Resveratrol

    Written by:
    Katherine Nguyen, Brady Holmer

    Fact-checked

    by:

    Gregory Lopez, Nick Milazzo
    Last Updated: June 3, 2024

    Resveratrol is a bioactive molecule found in plant sources such as grapes, peanuts, blueberries, and, famously, red wine. Resveratrol has anti-inflammatory and antioxidant properties that benefit cardiovascular function, glycemic control, and lipid metabolism. Although it’s promoted for lifespan extension, there’s no evidence for this in humans and limited evidence in animals.

    Overview

    Dosage information

    The therapeutic dose of resveratrol ranges from 8.1 mg per day to 3,000 mg per day.

    Studies in humans suggest resveratrol can be supplemented at dosages up to 5 grams (5,000 mg) daily with few to no side effects outside of some intestinal upset and nausea.[1][2]

    Frequently asked questions

    Update History

    Adjusted units in a FAQ

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    Reviewed by

    Nick Milazzo

    Examine Database References

    1. Blood Flow - Magyar K, Halmosi R, Palfi A, Feher G, Czopf L, Fulop A, Battyany I, Sumegi B, Toth K, Szabados ECardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery diseaseClin Hemorheol Microcirc.(2012 Jan 1)
    2. Total cholesterol - Abdelhaleem IA, Brakat AM, Adayel HM, Asla MM, Rizk MA, Aboalfetoh AYThe effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis.Med Clin (Barc).(2022-Jun-24)
    3. C-Reactive Protein (CRP) - Custodero C, Mankowski RT, Lee SA, Chen Z, Wu S, Manini TM, Hincapie Echeverri J, Sabbà C, Beavers DP, Cauley JA, Espeland MA, Fielding RA, Kritchevsky SB, Liu CK, McDermott MM, Miller ME, Tracy RP, Newman AB, Ambrosius WT, Pahor M, Anton SDEvidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis.Ageing Res Rev.(2018-Sep)
    4. C-Reactive Protein (CRP) - Haghighatdoost F, Hariri MCan resveratrol supplement change inflammatory mediators? A systematic review and meta-analysis on randomized clinical trials.Eur J Clin Nutr.(2019-Mar)
    5. Endothelial Function - Mohammadipoor N, Shafiee F, Rostami A, Kahrizi MS, Soleimanpour H, Ghodsi M, Ansari MJ, Bokov DO, Jannat B, Mosharkesh E, Pour Abbasi MSResveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials.Phytother Res.(2022-Sep)
    6. DNA methylation - Zhu W, Qin W, Zhang K, Rottinghaus GE, Chen YC, Kliethermes B, Sauter ERTrans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancerNutr Cancer.(2012 Apr)
    7. Fatigue Symptoms - Kennedy DO, Wightman EL, Reay JL, Lietz G, Okello EJ, Wilde A, Haskell CFEffects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigationAm J Clin Nutr.(2010 Jun)
    8. Oxidative Stress Biomarkers - Brasnyó P, Molnár GA, Mohás M, Markó L, Laczy B, Cseh J, Mikolás E, Szijártó IA, Mérei A, Halmai R, Mészáros LG, Sümegi B, Wittmann IResveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patientsBr J Nutr.(2011 Aug)
    9. Oxidative Stress Biomarkers - Zhu P, Jin Y, Sun J, Zhou XThe efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis.Front Endocrinol (Lausanne).(2024)
    10. Glycemic Control - Crandall JP, Oram V, Trandafirescu G, Reid M, Kishore P, Hawkins M, Cohen HW, Barzilai NPilot Study of Resveratrol in Older Adults With Impaired Glucose ToleranceJ Gerontol A Biol Sci Med Sci.(2012 Jan 4)
    11. Blood glucose - Liu K, Zhou R, Wang B, Mi MTEffect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials.Am J Clin Nutr.(2014-Jun)
    12. Blood glucose - Felipe Mendes Delpino, Lílian Munhoz FigueiredoResveratrol supplementation and type 2 diabetes: a systematic review and meta-analysisCrit Rev Food Sci Nutr.(2021 Jan 22)
    13. Blood glucose - García-Martínez BI, Ruiz-Ramos M, Pedraza-Chaverri J, Santiago-Osorio E, Mendoza-Núñez VMInfluence of Age and Dose on the Effect of Resveratrol for Glycemic Control in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis.Molecules.(2022-Aug-16)
    14. Blood glucose - Hausenblas HA, Schoulda JA, Smoliga JMResveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus--systematic review and meta-analysis.Mol Nutr Food Res.(2014 Aug 19)
    15. Blood glucose - Gu W, Geng J, Zhao H, Li X, Song GEffects of Resveratrol on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.Int J Clin Pract.(2022)
    16. Blood glucose - Sahar Rafiee, Hamed Mohammadi, Abed Ghavami, Erfan Sadeghi, Zahra Safari, Gholamreza AskariEfficacy of resveratrol supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trialsComplement Ther Clin Pract.(2020 Dec 4)
    17. Blood glucose - Sheida Zeraattalab-Motlagh, Ahmad Jayedi, Sakineh Shab-BidarThe effects of resveratrol supplementation in patients with type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease: an umbrella review of meta-analyses of randomized controlled trialsAm J Clin Nutr.(2021 Nov 8)
    18. Total cholesterol - Zhao H, Song A, Zhang Y, Shu L, Song G, Ma HEffect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.Obesity (Silver Spring).(2019-Jan)
    19. Blood Pressure - Samuel R Weaver, Catarina Rendeiro, Helen M McGettrick, Andrew Philp, Samuel J E LucasFine wine or sour grapes? A systematic review and meta-analysis of the impact of red wine polyphenols on vascular healthEur J Nutr.(2021 Feb)
    20. C-Reactive Protein (CRP) - Tabrizi R, Tamtaji OR, Lankarani KB, Mirhosseini N, Akbari M, Dadgostar E, Peymani P, Asemi ZThe effects of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.Food Funct.(2018-Dec-13)
    21. Weight - Mousavi SM, Milajerdi A, Sheikhi A, Kord-Varkaneh H, Feinle-Bisset C, Larijani B, Esmaillzadeh AResveratrol supplementation significantly influences obesity measures: a systematic review and dose-response meta-analysis of randomized controlled trials.Obes Rev.(2019-Mar)
    22. Creatinine - Abdollahi S, Vajdi M, Meshkini F, Vasmehjani AA, Sangsefidi ZS, Clark CCT, Soltani SResveratrol may mildly improve renal function in the general adult population: A systematic review and meta-analysis of randomized controlled clinical trials.Nutr Res.(2023-May)
    23. Triglycerides - Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MK, Kunz I, Schrauwen-Hinderling VB, Blaak EE, Auwerx J, Schrauwen PCalorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humansCell Metab.(2011 Nov 2)
    24. Liver Enzymes - Darand M, Farrokhzad A, Ghavami A, Hadi A, Karimi E, Fadel A, Askari GEffects of resveratrol supplementation on liver enzymes: A systematic review and meta-analysis of randomised controlled trials.Int J Clin Pract.(2021-Mar)
    25. Exercise Adaptations - Lasse Gliemann, Jakob Friis Schmidt, Jesper Olesen, Rasmus Sjørup Biensø, Sebastian Louis Peronard, Simon Udsen Grandjean, Stefan Peter Mortensen, Michael Nyberg, Jens Bangsbo, Henriette Pilegaard and Ylva HellstenResveratrol Blunts the Positive Effects of Exercise Training on Cardiovascular Health in Aged MenThe Journal of Physiology.()
    26. Endothelial Function - Akbari M, Tamtaji OR, Lankarani KB, Tabrizi R, Dadgostar E, Kolahdooz F, Jamilian M, Mirzaei H, Asemi ZThe Effects of Resveratrol Supplementation on Endothelial Function and Blood Pressures Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.High Blood Press Cardiovasc Prev.(2019 Jul 1)
    27. Fat Oxidation - Scribbans TD, Ma JK, Edgett BA, Vorobej KA, Mitchell AS, Zelt JG, Simpson CA, Quadrilatero J, Gurd BJResveratrol supplementation does not augment performance adaptations or fibre-type-specific responses to high-intensity interval training in humansAppl Physiol Nutr Metab.(2014 Nov)
    28. Acne Symptoms - Gabriella Fabbrocini, Stefania Staibano, Giuseppe De Rosa, Valeria Battimiello, Nunzio Fardella, Gennaro Ilardi, Maria Immacolata La Rotonda, Amelia Longobardi, Marialuisa Mazzella, Maria Siano, Francesco Pastore, Valerio De Vita, Maria Luisa Vecchione, Fabio AyalaResveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot studyAm J Clin Dermatol.(2011 Apr 1)
    29. Weight - Qian Zhou, Yanmei Wang, Xuke Han, Shunlian Fu, Chan Zhu, Qiu ChenEfficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic ReviewFront Physiol.(2022 Mar 31)
    30. Testosterone - Ali Fadlalmola H, Elhusein AM, Al-Sayaghi KM, Albadrani MS, Swamy DV, Mamanao DM, El-Amin EI, Ibrahim SE, Abbas SMEfficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.Pan Afr Med J.(2023)
    31. Testosterone - Larik MO, Ahmed A, Khan L, Iftekhar MAEffects of resveratrol on polycystic ovarian syndrome: a systematic review and meta-analysis of randomized controlled trials.Endocrine.(2024-Jan)
    32. Aerobic Exercise Metrics - Guille Martinez-Negrin, Jarred P Acton, Stuart P Cocksedge, Stephen J Bailey, Tom CliffordThe effect of dietary (poly)phenols on exercise-induced physiological adaptations: A systematic review and meta-analysis of human intervention trialsCrit Rev Food Sci Nutr.(2020 Dec 24)
    33. Body Mass Index (BMI) - Kailin Yang, Junpeng Chen, Tianqing Zhang, Xiao Yuan, Anqi Ge, Shanshan Wang, Hao Xu, Liuting Zeng, Jinwen GeEfficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysisFront Immunol.(2022 Sep 9)
    34. Liver Enzymes - Shumin Wei, Xiaoying YuEfficacy of resveratrol supplementation on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysisComplement Ther Med.(2020 Nov 30)
    35. Inflammatory Bowel Disease Symptoms - Joanna Giang, Xiao Lan, Megan Crichton, Wolfgang Marx, Skye MarshallEfficacy and safety of biophenol-rich nutraceuticals in adults with inflammatory gastrointestinal diseases or irritable bowel syndrome: A systematic literature review and meta-analysisNutr Diet.(2021 May 7)
    36. Pain - Nguyen C, Coudeyre E, Boutron I, Baron G, Daste C, Lefèvre-Colau MM, Sellam J, Zauderer J, Berenbaum F, Rannou FOral resveratrol in adults with knee osteoarthritis: A randomized placebo-controlled trial (ARTHROL).PLoS Med.(2024 Aug)
    37. Upper Respiratory Tract Infection Risk - Indolfi C, Mignini C, Valitutti F, Bizzarri I, Dinardo G, Klain A, Miraglia Del Giudice M, Di Cara GEffects of Nasal Solution Incorporating Resveratrol and Carboxymethyl-Β-Glucan in Preschool Non-Atopic Children with Wheezing.Nutrients.(2024 Jul 10)