What is Panax ginseng?
Panax ginseng (Korean ginseng) is an herbaceous plant used in traditional Chinese medicine for a wide variety of preventative purposes. It belongs to the Araliaceae family and is the most widely used species within the Panax genus for medicinal purposes.[4] The roots of the plant, typically harvested in early autumn from mature specimens aged at least 4 years, are the primary source of bioactive compounds and are usually the parts used in supplements.[5]
While there are 13 identified species of ginseng, the two most prevalent in supplements and the food industry are Panax ginseng, grown in China and Korea, and Panax quinquefolius (American ginseng), grown in regions of the United States and Canada. Panax ginseng supplements are often used to enhance mood, cognition, and immune function. Ginseng is also used as an ingredient in food and edible products (e.g., chewing gums, candies, and coffee).[6]
It is essential to distinguish genuine Panax ginseng from other herbal products marketed under the name of ginseng. Notably, Siberian ginseng (Eleutherococcus senticosus, also known as eleuthero), Brazilian ginseng (Pfaffia paniculata), and Indian ginseng (ashwagandha) are among the commercially available alternatives that do not originate from the Panax genus. Although they carry similar names, they do not contain the same bioactive compounds, and therefore they have completely different mechanisms of action and effects.[6]
What are Panax ginseng’s main benefits?
Research on the effects of Panax ginseng on mood and cognition yields mixed findings.
One study found that Panax ginseng may have a dose-dependent calming effect on mood,[7] but subsequent research failed to replicate these results.[8] Moreover, supplementation with Panax ginseng showed initial improvements in mental health at the 4-week mark, but this effect diminished by the end of the 8-week intervention period.[9] Overall, the evidence suggests that Panax ginseng's effects on mood may be short lived, lasting between 1 and 4 weeks before diminishing.
Similarly, the potential cognitive benefits of Panax ginseng remain inconclusive due to variations in study methodologies and inconsistent results.[10][1] While some studies reported enhancements in reaction time and accuracy with Panax ginseng supplementation, others failed to establish significant cognitive improvements.[7][11] Thus, further research is necessary to validate these effects and elucidate the mechanisms underlying Panax ginseng's impact on cognition.
Additionally, Panax ginseng extracts appear to have some immunomodulatory properties and to reduce the occurrence of the flu in humans when taken alongside flu vaccination.[12]
Can Panax ginseng be used to regulate appetite?
Are multivitamin supplements containing Panax ginseng effective?
Does Panax ginseng affect lipid profile and blood glucose?
Can Panax ginseng increase testosterone levels and help with erectile dysfunction?
Can Panax ginseng improve skin appearance?
Does Panax ginseng work for female sexual dysfunction?
Is Panax ginseng effective for menopausal symptoms?
What are Panax ginseng’s main drawbacks?
Panax ginseng supplements are generally considered safe. A systematic review assessing the safety of ginseng use in humans reported a low incidence of harm, with side effects primarily related to gastrointestinal symptoms such as diarrhea, nausea, vomiting, and cramps.[13][14]
However, high doses and long-term usage may lead to the development of the so-called “ginseng abuse syndrome”, characterized by symptoms such as hypertension, nervousness, sleeplessness, diarrhea, and skin eruptions when taking 3 grams of Panax ginseng per day. Higher dosages (15 grams per day or more) have also been associated with depersonalization, confusion, and depression.[15][16][17]
Furthermore, Panax ginseng exhibits mild inhibitory effects on some enzymes from the CYP450 family, such as CYP1A2, CYP2C9, and CYP3A4, which are involved in the metabolism of certain medications. This interaction appears to be of small significance and is unlikely to be clinically meaningful.[18]
How does Panax Ginseng work?
Panax ginseng contains various bioactive components, with ginsenosides being the main active compounds responsible for its pharmacological benefits. The types of ginsenosides in the plant extract and their concentration can vary depending on the extraction and preparation method used.[19] Other active ingredients found in Panax ginseng include polysaccharides, peptides, phytosterols, polyacetylenes, polyacetylenic alcohols, and fatty acids, which contribute to its overall therapeutic properties.[19]
The pharmacological effects of Panax ginseng are largely attributed to its ginsenoside content, which interacts with various molecular targets in the body to exert its beneficial effects. For example, certain ginsenosides found in red Panax ginseng, such as Ro and R(3), have been shown to inhibit the enzyme 5-alpha reductase. This enzyme is responsible for converting testosterone into dihydrotestosterone (DHT), and by inhibiting this enzyme, Panax ginseng may help increase testosterone levels.[20]
What are other names for Panax Ginseng (Korean Ginseng)
- Asian ginseng
- Asiatic ginseng
- Manchurian ginseng
- Mountain Ginseng
- True Ginseng
- Wild Ginseng
- 人蔘 or 人参 or 人參 (Rénshēn)
- 인삼; 人蔘 (Insam)
- 人参 (Ninjin)
- Siberian Ginseng
- American Ginseng
- Pseudoginseng
- Desert Ginseng
- Black Ginseng
- Cistanche spp
- Chinese Ginseng
Dosage information
Panax ginseng is typically consumed in daily doses ranging from 200 to 400 mg, with the 400 mg dosage showing the most notable cognitive benefits.[1] These doses refer to standardized ginseng extracts which contain around 4–10 % total ginsenosides (Panax ginseng’s primary bioactive compounds) and are taken once daily.
Higher doses (200–20,000 mg) have been used to target improvements in glucose and lipid profiles.[2]
For trials focusing on erectile health and libido enhancement, Korean red ginseng extract is commonly administered at a dosage of 3 grams daily, divided into three doses of 1 gram each.[3]
Examine Database: Panax Ginseng (Korean Ginseng)
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Frequently asked questions
Panax ginseng (Korean ginseng) is an herbaceous plant used in traditional Chinese medicine for a wide variety of preventative purposes. It belongs to the Araliaceae family and is the most widely used species within the Panax genus for medicinal purposes.[4] The roots of the plant, typically harvested in early autumn from mature specimens aged at least 4 years, are the primary source of bioactive compounds and are usually the parts used in supplements.[5]
While there are 13 identified species of ginseng, the two most prevalent in supplements and the food industry are Panax ginseng, grown in China and Korea, and Panax quinquefolius (American ginseng), grown in regions of the United States and Canada. Panax ginseng supplements are often used to enhance mood, cognition, and immune function. Ginseng is also used as an ingredient in food and edible products (e.g., chewing gums, candies, and coffee).[6]
It is essential to distinguish genuine Panax ginseng from other herbal products marketed under the name of ginseng. Notably, Siberian ginseng (Eleutherococcus senticosus, also known as eleuthero), Brazilian ginseng (Pfaffia paniculata), and Indian ginseng (ashwagandha) are among the commercially available alternatives that do not originate from the Panax genus. Although they carry similar names, they do not contain the same bioactive compounds, and therefore they have completely different mechanisms of action and effects.[6]
The term “ginseng” derives from the Chinese “jen-shen”, which translates to “plant-man”. This name probably stems from the resemblance of ginseng roots to the shape of a human body. The term Panax originates from the Greek “pan akheia” (panacea) meaning “cure of all diseases”.[6] In traditional Chinese medicine, ginseng holds significant importance and is also sometimes referred to as “the lord of herbs”, as it is believed that its roots contain the three main human essences: the body, the mind, and the spirit. The use of ginseng in traditional Chinese medicine dates back to Emperor Shennong (5000 years ago), who classified hundreds of medicinal and poisonous herbs, including ginseng, in what today we would call a pharmacopeia.[6]
There are multiple types of Panax ginseng that can be obtained by treating the plant with different mechanical processing methods. Depending on the method used, the ginsenoside composition in the plant changes. Red ginseng, also known as Korean red ginseng, is obtained by steaming Panax ginseng at 95–100°C, followed by drying it. This processing method leads to significant changes in the bioactive profile of the plant. While Panax ginseng typically contains ginsenosides Rb1, Ro, and Re as its main components, Korean red ginseng is characterized by a high content of ginsenoside Rb(3), which can be metabolized to Rb(2) by intestinal bacteria. Additionally, Korean red ginseng contains ginsenoside Rg(3), which is unique to this variety.[21] Another variety of ginseng, black ginseng, is obtained by subjecting Panax ginseng to nine cycles of steaming at a temperature of 98°C. However, black ginseng is not as commonly used in traditional medicine or supplements.[10] White Ginseng is a term used to refer to Panax ginseng that has been cultivated and then air dried, as opposed to steam dried. The air drying process involves peeling and drying the root until the moisture content is reduced to below 12% and the root acquires a yellowish-white color. Some of the bioactives may be lost during this process.[22]
Another relatively new type, sun ginseng, is obtained by processing Panax ginseng at higher temperatures, between 100–120°C, for 2 hours.[10]
Additionally, ginseng can undergo fermentation using fermentation organisms, such as Lactobacillus and Aspergillus, or various fungal species (e.g., Ganoderma lucidum).[10]
G115 is a patented extraction of Panax ginseng by Pharmaton (Switzerland) that contains 4% ginsenosides by total weight,[23][24] while NAGE is a standardized extract from the same company containing 10% ginsenosides by weight.[24] These standardized extracts are commonly used in research to ensure quality standards and control for the total amount of ginsenosides.
Research on the effects of Panax ginseng on mood and cognition yields mixed findings.
One study found that Panax ginseng may have a dose-dependent calming effect on mood,[7] but subsequent research failed to replicate these results.[8] Moreover, supplementation with Panax ginseng showed initial improvements in mental health at the 4-week mark, but this effect diminished by the end of the 8-week intervention period.[9] Overall, the evidence suggests that Panax ginseng's effects on mood may be short lived, lasting between 1 and 4 weeks before diminishing.
Similarly, the potential cognitive benefits of Panax ginseng remain inconclusive due to variations in study methodologies and inconsistent results.[10][1] While some studies reported enhancements in reaction time and accuracy with Panax ginseng supplementation, others failed to establish significant cognitive improvements.[7][11] Thus, further research is necessary to validate these effects and elucidate the mechanisms underlying Panax ginseng's impact on cognition.
Additionally, Panax ginseng extracts appear to have some immunomodulatory properties and to reduce the occurrence of the flu in humans when taken alongside flu vaccination.[12]
Animal studies suggest that the ginsenoside content in Korean red ginseng (and in Panax ginseng in general) may play a role in regulating abnormal feeding patterns, while it has no effect on normal feeding patterns. Surprisingly, little research has been done on the appetite-stimulating effects of ginseng, despite its traditional use for this purpose. There are no human studies directed to answer this topic, either, but potent acute suppression of appetite is seen in obese mice that overeat, and results are mixed in lean mice.[25][26][27]
The mechanism behind this appetite suppression may involve the downregulation of orexigenic neuropeptides, which stimulate appetite, and the upregulation of anorexigenic neuropeptides, which inhibit appetite.[28]
Ginseng might be a useful addition to multivitamin formulations for improving mood due to having some bioactivity at low doses (40–100mg).[29][30] However, data regarding its inclusion in multivitamin formulations is conflicting.
Whether Panax ginseng can have positive effects on metabolic parameters is still uncertain, with more high-quality studies needed to reach a conclusion.
One meta-analysis found that supplementation with 200–20,000 mg per day of Panax ginseng dry extract for 2–12 weeks decreased total cholesterol and low-density lipoprotein (LDL) levels compared to a placebo but didn't have a significant effect on triglycerides or high-density lipoprotein (HDL) levels. It's worth noting that the studies in this meta-analysis included people both with and without cardiovascular risk factors, and there was high variability in the types of ginseng extracts used and their administration frequencies.[5] Another meta-analysis found inconclusive results regarding the effect of ginseng on blood pressure while noting a decrease in total cholesterol, triglycerides, LDL levels, and body fat percentage compared to a placebo.[2]
Regarding blood glucose parameters, dosages of Panax ginseng between 200 mg and 8,000 mg per day were associated with a reduction in blood glucose levels compared to a placebo. However, no significant effect was observed on fasting blood glucose, fasting insulin, postprandial glucose (glucose levels after food), postprandial insulin, or Hb1Ac levels.[2] Similar results were reported in another meta-analysis where supplementation with 780 mg to 6 grams per day of red Korean ginseng for 12 weeks did significantly affect fasting blood glucose, fasting insulin, and HbA1c levels compared to a placebo.[31]
Preliminary evidence suggests that supplementation with Panax ginseng may not significantly increase testosterone levels in athletes, although the quality of the study providing this evidence is questionable.[32] However, Panax ginseng supplementation may be effective in cases where testosterone levels are suppressed during periods of infertility and hypogonadism (low testosterone production).[33]
In men with erectile dysfunction, Panax ginseng does not appear to affect testosterone levels.[34][3] Nevertheless, some studies have shown promising results regarding its efficacy in improving erectile function. One study found that a dosage of 1,000 mg of red Korean ginseng three times daily improved symptoms of mild to moderate erectile dysfunction compared to a placebo over a period of 3 months.[3] Another study noted a significant improvement in erectile function with 1,000 mg of Panax ginseng supplemented twice daily over 8 weeks, although the study suffered from a large dropout rate.[35] It can be concluded that Korean red ginseng holds promise as a potential treatment for erectile dysfunction, but further rigorous testing is needed to establish its efficacy and safety.
It has been suggested that Panax ginseng may improve skin quality and reduce wrinkles when taken orally, but the evidence is currently limited. Only one human study is available on this topic, and it involved the use of a combination of ginseng with two other herbs.[36] Further studies focusing solely on Panax ginseng supplementation and its effect on skin quality are necessary to establish its effectiveness in this area.
One meta-analysis revealed that Panax ginseng did not significantly improve overall sexual function in women compared to a placebo. However, subgroup analysis found that it did have a positive effect on specific domains of sexual function, including sexual arousal and sexual desire. Interestingly, no effects were observed on other aspects of sexual function such as orgasm, pain, lubrication, and sexual satisfaction.[37]
Only a limited number of clinical studies (human studies) have investigated the effect of Panax ginseng on menopausal symptoms, and the overall evidence remains inconclusive. While some studies found that supplementation with Korean red ginseng in menopausal women improved sexual arousal, overall health, and menopausal symptoms compared to a placebo, others failed to observe a significant reduction in hot flash frequency, although they found significant improvements in well-being and depression.[38]
It’s worth highlighting that one of these studies noted that physiological parameters such as follicle-stimulating hormone and estradiol levels, endometrial thickness, maturation index, and vaginal pH were not affected by supplementation with ginseng. This suggests that any potential beneficial effects of Panax ginseng on menopause are unlikely to be mediated by hormone-replacement-like mechanisms.[39] However, in vitro studies have reported that several ginsenosides are agonists (activators) of estrogen receptors.[40] Further research is required to clarify this mechanism of action.
Panax ginseng supplements are generally considered safe. A systematic review assessing the safety of ginseng use in humans reported a low incidence of harm, with side effects primarily related to gastrointestinal symptoms such as diarrhea, nausea, vomiting, and cramps.[13][14]
However, high doses and long-term usage may lead to the development of the so-called “ginseng abuse syndrome”, characterized by symptoms such as hypertension, nervousness, sleeplessness, diarrhea, and skin eruptions when taking 3 grams of Panax ginseng per day. Higher dosages (15 grams per day or more) have also been associated with depersonalization, confusion, and depression.[15][16][17]
Furthermore, Panax ginseng exhibits mild inhibitory effects on some enzymes from the CYP450 family, such as CYP1A2, CYP2C9, and CYP3A4, which are involved in the metabolism of certain medications. This interaction appears to be of small significance and is unlikely to be clinically meaningful.[18]
Panax ginseng contains various bioactive components, with ginsenosides being the main active compounds responsible for its pharmacological benefits. The types of ginsenosides in the plant extract and their concentration can vary depending on the extraction and preparation method used.[19] Other active ingredients found in Panax ginseng include polysaccharides, peptides, phytosterols, polyacetylenes, polyacetylenic alcohols, and fatty acids, which contribute to its overall therapeutic properties.[19]
The pharmacological effects of Panax ginseng are largely attributed to its ginsenoside content, which interacts with various molecular targets in the body to exert its beneficial effects. For example, certain ginsenosides found in red Panax ginseng, such as Ro and R(3), have been shown to inhibit the enzyme 5-alpha reductase. This enzyme is responsible for converting testosterone into dihydrotestosterone (DHT), and by inhibiting this enzyme, Panax ginseng may help increase testosterone levels.[20]
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References
Examine Database References
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- Cognition - Derek Ong Lai Teik, Xiao Shiang Lee, Chu Jian Lim, Chia Mei Low, Mariyam Muslima, Luca AquiliGinseng and Ginkgo Biloba Effects on Cognition as Modulated by Cardiovascular Reactivity: A Randomised TrialPLoS One.(2016 Mar 3)
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- Insomnia Signs and Symptoms - Won-Suk Sung, Ha-Ra Kang, Chan-Yung Jung, Seong-Sik Park, Seung-Ho Lee, Eun-Jung KimEfficacy of Korean red ginseng (Panax ginseng) for middle-aged and moderate level of chronic fatigue patients: A randomized, double-blind, placebo-controlled trialComplement Ther Med.(2020 Jan)
- Schizophrenia symptoms - Eric Y H Chen, Christy L M HuiHT1001, a proprietary North American ginseng extract, improves working memory in schizophrenia: a double-blind, placebo-controlled studyPhytother Res.(2012 Aug)
- Subjective Well-Being - Cardinal BJ, Engels HJGinseng does not enhance psychological well-being in healthy, young adults: results of a double-blind, placebo-controlled, randomized clinical trialJ Am Diet Assoc.(2001 Jun)
- Subjective Well-Being - Ellis JM, Reddy PEffects of Panax ginseng on quality of lifeAnn Pharmacother.(2002 Mar)
- Cognition - Masoud Etemadifar, Farnaz Sayahi, Seyed-Hossein Abtahi, Hamidreza Shemshaki, Gholam-Ali Dorooshi, Mohammad Goodarzi, Mojtaba Akbari, Mahboobeh Fereidan-EsfahaniGinseng in the treatment of fatigue in multiple sclerosis: a randomized, placebo-controlled, double-blind pilot studyInt J Neurosci.(2013 Jul)
- Sleep Quality - Kitaoka K, Uchida K, Okamoto N, Chikahisa S, Miyazaki T, Takeda E, Séi HFermented ginseng improves the first-night effect in humansSleep.(2009 Mar)
- Intermediate-Term Memory - Key-Chung Park, Hui Jin, Renhua Zheng, Sehyun Kim, Seung-Eun Lee, Bo-Hyung Kim, Sung-Vin YimCognition enhancing effect of panax ginseng in Korean volunteers with mild cognitive impairment: a randomized, double-blind, placebo-controlled clinical trialTransl Clin Pharmacol.(2019 Sep)
- Fatigue Symptoms - Namhun Lee, Suk-Hoon Lee, Ho-Ryong Yoo, Hwa Seung YooAnti-Fatigue Effects of Enzyme-Modified Ginseng Extract: A Randomized, Double-Blind, Placebo-Controlled TrialJ Altern Complement Med.(2016 Nov)
- Fatigue Symptoms - Li Zhang, Xiaoyun Chen, Yanqi Cheng, Qilong Chen, Hongsheng Tan, Dongwook Son, Dongpill Chang, Zhaoxiang Bian, Hong Fang, Hongxi XuSafety and antifatigue effect of Korean Red Ginseng: a randomized, double-blind, and placebo-controlled clinical trialJ Ginseng Res.(2019 Oct)