Leg Edema

    Last Updated: October 13, 2024

    Leg swelling is a transient state of edema caused by prolonged sitting, and may occur even during walking in persons with poor circulation or during the later months of pregnancy. Some supplements that improve blood circulation may help with leg swelling.

    3,309 participants in 19 trials

    Examine Database: Leg Edema

    Examine Database References

    1. Gotu Kola - Pointel JP, Boccalon H, Cloarec M, Ledevehat C, Joubert MTitrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbsAngiology.(1987 Jan)
    2. Curcumin - Appendino G, Belcaro G, Cornelli U, Luzzi R, Togni S, Dugall M, Cesarone MR, Feragalli B, Ippolito E, Errichi BM, Pellegrini L, Ledda A, Ricci A, Bavera P, Hosoi M, Stuard S, Corsi M, Errichi S, Gizzi GPotential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot studyPanminerva Med.(2011 Sep)
    3. Gotu Kola - M R Cesarone, L Incandela, M T De Sanctis, G Belcaro, G Geroulakos, M Griffin, A Lennox, A D Di Renzo, M Cacchio, M BucciFlight microangiopathy in medium- to long-distance flights: prevention of edema and microcirculation alterations with total triterpenic fraction of Centella asiaticaAngiology.(2001 Oct)
    4. Butcher's broom - Vanscheidt W, Jost V, Wolna P, Lücker PW, Müller A, Theurer C, Patz B, Grützner KIEfficacy and safety of a Butcher's broom preparation (Ruscus aculeatus L. extract) compared to placebo in patients suffering from chronic venous insufficiencyArzneimittelforschung.(2002)
    5. Horse Chestnut - Diehm C, Trampisch HJ, Lange S, Schmidt CComparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiencyLancet.(1996 Feb 3)
    6. Boswellia - Gupta PK, Samarakoon SM, Chandola HM, Ravishankar BClinical evaluation of Boswellia serrata (Shallaki) resin in the management of Sandhivata (osteoarthritis)Ayu.(2011 Oct)
    7. MSM - Tripathi R, Gupta S, Rai S, Mittal PCEffect of topical application of methylsulfonylmethane (MSM), EDTA on pitting edema and oxidative stress in a double blind, placebo-controlled studyCell Mol Biol (Noisy-le-grand).(2011 Feb 12)
    8. Pycnogenol - Rainer KochComparative study of Venostasin and Pycnogenol in chronic venous insufficiencyPhytother Res.(2002 Mar)
    9. Grape Seed Extract - Sano A, Tokutake S, Seo AProanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sittingJ Sci Food Agric.(2012 Jul 2)
    10. Gotu Kola - Incandela L, Belcaro G, Cesarone MR, De Sanctis MT, Nargi E, Patricelli P, Bucci MTreatment of diabetic microangiopathy and edema with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled randomized studyAngiology.(2001 Oct)
    11. Serrapeptase - P M Esch, H Gerngross, A Fabian[Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-- a prospective study]Fortschr Med.(1989 Feb 10)
    12. Gotu Kola - Cesarone MR, Belcaro G, Rulo A, Griffin M, Ricci A, Ippolito E, De Sanctis MT, Incandela L, Bavera P, Cacchio M, Bucci MMicrocirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetryAngiology.(2001 Oct)
    13. Chlorella - Shiro Nakano, Hideo Takekoshi, Masuo NakanoChlorella pyrenoidosa supplementation reduces the risk of anemia, proteinuria and edema in pregnant womenPlant Foods Hum Nutr.(2010 Mar)
    14. Gotu Kola - Allegra C, Pollari G, Criscuolo A, Bonifacio M, Tabassi DCentella asiatica extract in venous disorders of the lower limbs. Comparative clinico-instrumental studies with a placeboClin Ter.(1981 Dec 15)
    15. Serrapeptase - Tachibana M, Mizukoshi O, Harada Y, Kawamoto K, Nakai YA multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swellingPharmatherapeutica.(1984)
    16. Horse Chestnut - Pittler MH, Ernst EHorse chestnut seed extract for chronic venous insufficiencyCochrane Database Syst Rev.(2006 Jan 25)
    17. Pycnogenol - Belcaro G, Cesarone MR, Errichi S, Zulli C, Errichi BM, Vinciguerra G, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Errichi S, Gizzi G, Ippolito E, Ricci A, Cacchio M, Cipollone G, Ruffini I, Fano F, Hosoi M, Rohdewald PTreatment of osteoarthritis with Pycnogenol. The SVOS (San Valentino Osteo-arthrosis Study). Evaluation of signs, symptoms, physical performance and vascular aspectsPhytother Res.(2008 Apr)
    18. Pycnogenol - Chan V, Wang L, Allman-Farinelli MEfficacy of Functional Foods, Beverages, and Supplements Claiming to Alleviate Air Travel Symptoms: Systematic Review and Meta-Analysis.Nutrients.(2021-Mar-16)
    19. Sodium Bicarbonate - Wu Y, Wang Y, Huang W, Guo X, Hou B, Tang J, Wu Y, Zheng H, Pan Y, Liu WJEfficacy and safety of oral sodium bicarbonate in kidney-transplant recipients and non-transplant patients with chronic kidney disease: a systematic review and meta-analysis.Front Pharmacol.(2024)