Leptin

    Last Updated: October 13, 2024

    Leptin is a well-known adipokine (a signalling molecule made in body fat) that acts as a nutrient sensor and increases metabolic rate during periods of overfeeding. Its secretion is sensitive to carbohydrate ingestion, and its elevation during dieting desired.

    11,925 participants in 39 trials

    Examine Database: Leptin

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    Examine Database References

    1. Coenzyme Q10 - Gholami M, Zarei P, Sadeghi Sedeh B, Rafiei F, Khosrowbeygi AEffects of coenzyme Q10 supplementation on serum values of adiponectin, leptin, 8-isoprostane and malondialdehyde in women with type 2 diabetesGynecol Endocrinol.(2018 Dec)
    2. Zinc - Kelishadi R, Hashemipour M, Adeli K, Tavakoli N, Movahedian-Attar A, Shapouri J, Poursafa P, Rouzbahani AEffect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndromeMetab Syndr Relat Disord.(2010 Dec)
    3. Cannabis - Riggs PK, Vaida F, Rossi SS, Sorkin LS, Gouaux B, Grant I, Ellis RJA pilot study of the effects of cannabis on appetite hormones in HIV-infected adult menBrain Res.(2012 Jan 11)
    4. Melatonin - Celinski K, Konturek PC, Konturek SJ, Slomka M, Cichoz-Lach H, Brzozowski T, Bielanski WEffects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humansJ Physiol Pharmacol.(2011 Oct)
    5. Cannabis - Mehdi Farokhnia, Gray R McDiarmid, Matthew N Newmeyer, Vikas Munjal, Osama A Abulseoud, Marilyn A Huestis, Lorenzo LeggioEffects of oral, smoked, and vaporized cannabis on endocrine pathways related to appetite and metabolism: a randomized, double-blind, placebo-controlled, human laboratory studyTransl Psychiatry.(2020 Feb 19)
    6. Saffron - Soukhtanloo M, et alEffect of saffron on serum leptin levels in patients with metabolic syndrome, a double-blind, randomized and placebo-controlled trial studyProg Nutr.()
    7. Fenugreek - Brandon Bushey, Lem W. Taylor, Colin W. Wilborn, Chris Poole, Cliffa A. Foster, Bill Campbell, Richard B. Kreider, Darryn S. WilloughbyFenugreek Extract Supplementation Has No effect on the Hormonal Profile of Resitance-Trained MalesInternational Journal of Exercise Science.()
    8. Curcumin - Navekar R, Rafraf M, Ghaffari A, Asghari-Jafarabadi M, Khoshbaten MTurmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver DiseasesJ Am Coll Nutr.(2017 May-Jun)
    9. Curcumin - Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai SReduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trialJ Nutr Biochem.(2014 Feb)
    10. Cocoa Extract - Muniyappa R, Hall G, Kolodziej TL, Karne RJ, Crandon SK, Quon MJCocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertensionAm J Clin Nutr.(2008 Dec)
    11. L-Carnitine - Giuseppe Derosa, Pamela Maffioli, Ilaria Ferrari, Angela D'Angelo, Elena Fogari, Ilaria Palumbo, Sabrina Randazzo, Arrigo F G CiceroComparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patientsFundam Clin Pharmacol.(2011 Oct)
    12. Conjugated Linoleic Acid - Syvertsen C, Halse J, Høivik HO, Gaullier JM, Nurminiemi M, Kristiansen K, Einerhand A, O'Shea M, Gudmundsen OThe effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obeseInt J Obes (Lond).(2007 Jul)
    13. Niacin (Vitamin B3) - Westphal S, Borucki K, Taneva E, Makarova R, Luley CExtended-release niacin raises adiponectin and leptinAtherosclerosis.(2007 Aug)
    14. Ketogenic Diet - Brehm BJ, Seeley RJ, Daniels SR, D'Alessio DAA randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy womenJ Clin Endocrinol Metab.(2003 Apr)
    15. Fish Oil - Krebs JD, Browning LM, McLean NK, Rothwell JL, Mishra GD, Moore CS, Jebb SAAdditive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic womenInt J Obes (Lond).(2006 Oct)
    16. Melatonin - Gonciarz M, Bielański W, Partyka R, Brzozowski T, Konturek PC, Eszyk J, Celiński K, Reiter RJ, Konturek SJPlasma insulin, leptin, adiponectin, resistin, ghrelin, and melatonin in nonalcoholic steatohepatitis patients treated with melatoninJ Pineal Res.(2012 Jun 13)
    17. Ketogenic Diet - Varady KA, Bhutani S, Klempel MC, Phillips SAImprovements in vascular health by a low-fat diet, but not a high-fat diet, are mediated by changes in adipocyte biologyNutr J.(2011 Jan 20)
    18. African Mango - Ngondi JL, Etoundi BC, Nyangono CB, Mbofung CM, Oben JEIGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigationLipids Health Dis.(2009 Mar 2)
    19. Conjugated Linoleic Acid - Nazare JA, de la Perrière AB, Bonnet F, Desage M, Peyrat J, Maitrepierre C, Louche-Pelissier C, Bruzeau J, Goudable J, Lassel T, Vidal H, Laville MDaily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjectsBr J Nutr.(2007 Feb)
    20. Fish Oil - M Gorety Jacobo-Cejudo, Roxana Valdés-Ramos, Ana L Guadarrama-López, Rosa-Virgen Pardo-Morales, Beatriz E Martínez-Carrillo, Laurence S HarbigeEffect of n-3 Polyunsaturated Fatty Acid Supplementation on Metabolic and Inflammatory Biomarkers in Type 2 Diabetes Mellitus PatientsNutrients.(2017 Jun 3)
    21. Vegan Diet - F Eichelmann, L Schwingshackl, V Fedirko, K AleksandrovaEffect of plant-based diets on obesity-related inflammatory profiles: a systematic review and meta-analysis of intervention trialsObes Rev.(2016 Nov)
    22. 16:8 Intermittent Fasting - Matthew T Stratton, Grant M Tinsley, Michaela G Alesi, Garrett M Hester, Alex A Olmos, Paul R Serafini, Andrew S Modjeski, Gerald T Mangine, Kelsey King, Shelby N Savage, Austin T Webb, Trisha A VanDusseldorpFour Weeks of Time-Restricted Feeding Combined with Resistance Training Does Not Differentially Influence Measures of Body Composition, Muscle Performance, Resting Energy Expenditure, and Blood BiomarkersNutrients.(2020 Apr 17)
    23. Curcumin - Campbell MS, Ouyang A, I M K, Charnigo RJ, Westgate PM, Fleenor BSInfluence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: A double-blinded, randomized, controlled trialNutrition.(2019 Jun)
    24. Garlic - Gómez-Arbeláez D, Lahera V, Oubiña P, Valero-Muñoz M, de Las Heras N, Rodríguez Y, García RG, Camacho PA, López-Jaramillo PAged garlic extract improves adiponectin levels in subjects with metabolic syndrome: a double-blind, placebo-controlled, randomized, crossover studyMediators Inflamm.(2013)
    25. Japanese Knotweed - Ghanim H, Sia CL, Abuaysheh S, Korzeniewski K, Patnaik P, Marumganti A, Chaudhuri A, Dandona PAn antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrolJ Clin Endocrinol Metab.(2010 Sep)
    26. Fish Oil - Vargas ML, Almario RU, Buchan W, Kim K, Karakas SEMetabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndromeMetabolism.(2011 Dec)
    27. 16:8 Intermittent Fasting - Tatiana Moro, Grant Tinsley, Antonino Bianco, Giuseppe Marcolin, Quirico Francesco Pacelli, Giuseppe Battaglia, Antonio Palma, Paulo Gentil, Marco Neri, Antonio PaoliEffects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained malesJ Transl Med.(2016 Oct 13)
    28. Zinc - C S Mantzoros, A S Prasad, F W Beck, S Grabowski, J Kaplan, C Adair, G J BrewerZinc may regulate serum leptin concentrations in humansJ Am Coll Nutr.(1998 Jun)
    29. Ketogenic Diet - Boden G, Sargrad K, Homko C, Mozzoli M, Stein TPEffect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetesAnn Intern Med.(2005 Mar 15)
    30. L-Carnitine - Giuseppe Derosa, Pamela Maffioli, Sibilla A T Salvadeo, Ilaria Ferrari, Alessia Gravina, Roberto Mereu, Angela D'Angelo, Ilaria Palumbo, Sabrina Randazzo, Arrigo F G CiceroEffects of combination of sibutramine and L-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patientsMetabolism.(2011 Mar)
    31. OMAD And 20:4 Intermittent Fasting - Carlson O, Martin B, Stote KS, Golden E, Maudsley S, Najjar SS, Ferrucci L, Ingram DK, Longo DL, Rumpler WV, Baer DJ, Egan J, Mattson MPImpact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and womenMetabolism.(2007 Dec)
    32. Curcumin - Akbari M, Lankarani KB, Tabrizi R, Ghayour-Mobarhan M, Peymani P, Ferns G, Ghaderi A, Asemi ZThe Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Front Pharmacol.(2019)
    33. Resveratrol - Mohammadi-Sartang M, Mazloom Z, Sohrabi Z, Sherafatmanesh S, Barati-Boldaji RResveratrol supplementation and plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials.Pharmacol Res.(2017-Mar)
    34. Resveratrol - Qian Zhou, Yanmei Wang, Xuke Han, Shunlian Fu, Chan Zhu, Qiu ChenEfficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic ReviewFront Physiol.(2022 Mar 31)
    35. Vitamin K - Suksomboon N, Poolsup N, Darli Ko Ko HEffect of vitamin K supplementation on insulin sensitivity: a meta-analysis.Diabetes Metab Syndr Obes.(2017)
    36. Flaxseed - Jalili C, Pezeshki M, Askarpour M, Marx W, Hassani B, Hadi A, Ghaedi EThe effect of flaxseed supplementation on circulating adiponectin and leptin concentration in adults: A systematic review and meta-analysis of randomized controlled trials.Phytother Res.(2020 Jul)
    37. Flaxseed - Abbasi S, Karimi K, Hossein Moridpour A, Musazadeh V, Faghfouri AH, Jozi HCan flaxseed supplementation affect circulating adipokines in adults? An updated systematic review and meta-analysis of randomized controlled trials.Front Nutr.(2023)
    38. L-Carnitine - Gheysari R, Nikbaf-Shandiz M, Hosseini AM, Rasaei N, Hosseini S, Bahari H, Asbaghi O, Rastgoo S, Goudarzi K, Shiraseb F, Behmadi RThe effects of L-carnitine supplementation on cardiovascular risk factors in participants with impaired glucose tolerance and diabetes: a systematic review and dose-response meta-analysis.Diabetol Metab Syndr.(2024 Jul 31)
    39. 16:8 Intermittent Fasting - Dai Z, Wan K, Miyashita M, Ho RS, Zheng C, Poon ET, Wong SHThe Effect of Time-Restricted Eating Combined with Exercise on Body Composition and Metabolic Health: A Systematic Review and Meta-Analysis.Adv Nutr.(2024 Aug)