisJournal of Herbal Medicine.()
    80. Tribulus Terrestris - Antonio J, Uelmen J, Rodriguez R, Earnest CThe effects of Tribulus terrestris on body composition and exercise performance in resistance-trained malesInt J Sport Nutr Exerc Metab.(2000 Jun)
    81. L-Carnitine - Pistone G, Marino A, Leotta C, Dell'Arte S, Finocchiaro G, Malaguarnera MLevocarnitine administration in elderly subjects with rapid muscle fatigue: effect on body composition, lipid profile and fatigueDrugs Aging.(2003)
    82. Creatine - George Sakellaris, George Nasis, Maria Kotsiou, Maria Tamiolaki, Giorgos Charissis, Athanasios EvangeliouPrevention of traumatic headache, dizziness and fatigue with creatine administration. A pilot studyActa Paediatr.(2008 Jan)
    83. L-Carnitine - Vermeulen RC, Scholte HRExploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndromePsychosom Med.(2004 Mar-Apr)
    84. Branched-Chain Amino Acids - Blomstrand E, Hassmén P, Newsholme EAEffect of branched-chain amino acid supplementation on mental performanceActa Physiol Scand.(1991 Oct)
    85. Vitamin C - Huck CJ, Johnston CS, Beezhold BL, Swan PDVitamin C status and perception of effort during exercise in obese adults adhering to a calorie-reduced dietNutrition.(2012 Jun 5)
    86. Cannabis - Justin Matheson, Robert E Mann, Beth Sproule, Marilyn A Huestis, Christine M Wickens, Gina Stoduto, Tony P George, Jürgen Rehm, Bernard Le Foll, Bruna BrandsAcute and residual mood and cognitive performance of young adults following smoked cannabisPharmacol Biochem Behav.(2020 Jul)
    87. Coenzyme Q10 - Lee YJ, Cho WJ, Kim JK, Lee DCEffects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind randomized controlled studyJ Med Food.(2011 Apr)
    88. Coenzyme Q10 - Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe YAntifatigue effects of coenzyme Q10 during physical fatigueNutrition.(2008 Apr)
    89. L-Carnitine - Ciacci C, Peluso G, Iannoni E, Siniscalchi M, Iovino P, Rispo A, Tortora R, Bucci C, Zingone F, Margarucci S, Calvani ML-Carnitine in the treatment of fatigue in adult celiac disease patients: a pilot studyDig Liver Dis.(2007 Oct)
    90. Panax Ginseng (Korean Ginseng) - Namhun Lee, Suk-Hoon Lee, Ho-Ryong Yoo, Hwa Seung YooAnti-Fatigue Effects of Enzyme-Modified Ginseng Extract: A Randomized, Double-Blind, Placebo-Controlled TrialJ Altern Complement Med.(2016 Nov)
    91. Cannabis - Zajicek J, Fox P, Sanders H, Wright D, Vickery J, Nunn A, Thompson A, UK MS Research GroupCannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trialLancet.(2003 Nov 8)
    92. Vitamin D - Abdollahi R, Abiri B, Sarbakhsh P, Kashanian M, Vafa MThe Effect of Vitamin D Supplement Consumption on Premenstrual Syndrome in Vitamin D-Deficient Young Girls: A Randomized, Double-Blind, Placebo-Controlled Clinical TrialComplement Med Res.(2019)
    93. Coenzyme Q10 - Serag H, El Wakeel L, Adly ACoenzyme Q10 administration has no effect on sICAM-1 and metabolic parameters of pediatrics with type 1 diabetes mellitusInt J Vitam Nutr Res.(2020 Jan 16)
    94. L-Tyrosine - Erin E Sutton, M Regina Coill, Patricia A DeusterIngestion of tyrosine: effects on endurance, muscle strength, and anaerobic performanceInt J Sport Nutr Exerc Metab.(2005 Apr)
    95. Glycine - Kentaro Inagawa, Takenori Hiraoka, Tohru Kohda, Wataru Yamadera, Michio TakahashiSubjective effects of glycine ingestion before bedtime on sleep qualitySleep and Biological Rhythms.()
    96. Rhodiola Rosea - De Bock K, Eijnde BO, Ramaekers M, Hespel PAcute Rhodiola rosea intake can improve endurance exercise performanceInt J Sport Nutr Exerc Metab.(2004 Jun)
    97. Panax Ginseng (Korean Ginseng) - H J Engels, I Kolokouri, T J Cieslak 2nd, J C WirthEffects of ginseng supplementation on supramaximal exercise performance and short-term recoveryJ Strength Cond Res.(2001 Aug)
    98. Valerian - Barton DL, Atherton PJ, Bauer BA, Moore DF Jr, Mattar BI, Lavasseur BI, Rowland KM Jr, Zon RT, Lelindqwister NA, Nagargoje GG, Morgenthaler TI, Sloan JA, Loprinzi CLThe use of Valeriana officinalis (Valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5)J Support Oncol.(2011 Jan-Feb)
    99. L-Carnitine - Jee Hyun An, Yoon Jung Kim, Kyeong Jin Kim, Sun Hwa Kim, Nam Hoon Kim, Hee Young Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Sin Gon KimL-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trialEndocr J.(2016 Oct 29)
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