Fibromyalgia

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    Last Updated: October 13, 2024

    Fibromyalgia is a nonspecific pain disorder with currently unknown causes, although supplements are still being investigated for the purpose of reducing this pain.

    What is fibromyalgia?

    Fibromyalgia (FM) is a syndrome that is mainly characterized by widespread chronic (>3 months) musculoskeletal pain. If severe enough, people with FM can have trouble performing activities of daily living, such as working or basic self-care tasks. Currently, there are no standard treatments.[1]

    What are the main signs and symptoms of fibromyalgia?

    Chronic widespread pain is the most common and well-known symptom. However, further research has found that people with FM also experience a myriad of symptoms, such as:[2]

    • Fatigue
    • Sleep disturbances
    • Cognitive dysfunction
    • Migraines
    • Anxiety/depression
    • Digestive disturbances
    • Sensitivity to odors, lights, and sounds.

    How is fibromyalgia diagnosed?

    Diagnosis is based upon a thorough clinical evaluation from a healthcare provider. Currently, there are no tests for diagnosing FM. Since the symptoms of FM can also be caused by many other health conditions, other causes must be ruled out. It is a diagnosis of exclusion. [3]

    What are some of the main medical treatments for fibromyalgia?

    FM is typically treated with a combination of lifestyle changes and pharmacological interventions. [3]

    Lifestyle changes that may be implemented include:

    Medications that may be prescribed include:

    • Antidepressants
    • Anticonvulsants
    • Muscle relaxants
    • Antipsychotics
    • Medical cannabis

    The treatment must be tailored to the individual's responses to any of the previously mentioned interventions.[3]

    How could diet affect fibromyalgia?

    Some studies found that dietary changes can improve symptoms of FM. However, the quality of these studies was poor and varied in their dietary interventions. More randomized controlled trials are needed to understand the relationship between diet and FM.[4]

    Have any supplements been studied for fibromyalgia?

    Since there are no standard treatments for FM, dietary supplements are often used to ameliorate symptoms. The supplements with the greatest amount of research are vitamin-d and coenzyme-q10. With that being said, the findings are inconsistent and more evidence is needed before recommendations can be made.[5]

    Are there any other treatments for fibromyalgia?

    If initial therapies are not effective, people with FM may pursue alternative treatments to reduce symptoms. These treatments include:

    The evidence surrounding these interventions is scarce. Therefore, it is recommended to consult a healthcare professional before implementing any alternative treatments. [3]

    What causes fibromyalgia?

    The cause of FM is unknown. Current research suggests that environmental and genetic factors may play a role in the development of FM. Nonetheless, more research is needed before any conclusions can be drawn.[3]

    Examine Database: Fibromyalgia

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    Frequently asked questions

    What is fibromyalgia?

    Fibromyalgia (FM) is a syndrome characterized by widespread chronic musculoskeletal pain that lasts longer than 3 months, which can hinder daily activities like work and self-care. There are currently no standard treatments available for FM.

    Fibromyalgia (FM) is a syndrome that is mainly characterized by widespread chronic (>3 months) musculoskeletal pain. If severe enough, people with FM can have trouble performing activities of daily living, such as working or basic self-care tasks. Currently, there are no standard treatments.[1]

    What are the main signs and symptoms of fibromyalgia?

    The main sign of fibromyalgia is chronic widespread pain, but people with the condition also experience a variety of symptoms including fatigue, sleep disturbances, cognitive dysfunction, migraines, anxiety or depression, digestive issues, and sensitivity to sensory stimuli.

    Chronic widespread pain is the most common and well-known symptom. However, further research has found that people with FM also experience a myriad of symptoms, such as:[2]

    • Fatigue
    • Sleep disturbances
    • Cognitive dysfunction
    • Migraines
    • Anxiety/depression
    • Digestive disturbances
    • Sensitivity to odors, lights, and sounds.
    What can make fibromyalgia symptoms worse?
    Quick answer:

    Fibromyalgia symptoms can worsen due to additional stressors such as physical activity, psychological distress, sleep disturbances, poor diet, or infections, leading to a cycle of increased pain, fatigue, and cognitive dysfunction. Stress management is essential for reducing flare-ups and improving quality of life for people with fibromyalgia.

    The widespread pain, fatigue, and cognitive dysfunction of FM can cause significant bodily stress, so any additional stressors (like physical activity, psychological distress, sleep disturbances, poor diet, or infections) can cause a flare-up of FM symptoms. People with FM often have a decreased quality of life, which can further cause psychological distress, thereby creating a worsening cycle of symptoms. As such, finding ways to reduce stress is key to managing flare-ups.[8]

    How is fibromyalgia diagnosed?

    Fibromyalgia is diagnosed through a comprehensive clinical evaluation by a healthcare provider because there are no specific tests for the condition. The diagnosis is considered a diagnosis of exclusion, meaning that other potential causes for the symptoms must be ruled out.

    Diagnosis is based upon a thorough clinical evaluation from a healthcare provider. Currently, there are no tests for diagnosing FM. Since the symptoms of FM can also be caused by many other health conditions, other causes must be ruled out. It is a diagnosis of exclusion. [3]

    What tests or tools are used to diagnose fibromyalgia?
    Quick answer:

    Fibromyalgia is primarily diagnosed using the American College of Rheumatology criteria, which require widespread pain, symptom severity, and symptom duration of at least 3 months. The ACTTION-APS Pain Taxonomy (AAPT) criteria can also be used; this assessment focuses on pain locations and persistent symptoms, but no imaging or blood tests are available for diagnosis.

    The most widely used tool for diagnosing FM is the American College of Rheumatology (ACR) criteria. In order to reach a diagnosis of fibromyalgia, the following 3 conditions must be met:[6]

    • Widespread pain index (WPI) (the patient marks where their pain is located) ≥ 7 AND symptom severity scale (SSS) (the patient indicates how their symptoms interfere with their daily life) score ≥ 5 OR WPI of 4–6 AND SSS score ≥ 9.
    • Generalized pain, defined as pain in at least 4 of 5 regions (left upper region, left lower region, right upper region, right lower region, and axial) must be present.
    • Symptoms have been present for 3 months.

    The ACTTION-APS Pain Taxonomy (AAPT) diagnostic criteria can also be used, albeit less frequently[7]:

    • Pain in 6 or more of the following pain sites: head, left arm, right arm, chest, abdomen, upper back and spine, lower back and spine/buttocks, left leg, and right leg.
    • Moderate to severe sleep problems OR fatigue.
    • Pain and fatigue or sleep problems must be persistent for at least 3 months.

    To date, there are no imaging or blood tests used for diagnosis.

    What are some of the main medical treatments for fibromyalgia?

    Fibromyalgia is treated with a combination of lifestyle changes, such as improving sleep and increasing physical activity, and pharmacological interventions, including antidepressants and muscle relaxants. Treatment should be personalized based on the individual's response to these approaches.

    FM is typically treated with a combination of lifestyle changes and pharmacological interventions. [3]

    Lifestyle changes that may be implemented include:

    Medications that may be prescribed include:

    • Antidepressants
    • Anticonvulsants
    • Muscle relaxants
    • Antipsychotics
    • Medical cannabis

    The treatment must be tailored to the individual's responses to any of the previously mentioned interventions.[3]

    How could diet affect fibromyalgia?

    Some studies suggest that dietary changes may improve fibromyalgia symptoms, but the quality of these studies was poor and their dietary interventions were varied. Additional randomized controlled trials are necessary to clarify the relationship between diet and fibromyalgia.

    Some studies found that dietary changes can improve symptoms of FM. However, the quality of these studies was poor and varied in their dietary interventions. More randomized controlled trials are needed to understand the relationship between diet and FM.[4]

    Have any supplements been studied for fibromyalgia?

    Dietary supplements, particularly vitamin D and coenzyme Q10, have been studied for fibromyalgia, but the research findings are inconsistent, and more evidence is needed before making recommendations. There are currently no standard treatments for fibromyalgia, which has led to the use of these supplements to alleviate symptoms.

    Since there are no standard treatments for FM, dietary supplements are often used to ameliorate symptoms. The supplements with the greatest amount of research are vitamin-d and coenzyme-q10. With that being said, the findings are inconsistent and more evidence is needed before recommendations can be made.[5]

    Are there any other treatments for fibromyalgia?

    If initial therapies for fibromyalgia are ineffective, individuals may consider alternative treatments such as massage, chiropractic, and acupuncture, though evidence for these options is limited. It is advisable to consult a healthcare professional before trying any alternative treatments.

    If initial therapies are not effective, people with FM may pursue alternative treatments to reduce symptoms. These treatments include:

    The evidence surrounding these interventions is scarce. Therefore, it is recommended to consult a healthcare professional before implementing any alternative treatments. [3]

    What causes fibromyalgia?

    The cause of fibromyalgia is unknown, but current research indicates that both environmental and genetic factors may contribute to its development. Further research is necessary to draw definitive conclusions.

    The cause of FM is unknown. Current research suggests that environmental and genetic factors may play a role in the development of FM. Nonetheless, more research is needed before any conclusions can be drawn.[3]

    What causes pain in fibromyalgia?
    Quick answer:

    Fibromyalgia is now recognized as a true disorder that is characterized by improper pain signaling, which leads to hypersensitivity to pain. Research indicates that people with fibromyalgia have higher levels of glutamate and lower levels of GABA, which may contribute to this heightened pain sensitivity.

    Historically, whether fibromyalgia was a true condition has been debated, as many researchers and clinicians believed it was a purely psychological phenomenon. However, recent research has discovered that this is a true disorder with physical characteristics that can significantly impact quality of life.

    Now, fibromyalgia is thought to be a disorder characterized by improper pain signaling. People with FM tend to be hypersensitive to pain when compared to people without FM.[9] Additionally, people with FM also tend to have higher brain levels of glutamate[10] (an excitatory neurotransmitter) and decreased levels of GABA[11] (an inhibitory neurotransmitter), which may play a role in pain hypersensitivity.

    Examine Database References

    1. Fibromyalgia Symptoms - Elísabet Alcocer-Gómez, Jose Antonio Sánchez-Alcázar, Mario D CorderoCoenzyme q10 regulates serotonin levels and depressive symptoms in fibromyalgia patients: results of a small clinical trialJ Clin Psychopharmacol.(2014 Apr)
    2. Fibromyalgia Symptoms - Mario D Cordero, Elísabet Alcocer-Gómez, Manuel de Miguel, Ognjen Culic, Angel M Carrión, José Miguel Alvarez-Suarez, Pedro Bullón, Maurizio Battino, Ana Fernández-Rodríguez, José Antonio Sánchez-AlcazarCan coenzyme q10 improve clinical and molecular parameters in fibromyalgia?Antioxid Redox Signal.(2013 Oct 20)
    3. Fibromyalgia Symptoms - Sawaddiruk P, Apaijai N, Paiboonworachat S, Kaewchur T, Kasitanon N, Jaiwongkam T, Kerdphoo S, Chattipakorn N, Chattipakorn SCCoenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunctionFree Radic Res.(2019 Aug)
    4. Fibromyalgia Symptoms - Miyamae T, Seki M, Naga T, Uchino S, Asazuma H, Yoshida T, Iizuka Y, Kikuchi M, Imagawa T, Natsumeda Y, Yokota S, Yamamoto YIncreased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementationRedox Rep.(2013)
    5. Fibromyalgia Symptoms - Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JAOxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvementPLoS One.(2012)
    6. Fibromyalgia Symptoms - Christiano R R Alves, Bianca M Santiago, Fernanda R Lima, Maria C G Otaduy, Ana Luisa Calich, Aline C C Tritto, Ana Lúcia de Sá Pinto, Hamilton Roschel, Cláudia C Leite, Fabiana B Benatti, Eloisa Bonfá, Bruno GualanoCreatine supplementation in fibromyalgia: a randomized, double-blind, placebo-controlled trialArthritis Care Res (Hoboken).(2013 Sep)
    7. Fibromyalgia Symptoms - Avi Leader, Daniella Amital, Alan Rubinow, Howard AmitalAn open-label study adding creatine monohydrate to ongoing medical regimens in patients with the fibromyalgia syndromeAnn N Y Acad Sci.(2009 Sep)
    8. Fibromyalgia Symptoms - K Kaartinen, K Lammi, M Hypen, M Nenonen, O Hanninen, A L RaumaVegan diet alleviates fibromyalgia symptomsScand J Rheumatol.(2000)
    9. Fibromyalgia Symptoms - Carolina Chaves, Paulo Cesar T Bittencourt, Andreia PelegriniIngestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical TrialPain Med.(2020 Oct 1)
    10. Fibromyalgia Symptoms - Tine van de Donk, Marieke Niesters, Mikael A Kowal, Erik Olofsen, Albert Dahan, Monique van VelzenAn experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgiaPain.(2019 Apr)
    11. Pain - Martín-Sánchez E, Furukawa TA, Taylor J, Martin JLSystematic review and meta-analysis of cannabis treatment for chronic painPain Med.(2009 Nov)
    12. Myotonia Symptoms - Federica Montagnese, Kristina Stahl, Stephan Wenninger, Benedikt SchoserA role for cannabinoids in the treatment of myotonia? Report of compassionate use in a small cohort of patientsJ Neurol.(2020 Feb)
    13. Fibromyalgia Symptoms - Jacob E Teitelbaum, Clarence Johnson, John St CyrThe use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot studyJ Altern Complement Med.(2006 Nov)
    14. Fibromyalgia Symptoms - Merchant RE, Carmack CA, Wise CMNutritional supplementation with Chlorella pyrenoidosa for patients with fibromyalgia syndrome: a pilot studyPhytother Res.(2000 May)
    15. Fibromyalgia Symptoms - Jacobsen S, Danneskiold-Samsøe B, Andersen RBOral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluationScand J Rheumatol.(1991)
    16. Fibromyalgia Symptoms - Florian Wepner, Raphael Scheuer, Birgit Schuetz-Wieser, Peter Machacek, Elisabeth Pieler-Bruha, Heide S Cross, Julia Hahne, Martin FriedrichEffects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trialPain.(2014 Feb)
    17. Fibromyalgia Symptoms - Atalay Dogru, Ayse Balkarli, Veli Cobankara, Sevket Ercan Tunc, Mehmet SahinEffects of Vitamin D Therapy on Quality of Life in Patients with FibromyalgiaEurasian J Med.(2017 Jun)
    18. Fibromyalgia Symptoms - J F de Carvalho, F A G da Rocha Araújo, L M A da Mota, R B Aires, R P de AraujoVitamin D Supplementation Seems to Improve Fibromyalgia Symptoms: Preliminary ResultsIsr Med Assoc J.(2018 Jun)
    19. Fibromyalgia Symptoms - Rossini M, Di Munno O, Valentini G, Bianchi G, Biasi G, Cacace E, Malesci D, La Montagna G, Viapiana O, Adami SDouble-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patientsClin Exp Rheumatol.(2007 Mar-Apr)
    20. Fibromyalgia Symptoms - Axel Finckh, Isabelle Carey Berner, Bérengère Aubry-Rozier, Alexander Kai-Lik SoA randomized controlled trial of dehydroepiandrosterone in postmenopausal women with fibromyalgiaJ Rheumatol.(2005 Jul)
    21. Fibromyalgia Symptoms - Ana Paula Marum, Cátia Moreira, Fernando Saraiva, Pablo Tomas-Carus, Catarina Sousa-GuerreiroA low fermentable oligo-di-mono saccharides and polyols (FODMAP) diet reduced pain and improved daily life in fibromyalgia patientsScand J Pain.(2016 Oct)
    22. Fibromyalgia Symptoms - Selda Bagis, Mehmet Karabiber, Ismet As, Lülüfer Tamer, Canan Erdogan, Ayçe AtalayIs magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia?Rheumatol Int.(2013 Jan)
    23. Quality of Life - Macian N, Dualé C, Voute M, Leray V, Courrent M, Bodé P, Giron F, Sonneville S, Bernard L, Joanny F, Menard K, Ducheix G, Pereira B, Pickering GShort-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial.Nutrients.(2022-May-17)
    24. Fibromyalgia Symptoms - Chad S Boomershine, Todd A Koch, David MorrisA Blinded, Randomized, Placebo-Controlled Study to Investigate the Efficacy and Safety of Ferric Carboxymaltose in Iron-Deficient Patients with FibromyalgiaRheumatol Ther.(2018 Jun)
    25. Fibromyalgia Symptoms - Mansoor Shakiba, Ehsan Moazen-Zadeh, Ahmad Ali Noorbala, Morteza Jafarinia, Parisa Divsalar, Ladan Kashani, Nazila Shahmansouri, Abbas Tafakhori, Hannaneh Bayat, Shahin AkhondzadehSaffron ( Crocus sativus) versus duloxetine for treatment of patients with fibromyalgia: A randomized double-blind clinical trialAvicenna J Phytomed.(Nov-Dec 2018)
    26. Fibromyalgia Symptoms - Yeh SW, Hong CH, Shih MC, Tam KW, Huang YH, Kuan YCLow-Level Laser Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis.Pain Physician.(2019-May)
    27. Fibromyalgia Symptoms - Şevgin Ö, Buğday B, Aydoğan Baykara R, Günendi G, Akkurt B, Atasoy H, Dikmen Hoşbaş B, Akkurt MF, Karamancıoğlu BEfficacy of different exercises in women with fibromyalgia syndrome: a randomised controlled trial.Clin Exp Rheumatol.(2025 Feb 12)
    28. Fibromyalgia Symptoms - Caballol Angelats R, Gonçalves AQ, Abellana R, Carrasco-Querol N, Pàmies Corts A, González Serra G, Gràcia Benaiges D, Sancho Sol MC, Fusté Anguera I, Chavarria Jordana S, Cuevas Baticón B, Batlle Escolies G, Fibla Reverté M, Espuny Vallés N, Buera Pitarque N, Martí Cavallé M, Suazo NP, Estivill Bargalló J, López Guerrero MÀ, López Guerrero C, Pérez Acín P, Matamoros Callarisa I, Baucells J, Suazo Ciurana A, Fernández-Sáez J, Dalmau Llorca MR, Berenguera A, Aguilar Martín CEffectiveness of a Multicomponent Program for Fibromyalgia Patients in a Primary Care Setting (FIBROCARE Program): A Pragmatic Randomized Controlled Trial.J Clin Med.(2024 Dec 30)
    29. Pain - Donna D ZampiEfficacy of Theta Binaural Beats for the Treatment of Chronic PainAltern Ther Health Med.(Jan-Feb 2016)