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Oxidation of LDL

LDL oxidation is known to contribute to artherosclerosis (plaque buildup in arteries), and reducing the rate of LDL oxidation reduces artherosclerosis. Antioxidants that are potent enough and stay in serum can reduce this oxidation.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect oxidation of ldl
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Olive leaf extract Notable Very High See all 8 studies
The decrease in LDL oxidation seen with olive oil phenolics appears to be of notable potency due to its reliability (occurring in both healthy persons and diseased persons, chronically and acutely) and a reduction in LDL oxidation rates can exceed 25% in some studies with low intakes of olive phenolics (enough from virgin olive oil consumption)
grade-b Cocoa Extract - High See all 5 studies
The majority of evidence does not find a significant alteration in the rate of LDL oxidation with cocoa or its isolated flavanols relative to placebo.
grade-c Ginkgo biloba Notable Moderate See 2 studies
In high risk individuals, the reduction has been noted to be 17.0+/-5.5%
grade-c Licorice  
grade-c Blueberry  
grade-c Dehydroepiandrosterone  
grade-c Garlic  
grade-c Hesperidin  
grade-c Panax ginseng  
grade-c Policosanol  
grade-c Vitamin E  
grade-c Zinc  
grade-c Chromium  
grade-c Conjugated Linoleic Acid  
grade-c Fish Oil  
grade-c Grape Seed Extract  
grade-c Trimethylglycine  
grade-c Vitamin C  
grade-d Alpha-Lipoic Acid  
grade-d Green Tea Catechins  
grade-d Saffron  
grade-d Magnesium  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.