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Anti-Oxidant Enzyme Profile

Antioxidant enzymes (usually glutathione, superoxide dismutase, and catalase) are known to protect the body from oxidative damage, and increasing their levels or activity can confer protection from oxidative damage.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect anti-oxidant enzyme profile
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Notable Very High See all 7 studies
Although the exact enzyme that increases is not overly reliable (SOD, glutathione, and catalase), all three enzymes have individually been noted to be increased and they tend to do so to a large degree.
grade-b - High See all 4 studies
A lone study noted an increase in glutathione peroxidase, but the majority of the evidence finds no significant influence on antioxidant enzymes in the body (glutathione, SOD, or catalase).
grade-c Notable - See study
The lone study to assess superoxide dismutase found a doubling after 8 weeks of supplementation (in older individuals); needs replication in youth

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.

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