Overview
Testosterone is a hormone produced primarily in the testes in men and the ovaries in women. Testosterone is connected to sexual development, muscle building, fat loss, some aspects of cognition, and hair loss.[1]
Your testosterone levels may not tell the whole story of how testosterone is functioning in your body. Total testosterone can be divided into three categories.[2]
- Tightly bound testosterone: About two-thirds of the testosterone in your blood is bound to sex hormone binding globulin (SHBG). It is not readily available for use by your body.
- Loosely bound testosterone: About one-third of the testosterone in your blood is weakly bound to albumin. Once the bond is broken, the testosterone circulates as free testosterone in your body.
- Free testosterone: A small percentage of the testosterone in your blood (1–4%, as a rule) floats around freely. Your body can readily use it, and the enzyme 5-alpha-reductase can convert it to dihydrotestosterone (DHT), a very potent androgen.
Together, your loosely bound and free testosterone compose your bioavailable testosterone, which has a greater impact on your health than your total testosterone.
How are testosterone levels assessed?
A blood test is used to assess testosterone and its components (free T, bound T, etc). Abnormally low or high levels can cause health issues in males and females.
When your T levels are tested, the reference range can vary a lot from lab to lab. A recent study showed that the bottom of the range for males can be 5.55–10.4 nanomoles per liter, or nmol/L (160–300 nanograms per deciliter, or ng/dL), and the top of the range can be 25.17–39.18 nmol/L (726–1,130 ng/dL).[3] So if you get measured at 280 ng/dL, you may or may not be considered as having “low testosterone”.[3]
Because testosterone levels can fluctuate throughout the day, the test should be performed in the morning (8–11 a.m.). If the results come back low, a second test can be ordered to confirm the first result. As part of the workup, your physician may also measure your levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and the T4 thyroid hormone (thyroxine) to get an accurate diagnosis.
Assessing testosterone levels
Examine Database: Testosterone
Research FeedRead all studies
References
Examine Database References
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- Fenugreek - Brandon Bushey, Lem W. Taylor, Colin W. Wilborn, Chris Poole, Cliffa A. Foster, Bill Campbell, Richard B. Kreider, Darryn S. WilloughbyFenugreek Extract Supplementation Has No effect on the Hormonal Profile of Resitance-Trained MalesInternational Journal of Exercise Science.()
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- Tribulus Terrestris - Kamenov Z, Fileva S, Kalinov K, Jannini EAEvaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trialMaturitas.(2017 May)
- Tongkat Ali - Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske ERandomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in MenEvid Based Complement Alternat Med.(2012)
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- N-Acetylcysteine - Zahra Shahveghar Asl, Karim Parastouei, Eslam EskandariThe effects of N-acetylcysteine on ovulation and sex hormones profile in women with polycystic ovary syndrome: a systematic review and meta-analysisBr J Nutr.(2023 Jan 4)
- Inositol - Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Várbíró S, Horváth EMInositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.Reprod Biol Endocrinol.(2023-Jan-26)
- Chromium - Tang XL, Sun Z, Gong LChromium supplementation in women with polycystic ovary syndrome: Systematic review and meta-analysisJ Obstet Gynaecol Res.(2018 Jan)
- Red Clover Extract - Katharine E Reed, Juliana Camargo, Jill Hamilton-Reeves, Mindy Kurzer, Mark MessinaNeither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studiesReprod Toxicol.(2021 Mar)
- DHEA - Marina L, Sojat AS, Maseroli E, Spaggiari G, Pandurevic S, Santi DHormonal profile of menopausal women receiving androgen replacement therapy: a meta-analysis.J Endocrinol Invest.(2020-Jun)
- DHEA - Hu Y, Wan P, An X, Jiang GImpact of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and BMI in elderly women: A meta-analysis of randomized controlled trials.Complement Ther Med.(2021-Jan)
- DHEA - Li Y, Ren J, Li N, Liu J, Tan SC, Low TY, Ma ZA dose-response and meta-analysis of dehydroepiandrosterone (DHEA) supplementation on testosterone levels: perinatal prediction of randomized clinical trials.Exp Gerontol.(2020-Nov)
- DHEA - Giovanni Corona, Giulia Rastrelli, Vito A Giagulli, Annamaria Sila, Alessandra Sforza, Gianni Forti, Edoardo Mannucci, Mario MaggiDehydroepiandrosterone supplementation in elderly men: a meta-analysis study of placebo-controlled trialsJ Clin Endocrinol Metab.(2013 Sep)
- Coenzyme Q10 - Tianqing Zhang, Qi He, Hao Xiu, ZiZhu Zhang, Yao Liu, Zhenrong Chen, Hengjing HuEfficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysisReprod Sci.(2022 Aug 8)
- Resveratrol - Ali Fadlalmola H, Elhusein AM, Al-Sayaghi KM, Albadrani MS, Swamy DV, Mamanao DM, El-Amin EI, Ibrahim SE, Abbas SMEfficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.Pan Afr Med J.(2023)
- Resveratrol - Larik MO, Ahmed A, Khan L, Iftekhar MAEffects of resveratrol on polycystic ovarian syndrome: a systematic review and meta-analysis of randomized controlled trials.Endocrine.(2024-Jan)
- Ketogenic Diet - Joseph Whittaker, Miranda HarrisLow-carbohydrate diets and men's cortisol and testosterone: Systematic review and meta-analysisNutr Health.(2022 Mar 7)
- Ketogenic Diet - Furini C, Spaggiari G, Simoni M, Greco C, Santi DKetogenic state improves testosterone serum levels-results from a systematic review and meta-analysis.Endocrine.(2022-Sep-23)
- Flaxseed - Musazadeh V, Nazari A, Natami M, Hajhashemy Z, Kazemi KS, Torabi F, Moridpour AH, Vajdi M, Askari GThe effect of flaxseed supplementation on sex hormone profile in adults: a systematic review and meta-analysis.Front Nutr.(2023)
- Probiotics - Ljunggren L, Butler E, Axelsson J, Åström M, Ohlsson LEffects of probiotic supplementation on testosterone levels in healthy ageing men: A 12-week double-blind, placebo-controlled randomized clinical trial.Contemp Clin Trials Commun.(2024 Jun)