DNA Damage

    Last Updated: April 29, 2017

    DNA damage refers to oxidative changes to DNA, which can be measured in the urine or in white blood cells. Reductions in DNA damage from antioxidant supplements are thought to reduce the risk of cancer development and mutations.

    examine-databaseExamine Database

    Examine Database: DNA Damage

    A
    Moderate Improvement
    B
    Small Improvement
    D
    No effect

    Examine Database References

    1. Grape Juice - Rowe CA, Nantz MP, Nieves C Jr, West RL, Percival SSRegular consumption of concord grape juice benefits human immunityJ Med Food.(2011 Jan-Feb)
    2. Lemon Balm - Zeraatpishe A, Oryan S, Bagheri MH, Pilevarian AA, Malekirad AA, Baeeri M, Abdollahi MEffects of Melissa officinalis L. on oxidative status and DNA damage in subjects exposed to long-term low-dose ionizing radiationToxicol Ind Health.(2011 Apr)
    3. Vitamin E - Winterbone MS, Sampson MJ, Saha S, Hughes JC, Hughes DAPro-oxidant effect of alpha-tocopherol in patients with type 2 diabetes after an oral glucose tolerance test--a randomised controlled trialCardiovasc Diabetol.(2007 Feb 22)
    4. Astaxanthin - Chen JT, Kotani KEffects of Astaxanthin on Liver and Leukocyte Parameters in Healthy Climacteric Women: Preliminary DataJ Med Food.(2017 Jul)
    5. Grape Juice - Park YK, Lee SH, Park E, Kim JS, Kang MHChanges in antioxidant status, blood pressure, and lymphocyte DNA damage from grape juice supplementationAnn N Y Acad Sci.(2009 Aug)
    6. Sea Buckthorn - Rodhe Y, Woodhill T, Thorman R, Möller L, Hylander BThe effect of sea buckthorn supplement on oral health, inflammation, and DNA damage in hemodialysis patients: a double-blinded, randomized crossover studyJ Ren Nutr.(2013 May)
    7. Conjugated Linoleic Acid - Kim J, Paik HD, Shin MJ, Park EEight weeks of conjugated linoleic acid supplementation has no effect on antioxidant status in healthy overweight/obese Korean individualsEur J Nutr.(2012 Mar)
    8. Chromium - I Kato, J H Vogelman, V Dilman, J Karkoszka, K Frenkel, N P Durr, N Orentreich, P TonioloEffect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracilEur J Epidemiol.(1998 Sep)
    9. Vitamin E - Sampson MJ, Astley S, Richardson T, Willis G, Davies IR, Hughes DA, Southon SIncreased DNA oxidative susceptibility without increased plasma LDL oxidizability in Type II diabetes: effects of alpha-tocopherol supplementationClin Sci (Lond).(2001 Sep)
    10. Reishi - Wachtel-Galor S, Tomlinson B, Benzie IFGanoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation studyBr J Nutr.(2004 Feb)
    11. Eleuthero - Lee YJ, Chung HY, Kwak HK, Yoon SThe effects of A. senticosus supplementation on serum lipid profiles, biomarkers of oxidative stress, and lymphocyte DNA damage in postmenopausal womenBiochem Biophys Res Commun.(2008 Oct 10)
    12. Fish Oil - Rhodes LE, Shahbakhti H, Azurdia RM, Moison RM, Steenwinkel MJ, Homburg MI, Dean MP, McArdle F, Beijersbergen van Henegouwen GM, Epe B, Vink AAEffect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markersCarcinogenesis.(2003 May)
    13. Garlic - Veena Dhawan, Sanjay JainGarlic supplementation prevents oxidative DNA damage in essential hypertensionMol Cell Biochem.(2005 Jul)
    14. Creatine - Tarnopolsky MA, Mahoney DJ, Vajsar J, Rodriguez C, Doherty TJ, Roy BD, Biggar DCreatine monohydrate enhances strength and body composition in Duchenne muscular dystrophyNeurology.(2004 May 25)
    15. Vitamin C - Retana-Ugalde R, Casanueva E, Altamirano-Lozano M, González-Torres C, Mendoza-Núñez VMHigh dosage of ascorbic acid and alpha-tocopherol is not useful for diminishing oxidative stress and DNA damage in healthy elderly adultsAnn Nutr Metab.(2008)
    16. Conjugated Linoleic Acid - Kuhnt K, Wagner A, Kraft J, Basu S, Jahreis GDietary supplementation with 11trans- and 12trans-18:1 and oxidative stress in humansAm J Clin Nutr.(2006 Nov)
    17. Curcumin - Biswas J, Sinha D, Mukherjee S, Roy S, Siddiqi M, Roy MCurcumin protects DNA damage in a chronically arsenic-exposed population of West BengalHum Exp Toxicol.(2010 Jun)
    18. Blueberry - Wilms LC, Boots AW, de Boer VC, Maas LM, Pachen DM, Gottschalk RW, Ketelslegers HB, Godschalk RW, Haenen GR, van Schooten FJ, Kleinjans JCImpact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteersCarcinogenesis.(2007 Aug)
    19. Citrulline - Sureda A, Cordova A, Ferrer MD, Tauler P, Perez G, Tur JA, Pons AEffects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exerciseFree Radic Res.(2009 Sep)
    20. Blueberry - Lisa S McAnulty, David C Nieman, Charles L Dumke, Lesli A Shooter, Dru A Henson, Alan C Utter, Ginger Milne, Steven R McAnultyEffect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of runningAppl Physiol Nutr Metab.(2011 Dec)
    21. L-Carnitine - Gholamreza Pourmand, Mansooreh Movahedin, Sanaz Dehghani, Abdolrassul Mehrsai, Ayat Ahmadi, Maryam Pourhosein, Marzieh Hoseini, Marzieh Ziloochi, Fariba Heidari, Laleh Beladi, Mohammad NooriDoes L-carnitine therapy add any extra benefit to standard inguinal varicocelectomy in terms of deoxyribonucleic acid damage or sperm quality factor indices: a randomized studyUrology.(2014 Oct)
    22. Blueberry - Del Bo C, Riso P, Campolo J, Møller P, Loft S, Klimis-Zacas D, Brambilla A, Rizzolo A, Porrini MA single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteersNutr Res.(2013 Mar)
    23. Glutathione - Allen J, Bradley RDEffects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteersJ Altern Complement Med.(2011 Sep)
    24. Olive Leaf Extract - Weinbrenner T, Fitó M, de la Torre R, Saez GT, Rijken P, Tormos C, Coolen S, Albaladejo MF, Abanades S, Schroder H, Marrugat J, Covas MIOlive oils high in phenolic compounds modulate oxidative/antioxidative status in menJ Nutr.(2004 Sep)
    25. Blueberry - Riso P, Klimis-Zacas D, Del Bo' C, Martini D, Campolo J, Vendrame S, Møller P, Loft S, De Maria R, Porrini MEffect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factorsEur J Nutr.(2013 Apr)
    26. Chlorella - Lee SH, Kang HJ, Lee HJ, Kang MH, Park YKSix-week supplementation with Chlorella has favorable impact on antioxidant status in Korean male smokersNutrition.(2010 Feb)
    27. L-Carnitine - Eun Shil Hong, Eun Ky Kim, Seon Mee Kang, Ah Reum Khang, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Soo LimEffect of carnitine-orotate complex on glucose metabolism and fatty liver: a double-blind, placebo-controlled studyJ Gastroenterol Hepatol.(2014)
    28. Vitamin C - Guarnieri S, Riso P, Porrini MOrange juice vs vitamin C: effect on hydrogen peroxide-induced DNA damage in mononuclear blood cellsBr J Nutr.(2007 Apr)
    29. Panax Ginseng (Korean Ginseng) - Kim JY, Park JY, Kang HJ, Kim OY, Lee JHBeneficial effects of Korean red ginseng on lymphocyte DNA damage, antioxidant enzyme activity, and LDL oxidation in healthy participants: a randomized, double-blind, placebo-controlled trialNutr J.(2012 Jul 17)
    30. Watercress - Gill CI, Haldar S, Boyd LA, Bennett R, Whiteford J, Butler M, Pearson JR, Bradbury I, Rowland IRWatercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adultsAm J Clin Nutr.(2007 Feb)
    31. Fish Oil - Dawczynski C, Martin L, Wagner A, Jahreis Gn-3 LC-PUFA-enriched dairy products are able to reduce cardiovascular risk factors: a double-blind, cross-over studyClin Nutr.(2010 Oct)
    32. Creatine - Rahimi RCreatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exerciseJ Strength Cond Res.(2011 Dec)
    33. Astaxanthin - Park JS, Chyun JH, Kim YK, Line LL, Chew BPAstaxanthin decreased oxidative stress and inflammation and enhanced immune response in humansNutr Metab (Lond).(2010 Mar 5)