Uric Acid

    Last Updated: October 13, 2024

    Uric acid is a molecule (a byproduct of purine metabolism) that, in excessive levels, can contribute to gout and kidney stones. Despite this, uric acid is a potent antioxidant compound.

    5,233 participants in 57 trials

    Examine Database: Uric Acid

    Research FeedRead all studies

    Examine Database References

    1. Curcumin - Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mendía LE, Sahebkar ACurcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled TrialJ Cardiovasc Pharmacol.(2016 Sep)
    2. Jiaogulan - Chou SC, Chen KW, Hwang JS, Lu WT, Chu YY, Lin JD, Chang HJ, See LCThe add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver diseaseAltern Ther Health Med.(2006 May-Jun)
    3. Kefir - GÖLÜNÜK, S et alEffects of traditional fermented beverages on some blood parameters in aerobic exercises.Biomedical Research.()
    4. Ketogenic Diet - Partsalaki I, Karvela A, Spiliotis BEMetabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescentsJ Pediatr Endocrinol Metab.(2012)
    5. Quercetin - Abbey EL, Rankin JWEffect of quercetin supplementation on repeated-sprint performance, xanthine oxidase activity, and inflammationInt J Sport Nutr Exerc Metab.(2011 Apr)
    6. Tetradecyl Thioacetic Acid - Løvås K, Røst TH, Skorve J, Ulvik RJ, Gudbrandsen OA, Bohov P, Wensaas AJ, Rustan AC, Berge RK, Husebye ESTetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidationDiabetes Obes Metab.(2009 Apr)
    7. Cordyceps - Li Y, Xue WJ, Tian PX, Ding XM, Yan H, Pan XM, Feng XSClinical application of Cordyceps sinensis on immunosuppressive therapy in renal transplantationTransplant Proc.(2009 Jun)
    8. Astaxanthin - L. Wu, et alEffect of astaxanthin and exercise on antioxidant capacity of human body, blood lactic acid and blood uric acid metabolismSci Sports.()
    9. Creatine - Cancela P, Ohanian C, Cuitiño E, Hackney ACCreatine supplementation does not affect clinical health markers in football playersBr J Sports Med.(2008 Sep)
    10. Vitamin C - Nieman DC, Henson DA, McAnulty SR, McAnulty L, Swick NS, Utter AC, Vinci DM, Opiela SJ, Morrow JDInfluence of vitamin C supplementation on oxidative and immune changes after an ultramarathonJ Appl Physiol (1985).(2002 May)
    11. Black seed - Datau EA, Wardhana, Surachmanto EE, Pandelaki K, Langi JA, FiasEfficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese maleActa Med Indones.(2010 Jul)
    12. Tart Cherry Juice - Keith R Martin, Katie M ColesConsumption of 100% Tart Cherry Juice Reduces Serum Urate in Overweight and Obese AdultsCurr Dev Nutr.(2019 Feb 25)
    13. Vitamin C - Han-Yao Huang, Lawrence J Appel, Michael J Choi, Allan C Gelber, Jeanne Charleston, Edward P Norkus, Edgar R Miller 3rdThe effects of vitamin C supplementation on serum concentrations of uric acid: results of a randomized controlled trialArthritis Rheum.(2005 Jun)
    14. Curcumin - Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto THighly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPDInt J Chron Obstruct Pulmon Dis.(2016 Aug 26)
    15. Black seed - Dehkordi FR, Kamkhah AFAntihypertensive effect of Nigella sativa seed extract in patients with mild hypertensionFundam Clin Pharmacol.(2008 Aug)
    16. Astaxanthin - Tominaga K, Hongo N, Fujishita M, Takahashi Y, Adachi YProtective effects of astaxanthin on skin deteriorationJ Clin Biochem Nutr.(2017 Jul)
    17. Grape Juice - Castilla P, Echarri R, Dávalos A, Cerrato F, Ortega H, Teruel JL, Lucas MF, Gómez-Coronado D, Ortuño J, Lasunción MAConcentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjectsAm J Clin Nutr.(2006 Jul)
    18. Cocoa Extract - Grassi D, Desideri G, Necozione S, Lippi C, Casale R, Properzi G, Blumberg JB, Ferri CBlood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolateJ Nutr.(2008 Sep)
    19. Glutamine - Bassini-Cameron A, Monteiro A, Gomes A, Werneck-de-Castro JP, Cameron LGlutamine protects against increases in blood ammonia in football players in an exercise intensity-dependent wayBr J Sports Med.(2008 Apr)
    20. L-Carnitine - M R Rubin, J S Volek, A L Gómez, N A Ratamess, D N French, M J Sharman, W J KraemerSafety measures of L-carnitine L-tartrate supplementation in healthy menJ Strength Cond Res.(2001 Nov)
    21. Curcumin - Pannipa Bupparenoo, Rattapol Pakchotanon, Pongthorn Narongroeknawin, Paijit Asavatanabodee, Sumapa ChaiamnuayEffect of Curcumin on Serum Urate in Asymptomatic Hyperuricemia: A Randomized Placebo-Controlled TrialJ Diet Suppl.(2021)
    22. Ketogenic Diet - Athinarayanan SJ, Adams RN, Hallberg SJ, McKenzie AL, Bhanpuri NH, Campbell WW, Volek JS, Phinney SD, McCarter JPLong-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical TrialFront Endocrinol (Lausanne).(2019 Jun 5)
    23. Ketogenic Diet - Phillips MCL, Murtagh DKJ, Gilbertson LJ, Asztely FJS, Lynch CDPLow-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trialMov Disord.(2018 Aug)
    24. Creatine - Cancela P, Ohanian C, Cuitiño E, Hackney ACCreatine supplementation does not affect clinical health markers in soccer playersBr J Sports Med.(2007 Aug 23)
    25. L-Carnitine - Volek JS, Kraemer WJ, Rubin MR, Gómez AL, Ratamess NA, Gaynor PL-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stressAm J Physiol Endocrinol Metab.(2002 Feb)
    26. Ketogenic Diet - Urbain P, Strom L, Morawski L, Wehrle A, Deibert P, Bertz HImpact of a 6-week non-energy-restricted ketogenic diet on physical fitness, body composition and biochemical parameters in healthy adultsNutr Metab (Lond).(2017 Feb 20)
    27. Astaxanthin - Karppi J, Rissanen TH, Nyyssönen K, Kaikkonen J, Olsson AG, Voutilainen S, Salonen JTEffects of astaxanthin supplementation on lipid peroxidationInt J Vitam Nutr Res.(2007 Jan)
    28. L-Carnitine - Jun-jie Zhang, Zhi-bing Wu, You-jin Cai, Bin Ke, Ying-juan Huang, Chao-ping Qiu, Yu-bing Yang, Lan-ying Shi, Jian QinL-carnitine ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in patients with metabolic syndrome: a randomized controlled studyNutr J.(2014 Nov 26)
    29. Kefir - TAREK A. EL-BASHITI, BAKER M. ZABUT and FEDAA F. ABU SAFIAEffect of Probiotic Fermented Milk (Kefir) on Some Blood Biochemical Parameters Among Newly Diagnosed Type 2 Diabetic Adult Males in Gaza GovernorateCurrent Research in Nutrition and Food Science.()
    30. Vitamin C - Mason SA, Della Gatta PA, Snow RJ, Russell AP, Wadley GDAscorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled studyFree Radic Biol Med.(2016 Apr)
    31. Grape Juice - Toscano LT, Tavares RL, Toscano LT, Silva CS, Almeida AE, Biasoto AC, Gonçalves Mda C, Silva ASPotential ergogenic activity of grape juice in runnersAppl Physiol Nutr Metab.(2015 Sep)
    32. Saffron - Milajerdi A, et alThe effect of saffron (Crocus sativus L.) hydro-alcoholic extract on liver and renal functions in type 2 diabetic patients: A double-blinded randomized and placebo control trialJournal of Nutrition & Intermediary Metabolism.()
    33. Astaxanthin - Kim JH, Chang MJ, Choi HD, Youn YK, Kim JT, Oh JM, Shin WGProtective effects of Haematococcus astaxanthin on oxidative stress in healthy smokersJ Med Food.(2011 Nov)
    34. Garlic - Avci A, Atli T, Ergüder IB, Varli M, Devrim E, Aras S, Durak IEffects of garlic consumption on plasma and erythrocyte antioxidant parameters in elderly subjectsGerontology.(2008)
    35. Curcumin - Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai SReduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trialJ Nutr Biochem.(2014 Feb)
    36. Tetradecyl Thioacetic Acid - Reidar J Pettersen, Mohamed Salem, Jon Skorve, Rune J Ulvik, Rolf K Berge, Jan Erik NordrehaugPharmacology and safety of tetradecylthioacetic acid (TTA): phase-1 studyJ Cardiovasc Pharmacol.(2008 Apr)
    37. Riboflavin (Vitamin B2) - Tavares NR, Moreira PA, Amaral TFRiboflavin supplementation and biomarkers of cardiovascular disease in the elderlyJ Nutr Health Aging.(2009 May)
    38. Roselle - Frank T, Netzel G, Kammerer DR, Carle R, Kler A, Kriesl E, Bitsch I, Bitsch R, Netzel MConsumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjectsJ Sci Food Agric.(2012 Aug 15)
    39. Reishi - Wachtel-Galor S, Tomlinson B, Benzie IFGanoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation studyBr J Nutr.(2004 Feb)
    40. IP6 - Takeshi Ikenaga, Keiji Kakumoto, Noriyuki Kohda, Tetsuya YamamotoEffect of Inositol Hexaphosphate (IP 6) on Serum Uric Acid in Hyperuricemic Subjects: a Randomized, Double-Blind, Placebo-Controlled, Crossover StudyPlant Foods Hum Nutr.(2019 Sep)
    41. Astaxanthin - Baralic I, Andjelkovic M, Djordjevic B, Dikic N, Radivojevic N, Suzin-Zivkovic V, Radojevic-Skodric S, Pejic SEffect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer PlayersEvid Based Complement Alternat Med.(2015)
    42. Psyllium - Sierra M, García JJ, Fernández N, Diez MJ, Calle APTherapeutic effects of psyllium in type 2 diabetic patientsEur J Clin Nutr.(2002 Sep)
    43. Tart Cherry Juice - Angela R Hillman, Bryna C R ChrismasThirty Days of Montmorency Tart Cherry Supplementation Has No Effect on Gut Microbiome Composition, Inflammation, or Glycemic Control in Healthy AdultsFront Nutr.(2021 Sep 16)
    44. Rooibos - Débora Villaño, Monia Pecorari, Maria Francesca Testa, Anna Raguzzini, Angelique Stalmach, Alan Crozier, Claudio Tubili, Mauro SerafiniUnfermented and fermented rooibos teas (Aspalathus linearis) increase plasma total antioxidant capacity in healthy humansFood Chemistry.()
    45. Ketogenic Diet - Johnston CS, Tjonn SL, Swan PD, White A, Hutchins H, Sears BKetogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate dietsAm J Clin Nutr.(2006 May)
    46. Tart Cherry Juice - Lisa K Stamp, Peter Chapman, Christopher Frampton, Stephen B Duffull, Jill Drake, Yuqing Zhang, Tuhina NeogiLack of effect of tart cherry concentrate dose on serum urate in people with goutRheumatology (Oxford).(2020 Sep 1)
    47. Tart Cherry Juice - McCormick R, Peeling P, Binnie M, Dawson B, Sim MEffect of tart cherry juice on recovery and next day performance in well-trained Water Polo players.J Int Soc Sports Nutr.(2016)
    48. Tart Cherry Juice - Hillman AR, Uhranowsky KAcute Ingestion of Montmorency Tart Cherry Reduces Serum Uric Acid but Has no Impact on High Sensitivity C-Reactive Protein or Oxidative Capacity.Plant Foods Hum Nutr.(2021-Mar)
    49. Magnesium - Vázquez-Lorente H, Herrera-Quintana L, Molina-López J, Gamarra-Morales Y, López-González B, Miralles-Adell C, Planells EResponse of Vitamin D after Magnesium Intervention in a Postmenopausal Population from the Province of Granada, Spain.Nutrients.(2020-Jul-30)
    50. Magnesium - Salehidoost R, Taghipour Boroujeni G, Feizi A, Aminorroaya A, Amini MEffect of oral magnesium supplement on cardiometabolic markers in people with prediabetes: a double blind randomized controlled clinical trial.Sci Rep.(2022-Oct-28)
    51. Sauna - Fujita S, Ikeda Y, Miyata M, Shinsato T, Kubozono T, Kuwahata S, Hamada N, Miyauchi T, Yamaguchi T, Torii H, Hamasaki S, Tei CEffect of Waon therapy on oxidative stress in chronic heart failure.Circ J.(2011)
    52. Tongkat Ali - Chen CK, Mohamad WM, Ooi FK, Ismail SB, Abdullah MR, George ASupplementation of Eurycoma longifolia Jack Extract for 6 Weeks Does Not Affect Urinary Testosterone: Epitestosterone Ratio, Liver and Renal Functions in Male Recreational Athletes.Int J Prev Med.(2014-Jun)
    53. Resistant Starch - Du X, Wu J, Gao C, Tan Q, Xu YEffects of Resistant Starch on Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis.J Diabetes Res.(2022)
    54. Vitamin C - Xin-Xin Liu, Xiao-Xue Wang, Ling-Ling CuiAssociation between Oral vitamin C supplementation and serum uric acid: A meta-analysis of randomized controlled trialsComplement Ther Med.(2021 Aug)
    55. Resveratrol - Abdollahi S, Vajdi M, Meshkini F, Vasmehjani AA, Sangsefidi ZS, Clark CCT, Soltani SResveratrol may mildly improve renal function in the general adult population: A systematic review and meta-analysis of randomized controlled clinical trials.Nutr Res.(2023-May)
    56. Ketogenic Diet - Gohari S, Ghobadi S, Jafari A, Ahangar H, Gohari S, Mahjani MThe effect of dietary approaches to stop hypertension and ketogenic diets intervention on serum uric acid concentration: a systematic review and meta-analysis of randomized controlled trials.Sci Rep.(2023 Jun 28)
    57. Honey - Amna Ahmed, Zujaja Tul-Noor, Danielle Lee, Shamaila Bajwah, Zara Ahmed, Shanza Zafar, Maliha Syeda, Fakeha Jamil, Faizaan Qureshi, Fatima Zia, Rumsha Baig, Saniya Ahmed, Mobushra Tayyiba, Suleman Ahmad, Dan Ramdath, Rong Tsao, Steve Cui, Cyril W C Kendall, Russell J de Souza, Tauseef A Khan, John L SievenpiperEffect of honey on cardiometabolic risk factors: a systematic review and meta-analysisNutr Rev.(2022 Nov 16)