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Heart Rate

Heart Rate is a term used to refer to the amount of beats a heart gives in X amount of time, usually a minute. Heart rate is variable, and should be constant; arrythmia (irregular beats) are a cause for concern, and some supplements (usually stimulants) influence Heart Rate.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published:
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect heart rate
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Caffeine Minor High See all 6 studies
An increase in heart rate is noted, but not wholly consistent. It appears to affect those with lower caffeine tolerance or high overdoses of caffeine
grade-b Ephedrine Minor Moderate See all 5 studies
An increase in heart rate is present following ephedrine administration which correlates well with its psychostimulatory properties; this is not 100% reliable, and heart rate increases may not occur
grade-b Grape Seed Extract Minor - See study
A small decrease in heart rate may occur following grape seed extract, although the studies are currently in persons with metabolic syndrome and not healthy persons
grade-b Marijuana  
grade-b Arginine  
grade-b Cocoa Extract  
grade-b Colostrum  
grade-b Creatine  
grade-b Ginkgo biloba  
grade-b Modafinil  
grade-b Ornithine  
grade-b Sodium Bicarbonate  
grade-c Ashwagandha  
grade-c Green Coffee Extract  
grade-c Green Tea Catechins  
grade-c Hoodia gordonii  
grade-c L-Carnitine  
grade-c Lavender  
grade-c Nicotine  
grade-c Pyruvate  
grade-c Salvia sclarea  
grade-c Tribulus terrestris  
grade-c Vitamin C  
grade-c Yerba mate  
grade-c Yohimbine  
grade-c 1,3-Dimethylamylamine  
grade-c Alanylglutamine  
grade-c Alpha-Lipoic Acid  
grade-c Anatabine  
grade-c Anethum graveolens  
grade-c Astaxanthin  
grade-c Blueberry  
grade-c Branched Chain Amino Acids  
grade-c Capsaicin  
grade-c Centella asiatica  
grade-c Chlorella  
grade-c Chromium  
grade-c Citrulline  
grade-c Curcumin  
grade-c ECA  
grade-c Eucommia ulmoides  
grade-c Fish Oil  
grade-c L-Tyrosine  
grade-c Lactobacillus reuteri  
grade-c Maca  
grade-c Melatonin  
grade-c Nigella sativa  
grade-c Nitrate  
grade-c Panax ginseng  
grade-c Phosphatidylserine  
grade-c Pycnogenol  
grade-c Quercetin  
grade-c Red Clover Extract  
grade-c Rhodiola Rosea  
grade-c Rooibos  
grade-c Sceletium tortuosum  
grade-c Soy lecithin  
grade-c Stevia  
grade-c Synephrine  
grade-c Taurine  
grade-c Theanine  
grade-c Trimethylglycine  
grade-c Vitamin E  
grade-d Cissus quadrangularis  
grade-d Conjugated Linoleic Acid  
grade-d Eleutherococcus senticosus  
grade-d Garlic  
grade-d Grapefruit  
grade-d Tetradecyl Thioacetic Acid  

All comparative evidence is now gathered in our ​A-to-Z Supplement Reference.

The evidence for each separate supplement is still freely available ​here.