Osteoarthritis Symptoms

    Last Updated: October 13, 2024

    Symptoms of osteoarthritis (OA) tend to reflect mobility, joint pain and stiffness, as well as quality of life in persons with OA. Supplements that benefit these symptoms according to self-reported rating scales are prophylactic.

    42,362 participants in 82 trials

    Examine Database: Osteoarthritis Symptoms

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    Examine Database References

    1. Glucosamine - Chopra A, Saluja M, Tillu G, Sarmukkaddam S, Venugopalan A, Narsimulu G, Handa R, Sumantran V, Raut A, Bichile L, Joshi K, Patwardhan BAyurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trialRheumatology (Oxford).(2013 Jan 30)
    2. Glucosamine - Vlad SC, LaValley MP, McAlindon TE, Felson DTGlucosamine for pain in osteoarthritis: why do trial results differArthritis Rheum.(2007 Jul)
    3. Curcumin - Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, Saengsuwan J, Tantayakom K, Laongpech SEfficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter studyClin Interv Aging.(2014 Mar 20)
    4. Curcumin - Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino GEfficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patientsAltern Med Rev.(2010 Dec)
    5. Glucosamine - Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JYStructural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysisArch Intern Med.(2003 Jul 14)
    6. Curcumin - Haroyan A, Mukuchyan V, Mkrtchyan N, Minasyan N, Gasparyan S, Sargsyan A, Narimanyan M, Hovhannisyan AEfficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled studyBMC Complement Altern Med.(2018 Jan 9)
    7. Stinging Nettle - Keith Rayburn, Eric Fleischbein, Jessica Song, Blaine Allen, Mary Kundert, Charles Leiter, Thomas BushStinging nettle cream for osteoarthritisAltern Ther Health Med.(Jul-Aug 2009)
    8. Bromelain - Brien S, Lewith G, Walker AF, Middleton R, Prescott P, Bundy RBromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot studyQJM.(2006 Dec)
    9. Glucosamine - Yongsak Wangroongsub, Aree Tanavalee, Vajara Wilairatana, Srihatach NgarmukosComparable clinical outcomes between glucosamine sulfate-potassium chloride and glucosamine sulfate sodium chloride in patients with mild and moderate knee osteoarthritis: a randomized, double-blind studyJ Med Assoc Thai.(2010 Jul)
    10. S-adenosylmethionine - Soeken KL, Lee WL, Bausell RB, Agelli M, Berman BMSafety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritisJ Fam Pract.(2002 May)
    11. Feverfew - Pattrick M, Heptinstall S, Doherty MFeverfew in rheumatoid arthritis: a double blind, placebo controlled studyAnn Rheum Dis.(1989 Jul)
    12. Glucosamine - Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJGlucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritisN Engl J Med.(2006 Feb 23)
    13. Glucosamine - Wandel S, Jüni P, Tendal B, Nüesch E, Villiger PM, Welton NJ, Reichenbach S, Trelle SEffects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysisBMJ.(2010 Sep 16)
    14. Guggul - Singh BB, Mishra LC, Vinjamury SP, Aquilina N, Singh VJ, Shepard NThe effectiveness of Commiphora mukul for osteoarthritis of the knee: an outcomes studyAltern Ther Health Med.(2003 May-Jun)
    15. Glucosamine - Houpt JB, McMillan R, Wein C, Paget-Dellio SDEffect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the kneeJ Rheumatol.(1999 Nov)
    16. Curcumin - Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihira J, Nakamura TShort-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective studyJ Orthop Sci.(2014 Nov)
    17. Glucosamine - Towheed TE, Anastassiades TP, Shea B, Houpt J, Welch V, Hochberg MCGlucosamine therapy for treating osteoarthritisCochrane Database Syst Rev.(2001)
    18. Rose Hip - Odd Warholm, Sigrun Skaar, Ewa Hedman Hanna Maria Mølmen, Liv EikThe Effects of a Standardized Herbal Remedy Made from a Subtype of Rosa canina in Patients with Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Clinical TrialCurrent Therapeutic Research.()
    19. Type-II Collagen - P. Benito-RuizM.M. Camacho-Zambrano, J.N. Carrillo-Arcentales, M.A. Mestanza-Peralta, C.A. Vallejo-Flores, S.V. Vargas-López, R.A. Villacís-Tamayo and L.A. Zurita-GavilanesA randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfortInternational Journal of Food Sciences and Nutrition.()
    20. Glucosamine - McAlindon TE, LaValley MP, Gulin JP, Felson DTGlucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysisJAMA.(2000 Mar 15)
    21. Rose Hip - Winther K, Apel K, Thamsborg GA powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trialScand J Rheumatol.(2005 Jul-Aug)
    22. Glucosamine - Pujalte JM, Llavore EP, Ylescupidez FRDouble-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosisCurr Med Res Opin.(1980)
    23. Curcumin - Shep D, Khanwelkar C, Gade P, Karad SSafety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm studyTrials.(2019 Apr 11)
    24. Curcumin - Vilai Kuptniratsaikul, Sunee Thanakhumtorn, Pornsiri Chinswangwatanakul, Luksamee Wattanamongkonsil, Visanu ThamlikitkulEfficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritisJ Altern Complement Med.(2009 Aug)
    25. Devil's Claw - Chrubasik S, Künzel O, Thanner J, Conradt C, Black AA 1-year follow-up after a pilot study with Doloteffin for low back painPhytomedicine.(2005 Jan)
    26. Glucosamine - McAlindon T, Formica M, LaValley M, Lehmer M, Kabbara KEffectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trialAm J Med.(2004 Nov 1)
    27. Boswellia - Vishal AA, Mishra A, Raychaudhuri SPA double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of kneeInt J Med Sci.(2011)
    28. Curcumin - Panda SK, Nirvanashetty S, Parachur VA, Mohanty N, Swain TA Randomized, Double Blind, Placebo Controlled, Parallel-Group Study to Evaluate the Safety and Efficacy of Curene® versus Placebo in Reducing Symptoms of Knee OABiomed Res Int.(2018 Oct 25)
    29. Curcumin - Srivastava S, Saksena AK, Khattri S, Kumar S, Dagur RSCurcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trialInflammopharmacology.(2016 Dec)
    30. MSM - Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N, Elbaz A, Beer Y, Debi REfficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled studyBMC Complement Altern Med.(2011 Jun 27)
    31. Microlactin - Colker CM, Swain M, Lynch L, Gingerich DAEffects of a milk-based bioactive micronutrient beverage on pain symptoms and activity of adults with osteoarthritis: a double-blind, placebo-controlled clinical evaluationNutrition.(2002 May)
    32. Glucosamine - Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE, Gossett CLong-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trialLancet.(2001 Jan 27)
    33. Ginger - Zahmatkash M, Vafaeenasab MRComparing analgesic effects of a topical herbal mixed medicine with salicylate in patients with knee osteoarthritisPak J Biol Sci.(2011 Jul 1)
    34. Type-II Collagen - Crowley DC, Lau FC, Sharma P, Evans M, Guthrie N, Bagchi M, Bagchi D, Dey DK, Raychaudhuri SPSafety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trialInt J Med Sci.(2009 Oct 9)
    35. Boswellia - Sengupta K, Krishnaraju AV, Vishal AA, Mishra A, Trimurtulu G, Sarma KV, Raychaudhuri SK, Raychaudhuri SPComparative efficacy and tolerability of 5-Loxin and AflapinAgainst osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical studyInt J Med Sci.(2010 Nov 1)
    36. L-Carnitine - Mahdavi R, et alL-Carnitine supplementation ameliorates serum tumor necrosis factor-alpha and matrix metalloproteinase-3 in knee osteoarthritis womenBangladesh J Pharmacol.()
    37. Glucosamine - Herrero-Beaumont G, Ivorra JA, Del Carmen Trabado M, Blanco FJ, Benito P, Martín-Mola E, Paulino J, Marenco JL, Porto A, Laffon A, Araújo D, Figueroa M, Branco JGlucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparatorArthritis Rheum.(2007 Feb)
    38. Pycnogenol - Reza Farid, Zahra Mirfeizi, Mahyar Mirheidari, Zahra Rezaieyazdi, Hassan Mansouri, Habib Esmaelli, Sherma Zibadi, Peter Rohdewald, Ronald Ross WatsonPycnogenol supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritisNutrition Research.()
    39. Glucosamine - Pavelká K, Gatterová J, Olejarová M, Machacek S, Giacovelli G, Rovati LCGlucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind studyArch Intern Med.(2002 Oct 14)
    40. Ginger - Bliddal H, Rosetzsky A, Schlichting P, Weidner MS, Andersen LA, Ibfelt HH, Christensen K, Jensen ON, Barslev JA randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritisOsteoarthritis Cartilage.(2000 Jan)
    41. Glucosamine - Hughes R, Carr AA randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the kneeRheumatology (Oxford).(2002 Mar)
    42. Devil's Claw - Chrubasik S, Thanner J, Künzel O, Conradt C, Black A, Pollak SComparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hipPhytomedicine.(2002 Apr)
    43. S-adenosylmethionine - Kim J, Lee EY, Koh EM, Cha HS, Yoo B, Lee CK, Lee YJ, Ryu H, Lee KH, Song YWComparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patientsClin Ther.(2009 Dec)
    44. Glucosamine - Rindone JP, Hiller D, Collacott E, Nordhaugen N, Arriola GRandomized, controlled trial of glucosamine for treating osteoarthritis of the kneeWest J Med.(2000 Feb)
    45. Boswellia - Sengupta K, Alluri KV, Satish AR, Mishra S, Golakoti T, Sarma KV, Dey D, Raychaudhuri SPA double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the kneeArthritis Res Ther.(2008)
    46. Glucosamine - Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells GGlucosamine therapy for treating osteoarthritisCochrane Database Syst Rev.(2005 Apr 18)
    47. Curcumin - Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino GProduct-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritisPanminerva Med.(2010 Jun)
    48. Curcumin - Pinsornsak P, Niempoog SThe efficacy of Curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trialJ Med Assoc Thai.(2012 Jan)
    49. Stinging Nettle - Randall C, Dickens A, White A, Sanders H, Fox M, Campbell JNettle sting for chronic knee pain: a randomised controlled pilot studyComplement Ther Med.(2008 Apr)
    50. Curcumin - Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar ACurcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trialPhytother Res.(2014 Nov)
    51. Stinging Nettle - Randall C, Meethan K, Randall H, Dobbs FNettle sting of Urtica dioica for joint pain--an exploratory study of this complementary therapyComplement Ther Med.(1999 Sep)
    52. Curcumin - Madhu K, Chanda K, Saji MJSafety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trialInflammopharmacology.(2013 Apr)
    53. L-Carnitine - Aida Malek Mahdavi, Reza Mahdavi, Sousan KolahiEffects of l-Carnitine Supplementation on Serum Inflammatory Factors and Matrix Metalloproteinase Enzymes in Females with Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Pilot StudyJ Am Coll Nutr.(Sep-Oct 2016)
    54. Rose Hip - Rein E, Kharazmi A, Winther KA herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis--a double-blind, placebo-controlled, randomised trialPhytomedicine.(2004 Jul)
    55. Vitamin C - Vikram Sinai Talaulikar, Timothy Chambers, Isaac ManyondaExploiting the antioxidant potential of a common vitamin: could vitamin C prevent postmenopausal osteoporosis?J Obstet Gynaecol Res.(2012 Jan)
    56. Vitamin D - McAlindon T, LaValley M, Schneider E, Nuite M, Lee JY, Price LL, Lo G, Dawson-Hughes BEffect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trialJAMA.(2013 Jan 9)
    57. Stinging Nettle - Randall C, Randall H, Dobbs F, Hutton C, Sanders HRandomized controlled trial of nettle sting for treatment of base-of-thumb painJ R Soc Med.(2000 Jun)
    58. Creatine - Neves M Jr, Gualano B, Roschel H, Fuller R, Benatti FB, Pinto AL, Lima FR, Pereira RM, Lancha AH Jr, Bonfá EBeneficial effect of creatine supplementation in knee osteoarthritisMed Sci Sports Exerc.(2011 Aug)
    59. Curcumin - Henrotin et alBio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm studyArthritis Res Ther.()
    60. Glucosamine - Usha PR, Naidu MURandomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in OsteoarthritisClin Drug Investig.(2004)
    61. S-adenosylmethionine - Caruso I, Pietrogrande VItalian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint diseaseAm J Med.(1987 Nov 20)
    62. Ashwagandha - Ramakanth GS, Uday Kumar C, Kishan PV, Usharani PA randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint painJ Ayurveda Integr Med.(2016 Jul - Sep)
    63. Devil's Claw - Chrubasik S, Model A, Black A, Pollak SA randomized double-blind pilot study comparing Doloteffin and Vioxx in the treatment of low back painRheumatology (Oxford).(2003 Jan)
    64. Pycnogenol - Belcaro G, Cesarone MR, Errichi S, Zulli C, Errichi BM, Vinciguerra G, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Errichi S, Gizzi G, Ippolito E, Ricci A, Cacchio M, Cipollone G, Ruffini I, Fano F, Hosoi M, Rohdewald PTreatment of osteoarthritis with Pycnogenol. The SVOS (San Valentino Osteo-arthrosis Study). Evaluation of signs, symptoms, physical performance and vascular aspectsPhytother Res.(2008 Apr)
    65. L-Carnitine - Kolahi S, et alEffect of l-carnitine supplementation on clinical symptoms in women with osteoarthritis of the knee: A randomized, double-blind, placebo-controlled trialEur J Integr Med.()
    66. S-adenosylmethionine - Wadie I Najm, Sibylle Reinsch, Fred Hoehler, Jerome S Tobis, Phillip W HarveyS-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]BMC Musculoskelet Disord.(2004 Feb 26)
    67. Boswellia - Gupta PK, Samarakoon SM, Chandola HM, Ravishankar BClinical evaluation of Boswellia serrata (Shallaki) resin in the management of Sandhivata (osteoarthritis)Ayu.(2011 Oct)
    68. Chondroitin - Lee YH, Woo JH, Choi SJ, Ji JD, Song GGEffect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis.Rheumatol Int.(2010-Jan)
    69. Chondroitin - Hochberg MCStructure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration.Osteoarthritis Cartilage.(2010-Jun)
    70. Chondroitin - Honvo G, Bruyère O, Geerinck A, Veronese N, Reginster JYEfficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials.Adv Ther.(2019-May)
    71. Chondroitin - Xiaoqian Liu, Gustavo C Machado, Jillian P Eyles, Varshini Ravi, David J HunterDietary supplements for treating osteoarthritis: a systematic review and meta-analysisBr J Sports Med.(2018 Feb)
    72. Red Light Therapy - Stausholm MB, Naterstad IF, Joensen J, Lopes-Martins RÁB, Sæbø H, Lund H, Fersum KV, Bjordal JMEfficacy of low-level laser therapy on pain and disability in knee osteoarthritis: systematic review and meta-analysis of randomised placebo-controlled trials.BMJ Open.(2019-Oct-28)
    73. Fish Oil - Deng W, Yi Z, Yin E, Lu R, You H, Yuan XEffect of omega-3 polyunsaturated fatty acids supplementation for patients with osteoarthritis: a meta-analysis.J Orthop Surg Res.(2023-May-24)
    74. Basil - Askari A, Hasheminasab FS, Sadeghpour O, Naghizadehd MM, Ravansalar SA, Iraji A, Hashempur MHA randomized double-blind active-controlled clinical trial on the efficacy of topical basil (Ocimum basilicum) oil in knee osteoarthritis.Front Pharmacol.(2024)
    75. S-adenosylmethionine - Hardy ML, Coulter I, Morton SC, Favreau J, Venuturupalli S, Chiappelli F, Rossi F, Orshansky G, Jungvig LK, Roth EA, Suttorp MJ, Shekelle PS-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease.Evid Rep Technol Assess (Summ).(2003 Aug)
    76. S-adenosylmethionine - Rutjes AW, Nüesch E, Reichenbach S, Jüni PS-Adenosylmethionine for osteoarthritis of the knee or hip.Cochrane Database Syst Rev.(2009 Oct 7)
    77. Resveratrol - Nguyen C, Coudeyre E, Boutron I, Baron G, Daste C, Lefèvre-Colau MM, Sellam J, Zauderer J, Berenbaum F, Rannou FOral resveratrol in adults with knee osteoarthritis: A randomized placebo-controlled trial (ARTHROL).PLoS Med.(2024 Aug)
    78. Boswellia - Majeed A, Majeed S, Satish G, Manjunatha R, Rabbani SN, Patil NVP, Mundkur LA standardized Boswellia serrata extract shows improvements in knee osteoarthritis within five days-a double-blind, randomized, three-arm, parallel-group, multi-center, placebo-controlled trial.Front Pharmacol.(2024)
    79. Boswellia - Del Grossi Moura M, Lopes LC, Biavatti MW, Kennedy SA, de Oliveira E Silva MC, Silva MT, de Cássia Bergamaschi COral herbal medicines marketed in Brazil for the treatment of osteoarthritis: A systematic review and meta-analysis.Phytother Res.(2017 Nov)
    80. Boswellia - Cameron M, Chrubasik SOral herbal therapies for treating osteoarthritis.Cochrane Database Syst Rev.(2014 May 22)
    81. Boswellia - Raveendhara R Bannuru, Mikala C Osani, Fatimah Al-Eid, Chenchen WangEfficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysisSemin Arthritis Rheum.(2018 Dec)
    82. Boswellia - Dubey V, Kheni D, Sureja VEfficacy evaluation of standardized Boswellia serrata extract (Aflapin(Ⓡ)) in osteoarthritis: A systematic review and sub-group meta-analysis study.Explore (NY).(2024 Feb 10)