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General Oxidation

General oxidation refers to a collection of biomarkers in the blood that are thought to reflect oxidative damage to the body. A reduction in these biomarkers is antioxidative, while an increase in prooxidative.

Research analysis lead by Kamal Patel
All content reviewed by Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect general oxidation
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Alpha-Lipoic Acid Minor High See all 6 studies
Appears to reduce biomarkers of oxidation
grade-b Cocoa Extract Minor Moderate See all 6 studies
A potential yet unreliable decrease in biomarkers of oxidation in serum following ingestion.
grade-b Coenzyme Q10 Minor High See all 6 studies
Appears to generally reduce pro-oxidative biomarkers in the body
grade-b Curcumin  
grade-b Rooibos  
grade-b Vitamin C  
grade-b Vitamin E  
grade-b Astaxanthin  
grade-c Spirulina  
grade-c Arginine  
grade-c Blueberry  
grade-c Chromium  
grade-c Fish Oil  
grade-c Ginkgo biloba  
grade-c Grape Seed Extract  
grade-c Inositol  
grade-c Japanese Knotweed  
grade-c Melatonin  
grade-c Methylsulfonylmethane  
grade-c Olive leaf extract  
grade-c Panax ginseng  
grade-c Pycnogenol  
grade-c Quercetin  
grade-c Resveratrol  
grade-c Creatine  
grade-c Ganoderma lucidum  
grade-c Glutathione  
grade-c Hesperidin  
grade-c Red Clover Extract  
grade-c Zinc  
grade-d Aronia melanocarpa  
grade-d Garlic  
grade-d Green Tea Catechins  
grade-d Hibiscus sabdariffa  
grade-d L-Carnitine  
grade-d Melissa officinalis  
grade-d Punicalagins  
grade-d Yerba mate  
grade-d Mangifera indica  
grade-d Pyrroloquinoline quinone  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.