Last Updated: September 28, 2022

    Methylsulfonylmethane (Dimethylsulfone or, more commonly, MSM) is a small DMSO-related sulfur-containing molecule used for its antioxidative and anti-inflammatory properties. It holds potential for joint health (not significantly different than glucosamine sulfate).

    MSM is most often used for .

    What are other names for MSM

    Note that MSM is also known as:
    • MSM
    • Dimethyl Sulfone
    • Dimethylsulfone
    • Methylsulfonylmethane
    MSM should not be confused with:
    • DMSO (reduced form of MSM)

    Dosage information

    Supplementation of MSM tends to be taken at up to 3,000mg daily, which seems to be effective for reducing symptoms of osteoarthritis and conferring some antioxidant protection to the body. It is unsure if higher supplemental doses are better than 3,000mg, so sticking to that dose may be prudent.

    Examine Database: MSM

    Research FeedRead all studies

    Examine Database References

    1. Muscle Damage - Barmaki S, Bohlooli S, Khoshkhahesh F, Nakhostin-Roohi BEffect of methylsulfonylmethane supplementation on exercise - Induced muscle damage and total antioxidant capacityJ Sports Med Phys Fitness.(2012 Apr)
    2. Exercise-Induced Oxidation - Nakhostin-Roohi B, Barmaki S, Khoshkhahesh F, Bohlooli SEffect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy menJ Pharm Pharmacol.(2011 Oct)
    3. Fatigue Symptoms - Kalman DS, Feldman S, Scheinberg AR, Krieger DR, Bloomer RJInfluence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot studyJ Int Soc Sports Nutr.(2012 Sep 27)
    4. Leg Edema - Tripathi R, Gupta S, Rai S, Mittal PCEffect of topical application of methylsulfonylmethane (MSM), EDTA on pitting edema and oxidative stress in a double blind, placebo-controlled studyCell Mol Biol (Noisy-le-grand).(2011 Feb 12)
    5. Osteoarthritis Symptoms - Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N, Elbaz A, Beer Y, Debi REfficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled studyBMC Complement Altern Med.(2011 Jun 27)
    6. Nasal Congestion - Eleanor Barrager, Joseph R Veltmann Jr, Alexander G Schauss, Rebecca N SchillerA multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitisJ Altern Complement Med.(2002 Apr)