Oxidation of LDL Research Analysis

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect oxidation of ldl

Grade	Level of Evidence [show legend]
	Robust research conducted with repeated double-blind clinical trials
	Multiple studies where at least two are double-blind and placebo controlled
	Single double-blind study or multiple cohort studies
	Uncontrolled or observational studies only

Outcome	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
Olive leaf extract	Notable	Very High See all 8 studies	The decrease in LDL oxidation seen with olive oil phenolics appears to be of notable potency due to its reliability (occurring in both healthy persons and diseased persons, chronically and acutely) and a reduction in LDL oxidation rates can exceed 25% in some studies with low intakes of olive phenolics (enough from virgin olive oil consumption)
Cocoa Extract	-	High See all 5 studies	The majority of evidence does not find a significant alteration in the rate of LDL oxidation with cocoa or its isolated flavanols relative to placebo.
Ginkgo biloba	Notable	Moderate See 2 studies	In high risk individuals, the reduction has been noted to be 17.0+/-5.5%
Licorice
Blueberry
Dehydroepiandrosterone
Garlic
Hesperidin
Panax ginseng
Policosanol
Vitamin E
Zinc
Chromium
Conjugated Linoleic Acid
Fish Oil
Grape Seed Extract
Trimethylglycine
Vitamin C
Alpha-Lipoic Acid
Green Tea Catechins
Saffron
Magnesium

All comparative evidence is now gathered in our A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available here.