Overview
What is citrulline?
What are citrulline’s main benefits?
What are citrulline’s main drawbacks?
How does citrulline work?
Dosage Information
To supplement L-citrulline for circulatory health or to alleviate erectile dysfunction, take 2,000 mg of citrulline, three times a day with meals, for a total daily dose of 6,000 mg. L-citrulline does not need to be taken with meals, however.
To supplement for circulatory health with a citrulline malate supplement, take 1.76 g of citrulline malate for every 1 gram of citrulline you would normally take.
To supplement L-citrulline to enhance sports performance, take 6,000 – 8,000 mg of citrulline malate about an hour before exercise. On days that you don't exercise, it can be broken up into smaller doses.
Frequently Asked Questions
What’s the difference between L-citrulline and citrulline malate?
Which foods are rich in citrulline?
Does citrulline improve exercise performance?
Does citrulline reduce blood pressure?
Can citrulline help improve symptoms of erectile dysfunction?
Are there any side effects of taking high doses of citrulline?
How is citrulline created in the body?
Where is citrulline metabolized in the body after consumption?
Does citrulline impact muscle protein synthesis?
Does citrulline interact with other nutrients, supplements, or medications?
What are other names for Citrulline?
Update History
February 23, 2026
Examine Database update
minor
September 4, 2025
Safety Information added
major
Research Breakdown
The Examine Research Breakdown has been archived. The Examine team will be incorporating the information in this section throughout the site after a thorough review to ensure it is up to date.
