Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that is used as a marker of inflammation. Its reduction is thought to reflect a lesser state of inflammation in the body.

Research analysis by and verified by the Research Team. Last updated on Apr 29, 2017.

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect tnf-alpha

Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Fish Oil
All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.
The evidence for each separate supplement is still freely available ​here.
Conjugated Linoleic Acid  
Ganoderma lucidum  
Japanese Knotweed  
Tetradecyl Thioacetic Acid  
Vitamin D  
Cocoa Extract  
Lactobacillus reuteri  
Punicic Acid  
Rose Hip  
Stinging Nettle  
Vitamin B3 (Niacin)  
Vitamin E  
Perilla Oil  

Cite this page

"TNF-Alpha,", published on 5 July 2013, last updated on 29 April 2017,