Overview
What is prediabetes?
What are the main signs and symptoms of prediabetes?
How is prediabetes diagnosed?
What are some of the main medical treatments for prediabetes?
How could diet affect prediabetes?
Have any supplements been studied for prediabetes?
Are there any other treatments for prediabetes?
What causes prediabetes?
Examine Database: Prediabetes
Research FeedRead all studies
Does the timing of unsaturated fat intake influence insulin sensitivity?New
In this 12-week randomized controlled trial in 60 participants with prediabetes, eating more unsaturated fat at lunch than at dinner improved insulin sensitivity.
Vitamin D might support prediabetes remission
Full-fat yogurt vs. nonfat yogurt for glycemic control
Does time-restricted eating affect sleep?
Do noncaloric beverages alter the glycemic index of meals?
Frequently asked questions
Do clinical features differ between people with prediabetes?
How does a high-protein diet affect people with prediabetes?
References
Examine Database References
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- HbA1c - Thota RN, Acharya SH, Garg MLCurcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trialLipids Health Dis.(2019 Jan 26)
- HbA1c - Miñambres I, Cuixart G, Gonçalves A, Corcoy REffects of inositol on glucose homeostasis: Systematic review and meta-analysis of randomized controlled trialsClin Nutr.(2019 Jun)
- HbA1c - Bruls Y, et alCarnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trialEBioMedicine.()
- HbA1c - Zamani M, Pahlavani N, Nikbaf-Shandiz M, Rasaei N, Ghaffarian-Ensaf R, Asbaghi O, Shiraseb F, Rastgoo SThe effects of L-carnitine supplementation on glycemic markers in adults: A systematic review and dose-response meta-analysis.Front Nutr.(2022)
- HbA1c - Gheysari R, Nikbaf-Shandiz M, Hosseini AM, Rasaei N, Hosseini S, Bahari H, Asbaghi O, Rastgoo S, Goudarzi K, Shiraseb F, Behmadi RThe effects of L-carnitine supplementation on cardiovascular risk factors in participants with impaired glucose tolerance and diabetes: a systematic review and dose-response meta-analysis.Diabetol Metab Syndr.(2024 Jul 31)
- HbA1c - Karimi-Nazari E, et alEffect of saffron (Crocus sativus L.) on lipid profile, glycemic indices and antioxidant status among overweight/obese prediabetic individuals: A double-blinded, randomized controlled trialClin Nutr ESPEN.()
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- Oxidative Stress Biomarkers - Abedi A, Ghobadi H, Sharghi A, Iranpour S, Fazlzadeh M, Aslani MREffect of saffron supplementation on oxidative stress markers (MDA, TAC, TOS, GPx, SOD, and pro-oxidant/antioxidant balance): An updated systematic review and meta-analysis of randomized placebo-controlled trials.Front Med (Lausanne).(2023)
- Sperm Count - Elham Karimi-Nazari, Azadeh Nadjarzadeh, Roghayyeh Masoumi, Ameneh Marzban, Seyed Ahmad Mohajeri, Nahid Ramezani-Jolfaie, Amin Salehi-AbargoueiEffect of saffron (Crocus sativus L.) on lipid profile, glycemic indices and antioxidant status among overweight/obese prediabetic individuals: A double-blinded, randomized controlled trialClin Nutr ESPEN.(2019 Dec)
- HbA1c - Dludla PV, Nyambuya TM, Orlando P, Silvestri S, Mxinwa V, Mokgalaboni K, Nkambule BB, Louw J, Muller CJF, Tiano LThe impact of coenzyme Q on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta-analysis of randomized controlled trials.Endocrinol Diabetes Metab.(2020-Apr)
- HbA1c - Wang L, Yang H, Huang H, Zhang C, Zuo HX, Xu P, Niu YM, Wu SSInulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose-response meta-analysis of 33 randomized controlled trials.J Transl Med.(2019-Dec-05)
- HbA1c - Salehidoost R, Taghipour Boroujeni G, Feizi A, Aminorroaya A, Amini MEffect of oral magnesium supplement on cardiometabolic markers in people with prediabetes: a double blind randomized controlled clinical trial.Sci Rep.(2022-Oct-28)
- HbA1c - Xiong K, Wang J, Kang T, Xu F, Ma AEffects of resistant starch on glycaemic control: a systematic review and meta-analysis.Br J Nutr.(2021-Jun-14)
- HbA1c - Parry-Strong A, Wright-McNaughton M, Weatherall M, Hall RM, Coppell KJ, Barthow C, Krebs JDVery low carbohydrate (ketogenic) diets in type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.Diabetes Obes Metab.(2022-Dec)
- HbA1c - N Suksomboon, N Poolsup, S PunthanitisarnEffect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysisJ Clin Pharm Ther.(2016 Apr)
- HbA1c - Yiyi Zhang, Wen Liu, Dan Liu, Tieyun Zhao, Haoming TianEfficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsNutrients.(2016 Jun 23)
- HbA1c - Park SH, Chung S, Chung MY, Choi HK, Hwang JT, Park JHEffects of Panax ginseng on hyperglycemia, hypertension, and hyperlipidemia: A systematic review and meta-analysis.J Ginseng Res.(2022 Mar)
- HbA1c - Mohammadi-Sartang M, Sohrabi Z, Barati-Boldaji R, Raeisi-Dehkordi H, Mazloom ZFlaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials.Nutr Rev.(2018 Feb 1)
- HbA1c - Villarreal-Renteria AI, Herrera-Echauri DD, Rodríguez-Rocha NP, Zuñiga LY, Muñoz-Valle JF, García-Arellano S, Bernal-Orozco MF, Macedo-Ojeda GEffect of flaxseed (Linum usitatissimum) supplementation on glycemic control and insulin resistance in prediabetes and type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.Complement Ther Med.(2022 Nov)
- Leptin - Abbasi S, Karimi K, Hossein Moridpour A, Musazadeh V, Faghfouri AH, Jozi HCan flaxseed supplementation affect circulating adipokines in adults? An updated systematic review and meta-analysis of randomized controlled trials.Front Nutr.(2023)
- HbA1c - Daneshvar M, Ghaheri M, Safarzadeh D, Karimi F, Adib-Hajbagheri P, Ahmadzade M, Haedi AEffect of zinc supplementation on glycemic biomarkers: an umbrella of interventional meta-analyses.Diabetol Metab Syndr.(2024 Jun 8)
- HbA1c - Bahari H, Shahraki Jazinaki M, Rahnama I, Aghakhani L, Amini MR, Malekahmadi MThe cardiometabolic benefits of okra-based treatment in prediabetes and diabetes: a systematic review and meta-analysis of randomized controlled trials.Front Nutr.(2024)
- HbA1c - Japar KV, Hariyanto TI, Hamzah DV, Prasetya IB, Suastika KProbiotics Supplementation for Improving Glucolipid Parameters in Individuals with Prediabetes: A Systematic Review and Meta-Analysis of Randomized Trials.Probiotics Antimicrob Proteins.(2025 Jan 14)
- Insulin Resistance - Mihoko Yoshino, Jun Yoshino, Brandon D Kayser, Gary J Patti, Michael P Franczyk, Kathryn F Mills, Miriam Sindelar, Terri Pietka, Bruce W Patterson, Shin-Ichiro Imai, Samuel KleinNicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic womenScience.(2021 Jun 11)
- Insulin Resistance - Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CMEarly Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with PrediabetesCell Metab.(2018 Jun 5)
- Insulin Resistance - Wallace HJ, Holmes L, Ennis CN, Cardwell CR, Woodside JV, Young IS, Bell PM, Hunter SJ, McKinley MCEffect of vitamin D3 supplementation on insulin resistance and β-cell function in prediabetes: a double-blind, randomized, placebo-controlled trial.Am J Clin Nutr.(2019-Nov-01)
- Glycemic Control - Harris SS, Pittas AG, Palermo NJA randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African AmericansDiabetes Obes Metab.(2012 Sep)
- Glycemic Control - Shaban Nazarian, John V St Peter, Raymond C Boston, Sidney A Jones, Cary N MariashVitamin D3 supplementation improves insulin sensitivity in subjects with impaired fasting glucoseTransl Res.(2011 Nov)
- Type 2 Diabetes Incidence - Tobias DK, Pradhan AD, Duran EK, Li C, Song Y, Buring JE, Cook NR, Mora S, Manson JEVitamin D supplementation vs. placebo and incident type 2 diabetes in an ancillary study of the randomized Vitamin D and Omega-3 Trial.Nat Commun.(2025 Apr 8)
- Blood glucose - Johnston CS, Kim CM, Buller AJVinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetesDiabetes Care.(2004 Jan)
- Blood glucose - Lari A, Sohouli MH, Fatahi S, Cerqueira HS, Santos HO, Pourrajab B, Rezaei M, Saneie S, Rahideh STThe effects of the Dietary Approaches to Stop Hypertension (DASH) diet on metabolic risk factors in patients with chronic disease: A systematic review and meta-analysis of randomized controlled trials.Nutr Metab Cardiovasc Dis.(2021 Sep 22)
- High-density lipoprotein (HDL) - Alaei-Shahmiri F, Soares MJ, Zhao Y, Sherriff JThe impact of thiamine supplementation on blood pressure, serum lipids and C-reactive protein in individuals with hyperglycemia: a randomised, double-blind cross-over trialDiabetes Metab Syndr.(2015 Oct-Dec)
- Glycemic Control - Crandall JP, Oram V, Trandafirescu G, Reid M, Kishore P, Hawkins M, Cohen HW, Barzilai NPilot Study of Resveratrol in Older Adults With Impaired Glucose ToleranceJ Gerontol A Biol Sci Med Sci.(2012 Jan 4)
- Glycemic Control - Hosseini E, Mokhtari Z, Askari GEffect of Prebiotic Supplementation on Health Status in Adults with Prediabetes: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.J Nutr.(2025 Jan 10)
- Endothelial Function - Shannon OM, Mendes I, Köchl C, Mazidi M, Ashor AW, Rubele S, Minihane AM, Mathers JC, Siervo MMediterranean Diet Increases Endothelial Function in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.J Nutr.(2020-May-01)
- Body Fat - Saadati S, Jansons P, Scott D, de Courten M, Mousa A, Feehan J, Mesinovic J, de Courten BThe Effect of Carnosine Supplementation on Musculoskeletal Health in Adults with Prediabetes and Type 2 Diabetes: A Secondary Analysis of a Randomized Controlled Trial.Nutrients.(2024 Dec 15)