Anti-Oxidant Enzyme Profile

    Last Updated: October 13, 2024

    Antioxidant enzymes (usually glutathione, superoxide dismutase, and catalase) are known to protect the body from oxidative damage, and increasing their levels or activity can confer protection from oxidative damage.

    3,658 participants in 78 trials

    Examine Database: Anti-Oxidant Enzyme Profile

    InterventionGradeEffectDetail
    Curcumin
    A
    Tart Cherry Juice
    D
    Coenzyme Q10
    B
    Spirulina
    Chromium
    Astaxanthin
    Garlic
    Panax Ginseng (Korean Ginseng)
    Ginkgo Biloba
    Whey Protein
    Vitamin C
    Vitamin E
    Zinc
    Melatonin
    Olive Oil
    Yerba Mate
    Reishi
    L-Carnitine
    Grape Juice
    Rhodiola Rosea
    Stinging Nettle
    Ginger
    Ashwagandha
    Black Ginger
    Rose Hip
    Arginine
    Riboflavin (Vitamin B2)
    Shilajit
    Korean black raspberry
    Mango
    Watercress
    Chlorella
    Citrulline
    N-Acetylcysteine
    Alpha-Lipoic Acid
    Creatine
    Glutathione

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    Examine Database References

    1. Olive Oil - Fitó M, Cladellas M, de la Torre R, Martí J, Alcántara M, Pujadas-Bastardes M, Marrugat J, Bruguera J, López-Sabater MC, Vila J, Covas MI; members of the SOLOS InvestigatorsAntioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trialAtherosclerosis.(2005 Jul)
    2. Shilajit - Sharma P, Jha J, Shrinivas V, Dwivedi LK, Suresh P, Sinha MShilajit: evalution of its effects on blood chemistry of normal human subjectsAnc Sci Life.(2003 Oct)
    3. Vitamin C - Ruiz-Ramos M, Vargas LA, Fortoul Van der Goes TI, Cervantes-Sandoval A, Mendoza-Nunez VMSupplementation of ascorbic acid and alpha-tocopherol is useful to preventing bone loss linked to oxidative stress in elderlyJ Nutr Health Aging.(2010 Jun)
    4. Coenzyme Q10 - Dai YL, Luk TH, Yiu KH, Wang M, Yip PM, Lee SW, Li SW, Tam S, Fong B, Lau CP, Siu CW, Tse HFReversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trialAtherosclerosis.(2011 Jun)
    5. Mango - Pardo-Andreu GL, Philip SJ, Riaño A, Sánchez C, Viada C, Núñez-Sellés AJ, Delgado RMangifera indica L. (Vimang) protection against serum oxidative stress in elderly humansArch Med Res.(2006 Jan)
    6. Spirulina - Shariat A, Farhangi M, Zeinalian RSpirulina platensis supplementation, macrophage inhibitory cytokine-1 (MIC-1), oxidative stress markers and anthropometric features in obese individuals: A randomized controlled trialJ Herb Med.()
    7. Stinging Nettle - Namazi N, Tarighat A, Bahrami AThe effect of hydro alcoholic nettle (Urtica dioica) extract on oxidative stress in patients with type 2 diabetes: a randomized double-blind clinical trialPak J Biol Sci.(2012 Jan 15)
    8. Astaxanthin - Kim JH, Chang MJ, Choi HD, Youn YK, Kim JT, Oh JM, Shin WGProtective effects of Haematococcus astaxanthin on oxidative stress in healthy smokersJ Med Food.(2011 Nov)
    9. Rose Hip - Kirkeskov B, Christensen R, Bügel S, Bliddal H, Danneskiold-Samsøe B, Christensen LP, Andersen JRThe effects of rose hip (Rosa canina) on plasma antioxidative activity and C-reactive protein in patients with rheumatoid arthritis and normal controls: a prospective cohort studyPhytomedicine.(2011 Aug 15)
    10. Melatonin - Koziróg M, Poliwczak AR, Duchnowicz P, Koter-Michalak M, Sikora J, Broncel MMelatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndromeJ Pineal Res.(2011 Apr)
    11. Panax Ginseng (Korean Ginseng) - Kim HG, Yoo SR, Park HJ, Lee NH, Shin JW, Sathyanath R, Cho JH, Son CGAntioxidant effects of Panax ginseng C.A. Meyer in healthy subjects: a randomized, placebo-controlled clinical trialFood Chem Toxicol.(2011 Sep)
    12. Citrulline - S Azizi, M Ebrahimi-Mameghani, M Mobasseri, N Karamzad, R MahdaviOxidative stress and nitrate/nitrite (NOx) status following citrulline supplementation in type 2 diabetes: a randomised, double-blind, placebo-controlled trialJ Hum Nutr Diet.(2020 Jul 19)
    13. Curcumin - Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar AAntioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysisClin Nutr.(2015 Dec)
    14. Olive Oil - Weinbrenner T, Fitó M, de la Torre R, Saez GT, Rijken P, Tormos C, Coolen S, Albaladejo MF, Abanades S, Schroder H, Marrugat J, Covas MIOlive oils high in phenolic compounds modulate oxidative/antioxidative status in menJ Nutr.(2004 Sep)
    15. Ginkgo Biloba - Rodríguez M, Ringstad L, Schäfer P, Just S, Hofer HW, Malmsten M, Siegel GReduction of atherosclerotic nanoplaque formation and size by Ginkgo biloba (EGb 761) in cardiovascular high-risk patientsAtherosclerosis.(2007 Jun)
    16. Yerba Mate - Brunna Cristina Bremer Boaventura, Patrícia Faria Di Pietro, Aliny Stefanuto, Graziela Alessandra Klein, Elayne Cristina de Morais, Fernanda de Andrade, Elisabeth Wazlawik, Edson Luiz da SilvaAssociation of mate tea (Ilex paraguariensis) intake and dietary intervention and effects on oxidative stress biomarkers of dyslipidemic subjectsNutrition.(2012 Jun)
    17. Coenzyme Q10 - Nadjarzadeh A, Shidfar F, Amirjannati N, Vafa MR, Motevalian SA, Gohari MR, Nazeri Kakhki SA, Akhondi MM, Sadeghi MREffect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trialAndrologia.(2014 Mar)
    18. Watercress - Hofmann T, Kuhnert A, Schubert A, Gill C, Rowland IR, Pool-Zobel BL, Glei MModulation of detoxification enzymes by watercress: in vitro and in vivo investigations in human peripheral blood cellsEur J Nutr.(2009 Dec)
    19. Zinc - Kara E, Gunay M, Cicioglu I, Ozal M, Kilic M, Mogulkoc R, Baltaci AKEffect of zinc supplementation on antioxidant activity in young wrestlersBiol Trace Elem Res.(2010 Apr)
    20. Ginger - Waleed Abid Al-Kadir Mares, Wisam S. NajamThe effect of Ginger on semen parameters and serum FSH, LH & testosterone of infertile menTikrit Medical Journal.()
    21. Curcumin - Yang H, Xu W, Zhou Z, Liu J, Li X, Chen L, Weng J, Yu ZCurcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficaciesExp Clin Endocrinol Diabetes.(2015 Jun)
    22. Curcumin - T Krishnareddy N, Thomas JV, Nair SS, N Mulakal J, Maliakel BP, Krishnakumar IMA Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled StudyBiomed Res Int.(2018 Sep 23)
    23. Coenzyme Q10 - Lee BJ, Huang YC, Chen SJ, Lin PTCoenzyme Q10 supplementation reduces oxidative stress and increase antioxidant enzyme activity in patients with coronary artery diseaseNutrition.(2011 Oct 11)
    24. Spirulina - Jesús Martínez-Sámano, Adriana Torres-Montes de Oca, Oscar Ivan Luqueño-Bocardo, Patricia V Torres-Durán, Marco A Juárez-OropezaSpirulina maxima Decreases Endothelial Damage and Oxidative Stress Indicators in Patients with Systemic Arterial Hypertension: Results from Exploratory Controlled Clinical TrialMar Drugs.(2018 Dec 8)
    25. Chromium - Anderson RA, Roussel AM, Zouari N, Mahjoub S, Matheau JM, Kerkeni APotential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitusJ Am Coll Nutr.(2001 Jun)
    26. Garlic - Budoff MJ, Takasu J, Flores FR, Niihara Y, Lu B, Lau BH, Rosen RT, Amagase HInhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary studyPrev Med.(2004 Nov)
    27. Garlic - Avci A, Atli T, Ergüder IB, Varli M, Devrim E, Aras S, Durak IEffects of garlic consumption on plasma and erythrocyte antioxidant parameters in elderly subjectsGerontology.(2008)
    28. Reishi - Wachtel-Galor S, Tomlinson B, Benzie IFGanoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation studyBr J Nutr.(2004 Feb)
    29. Chlorella - Lee SH, Kang HJ, Lee HJ, Kang MH, Park YKSix-week supplementation with Chlorella has favorable impact on antioxidant status in Korean male smokersNutrition.(2010 Feb)
    30. Whey Protein - Chitapanarux T, Tienboon P, Pojchamarnwiputh S, Leelarungrayub DOpen-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patientsJ Gastroenterol Hepatol.(2009 Jun)
    31. Garlic - Nantz MP, Rowe CA, Muller CE, Creasy RA, Stanilka JM, Percival SSSupplementation with aged garlic extract improves both NK and γδ-T cell function and reduces the severity of cold and flu symptoms: a randomized, double-blind, placebo-controlled nutrition interventionClin Nutr.(2012 Jun)
    32. Curcumin - Biswas J, Sinha D, Mukherjee S, Roy S, Siddiqi M, Roy MCurcumin protects DNA damage in a chronically arsenic-exposed population of West BengalHum Exp Toxicol.(2010 Jun)
    33. Korean black raspberry - Ji Eun Lee, Eunkyo Park, Jung Eun Lee, Joong Hyuck Auh, Hyung-Kyoon Choi, Jaehwi Lee, Soomuk Cho, Jung-Hyun KimEffects of a Rubus coreanus Miquel supplement on plasma antioxidant capacity in healthy Korean menNutr Res Pract.(2011 Oct)
    34. Chromium - Racek J, Trefil L, Rajdl D, Mudrová V, Hunter D, Senft VInfluence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitusBiol Trace Elem Res.(2006 Mar)
    35. Curcumin - Maithili Karpaga Selvi N, Sridhar MG, Swaminathan RP, Sripradha REfficacy of Turmeric as Adjuvant Therapy in Type 2 Diabetic PatientsIndian J Clin Biochem.(2015 Apr)
    36. Spirulina - Radhey Shyam, Som N Singh, Praveen Vats, Vijay K Singh, Rajeev Bajaj, Shashi B Singh, Pratul K BanerjeeWheat grass supplementation decreases oxidative stress in healthy subjects: a comparative study with spirulinaJ Altern Complement Med.(2007 Oct)
    37. Curcumin - DiSilvestro RA, Joseph E, Zhao S, Bomser JDiverse effects of a low dose supplement of lipidated curcumin in healthy middle aged peopleNutr J.(2012 Sep 26)
    38. Glutathione - Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JERandomized controlled trial of oral glutathione supplementation on body stores of glutathioneEur J Nutr.(2015 Mar)
    39. Vitamin E - Meydani SN, Meydani M, Blumberg JB, Leka LS, Pedrosa M, Diamond R, Schaefer EJAssessment of the safety of supplementation with different amounts of vitamin E in healthy older adultsAm J Clin Nutr.(1998 Aug)
    40. Vitamin C - Mason SA, Della Gatta PA, Snow RJ, Russell AP, Wadley GDAscorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled studyFree Radic Biol Med.(2016 Apr)
    41. Whey Protein - Vatani DS, Golzar FAChanges in antioxidant status and cardiovascular risk factors of overweight young men after six weeks supplementation of whey protein isolate and resistance trainingAppetite.(2012 Aug 10)
    42. N-Acetylcysteine - Kasperczyk S, Dobrakowski M, Kasperczyk A, Ostałowska A, Birkner EThe administration of N-acetylcysteine reduces oxidative stress and regulates glutathione metabolism in the blood cells of workers exposed to leadClin Toxicol (Phila).(2013 Jul)
    43. Melatonin - Maldonado MD, Manfredi M, Ribas-Serna J, Garcia-Moreno H, Calvo JRMelatonin administrated immediately before an intense exercise reverses oxidative stress, improves immunological defenses and lipid metabolism in football playersPhysiol Behav.(2012 Mar 20)
    44. Alpha-Lipoic Acid - Martins VD, Manfredini V, Peralba MC, Benfato MSAlpha-lipoic acid modifies oxidative stress parameters in sickle cell trait subjects and sickle cell patientsClin Nutr.(2009 Apr)
    45. Vitamin E - Wu JH, Ward NC, Indrawan AP, Almeida CA, Hodgson JM, Proudfoot JM, Puddey IB, Croft KDEffects of alpha-tocopherol and mixed tocopherol supplementation on markers of oxidative stress and inflammation in type 2 diabetesClin Chem.(2007 Mar)
    46. Riboflavin (Vitamin B2) - Naghashpour M, Majdinasab N, Shakerinejad G, Kouchak M, Haghighizadeh MH, Jarvandi F, Hajinajaf SRiboflavin supplementation to patients with multiple sclerosis does not improve disability status nor is riboflavin supplementation correlated to homocysteineInt J Vitam Nutr Res.(2013)
    47. Chromium - Lai MHAntioxidant effects and insulin resistance improvement of chromium combined with vitamin C and e supplementation for type 2 diabetes mellitusJ Clin Biochem Nutr.(2008 Nov)
    48. Panax Ginseng (Korean Ginseng) - Kim JY, Park JY, Kang HJ, Kim OY, Lee JHBeneficial effects of Korean red ginseng on lymphocyte DNA damage, antioxidant enzyme activity, and LDL oxidation in healthy participants: a randomized, double-blind, placebo-controlled trialNutr J.(2012 Jul 17)
    49. Coenzyme Q10 - Jahangard L, Yasrebifar F, Haghighi M, Ranjbar A, Mehrpooya MInfluence of adjuvant Coenzyme Q10 on inflammatory and oxidative stress biomarkers in patients with bipolar disorders during the depressive episodeMol Biol Rep.(2019 Oct)
    50. Rhodiola Rosea - Jówko E, Sadowski J, Długołęcka B, Gierczuk D, Opaszowski B, Cieśliński IEffects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy menJ Sport Health Sci.(2018 Oct)
    51. L-Carnitine - Fatouros IG, Douroudos I, Panagoutsos S, Pasadakis P, Nikolaidis MG, Chatzinikolaou A, Sovatzidis A, Michailidis Y, Jamurtas AZ, Mandalidis D, Taxildaris K, Vargemezis VEffects of L-carnitine on oxidative stress responses in patients with renal diseaseMed Sci Sports Exerc.(2010 Oct)
    52. Black Ginger - Wattanathorn J, Muchimapura S, Tong-Un T, Saenghong N, Thukhum-Mee W, Sripanidkulchai BPositive Modulation Effect of 8-Week Consumption of Kaempferia parviflora on Health-Related Physical Fitness and Oxidative Status in Healthy Elderly VolunteersEvid Based Complement Alternat Med.(2012)
    53. Ashwagandha - Kuchewar VV, Borkar MA, Nisargandha MAEvaluation of antioxidant potential of Rasayana drugs in healthy human volunteersAyu.(2014 Jan)
    54. Coenzyme Q10 - Sawaddiruk P, Apaijai N, Paiboonworachat S, Kaewchur T, Kasitanon N, Jaiwongkam T, Kerdphoo S, Chattipakorn N, Chattipakorn SCCoenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunctionFree Radic Res.(2019 Aug)
    55. Grape Juice - Park YK, Lee SH, Park E, Kim JS, Kang MHChanges in antioxidant status, blood pressure, and lymphocyte DNA damage from grape juice supplementationAnn N Y Acad Sci.(2009 Aug)
    56. Ginkgo Biloba - Atmaca M, Tezcan E, Kuloglu M, Ustundag B, Kirtas OThe effect of extract of ginkgo biloba addition to olanzapine on therapeutic effect and antioxidant enzyme levels in patients with schizophreniaPsychiatry Clin Neurosci.(2005 Dec)
    57. Curcumin - Durgaprasad S, Pai CG, Vasanthkumar, Alvres JF, Namitha SA pilot study of the antioxidant effect of curcumin in tropical pancreatitisIndian J Med Res.(2005 Oct)
    58. Astaxanthin - Choi HD, Youn YK, Shin WGPositive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjectsPlant Foods Hum Nutr.(2011 Nov)
    59. Astaxanthin - Choi HD, Kim JH, Chang MJ, Kyu-Youn Y, Shin WGEffects of astaxanthin on oxidative stress in overweight and obese adultsPhytother Res.(2011 Dec)
    60. Spirulina - Park HJ, Lee YJ, Ryu HK, Kim MH, Chung HW, Kim WYA randomized double-blind, placebo-controlled study to establish the effects of spirulina in elderly KoreansAnn Nutr Metab.(2008)
    61. L-Carnitine - Yu Cao, Hai-Jun Qu, Ping Li, Chun-Bo Wang, Le-Xin Wang, Zhi-Wu HanSingle dose administration of L-carnitine improves antioxidant activities in healthy subjectsTohoku J Exp Med.(2011 Jul)
    62. Coenzyme Q10 - Mirhashemi SM, Najafi V, Raygan F, Asemi ZThe effects of coenzyme Q10 supplementation on cardiometabolic markers in overweight type 2 diabetic patients with stable myocardial infarction: A randomized, double-blind, placebo-controlled trialARYA Atheroscler.(2016 Jul)
    63. Curcumin - Kalpravidh RW, Siritanaratkul N, Insain P, Charoensakdi R, Panichkul N, Hatairaktham S, Srichairatanakool S, Phisalaphong C, Rachmilewitz E, Fucharoen SImprovement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoidsClin Biochem.(2010 Mar)
    64. Spirulina - Hsueh-Kuan Lu, Chin-Cheng Hsieh, Jen-Jung Hsu, Yuh-Kuan Yang, Hong-Nong ChouPreventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stressEur J Appl Physiol.(2006 Sep)
    65. Coenzyme Q10 - Mousavinejad E, Ghaffari MA, Riahi F, Hajmohammadi M, Tiznobeyk Z, Mousavinejad MCoenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disordersPsychiatry Res.(2018 Jul)
    66. Zinc - Jafari F, Amani R, Tarrahi MJEffect of Zinc Supplementation on Physical and Psychological Symptoms, Biomarkers of Inflammation, Oxidative Stress, and Brain-Derived Neurotrophic Factor in Young Women with Premenstrual Syndrome: a Randomized, Double-Blind, Placebo-Controlled TrialBiol Trace Elem Res.(2019 Jun 2)
    67. Chromium - Cheng HH, Lai MH, Hou WC, Huang CLAntioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjectsJ Agric Food Chem.(2004 Mar 10)
    68. Arginine - Lucotti P, Setola E, Monti LD, Galluccio E, Costa S, Sandoli EP, Fermo I, Rabaiotti G, Gatti R, Piatti PBeneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patientsAm J Physiol Endocrinol Metab.(2006 Nov)
    69. Yerba Mate - Ruth L T Matsumoto, Deborah H M Bastos, Simone Mendonça, Valéria S Nunes, Waldemar Bartchewsky, Marcelo L Ribeiro, Patrícia de Oliveira CarvalhoEffects of mate tea (Ilex paraguariensis) ingestion on mRNA expression of antioxidant enzymes, lipid peroxidation, and total antioxidant status in healthy young womenJ Agric Food Chem.(2009 Mar 11)
    70. Reishi - Chu TT, Benzie IF, Lam CW, Fok BS, Lee KK, Tomlinson BStudy of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trialBr J Nutr.(2012 Apr)
    71. Creatine - Deminice R, Rosa FT, Franco GS, Jordao AA, de Freitas ECEffects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humansNutrition.(2013 Sep)
    72. Tart Cherry Juice - Hillman AR, Uhranowsky KAcute Ingestion of Montmorency Tart Cherry Reduces Serum Uric Acid but Has no Impact on High Sensitivity C-Reactive Protein or Oxidative Capacity.Plant Foods Hum Nutr.(2021-Mar)
    73. Tart Cherry Juice - Johnson SA, Navaei N, Pourafshar S, Jaime SJ, Akhavan NS, Alvarez-Alvarado S, Proaño GV, Litwin NS, Clark EA, Foley EM, George KS, Elam ML, Payton ME, Arjmandi BH, Figueroa AEffects of Montmorency Tart Cherry Juice Consumption on Cardiometabolic Biomarkers in Adults with Metabolic Syndrome: A Randomized Controlled Pilot Trial.J Med Food.(2020-Dec)
    74. Tart Cherry Juice - Desai T, Bottoms L, Roberts MThe effects of Montmorency tart cherry juice supplementation and FATMAX exercise on fat oxidation rates and cardio-metabolic markers in healthy humans.Eur J Appl Physiol.(2018-Dec)
    75. Tart Cherry Juice - Bowtell JL, Sumners DP, Dyer A, Fox P, Mileva KNMontmorency cherry juice reduces muscle damage caused by intensive strength exerciseMed Sci Sports Exerc.(2011 Aug)
    76. Tart Cherry Juice - Polley KR, Oswell NJ, Pegg RB, Cooper JATart cherry consumption with or without prior exercise increases antioxidant capacity and decreases triglyceride levels following a high-fat meal.Appl Physiol Nutr Metab.(2019-Nov)
    77. Tart Cherry Juice - Wangdi JT, O'Leary MF, Kelly VG, Jackman SR, Tang JCY, Dutton J, Bowtell JLTart Cherry Supplement Enhances Skeletal Muscle Glutathione Peroxidase Expression and Functional Recovery after Muscle Damage.Med Sci Sports Exerc.(2022-Apr-01)
    78. Tart Cherry Juice - Lynn A, Mathew S, Moore CT, Russell J, Robinson E, Soumpasi V, Barker MEEffect of a tart cherry juice supplement on arterial stiffness and inflammation in healthy adults: a randomised controlled trial.Plant Foods Hum Nutr.(2014-Jun)