Blood Lactate (Exercise)

    Last Updated: October 13, 2024

    Lactate can be produced during prolonged exercise, and while it is not thought to contribute to muscular failure it seems to be a good biomarker of it. Reductions in lactate production tend to be associated with prolonged physical endurance.

    3,380 participants in 113 trials

    Examine Database: Blood Lactate (Exercise)

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    Examine Database References

    1. Chromium - Volek JS, Silvestre R, Kirwan JP, Sharman MJ, Judelson DA, Spiering BA, Vingren JL, Maresh CM, Vanheest JL, Kraemer WJEffects of chromium supplementation on glycogen synthesis after high-intensity exerciseMed Sci Sports Exerc.(2006 Dec)
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    4. Caffeine - Glaister M, Patterson SD, Foley P, Pedlar CR, Pattison JR, McInnes GCaffeine and sprinting performance: dose responses and efficacyJ Strength Cond Res.(2012 Apr)
    5. Sodium Bicarbonate - Price MJ, Simons CThe effect of sodium bicarbonate ingestion on high-intensity intermittent running and subsequent performanceJ Strength Cond Res.(2010 Jul)
    6. Cocoa Extract - Glen Davison, Robin Callister, Gary Williamson, Karen A Cooper, Michael GleesonThe effect of acute pre-exercise dark chocolate consumption on plasma antioxidant status, oxidative stress and immunoendocrine responses to prolonged exerciseEur J Nutr.(2012 Feb)
    7. Caffeine - Karapetian GK, Engels HJ, Gretebeck KA, Gretebeck RJEffect of Caffeine on LT, VT and HRVTInt J Sports Med.(2012 Apr 12)
    8. Sodium Bicarbonate - Kilding AE, Overton C, Gleave JEffects of caffeine, sodium bicarbonate, and their combined ingestion on high-intensity cycling performanceInt J Sport Nutr Exerc Metab.(2012 Jun)
    9. Chromium - Davis JM, Welsh RS, Alerson NAEffects of carbohydrate and chromium ingestion during intermittent high-intensity exercise to fatigueInt J Sport Nutr Exerc Metab.(2000 Dec)
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    20. L-Carnitine - Gamze E Orer, Nevin A GuzelThe effects of acute L-carnitine supplementation on endurance performance of athletesJ Strength Cond Res.(2014 Feb)
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    23. L-Carnitine - Jacobs PL, Goldstein ER, Blackburn W, Orem I, Hughes JJGlycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained malesJ Int Soc Sports Nutr.(2009 Apr 2)
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    25. Alanylglutamine - Hoffman JR, Ratamess NA, Kang J, Rashti SL, Kelly N, Gonzalez AM, Stec M, Anderson S, Bailey BL, Yamamoto LM, Hom LL, Kupchak BR, Faigenbaum AD, Maresh CMExamination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exerciseJ Int Soc Sports Nutr.(2010 Feb 3)
    26. Sodium Bicarbonate - Zabala M, Requena B, Sánchez-Muñoz C, González-Badillo JJ, García I, Oöpik V, Pääsuke MEffects of sodium bicarbonate ingestion on performance and perceptual responses in a laboratory-simulated BMX cycling qualification seriesJ Strength Cond Res.(2008 Sep)
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    33. Sodium Bicarbonate - Sale C, Saunders B, Hudson S, Wise JA, Harris RC, Sunderland CDEffect of β-alanine plus sodium bicarbonate on high-intensity cycling capacityMed Sci Sports Exerc.(2011 Oct)
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    35. Caffeine - Glaister M, Howatson G, Abraham CS, Lockey RA, Goodwin JE, Foley P, McInnes GCaffeine supplementation and multiple sprint running performanceMed Sci Sports Exerc.(2008 Oct)
    36. L-Carnitine - G A Barker, S Green, C D Askew, A A Green, P J WalkerEffect of propionyl-L-carnitine on exercise performance in peripheral arterial diseaseMed Sci Sports Exerc.(2001 Sep)
    37. Theanine - A Juszkiewicz, A Glapa, P Basta, E Petriczko, K Żołnowski, B Machaliński, J Trzeciak, K Łuczkowska, A Skarpańska-StejnbornThe effect of L-theanine supplementation on the immune system of athletes exposed to strenuous physical exerciseJ Int Soc Sports Nutr.(2019 Feb 15)
    38. L-Carnitine - Majid S Koozehchian, Amin Daneshfar, Ebrahim Fallah, Hamid Agha-Alinejad, Mohammad Samadi, Mojtaba Kaviani, Maryam Kaveh B, Y Peter Jung, Mozhgan Hassanzadeh Sablouei, Najmeh Moradi, Conrad P Earnest, T Jeff Chandler, Richard B KreiderEffects of nine weeks L-Carnitine supplementation on exercise performance, anaerobic power, and exercise-induced oxidative stress in resistance-trained malesJ Exerc Nutrition Biochem.(2018 Dec 31)
    39. Creatine - Manjarrez-Montes de Oca R, Farfán-González F, Camarillo-Romero S, Tlatempa-Sotelo P, Francisco-Argüelles C, Kormanowski A, González-Gallego J, Alvear-Ordenes IEffects of creatine supplementation in taekwondo practitionersNutr Hosp.(2013 Mar-Apr)
    40. Astaxanthin - L. Wu, et alEffect of astaxanthin and exercise on antioxidant capacity of human body, blood lactic acid and blood uric acid metabolismSci Sports.()
    41. Sodium Bicarbonate - Artioli GG, Gualano B, Coelho DF, Benatti FB, Gailey AW, Lancha AH JrDoes sodium-bicarbonate ingestion improve simulated judo performanceInt J Sport Nutr Exerc Metab.(2007 Apr)
    42. Creatine - Mujika I, Chatard JC, Lacoste L, Barale F, Geyssant ACreatine supplementation does not improve sprint performance in competitive swimmersMed Sci Sports Exerc.(1996 Nov)
    43. Panax Ginseng (Korean Ginseng) - H J Engels, J C WirthNo ergogenic effects of ginseng (Panax ginseng C.A. Meyer) during graded maximal aerobic exerciseJ Am Diet Assoc.(1997 Oct)
    44. Arginine - Abel T, Knechtle B, Perret C, Eser P, von Arx P, Knecht HInfluence of chronic supplementation of arginine aspartate in endurance athletes on performance and substrate metabolism - a randomized, double-blind, placebo-controlled studyInt J Sports Med.(2005 Jun)
    45. Vitamin E - Rokitzki L, Logemann E, Huber G, Keck E, Keul Jalpha-Tocopherol supplementation in racing cyclists during extreme endurance trainingInt J Sport Nutr.(1994 Sep)
    46. Citrulline - Hickner RC, Tanner CJ, Evans CA, Clark PD, Haddock A, Fortune C, Geddis H, Waugh W, McCammon ML-citrulline reduces time to exhaustion and insulin response to a graded exercise testMed Sci Sports Exerc.(2006 Apr)
    47. Sodium Bicarbonate - Stephens TJ, McKenna MJ, Canny BJ, Snow RJ, McConell GKEffect of sodium bicarbonate on muscle metabolism during intense endurance cyclingMed Sci Sports Exerc.(2002 Apr)
    48. Sodium Bicarbonate - Carr AJ, Gore CJ, Dawson BInduced alkalosis and caffeine supplementation: effects on 2,000-m rowing performanceInt J Sport Nutr Exerc Metab.(2011 Oct)
    49. Sodium Bicarbonate - Cameron SL, McLay-Cooke RT, Brown RC, Gray AR, Fairbairn KAIncreased blood pH but not performance with sodium bicarbonate supplementation in elite rugby union playersInt J Sport Nutr Exerc Metab.(2010 Aug)
    50. Spirulina - Artur Juszkiewicz, Piotr Basta, Elżbieta Petriczko, Bogusław Machaliński, Jerzy Trzeciak, Karolina Łuczkowska, Anna Skarpańska-StejnbornAn attempt to induce an immunomodulatory effect in rowers with spirulina extractJ Int Soc Sports Nutr.(2018 Feb 20)
    51. Phosphatidylserine - Monteleone P, Maj M, Beinat L, Natale M, Kemali DBlunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy menEur J Clin Pharmacol.(1992)
    52. Sodium Bicarbonate - Gaitanos GC, Nevill ME, Brooks S, Williams CRepeated bouts of sprint running after induced alkalosisJ Sports Sci.(1991 Winter)
    53. Caffeine - Duncan MJ, Oxford SWThe effect of caffeine ingestion on mood state and bench press performance to failureJ Strength Cond Res.(2011 Jan)
    54. Sodium Bicarbonate - Tiryaki GR, Atterbom HAThe effects of sodium bicarbonate and sodium citrate on 600 m running time of trained femalesJ Sports Med Phys Fitness.(1995 Sep)
    55. Sodium Bicarbonate - Hunter AM, De Vito G, Bolger C, Mullany H, Galloway SDThe effect of induced alkalosis and submaximal cycling on neuromuscular response during sustained isometric contractionJ Sports Sci.(2009 Oct)
    56. L-Tyrosine - Li J, Zie FEffects of tyrosine supplementation ration on anaerobic sports capacity and plasma catecholamine levels in soccer athletesBiomed Res.()
    57. Sodium Bicarbonate - L Mc Naughton, D ThompsonAcute versus chronic sodium bicarbonate ingestion and anaerobic work and power outputJ Sports Med Phys Fitness.(2001 Dec)
    58. Branched-Chain Amino Acids - Gualano AB, Bozza T, Lopes De Campos P, Roschel H, Dos Santos Costa A, Luiz Marquezi M, Benatti F, Herbert Lancha Junior ABranched-chain amino acids supplementation enhances exercise capacity and lipid oxidation during endurance exercise after muscle glycogen depletionJ Sports Med Phys Fitness.(2011 Mar)
    59. Sodium Bicarbonate - Vanhatalo A, McNaughton LR, Siegler J, Jones AMEffect of induced alkalosis on the power-duration relationship of "all-out" exerciseMed Sci Sports Exerc.(2010 Mar)
    60. Rhodiola Rosea - Noreen EE, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJThe effects of an acute dose of Rhodiola rosea on endurance exercise performanceJ Strength Cond Res.(2013 Mar)
    61. L-Carnitine - Weronika N Abramowicz, Stuart D R GallowayEffects of acute versus chronic L-carnitine L-tartrate supplementation on metabolic responses to steady state exercise in males and femalesInt J Sport Nutr Exerc Metab.(2005 Aug)
    62. L-Carnitine - S W Trappe, D L Costill, B Goodpaster, M D Vukovich, W J FinkThe effects of L-carnitine supplementation on performance during interval swimmingInt J Sports Med.(1994 May)
    63. Creatine - Deminice R, Rosa FT, Franco GS, Jordao AA, de Freitas ECEffects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humansNutrition.(2013 Sep)
    64. Citrulline - Benjamin Wax, Andreas N Kavazis, William LuckettEffects of Supplemental Citrulline-Malate Ingestion on Blood Lactate, Cardiovascular Dynamics, and Resistance Exercise Performance in Trained MalesJ Diet Suppl.(2016)
    65. L-Tyrosine - Erin E Sutton, M Regina Coill, Patricia A DeusterIngestion of tyrosine: effects on endurance, muscle strength, and anaerobic performanceInt J Sport Nutr Exerc Metab.(2005 Apr)
    66. L-Carnitine - Ho JY, Kraemer WJ, Volek JS, Fragala MS, Thomas GA, Dunn-Lewis C, Coday M, Häkkinen K, Maresh CMl-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and womenMetabolism.(2010 Aug)
    67. L-Carnitine - E P Brass, C L Hoppel, W R HiattEffect of intravenous L-carnitine on carnitine homeostasis and fuel metabolism during exercise in humansClin Pharmacol Ther.(1994 Jun)
    68. Citrulline - Eric T Trexler, Dale S Keith, Todd A Schwartz, Eric D Ryan, Lee Stoner, Adam M Persky, Abbie E Smith-RyanEffects of Citrulline Malate and Beetroot Juice Supplementation on Blood Flow, Energy Metabolism, and Performance During Maximum Effort Leg Extension ExerciseJ Strength Cond Res.(2019 Sep)
    69. Sodium Bicarbonate - Edge J, Bishop D, Goodman CEffects of chronic NaHCO3 ingestion during interval training on changes to muscle buffer capacity, metabolism, and short-term endurance performanceJ Appl Physiol.(2006 Sep)
    70. Sodium Bicarbonate - D Ball, P L Greenhaff, R J MaughanThe acute reversal of a diet-induced metabolic acidosis does not restore endurance capacity during high-intensity exercise in manEur J Appl Physiol Occup Physiol.(1996)
    71. Sodium Bicarbonate - Kupcis PD, Slater GJ, Pruscino CL, Kemp JGInfluence of sodium bicarbonate on performance and hydration in lightweight rowingInt J Sports Physiol Perform.(2012 Mar)
    72. L-Tyrosine - Troy D Chinevere, Robert D Sawyer, Andrew R Creer, Robert K Conlee, Allen C ParcellEffects of L-tyrosine and carbohydrate ingestion on endurance exercise performanceJ Appl Physiol (1985).(2002 Nov)
    73. Panax Ginseng (Korean Ginseng) - Ping FW, Keong CC, Bandyopadhyay AEffects of acute supplementation of Panax ginseng on endurance running in a hot & humid environmentIndian J Med Res.(2011 Jan)
    74. Sodium Bicarbonate - Bishop D, Claudius BEffects of induced metabolic alkalosis on prolonged intermittent-sprint performanceMed Sci Sports Exerc.(2005 May)
    75. L-Carnitine - Khadijeh Parandak, Hamid Arazi, Faegheh Khoshkhahesh, Babak Nakhostin-RoohiThe effect of two-week L-carnitine supplementation on exercise -induced oxidative stress and muscle damageAsian J Sports Med.(2014 Jun)
    76. Colostrum - Buckley JD, Abbott MJ, Brinkworth GD, Whyte PBBovine colostrum supplementation during endurance running training improves recovery, but not performanceJ Sci Med Sport.(2002 Jun)
    77. Sodium Bicarbonate - Driller MW, Gregory JR, Williams AD, Fell JWThe effects of serial and acute NaHCO3 loading in well-trained cyclistsJ Strength Cond Res.(2012 Oct)
    78. Sodium Bicarbonate - Brien DM, McKenzie DCThe effect of induced alkalosis and acidosis on plasma lactate and work output in elite oarsmenEur J Appl Physiol Occup Physiol.(1989)
    79. Sodium Bicarbonate - Douroudos II, Fatouros IG, Gourgoulis V, Jamurtas AZ, Tsitsios T, Hatzinikolaou A, Margonis K, Mavromatidis K, Taxildaris KDose-related effects of prolonged NaHCO3 ingestion during high-intensity exerciseMed Sci Sports Exerc.(2006 Oct)
    80. Creatine - Mendes RR, Pires I, Oliveira A, Tirapegui JEffects of creatine supplementation on the performance and body composition of competitive swimmersJ Nutr Biochem.(2004 Aug)
    81. Sodium Bicarbonate - Marx JO, Gordon SE, Vos NH, Nindl BC, Gómez AL, Volek JS, Pedro J, Ratamess N, Newton RU, French DN, Rubin MR, Häkkinen K, Kraemer WJEffect of alkalosis on plasma epinephrine responses to high intensity cycle exercise in humansEur J Appl Physiol.(2002 May)
    82. Rhodiola Rosea - Jówko E, Sadowski J, Długołęcka B, Gierczuk D, Opaszowski B, Cieśliński IEffects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy menJ Sport Health Sci.(2018 Oct)
    83. Citrulline - Brian Cunniffe, Maria Papageorgiou, Barbara OʼBrien, Nathan A Davies, George K Grimble, Marco CardinaleAcute Citrulline-Malate Supplementation and High-Intensity Cycling PerformanceJ Strength Cond Res.(2016 Sep)
    84. L-Carnitine - Jacobs PL, Goldstein ERLong-term glycine propionyl-l-carnitine supplemention and paradoxical effects on repeated anaerobic sprint performanceJ Int Soc Sports Nutr.(2010 Oct 28)
    85. Sodium Bicarbonate - Gao JP, Costill DL, Horswill CA, Park SHSodium bicarbonate ingestion improves performance in interval swimmingEur J Appl Physiol Occup Physiol.(1988)
    86. Sodium Bicarbonate - Nielsen HB, Bredmose PP, Strømstad M, Volianitis S, Quistorff B, Secher NHBicarbonate attenuates arterial desaturation during maximal exercise in humansJ Appl Physiol.(2002 Aug)
    87. Astaxanthin - Res PT, Cermak NM, Stinkens R, Tollakson TJ, Haenen GR, Bast A, Van Loon LJAstaxanthin supplementation does not augment fat use or improve endurance performanceMed Sci Sports Exerc.(2013 Jun)
    88. Sodium Bicarbonate - Lindh AM, Peyrebrune MC, Ingham SA, Bailey DM, Folland JPSodium bicarbonate improves swimming performanceInt J Sports Med.(2008 Jun)
    89. Creatine - Dabidi Roshan V, Babaei H, Hosseinzadeh M, Arendt-Nielsen LThe effect of creatine supplementation on muscle fatigue and physiological indices following intermittent swimming boutsJ Sports Med Phys Fitness.(2013 Jun)
    90. Sodium Bicarbonate - Volianitis S, Rasmussen P, Seifert T, Nielsen HB, Secher NHPlasma pH does not influence the cerebral metabolic ratio during maximal whole body exerciseJ Physiol.(2011 Jan 15)
    91. Sodium Bicarbonate - Bishop D, Edge J, Davis C, Goodman CInduced metabolic alkalosis affects muscle metabolism and repeated-sprint abilityMed Sci Sports Exerc.(2004 May)
    92. Sodium Bicarbonate - Webster MJ, Webster MN, Crawford RE, Gladden LBEffect of sodium bicarbonate ingestion on exhaustive resistance exercise performanceMed Sci Sports Exerc.(1993 Aug)
    93. Sodium Bicarbonate - Potteiger JA, Webster MJ, Nickel GL, Haub MD, Palmer RJThe effects of buffer ingestion on metabolic factors related to distance running performanceEur J Appl Physiol Occup Physiol.(1996)
    94. L-Carnitine - Volek JS, Kraemer WJ, Rubin MR, Gómez AL, Ratamess NA, Gaynor PL-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stressAm J Physiol Endocrinol Metab.(2002 Feb)
    95. Sodium Bicarbonate - McNaughton L, Dalton B, Palmer GSodium bicarbonate can be used as an ergogenic aid in high-intensity, competitive cycle ergometry of 1 h durationEur J Appl Physiol Occup Physiol.(1999 Jun)
    96. Creatine - van Loon LJ, Oosterlaar AM, Hartgens F, Hesselink MK, Snow RJ, Wagenmakers AJEffects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humansClin Sci (Lond).(2003 Feb)
    97. Colostrum - A Mero, H Miikkulainen, J Riski, R Pakkanen, J Aalto, T TakalaEffects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during trainingJ Appl Physiol (1985).(1997 Oct)
    98. Caffeine - Astrup A, Toubro S, Cannon S, Hein P, Breum L, Madsen JCaffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteersAm J Clin Nutr.(1990 May)
    99. L-Carnitine - A Borghi-Silva, V Baldissera, L M M Sampaio, V A Pires-DiLorenzo, M Jamami, A Demonte, J S Marchini, D CostaL-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programsBraz J Med Biol Res.(2006 Apr)
    100. Rhodiola Rosea - Parisi A, Tranchita E, Duranti G, Ciminelli E, Quaranta F, Ceci R, Cerulli C, Borrione P, Sabatini SEffects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary resultsJ Sports Med Phys Fitness.(2010 Mar)
    101. Branched-Chain Amino Acids - Wiśnik P, Chmura J, Ziemba AW, Mikulski T, Nazar KThe effect of branched chain amino acids on psychomotor performance during treadmill exercise of changing intensity simulating a soccer gameAppl Physiol Nutr Metab.(2011 Dec)
    102. Betaine - Apicella JM, Lee EC, Bailey BL, Saenz C, Anderson JM, Craig SA, Kraemer WJ, Volek JS, Maresh CMBetaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exerciseEur J Appl Physiol.(2013 Mar)
    103. Branched-Chain Amino Acids - Shimomura Y, Inaguma A, Watanabe S, Yamamoto Y, Muramatsu Y, Bajotto G, Sato J, Shimomura N, Kobayashi H, Mawatari KBranched-chain amino acid supplementation before squat exercise and delayed-onset muscle sorenessInt J Sport Nutr Exerc Metab.(2010 Jun)
    104. L-Carnitine - Barry A Spiering, William J Kraemer, Jakob L Vingren, Disa L Hatfield, Maren S Fragala, Jen-Yu Ho, Carl M Maresh, Jeffrey M Anderson, Jeff S VolekResponses of criterion variables to different supplemental doses of L-carnitine L-tartrateJ Strength Cond Res.(2007 Feb)
    105. Sodium Bicarbonate - Portington KJ, Pascoe DD, Webster MJ, Anderson LH, Rutland RR, Gladden LBEffect of induced alkalosis on exhaustive leg press performanceMed Sci Sports Exerc.(1998 Apr)
    106. Sodium Bicarbonate - Price M, Moss P, Rance SEffects of sodium bicarbonate ingestion on prolonged intermittent exerciseMed Sci Sports Exerc.(2003 Aug)
    107. Tart Cherry Juice - Keane KM, Bailey SJ, Vanhatalo A, Jones AM, Howatson GEffects of montmorency tart cherry (L. Prunus Cerasus) consumption on nitric oxide biomarkers and exercise performance.Scand J Med Sci Sports.(2018-Jul)
    108. Beta-Alanine - Huerta Ojeda Á, Tapia Cerda C, Poblete Salvatierra MF, Barahona-Fuentes G, Jorquera Aguilera CEffects of Beta-Alanine Supplementation on Physical Performance in Aerobic-Anaerobic Transition Zones: A Systematic Review and Meta-Analysis.Nutrients.(2020-Aug-19)
    109. L-Carnitine - Vecchio M, Chiaramonte R, Testa G, Pavone VClinical Effects of L-Carnitine Supplementation on Physical Performance in Healthy Subjects, the Key to Success in Rehabilitation: A Systematic Review and Meta-Analysis from the Rehabilitation Point of View.J Funct Morphol Kinesiol.(2021-Nov-04)
    110. Caffeine - Glaister M, Gissane CCaffeine and Physiological Responses to Submaximal Exercise: A Meta-AnalysisInt J Sports Physiol Perform.(2017 Sep 5)
    111. Molecular Hydrogen - Zhou K, Liu M, Wang Y, Liu H, Manor B, Bao D, Zhang L, Zhou JEffects of molecular hydrogen supplementation on fatigue and aerobic capacity in healthy adults: A systematic review and meta-analysis.Front Nutr.(2023)
    112. Sodium Bicarbonate - Calvo JL, Xu H, Mon-López D, Pareja-Galeano H, Jiménez SLEffect of sodium bicarbonate contribution on energy metabolism during exercise: a systematic review and meta-analysis.J Int Soc Sports Nutr.(2021-Feb-05)
    113. Nitrate - The effects of dietary nitrate supplementation on endurance exercise performance and cardiorespiratory measures in healthy adults: a systematic review and meta-analysis..()