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Anti-Oxidant Enzyme Profile

Antioxidant enzymes (usually glutathione, superoxide dismutase, and catalase) are known to protect the body from oxidative damage, and increasing their levels or activity can confer protection from oxidative damage.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect anti-oxidant enzyme profile
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Curcumin Notable Very High See all 4 studies
Although the exact enzyme that increases is not overly reliable (SOD, glutathione, and catalase), all three enzymes have individually been noted to be increased and they tend to do so to a large degree.
grade-b Chromium - High See all 4 studies
A lone study noted an increase in glutathione peroxidase, but the majority of the evidence finds no significant influence on antioxidant enzymes in the body (glutathione, SOD, or catalase).
grade-c Kaempferia parviflora Notable - See study
The lone study to assess superoxide dismutase found a doubling after 8 weeks of supplementation (in older individuals); needs replication in youth
grade-c N-Acetylcysteine  
grade-c Arginine  
grade-c Chlorella  
grade-c Coenzyme Q10  
grade-c Garlic  
grade-c Ginkgo biloba  
grade-c L-Carnitine  
grade-c Melatonin  
grade-c Olive leaf extract  
grade-c Panax ginseng  
grade-c Shilajit  
grade-c Spirulina  
grade-c Stinging Nettle  
grade-c Vitamin C  
grade-c Watercress  
grade-c Whey Protein  
grade-c Zinc  
grade-c Alpha-Lipoic Acid  
grade-c Astaxanthin  
grade-c Creatine  
grade-c Ganoderma lucidum  
grade-c Glutathione  
grade-c Vitamin B2  
grade-c Vitamin E  
grade-d Ginger  
grade-d Rubus coreanus  
grade-d Yerba mate  
grade-d Mangifera indica  
grade-d Rose Hip  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.