Blood Pressure

    Last Updated: October 13, 2024

    Blood pressure is the force that blood exerts on blood vessels as it circulates. High blood pressure (hypertension) and low blood pressure (hypotension) can each lead to a variety of health issues.

    Overview

    Blood pressure (BP) refers to the force that blood exerts on the blood vessels as it circulates through your body. It plays a central role in heart health: cardiovascular disease risk is strongly associated with an increase in blood pressure, even when BP is within normal range.[1][2]

    As your blood pressure increases, it strains your blood vessels and heart. If it remains too high (hypertension), this can increase your risk for heart attacks, strokes, vascular diseases, eye damage, kidney disease, and more.

    As your BP drops, the pressure on the blood vessel walls decreases. If it remains too low (hypotension), you may not get enough oxygen to critical parts of your body, such as the brain and heart.

    There are multiple risk factors that can contribute to the development of high blood pressure.

    • Age: As you age, blood pressure tends to go up.
    • Family history: Nearly 100 genetic variations have been associated with high blood pressure. While a family history of high BP raises your risk, the exact pattern of genetic inheritance is not known.
    • Lifestyle: Too much sodium (salt), insufficient potassium, not enough exercise, excessive alcohol intake, and smoking can all contribute to high blood pressure.
    • Race/ethnicity: Black adults experience high blood pressure more frequently.
    • Sex: Prior to age 55, males are more likely to develop high blood pressure. After 55, females are more likely to develop it.
    • Weight: People who carry too much fat have an increased risk of high blood pressure.

    How are blood pressure levels assessed?

    Blood pressure is most commonly measured using a blood pressure monitor or gauge (where a cuff is placed around your upper arm). It can be measured either in a single sitting or via ambulatory blood pressure monitoring (ABPM) over 24 hours with a leave-on cuff. The latter is likely to be more accurate and result in fewer anomalous measurements since blood pressure can naturally fluctuate throughout the day.

    Blood pressure is reported in two numbers; e.g., 120/80 mmHg (millimeters of mercury — a unit of pressure).

    • The first number, systolic blood pressure, tells us how much pressure your blood is exerting against the arterial walls when your heart contracts.
    • The second number, diastolic blood pressure, signifies how much pressure your blood is exerting when the heart is relaxed and refilling with blood.

    Blood pressure measurements are generally divided into the five categories below.

    Blood pressure category cutoffs (mmHg)

    CATEGORYSYSTOLICDIASTOLIC
    Low blood pressure
    ≤90
    ≤65
    Normal blood pressure
    <120
    <80
    Elevated blood pressure
    120–129
    <80
    Stage 1 hypertension
    130–139
    80–89
    Stage 2 hypertension
    ≥140
    ≥90

    Adapted from Whelton et al. Hypertension. 2018.[3]

    In adults 65 or older, a blood pressure goal of 125–130 systolic and <80 diastolic is recommended.

    Examine Database: Blood Pressure

    B
    Moderate Decrease
    D
    No effect
    D
    No effect

    Research FeedRead all studies

    References

    1. ^The content of this page was partially adapted from MedlinePlus of the National Library of Medicine
    2. ^Pei D, Chen YL, Tang SH, Wu CZ, Lin JD, Chang YL, Hsu CH, Wang CY, Wang K, Wang JYRelationship of blood pressure and cardiovascular disease risk factors in normotensive middle-aged menMedicine (Baltimore).(2011 Sep)
    3. ^Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, DePalma SM, Gidding S, Jamerson KA, Jones DW, MacLaughlin EJ, Muntner P, Ovbiagele B, Smith SC Jr, Spencer CC, Stafford RS, Taler SJ, Thomas RJ, Williams KA Sr, Williamson JD, Wright JT Jr2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice GuidelinesHypertension.(2018 Jun)
    4. ^Peti-Peterdi J, Harris RCMacula densa sensing and signaling mechanisms of renin releaseJ Am Soc Nephrol.(2010 Jul)
    5. ^Appel LJ, Brands MW, Daniels SR, Karanja N, Elmer PJ, Sacks FM, American Heart AssociationDietary approaches to prevent and treat hypertension: a scientific statement from the American Heart AssociationHypertension.(2006 Feb)
    6. ^National High Blood Pressure Education ProgramThe Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
    7. ^Tielemans SM, Altorf-van der Kuil W, Engberink MF, Brink EJ, van Baak MA, Bakker SJ, Geleijnse JMIntake of total protein, plant protein and animal protein in relation to blood pressure: a meta-analysis of observational and intervention studiesJ Hum Hypertens.(2013 Sep)
    8. ^Rebholz CM, Friedman EE, Powers LJ, Arroyave WD, He J, Kelly TNDietary protein intake and blood pressure: a meta-analysis of randomized controlled trialsAm J Epidemiol.(2012 Oct 1)
    9. ^Fekete ÁA, Giromini C, Chatzidiakou Y, Givens DI, Lovegrove JAWhey protein lowers blood pressure and improves endothelial function and lipid biomarkers in adults with prehypertension and mild hypertension: results from the chronic Whey2Go randomized controlled trialAm J Clin Nutr.(2016 Dec)
    10. ^Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, DePalma SM, Gidding S, Jamerson KA, Jones DW, MacLaughlin EJ, Muntner P, Ovbiagele B, Smith SC Jr, Spencer CC, Stafford RS, Taler SJ, Thomas RJ, Williams KA Sr, Williamson JD, Wright JT Jr2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice GuidelinesHypertension.(2018 Jun)

    Examine Database References

    1. Garlic - Ried K, Frank OR, Stocks NPAged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trialMaturitas.(2010 Oct)
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    7. Potatoes - Michael S Stone, Berdine R Martin, Connie M WeaverShort-Term RCT of Increased Dietary Potassium from Potato or Potassium Gluconate: Effect on Blood Pressure, Microcirculation, and Potassium and Sodium Retention in Pre-Hypertensive-to-Hypertensive AdultsNutrients.(2021 May 11)
    8. Garlic - Sobenin IA, Andrianova IV, Demidova ON, Gorchakova T, Orekhov ANLipid-lowering effects of time-released garlic powder tablets in double-blinded placebo-controlled randomized studyJ Atheroscler Thromb.(2008 Dec)
    9. Yerba Mate - Martinet A, Hostettmann K, Schutz YThermogenic effects of commercially available plant preparations aimed at treating human obesityPhytomedicine.(1999 Oct)
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    11. 16:8 Intermittent Fasting - Kelsey Gabel, Jarrad Marcell, Kate Cares, Faiza Kalam, Sofia Cienfuegos, Mark Ezpeleta, Krista A VaradyEffect of time restricted feeding on the gut microbiome in adults with obesity: A pilot studyNutr Health.(2020 Jun)
    12. Citrulline - Karla Balderas-Munoz, Lilia Castillo-Martínez, Arturo Orea-Tejeda, Oscar Infante-Vázquez, Marcelo Utrera-Lagunas, Raúl Martínez-Memije, Candace Keirns-Davis, Bryan Becerra-Luna, Gabriela Sánchez-VidalImprovement of ventricular function in systolic heart failure patients with oral L-citrulline supplementationCardiol J.(2012)
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    15. Vitamin C - Mason SA, Rasmussen B, van Loon LJC, Salmon J, Wadley GDAscorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trialDiabetes Obes Metab.(2019 Mar)
    16. Chromium - Kleefstra N, Houweling ST, Bakker SJ, Verhoeven S, Gans RO, Meyboom-de Jong B, Bilo HJChromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled trialDiabetes Care.(2007 May)
    17. Chlorella - Shimada M, Hasegawa T, Nishimura C, Kan H, Kanno T, Nakamura T, Matsubayashi TAnti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind studyClin Exp Hypertens.(2009 Jun)
    18. Coenzyme Q10 - Shah SA, Sander S, Cios D, Lipeika J, Kluger J, White CMElectrocardiographic and hemodynamic effects of coenzyme Q10 in healthy individuals: a double-blind, randomized controlled trialAnn Pharmacother.(2007 Mar)
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    23. Black Cohosh - Ahmed Nasr, Hanan NafehInfluence of black cohosh (Cimicifuga racemosa) use by postmenopausal women on total hepatic perfusion and liver functionsFertil Steril.(2009 Nov)
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    25. Cocoa Extract - Crews WD Jr, Harrison DW, Wright JWA double-blind, placebo-controlled, randomized trial of the effects of dark chocolate and cocoa on variables associated with neuropsychological functioning and cardiovascular health: clinical findings from a sample of healthy, cognitively intact older adultsAm J Clin Nutr.(2008 Apr)
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    29. Cocoa Extract - Lívia de Paula Nogueira, Marcela Paranhos Knibel, Márcia Regina Simas Gonçalves Torres, José Firmino Nogueira Neto, Antonio Felipe SanjulianiConsumption of high-polyphenol dark chocolate improves endothelial function in individuals with stage 1 hypertension and excess body weightInt J Hypertens.(2012)
    30. Rhodiola Rosea - Wing SL, Askew EW, Luetkemeier MJ, Ryujin DT, Kamimori GH, Grissom CKLack of effect of Rhodiola or oxygenated water supplementation on hypoxemia and oxidative stressWilderness Environ Med.(2003 Spring)
    31. Calcium - Crowther CA, Hiller JE, Pridmore B, Bryce R, Duggan P, Hague WM, Robinson JSCalcium supplementation in nulliparous women for the prevention of pregnancy-induced hypertension, preeclampsia and preterm birth: an Australian randomized trial. FRACOG and the ACT Study GroupAust N Z J Obstet Gynaecol.(1999 Feb)
    32. Coenzyme Q10 - Abdollahzad H, et alCoenzyme Q10 supplementation in patients with rheumatoid arthritis: Are there any effects on cardiovascular risk factors?Eur J Integr Med..()
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    36. Lavender - Sayorwan W, Siripornpanich V, Piriyapunyaporn T, Hongratanaworakit T, Kotchabhakdi N, Ruangrungsi NThe effects of lavender oil inhalation on emotional states, autonomic nervous system, and brain electrical activityJ Med Assoc Thai.(2012 Apr)
    37. Quercetin - Randi L. Edwards, Tiffany Lyon, Sheldon E. Litwin, Alexander Rabovsky, J. David Symons, and Thunder JaliliQuercetin Reduces Blood Pressure in Hypertensive SubjectsAmerican Society for Nutrition.()
    38. Coenzyme Q10 - Burke BE, Neuenschwander R, Olson RDRandomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertensionSouth Med J.(2001 Nov)
    39. Saffron - Modaghegh MH, Shahabian M, Esmaeili HA, Rajbai O, Hosseinzadeh HSafety evaluation of saffron (Crocus sativus) tablets in healthy volunteersPhytomedicine.(2008 Dec)
    40. Panax Ginseng (Korean Ginseng) - Derek Ong Lai Teik, Xiao Shiang Lee, Chu Jian Lim, Chia Mei Low, Mariyam Muslima, Luca AquiliGinseng and Ginkgo Biloba Effects on Cognition as Modulated by Cardiovascular Reactivity: A Randomised TrialPLoS One.(2016 Mar 3)
    41. Ketogenic Diet - Yancy WS Jr, Westman EC, McDuffie JR, Grambow SC, Jeffreys AS, Bolton J, Chalecki A, Oddone EZA randomized trial of a low-carbohydrate diet vs orlistat plus a low-fat diet for weight lossArch Intern Med.(2010 Jan 25)
    42. Garlic - Adler AJ, Holub BJEffect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic menAm J Clin Nutr.(1997 Feb)
    43. Citrulline - Huan-Huan Yang, Xin-Li Li, Wei-Guo Zhang, Arturo Figueroa, Li-Hua Chen, Li-Qiang QinEffect of oral L-citrulline on brachial and aortic blood pressure defined by resting status: evidence from randomized controlled trialsNutr Metab (Lond).(2019 Dec 26)
    44. Curcumin - Cicero AFG, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi CEffects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trialEur J Nutr.(2019 Feb 22)
    45. Kanna - Nell H, Siebert M, Chellan P, Gericke NA randomized, double-blind, parallel-group, placebo-controlled trial of Extract Sceletium tortuosum (Zembrin) in healthy adultsJ Altern Complement Med.(2013 Nov)
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    47. Cocoa Extract - Karin Ried, Oliver R Frank, Nigel P StocksDark chocolate or tomato extract for prehypertension: a randomised controlled trialBMC Complement Altern Med.(2009 Jul 8)
    48. Magnesium - Guerrero-Romero F, Rodríguez-Morán MMagnesium improves the beta-cell function to compensate variation of insulin sensitivity: double-blind, randomized clinical trialEur J Clin Invest.(2011 Apr)
    49. Melatonin - Cagnacci A, Arangino S, Angiolucci M, Maschio E, Melis GBInfluences of melatonin administration on the circulation of womenAm J Physiol.(1998 Feb)
    50. Citrulline - Juan José Orozco-Gutiérrez, Lilia Castillo-Martínez, Arturo Orea-Tejeda, Oscar Vázquez-Díaz, Adrián Valdespino-Trejo, René Narváez-David, Candace Keirns-Davis, Olín Carrasco-Ortiz, Adolfo Navarro-Navarro, Rocío Sánchez-SantillánEffect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fractionCardiol J.(2010)
    51. Arginine - Stephen J. Bailey, Paul G. Winyard, Anni Vanhatalo, Jamie R. Blackwell, Fred J. DiMenna, Daryl Paul Wilkerson, and Andrew M. JonesAcute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise toleranceJournal of Applied Physiology.()
    52. Curcumin - Barber-Chamoux N, Milenkovic D, Verny MA, Habauzit V, Pereira B, Lambert C, Richard D, Boby C, Mazur A, Lusson JR, Dubray C, Morand CSubstantial Variability Across Individuals in the Vascular and Nutrigenomic Response to an Acute Intake of Curcumin: A Randomized Controlled TrialMol Nutr Food Res.(2018 Mar)
    53. Magnesium - Sacks FM, Willett WC, Smith A, Brown LE, Rosner B, Moore TJEffect on blood pressure of potassium, calcium, and magnesium in women with low habitual intakeHypertension.(1998 Jan)
    54. Magnesium - de Valk HW, Verkaaik R, van Rijn HJ, Geerdink RA, Struyvenberg AOral magnesium supplementation in insulin-requiring Type 2 diabetic patientsDiabet Med.(1998 Jun)
    55. Nitrate - Bondonno CP, Liu AH, Croft KD, Ward NC, Shinde S, Moodley Y, Lundberg JO, Puddey IB, Woodman RJ, Hodgson JMAbsence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomized controlled trialAm J Clin Nutr.(2015 Aug)
    56. Magnesium - Doyle L, Flynn A, Cashman KThe effect of magnesium supplementation on biochemical markers of bone metabolism or blood pressure in healthy young adult femalesEur J Clin Nutr.(1999 Apr)
    57. Cocoa Extract - West SG, McIntyre MD, Piotrowski MJ, Poupin N, Miller DL, Preston AG, Wagner P, Groves LF, Skulas-Ray ACEffects of dark chocolate and cocoa consumption on endothelial function and arterial stiffness in overweight adultsBr J Nutr.(2014 Feb)
    58. Cocoa Extract - De Gottardi A, Berzigotti A, Seijo S, D'Amico M, Thormann W, Abraldes JG, García-Pagán JC, Bosch JPostprandial effects of dark chocolate on portal hypertension in patients with cirrhosis: results of a phase 2, double-blind, randomized controlled trialAm J Clin Nutr.(2012 Sep)
    59. Ketogenic Diet - Ranjan A, Schmidt S, Damm-Frydenberg C, Holst JJ, Madsbad S, Nørgaard KShort-term effects of a low carbohydrate diet on glycaemic variables and cardiovascular risk markers in patients with type 1 diabetes: A randomized open-label crossover trialDiabetes Obes Metab.(2017 Oct)
    60. Nitrate - Coles LT, Clifton PMEffect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trialNutr J.(2012 Dec 11)
    61. Nicotine - Harte CB, Meston CMAcute effects of nicotine on physiological and subjective sexual arousal in nonsmoking men: a randomized, double-blind, placebo-controlled trialJ Sex Med.(2008 Jan)
    62. Garlic - Breithaupt-Grögler K, Ling M, Boudoulas H, Belz GGProtective effect of chronic garlic intake on elastic properties of aorta in the elderlyCirculation.(1997 Oct 21)
    63. Ginkgo Biloba - Moraga FA, Flores A, Serra J, Esnaola C, Barriento CGinkgo biloba decreases acute mountain sickness in people ascending to high altitude at Ollagüe (3696 m) in northern ChileWilderness Environ Med.(2007 Winter)
    64. Panax Ginseng (Korean Ginseng) - Kim JY, Park JY, Kang HJ, Kim OY, Lee JHBeneficial effects of Korean red ginseng on lymphocyte DNA damage, antioxidant enzyme activity, and LDL oxidation in healthy participants: a randomized, double-blind, placebo-controlled trialNutr J.(2012 Jul 17)
    65. Ephedrine - Hackman RM, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, Stohs SJ, Stern JS, Keen CLMultinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trialInt J Obes (Lond).(2006 Oct)
    66. Astaxanthin - Chen JT, Kotani KEffects of Astaxanthin on Liver and Leukocyte Parameters in Healthy Climacteric Women: Preliminary DataJ Med Food.(2017 Jul)
    67. Echinacea - Shah SA, Schlesselman L, Cios D, Lipeika J, Patel AA, Kluger J, White CMEffects of echinacea on electrocardiographic and blood pressure measurementsAm J Health Syst Pharm.(2007 Aug 1)
    68. Yohimbine - O G Cameron, J K Zubieta, L Grunhaus, S MinoshimaEffects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humansPsychosom Med.(Jul-Aug 2000)
    69. Alpha-Lipoic Acid - M G Carbonelli, L Di Renzo, M Bigioni, N Di Daniele, A De Lorenzo, M A FuscoAlpha-lipoic acid supplementation: a tool for obesity therapy?Curr Pharm Des.(2010)
    70. Chlorogenic Acid - Watanabe T, Arai Y, Mitsui Y, Kusaura T, Okawa W, Kajihara Y, Saito IThe blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertensionClin Exp Hypertens.(2006 Jul)
    71. Citrulline - Babak Sharif Kashani, Paritash Tahmaseb Pour, Majid Malekmohammad, Neda Behzadnia, Faezeh Sheybani-Afshar, Mohammad Fakhri, Samira Chaibakhsh, Farah Naghashzadeh, Salavan AidenlouOral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trialJ Cardiol.(2014 Sep)
    72. Vitamin C - Mullan BA, Ennis CN, Fee HJ, Young IS, McCance DRPretreatment with intravenous ascorbic acid preserves endothelial function during acute hyperglycaemia (R1)Clin Exp Pharmacol Physiol.(2005 May-Jun)
    73. CDP-Choline - Alvarez XA, Laredo M, Corzo D, Fernández-Novoa L, Mouzo R, Perea JE, Daniele D, Cacabelos RCiticoline improves memory performance in elderly subjectsMethods Find Exp Clin Pharmacol.(1997 Apr)
    74. Cocoa Extract - d'El-Rei J, Cunha AR, Burlá A, Burlá M, Oigman W, Neves MF, Virdis A, Medeiros FCharacterisation of hypertensive patients with improved endothelial function after dark chocolate consumptionInt J Hypertens.(2013)
    75. Chromium - Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal VBeneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetesJ Trace Elem Med Biol.(2011 Jul)
    76. Grape Juice - Dohadwala MM, Hamburg NM, Holbrook M, Kim BH, Duess MA, Levit A, Titas M, Chung WB, Vincent FB, Caiano TL, Frame AA, Keaney JF Jr, Vita JAEffects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertensionAm J Clin Nutr.(2010 Nov)
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    78. Blueberry - Johnson SA, Figueroa A, Navaei N, Wong A, Kalfon R, Ormsbee LT, Feresin RG, Elam ML, Hooshmand S, Payton ME, Arjmandi BHDaily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trialJ Acad Nutr Diet.(2015 Mar)
    79. Green Tea Extract - Brown AL, Lane J, Coverly J, Stocks J, Jackson S, Stephen A, Bluck L, Coward A, Hendrickx HEffects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trialBr J Nutr.(2009 Mar)
    80. Ginkgo Biloba - Mehlsen J, Drabaek H, Wiinberg N, Winther KEffects of a Ginkgo biloba extract on forearm haemodynamics in healthy volunteersClin Physiol Funct Imaging.(2002 Nov)
    81. Citrulline - Arturo Figueroa, Stacey Alvarez-Alvarado, Salvador J Jaime, Roy Kalfonl-Citrulline supplementation attenuates blood pressure, wave reflection and arterial stiffness responses to metaboreflex and cold stress in overweight menBr J Nutr.(2016 Jul)
    82. Coenzyme Q10 - Hodgson JM, Watts GF, Playford DA, Burke V, Croft KDCoenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetesEur J Clin Nutr.(2002 Nov)
    83. Spirulina - Gitte S Jensen, Cassandra Drapeau, Miki Lenninger, Kathleen F BensonClinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet ActivationJ Med Food.(2016 Jul)
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    86. Olive Oil - Fitó M, Cladellas M, de la Torre R, Martí J, Alcántara M, Pujadas-Bastardes M, Marrugat J, Bruguera J, López-Sabater MC, Vila J, Covas MI; members of the SOLOS InvestigatorsAntioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trialAtherosclerosis.(2005 Jul)
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    89. Curcumin - Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto THighly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPDInt J Chron Obstruct Pulmon Dis.(2016 Aug 26)
    90. Garlic - Gómez-Arbeláez D, Lahera V, Oubiña P, Valero-Muñoz M, de Las Heras N, Rodríguez Y, García RG, Camacho PA, López-Jaramillo PAged garlic extract improves adiponectin levels in subjects with metabolic syndrome: a double-blind, placebo-controlled, randomized, crossover studyMediators Inflamm.(2013)
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    92. Clary sage - Seol GH, Lee YH, Kang P, You JH, Park M, Min SSRandomized Controlled Trial for Salvia sclarea or Lavandula angustifolia: Differential Effects on Blood Pressure in Female Patients with Urinary Incontinence Undergoing Urodynamic ExaminationJ Altern Complement Med.(2013 Jan 29)
    93. Astaxanthin - Yoshida H, Yanai H, Ito K, Tomono Y, Koikeda T, Tsukahara H, Tada NAdministration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemiaAtherosclerosis.(2010 Apr)
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    98. Kefir - Ghizi ACdS et alKefir improves blood parameters and reduces cardiovascular risks in patients with metabolic syndromePharmaNutrition.()
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    100. Citrulline - Benjamin Wax, Andreas N Kavazis, William LuckettEffects of Supplemental Citrulline-Malate Ingestion on Blood Lactate, Cardiovascular Dynamics, and Resistance Exercise Performance in Trained MalesJ Diet Suppl.(2016)
    101. Rose Essential Oil - Hongratanaworakit TRelaxing effect of rose oil on humansNat Prod Commun.(2009 Feb)
    102. Grape Juice - Krikorian R, Boespflug EL, Fleck DE, Stein AL, Wightman JD, Shidler MD, Sadat-Hossieny SConcord grape juice supplementation and neurocognitive function in human agingJ Agric Food Chem.(2012 Jun 13)
    103. Saffron - Tayebe Kermani, Maedeh Zebarjadi, Hassan Mehrad-Majd, Seyed-Reza Mirhafez, Maryam Shemshian, Faezeh Ghasemi, Elham Mohammadzadeh, Seyed Hadi Mousavi, Abdolreza Norouzy, Toktam Moghiman, Akram Sadeghi, Gordon Ferns, Amir Avan, Elaheh Mahdipour, Majid Ghayour-MobarhanAnti-Inflammatory Effect of Crocus sativus on Serum Cytokine Levels in Subjects with Metabolic Syndrome: A Randomized, Double-Blind, Placebo- Controlled TrialCurr Clin Pharmacol.(2017)
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    105. Cannabis - R J Mathew, W H Wilson, D F Humphreys, J V Lowe, K E WietheRegional cerebral blood flow after marijuana smokingJ Cereb Blood Flow Metab.(1992 Sep)
    106. Conjugated Linoleic Acid - M F Engberink, J M Geleijnse, A J Wanders, I A BrouwerThe effect of conjugated linoleic acid, a natural trans fat from milk and meat, on human blood pressure: results from a randomized crossover feeding studyJ Hum Hypertens.(2012 Feb)
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    108. Pycnogenol - Enseleit F, Sudano I, Périat D, Winnik S, Wolfrum M, Flammer AJ, Fröhlich GM, Kaiser P, Hirt A, Haile SR, Krasniqi N, Matter CM, Uhlenhut K, Högger P, Neidhart M, Lüscher TF, Ruschitzka F, Noll GEffects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over studyEur Heart J.(2012 Jul)
    109. Conjugated Linoleic Acid - Raff M, Tholstrup T, Sejrsen K, Straarup EM, Wiinberg NDiets rich in conjugated linoleic acid and vaccenic acid have no effect on blood pressure and isobaric arterial elasticity in healthy young menJ Nutr.(2006 Apr)
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    113. Creatine - Weiss BA, Powers MECreatine supplementation does not impair the thermoregulatory response during a bout of exercise in the heatJ Sports Med Phys Fitness.(2006 Dec)
    114. Ketogenic Diet - Parker N Hyde, Teryn N Sapper, Christopher D Crabtree, Richard A LaFountain, Madison L Bowling, Alex Buga, Brandon Fell, Fionn T McSwiney, Ryan M Dickerson, Vincent J Miller, Debbie Scandling, Orlando P Simonetti, Stephen D Phinney, William J Kraemer, Sarah A King, Ronald M Krauss, Jeff S VolekDietary carbohydrate restriction improves metabolic syndrome independent of weight lossJCI Insight.(2019 Jun 20)
    115. Whey Protein - Pal S, Ellis VAcute effects of whey protein isolate on blood pressure, vascular function and inflammatory markers in overweight postmenopausal womenBr J Nutr.(2011 May)
    116. Citrulline - Ochiai M, Hayashi T, Morita M, Ina K, Maeda M, Watanabe F, Morishita KShort-term effects of L-citrulline supplementation on arterial stiffness in middle-aged menInt J Cardiol.(2012 Mar 8)
    117. Citrulline - Figueroa A, Trivino JA, Sanchez-Gonzalez MA, Vicil FOral L-citrulline supplementation attenuates blood pressure response to cold pressor test in young menAm J Hypertens.(2010 Jan)
    118. Roselle - Herrera-Arellano A, Miranda-Sánchez J, Avila-Castro P, Herrera-Alvarez S, Jiménez-Ferrer JE, Zamilpa A, Román-Ramos R, Ponce-Monter H, Tortoriello JClinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trialPlanta Med.(2007 Jan)
    119. Fish Oil - Morgan WA, Raskin P, Rosenstock JA comparison of fish oil or corn oil supplements in hyperlipidemic subjects with NIDDMDiabetes Care.(1995 Jan)
    120. Theanine - Peter J Rogers, Jessica E Smith, Susan V Heatherley, C W Pleydell-PearceTime for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and togetherPsychopharmacology (Berl).(2008 Jan)
    121. Garlic - Veena Dhawan, Sanjay JainGarlic supplementation prevents oxidative DNA damage in essential hypertensionMol Cell Biochem.(2005 Jul)
    122. Nitrate - Gilchrist M, Winyard PG, Aizawa K, Anning C, Shore A, Benjamin NEffect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetesFree Radic Biol Med.(2013 Feb 7)
    123. Cissus Quadrangularis - Richard J Bloomer, Tyler M Farney, Cameron G McCarthy, Sang-Rok LeeCissus quadrangularis reduces joint pain in exercise-trained men: a pilot studyPhys Sportsmed.(2013 Sep)
    124. Vegan Diet - Persio D Lopez, Eder H Cativo, Steven A Atlas, Clive RosendorffThe Effect of Vegan Diets on Blood Pressure in Adults: A Meta-Analysis of Randomized Controlled TrialsAm J Med.(2019 Jul)
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    126. Dill - Mansouri M, Nayebi N, Keshtkar A, Hasani-Ranjbar S, Taheri E, Larijani BThe effect of 12 weeks Anethum graveolens (dill) on metabolic markers in patients with metabolic syndrome; a randomized double blind controlled trialDaru.(2012 Oct 4)
    127. Theanine - Ai Yoto, Mao Motoki, Sato Murao, Hidehiko YokogoshiEffects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stressesJ Physiol Anthropol.(2012 Oct 29)
    128. Cocoa Extract - Shiina Y, Funabashi N, Lee K, Murayama T, Nakamura K, Wakatsuki Y, Daimon M, Komuro IAcute effect of oral flavonoid-rich dark chocolate intake on coronary circulation, as compared with non-flavonoid white chocolate, by transthoracic Doppler echocardiography in healthy adultsInt J Cardiol.(2009 Jan 24)
    129. Maca - Tsuyoshi Takewaka, Kiyoshi HaraClinical Effect of Oral Administration of Maca (Lepidium meyenii) Extract on Japanese Peri-Menopausal Women Subjects: A Randomized, Double-Blind, Placebo-Controlled StudyInt J Biomed Sci.()
    130. Fish Oil - Simão AN, Lozovoy MA, Bahls LD, Morimoto HK, Simão TN, Matsuo T, Dichi IBlood pressure decrease with ingestion of a soya product (kinako) or fish oil in women with the metabolic syndrome: role of adiponectin and nitric oxideBr J Nutr.(2012 Feb 8)
    131. Inositol - Maeba R, Hara H, Ishikawa H, Hayashi S, Yoshimura N, Kusano J, Takeoka Y, Yasuda D, Okazaki T, Kinoshita M, Teramoto TMyo-inositol treatment increases serum plasmalogens and decreases small dense LDL, particularly in hyperlipidemic subjects with metabolic syndromeJ Nutr Sci Vitaminol (Tokyo).(2008 Jun)
    132. Paleolithic Diet - Barbara Frączek, Aleksandra Pięta, Adrian Burda, Paulina Mazur-Kurach, Florentyna TyrałaPaleolithic Diet-Effect on the Health Status and Performance of Athletes?Nutrients.(2021 Mar 21)
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    134. Arginine - Monti LD, Setola E, Lucotti PC, Marrocco-Trischitta MM, Comola M, Galluccio E, Poggi A, Mammì S, Catapano AL, Comi G, Chiesa R, Bosi E, Piatti PMEffect of a long-term oral l-arginine supplementation on glucose metabolism: a randomized, double-blind, placebo-controlled trialDiabetes Obes Metab.(2012 Oct)
    135. Citrulline - Casonatto J, et alCitrulline malate supplementation might potentiate post-exercise hypotension in hypertensives: A 24-hour analysisSci Sport.()
    136. Ginkgo Biloba - Wimpissinger B, Berisha F, Garhoefer G, Polak K, Schmetterer LInfluence of Ginkgo biloba on ocular blood flowActa Ophthalmol Scand.(2007 Jun)
    137. Melatonin - Nishiyama K, Yasue H, Moriyama Y, Tsunoda R, Ogawa H, Yoshimura M, Kugiyama KAcute effects of melatonin administration on cardiovascular autonomic regulation in healthy menAm Heart J.(2001 May)
    138. Nattokinase - Kim JY, Gum SN, Paik JK, Lim HH, Kim KC, Ogasawara K, Inoue K, Park S, Jang Y, Lee JHEffects of nattokinase on blood pressure: a randomized, controlled trialHypertens Res.(2008 Aug)
    139. Pycnogenol - Liu X, Wei J, Tan F, Zhou S, Würthwein G, Rohdewald PPycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patientsLife Sci.(2004 Jan 2)
    140. Cocoa Extract - Engler MB, Engler MM, Chen CY, Malloy MJ, Browne A, Chiu EY, Kwak HK, Milbury P, Paul SM, Blumberg J, Mietus-Snyder MLFlavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adultsJ Am Coll Nutr.(2004 Jun)
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    144. Tetradecyl Thioacetic Acid - Reidar J Pettersen, Mohamed Salem, Jon Skorve, Rune J Ulvik, Rolf K Berge, Jan Erik NordrehaugPharmacology and safety of tetradecylthioacetic acid (TTA): phase-1 studyJ Cardiovasc Pharmacol.(2008 Apr)
    145. Hesperidin - Rizza S, Muniyappa R, Iantorno M, Kim JA, Chen H, Pullikotil P, Senese N, Tesauro M, Lauro D, Cardillo C, Quon MJCitrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndromeJ Clin Endocrinol Metab.(2011 May)
    146. African Mango - Ngondi JL, Oben JE, Minka SRThe effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in CameroonLipids Health Dis.(2005 May 25)
    147. Kava - Cropley M, Cave Z, Ellis J, Middleton RWEffect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditionsPhytother Res.(2002 Feb)
    148. L-Carnitine - Munji Choi, Seongmin Park, Myoungsook LeeL-Carnitine's Effect on the Biomarkers of Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsNutrients.(2020 Sep 12)
    149. OMAD And 20:4 Intermittent Fasting - Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CMEarly Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with PrediabetesCell Metab.(2018 Jun 5)
    150. Fish Oil - Rizza S, Tesauro M, Cardillo C, Galli A, Iantorno M, Gigli F, Sbraccia P, Federici M, Quon MJ, Lauro DFish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetesAtherosclerosis.(2009 Oct)
    151. Spirulina - Jesús Martínez-Sámano, Adriana Torres-Montes de Oca, Oscar Ivan Luqueño-Bocardo, Patricia V Torres-Durán, Marco A Juárez-OropezaSpirulina maxima Decreases Endothelial Damage and Oxidative Stress Indicators in Patients with Systemic Arterial Hypertension: Results from Exploratory Controlled Clinical TrialMar Drugs.(2018 Dec 8)
    152. Fish Oil - Krebs JD, Browning LM, McLean NK, Rothwell JL, Mishra GD, Moore CS, Jebb SAAdditive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic womenInt J Obes (Lond).(2006 Oct)
    153. Citrulline - Alexei Wong, Oksana Chernykh, Arturo FigueroaChronic l-citrulline supplementation improves cardiac sympathovagal balance in obese postmenopausal women: A preliminary reportAuton Neurosci.(2016 Jul)
    154. Spirulina - Sajjad Moradi, Mehdi Zobeiri, Awat Feizi, Cain C T Clark, Mohammad Hassan EntezariThe effects of spirulina (Arthrospira platensis) supplementation on anthropometric indices, blood pressure, sleep quality, mental health, fatigue status and quality of life in patients with ulcerative colitis: A randomised, double-blinded, placebo-controlled trialInt J Clin Pract.(2021 Jun 9)
    155. Cocoa Extract - Mogollon JA, Bujold E, Lemieux S, Bourdages M, Blanchet C, Bazinet L, Couillard C, Noël M, Dodin SBlood pressure and endothelial function in healthy, pregnant women after acute and daily consumption of flavanol-rich chocolate: a pilot, randomized controlled trialNutr J.(2013 Apr 8)
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    157. Red Clover Extract - Howes JB, Sullivan D, Lai N, Nestel P, Pomeroy S, West L, Eden JA, Howes LGThe effects of dietary supplementation with isoflavones from red clover on the lipoprotein profiles of post menopausal women with mild to moderate hypercholesterolaemiaAtherosclerosis.(2000 Sep)
    158. Cocoa Extract - Ottaviani JI, Balz M, Kimball J, Ensunsa JL, Fong R, Momma TY, Kwik-Uribe C, Schroeter H, Keen CLSafety and efficacy of cocoa flavanol intake in healthy adults: a randomized, controlled, double-masked trialAm J Clin Nutr.(2015 Dec)
    159. Riboflavin (Vitamin B2) - Horigan G, McNulty H, Ward M, Strain JJ, Purvis J, Scott JMRiboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFRJ Hypertens.(2010 Mar)
    160. Cannabis - R D Steadward, M SinghThe effects of smoking marihuana on physical performanceMed Sci Sports.(Winter 1975)
    161. Citrulline - Juliano Casonatto, Daniel Massaharu Enokida, Kamila GrandolfiInter-Individual Responses to Citrulline Malate Oral Supplementation on Post-Exercise Hypotension in Hypertensives: A 24-Hour AnalysisArq Bras Cardiol.(2019 Jul 10)
    162. Whey Protein - Vatani DS, Golzar FAChanges in antioxidant status and cardiovascular risk factors of overweight young men after six weeks supplementation of whey protein isolate and resistance trainingAppetite.(2012 Aug 10)
    163. Apple Cider Vinegar - Kondo T, Kishi M, Fushimi T, Ugajin S, Kaga TVinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjectsBiosci Biotechnol Biochem.(2009 Aug)
    164. Curcumin - Khajehdehi P, Zanjaninejad B, Aflaki E, Nazarinia M, Azad F, Malekmakan L, Dehghanzadeh GROral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled studyJ Ren Nutr.(2012 Jan)
    165. Garlic - Ried K, Frank OR, Stocks NPAged garlic extract reduces blood pressure in hypertensives: a dose-response trialEur J Clin Nutr.(2013 Jan)
    166. Paleolithic Diet - Mohammad Hassan Sohouli, Somaye Fatahi, Abolfazl Lari, Mojtaba Lotfi, Maryam Seifishahpar, Mihnea-Alexandru Găman, Seyedeh Tayebeh Rahideh, Saud K AlBatati, Abdullah M AlHossan, Sara A Alkhalifa, Sara A Alomar, Ahmed Abu-ZaidThe effect of paleolithic diet on glucose metabolism and lipid profile among patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trialsCrit Rev Food Sci Nutr.(2021 Jan 25)
    167. Soy Protein - Maedeh Moradi, Elnaz Daneshzad, Leila AzadbakhtThe Effects of Isolated Soy Protein, Isolated Soy Isoflavones and Soy Protein Containing Isoflavones on Serum Lipids in Postmenopausal Women: A Systematic Review and Meta-AnalysisCrit Rev Food Sci Nutr.(2019 Dec 20)
    168. L-Tyrosine - Thomas J, Lockwood P, Singh, A, Patricia, DTyrosine Improves Working Memory in a Multitasking EnvironmentPharmacol Biochem.()
    169. Fish Oil - Campbell F, Dickinson HO, Critchley JA, Ford GA, Bradburn MA systematic review of fish-oil supplements for the prevention and treatment of hypertensionEur J Prev Cardiolog.(2012 Jan 30)
    170. 1,3-Dimethylamylamine - Bloomer RJ, Harvey IC, Farney TM, Bell ZW, Canale REEffects of 1,3-dimethylamylamine and caffeine alone or in combination on heart rate and blood pressure in healthy men and womenPhys Sportsmed.(2011 Sep)
    171. Saffron - Milajerdi A, Jazayeri S, Hashemzadeh N, Shirzadi E, Derakhshan Z, Djazayeri A, Akhondzadeh SThe effect of saffron (Crocus sativus L.) hydroalcoholic extract on metabolic control in type 2 diabetes mellitus: A triple-blinded randomized clinical trialJ Res Med Sci.(2018 Feb 20)
    172. Rose Hip - Andersson U, Berger K, Högberg A, Landin-Olsson M, Holm CEffects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese personsEur J Clin Nutr.(2012 May)
    173. Pycnogenol - Zibadi S, Rohdewald PJ, Park D, Watson RRReduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementationNutr Res.(2008 May)
    174. Alpha-Lipoic Acid - Sola S, Mir MQ, Cheema FA, Khan-Merchant N, Menon RG, Parthasarathy S, Khan BVIrbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) studyCirculation.(2005 Jan 25)
    175. Ketogenic Diet - Phillips SA, Jurva JW, Syed AQ, Syed AQ, Kulinski JP, Pleuss J, Hoffmann RG, Gutterman DDBenefit of low-fat over low-carbohydrate diet on endothelial health in obesityHypertension.(2008 Feb)
    176. Conjugated Linoleic Acid - Diaz ML, Watkins BA, Li Y, Anderson RA, Campbell WWChromium picolinate and conjugated linoleic acid do not synergistically influence diet- and exercise-induced changes in body composition and health indexes in overweight womenJ Nutr Biochem.(2008 Jan)
    177. Fish Oil - L Axelrod, J Camuso, E Williams, K Kleinman, E Briones, D SchoenfeldEffects of a Small Quantity of omega-3 Fatty Acids on Cardiovascular Risk Factors in NIDDM. A Randomized, Prospective, Double-Blind, Controlled StudyDiabetes Care.(1994 Jan)
    178. Astaxanthin - Nakagawa K, Kiko T, Miyazawa T, Carpentero Burdeos G, Kimura F, Satoh A, Miyazawa TAntioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytesBr J Nutr.(2011 Jun)
    179. Mango - Shirley F Evans, Maureen Meister, Maryam Mahmood, Heba Eldoumi, Sandra Peterson, Penelope Perkins-Veazie, Stephen L Clarke, Mark Payton, Brenda J Smith, Edralin A LucasMango supplementation improves blood glucose in obese individualsNutr Metab Insights.(2014 Aug 28)
    180. Citrulline - Joaquin U Gonzales, Andrea Raymond, John Ashley, Youngdeok KimDoes l-citrulline supplementation improve exercise blood flow in older adults?Exp Physiol.(2017 Dec 1)
    181. Kefir - Ezgi Bellikci-Koyu, Banu Pınar Sarer-Yurekli, Yakut Akyon, Fadime Aydin-Kose, Cem Karagozlu, Ahmet Gokhan Ozgen, Annika Brinkmann, Andreas Nitsche, Koray Ergunay, Engin Yilmaz, Zehra BuyuktuncerEffects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled StudyNutrients.(2019 Sep 4)
    182. Ashwagandha - Choudhary D, Bhattacharyya S, Joshi KBody Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled TrialJ Evid Based Complementary Altern Med.(2017 Jan)
    183. Red Clover Extract - Howes JB, Bray K, Lorenz L, Smerdely P, Howes LGThe effects of dietary supplementation with isoflavones from red clover on cognitive function in postmenopausal womenClimacteric.(2004 Mar)
    184. Psyllium - Pal S, Khossousi A, Binns C, Dhaliwal S, Radavelli-Bagatini SThe effects of 12-week psyllium fibre supplementation or healthy diet on blood pressure and arterial stiffness in overweight and obese individualsBr J Nutr.(2012 Mar)
    185. OMAD And 20:4 Intermittent Fasting - B D Horne, J B Muhlestein, D L Lappé, H T May, J F Carlquist, O Galenko, K D Brunisholz, J L AndersonRandomized cross-over trial of short-term water-only fasting: metabolic and cardiovascular consequencesNutr Metab Cardiovasc Dis.(2013 Nov)
    186. Psyllium - de Bock M, Derraik JG, Brennan CM, Biggs JB, Smith GC, Cameron-Smith D, Wall CR, Cutfield WSPsyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trialPLoS One.(2012)
    187. Riboflavin (Vitamin B2) - Wilson CP, McNulty H, Ward M, Strain JJ, Trouton TG, Hoeft BA, Weber P, Roos FF, Horigan G, McAnena L, Scott JMBlood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trialHypertension.(2013 Jun)
    188. Vegan Diet - Amir Abbasnezhad, Ebrahim Falahi, Michael J Gonzalez, Parivash Kavehi, Faezeh Fouladvand, Razieh ChoghakhoriEffect of Different Dietary Approaches Compared With a Regular Diet on Systolic and Diastolic Blood Pressure in Patients With Type 2 Diabetes: A Systematic Review and Meta-AnalysisDiabetes Res Clin Pract.(2020 May)
    189. Bacopa Monnieri - Luke A Downey, James Kean, Fiona Nemeh, Angela Lau, Alex Poll, Rebecca Gregory, Margaret Murray, Johanna Rourke, Brigit Patak, Matthew P Pase, Andrea Zangara, Justine Lomas, Andrew Scholey, Con StoughAn acute, double-blind, placebo-controlled crossover study of 320 mg and 640 mg doses of a special extract of Bacopa monnieri (CDRI 08) on sustained cognitive performancePhytother Res.(2013 Sep)
    190. Curcumin - Santos-Parker JR, Strahler TR, Bassett CJ, Bispham NZ, Chonchol MB, Seals DRCurcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stressAging (Albany NY).(2017 Jan 3)
    191. Licorice - Decio Armanini, Mee Jung Mattarello, Cristina Fiore, Guglielmo Bonanni, Carla Scaroni, Paola Sartorato, Mario PalermoLicorice reduces serum testosterone in healthy womenSteroids.(Oct-Nov 2004)
    192. Astaxanthin - Mashhadi NS, Zakerkish M, Mohammadiasl J, Zarei M, Mohammadshahi M, Haghighizadeh MHAstaxanthin improves glucose metabolism and reduces blood pressure in patients with type 2 diabetes mellitusAsia Pac J Clin Nutr.(2018)
    193. Panax Ginseng (Korean Ginseng) - Rhee MY, Kim YS, Bae JH, Nah DY, Kim YK, Lee MM, Kim HYEffect of Korean red ginseng on arterial stiffness in subjects with hypertensionJ Altern Complement Med.(2011 Jan)
    194. Taurine - Beyranvand MR, Khalafi MK, Roshan VD, Choobineh S, Parsa SA, Piranfar MAEffect of taurine supplementation on exercise capacity of patients with heart failureJ Cardiol.(2011 May)
    195. Vitamin E - Economides PA, Khaodhiar L, Caselli A, Caballero AE, Keenan H, Bursell SE, King GL, Johnstone MT, Horton ES, Veves AThe effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patientsDiabetes.(2005 Jan)
    196. Cocoa Extract - Verawati Sudarma, Sri Sukmaniah, Parlindungan SiregarEffect of dark chocolate on nitric oxide serum levels and blood pressure in prehypertension subjectsActa Med Indones.(2011 Oct)
    197. Paleolithic Diet - Ehsan Ghaedi, Mohammad Mohammadi, Hamed Mohammadi, Nahid Ramezani-Jolfaie, Janmohamad Malekzadeh, Mahdieh Hosseinzadeh, Amin Salehi-AbargoueiEffects of a Paleolithic Diet on Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsAdv Nutr.(2019 Jul 1)
    198. Cocoa Extract - Muniyappa R, Hall G, Kolodziej TL, Karne RJ, Crandon SK, Quon MJCocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertensionAm J Clin Nutr.(2008 Dec)
    199. Tribulus Terrestris - Kamenov Z, Fileva S, Kalinov K, Jannini EAEvaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trialMaturitas.(2017 May)
    200. ECA - Daly PA, Krieger DR, Dulloo AG, Young JB, Landsberg LEphedrine, caffeine and aspirin: safety and efficacy for treatment of human obesityInt J Obes Relat Metab Disord.(1993 Feb)
    201. Ketogenic Diet - Noakes M, Foster PR, Keogh JB, James AP, Mamo JC, Clifton PMComparison of isocaloric very low carbohydrate/high saturated fat and high carbohydrate/low saturated fat diets on body composition and cardiovascular riskNutr Metab (Lond).(2006 Jan 11)
    202. Curcumin - Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda SCurcumin ingestion and exercise training improve vascular endothelial function in postmenopausal womenNutr Res.(2012 Oct)
    203. Ashwagandha - Chengappa KNR, Brar JS, Gannon JM, Schlicht PJAdjunctive Use of a Standardized Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled StudyJ Clin Psychiatry.(2018 Jul 10)
    204. Curcumin - Campbell MS, Ouyang A, I M K, Charnigo RJ, Westgate PM, Fleenor BSInfluence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: A double-blinded, randomized, controlled trialNutrition.(2019 Jun)
    205. Phosphatidylserine - Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori TSoybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaintsJ Clin Biochem Nutr.(2010 Nov)
    206. Creatine - Branch JD, Schwarz WD, Van Lunen BEffect of creatine supplementation on cycle ergometer exercise in a hyperthermic environmentJ Strength Cond Res.(2007 Feb)
    207. Vitamin C - JAYESH K BHATT, SABIN THOMAS, NANJAN MJEFFECT OF ORAL SUPPLEMENTATION OF VITAMIN C ON GLYCEMIC CONTROL AND LIPID PROFILE IN PATIENTS WITH TYPE 2 DIABETES MELLITUSInternational Journal of Pharmacy and Pharmaceutical Sciences.()
    208. Melatonin - Koziróg M, Poliwczak AR, Duchnowicz P, Koter-Michalak M, Sikora J, Broncel MMelatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndromeJ Pineal Res.(2011 Apr)
    209. Hesperidin - Mohammadi M, Ramezani-Jolfaie N, Lorzadeh E, Khoshbakht Y, Salehi-Abargouei AHesperidin, a major flavonoid in orange juice, might not affect lipid profile and blood pressure: A systematic review and meta-analysis of randomized controlled clinical trialsPhytother Res.(2019 Mar)
    210. Red Clover Extract - Hidalgo LA, Chedraui PA, Morocho N, Ross S, San Miguel GThe effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled studyGynecol Endocrinol.(2005 Nov)
    211. Sesamin - Miyawaki T, Aono H, Toyoda-Ono Y, Maeda H, Kiso Y, Moriyama KAntihypertensive effects of sesamin in humansJ Nutr Sci Vitaminol (Tokyo).(2009 Feb)
    212. Saffron - Safarinejad MR, Shafiei N, Safarinejad SA prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermiaPhytother Res.(2011 Apr)
    213. Zinc - Seet RC, Lee CY, Lim EC, Quek AM, Huang H, Huang SH, Looi WF, Long LH, Halliwell BOral zinc supplementation does not improve oxidative stress or vascular function in patients with type 2 diabetes with normal zinc levelsAtherosclerosis.(2011 Nov)
    214. Nitrate - Murphy M, Eliot K, Heuertz RM, Weiss EWhole beetroot consumption acutely improves running performanceJ Acad Nutr Diet.(2012 Apr)
    215. Ashwagandha - Auddy, B, et alA Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled StudyJ Am Nut Assn.()
    216. Vegan Diet - Richard J Bloomer, Trint A Gunnels, JohnHenry M SchrieferComparison of a Restricted and Unrestricted Vegan Diet Plan with a Restricted Omnivorous Diet Plan on Health-Specific MeasuresHealthcare (Basel).(2015 Jul 14)
    217. Stevia - Hsieh MH, Chan P, Sue YM, Liu JC, Liang TH, Huang TY, Tomlinson B, Chow MS, Kao PF, Chen YJEfficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled studyClin Ther.(2003 Nov)
    218. Cocoa Extract - Grassi D, Necozione S, Lippi C, Croce G, Valeri L, Pasqualetti P, Desideri G, Blumberg JB, Ferri CCocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensivesHypertension.(2005 Aug)
    219. Garlic - Simons LA, Balasubramaniam S, von Konigsmark M, Parfitt A, Simons J, Peters WOn the effect of garlic on plasma lipids and lipoproteins in mild hypercholesterolaemiaAtherosclerosis.(1995 Mar)
    220. Cannabis - Aronow W, Cassidy JEffect of smoking marihuana and of a high-nicotine cigarette on angina pectoris Clin Pharm.()
    221. Chlorella - Lee SH, Kang HJ, Lee HJ, Kang MH, Park YKSix-week supplementation with Chlorella has favorable impact on antioxidant status in Korean male smokersNutrition.(2010 Feb)
    222. Ecklonia Cava - Shin HC, Kim SH, Park Y, Lee BH, Hwang HJEffects of 12-week oral supplementation of Ecklonia cava polyphenols on anthropometric and blood lipid parameters in overweight Korean individuals: a double-blind randomized clinical trialPhytother Res.(2012 Mar)
    223. Curcumin - Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar AAntioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysisClin Nutr.(2015 Dec)
    224. Magnesium - Hatzistavri LS, Sarafidis PA, Georgianos PI, Tziolas IM, Aroditis CP, Zebekakis PE, Pikilidou MI, Lasaridis ANOral magnesium supplementation reduces ambulatory blood pressure in patients with mild hypertensionAm J Hypertens.(2009 Oct)
    225. L-Carnitine - V Wyss, G P Ganzit, A RienziEffects of L-carnitine administration on VO2max and the aerobic-anaerobic threshold in normoxia and acute hypoxiaEur J Appl Physiol Occup Physiol.(1990)
    226. Ketogenic Diet - Brehm BJ, Seeley RJ, Daniels SR, D'Alessio DAA randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy womenJ Clin Endocrinol Metab.(2003 Apr)
    227. 16:8 Intermittent Fasting - Grant M Tinsley, M Lane Moore, Austin J Graybeal, Antonio Paoli, Youngdeok Kim, Joaquin U Gonzales, John R Harry, Trisha A VanDusseldorp, Devin N Kennedy, Megan R CruzTime-restricted feeding plus resistance training in active females: a randomized trialAm J Clin Nutr.(2019 Sep 1)
    228. Inositol - M Nordio, E ProiettiThe combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation aloneEur Rev Med Pharmacol Sci.(2012 May)
    229. Gotu Kola - Bradwejn J, Zhou Y, Koszycki D, Shlik JA double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjectsJ Clin Psychopharmacol.(2000 Dec)
    230. Alanylglutamine - Hoffman JR, Ratamess NA, Kang J, Rashti SL, Kelly N, Gonzalez AM, Stec M, Anderson S, Bailey BL, Yamamoto LM, Hom LL, Kupchak BR, Faigenbaum AD, Maresh CMExamination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exerciseJ Int Soc Sports Nutr.(2010 Feb 3)
    231. 16:8 Intermittent Fasting - Kelsey Gabel, Kristin K Hoddy, Nicole Haggerty, Jeehee Song, Cynthia M Kroeger, John F Trepanowski, Satchidananda Panda, Krista A VaradyEffects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot studyNutr Healthy Aging.(2018 Jun 15)
    232. Benfotiamine - Alkhalaf A, Klooster A, van Oeveren W, Achenbach U, Kleefstra N, Slingerland RJ, Mijnhout GS, Bilo HJ, Gans RO, Navis GJ, Bakker SJA double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathyDiabetes Care.(2010 Jul)
    233. Bitter Cucumber - Huseini HF, Darvishzadeh F, Heshmat R, Jafariazar Z, Raza M, Larijani BThe clinical investigation of Citrullus colocynthis (L.) schrad fruit in treatment of Type II diabetic patients: a randomized, double blind, placebo-controlled clinical trialPhytother Res.(2009 Aug)
    234. Cocoa Extract - Eunice K Chan, Jon Quach, Fiona K Mensah, Valerie Sung, Michael Cheung, Melissa WakeDark chocolate for children's blood pressure: randomised trialArch Dis Child.(2012 Jul)
    235. L-Carnitine - Hadier M El-Sheikh, Sahar M El-Haggar, Tamer A ElbedewyComparative study to evaluate the effect of l-carnitine plus glimepiride versus glimepiride alone on insulin resistance in type 2 diabetic patientsDiabetes Metab Syndr.(Jan-Feb 2019)
    236. Stevia - Barriocanal LA, Palacios M, Benitez G, Benitez S, Jimenez JT, Jimenez N, Rojas VApparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeticsRegul Toxicol Pharmacol.(2008 Jun)
    237. Stevia - Maki KC, Curry LL, Carakostas MC, Tarka SM, Reeves MS, Farmer MV, McKenney JM, Toth PD, Schwartz SL, Lubin BC, Dicklin MR, Boileau AC, Bisognano JDThe hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressureFood Chem Toxicol.(2008 Jul)
    238. Roselle - Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, Fatehi F, Noori-Shadkam MThe effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetesJ Hum Hypertens.(2009 Jan)
    239. Citrulline - Marcos Angel Sanchez-Gonzalez, Andrew Paul Koutnik, Katherine Ramirez, Alexei Wong, Arturo FigueroaThe effects of short term L-citrulline supplementation on wave reflection responses to cold exposure with concurrent isometric exerciseAm J Hypertens.(2013 Apr)
    240. Fish Oil - Cazzola R, Russo-Volpe S, Miles EA, Rees D, Banerjee T, Roynette CE, Wells SJ, Goua M, Wahle KW, Calder PC, Cestaro BAge- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjectsAtherosclerosis.(2007 Jul)
    241. L-Tyrosine - Banderet LE, Lieberman HRTreatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humansBrain Res Bull.(1989 Apr)
    242. Spirulina - Patricia V Torres-Duran, Aldo Ferreira-Hermosillo, Marco A Juarez-OropezaAntihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of Mexican population: a preliminary reportLipids Health Dis.(2007 Nov 26)
    243. Chromium - Ghosh D, Bhattacharya B, Mukherjee B, Manna B, Sinha M, Chowdhury J, Chowdhury SRole of chromium supplementation in Indians with type 2 diabetes mellitusJ Nutr Biochem.(2002 Nov)
    244. Citrulline - Sean T Stanelle, Kelsey L McLaughlin, Stephen F CrouseOne Week of L-Citrulline Supplementation Improves Performance in Trained CyclistsJ Strength Cond Res.(2020 Mar)
    245. Blueberry - Stull AJ, Cash KC, Johnson WD, Champagne CM, Cefalu WTBioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and womenJ Nutr.(2010 Oct)
    246. Ginkgo Biloba - Chung HS, Harris A, Kristinsson JK, Ciulla TA, Kagemann C, Ritch RGinkgo biloba extract increases ocular blood flow velocityJ Ocul Pharmacol Ther.(1999 Jun)
    247. Black seed - Qidwai W, Hamza HB, Qureshi R, Gilani AEffectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trialJ Altern Complement Med.(2009 Jun)
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    249. Potatoes - E A Johnston, K S Petersen, P M Kris-EthertonDaily intake of non-fried potato does not affect markers of glycaemia and is associated with better diet quality compared with refined grains: a randomised, crossover study in healthy adultsBr J Nutr.(2020 May 14)
    250. Roselle - M Haji Faraji, A Haji TarkhaniThe effect of sour tea (Hibiscus sabdariffa) on essential hypertensionJ Ethnopharmacol.(1999 Jun)
    251. Curcumin - Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai SReduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trialJ Nutr Biochem.(2014 Feb)
    252. L-Tyrosine - Deijen JB, Orlebeke JFEffect of tyrosine on cognitive function and blood pressure under stressBrain Res Bull.(1994)
    253. Citrulline - Qiu J, et all-citrulline supplementation reduced peripheral blood pressure in Chinese adults with prehypertensionJ Hypertens.()
    254. Microlactin - Sharpe SJ, Gamble GD, Sharpe DNCholesterol-lowering and blood pressure effects of immune milkAm J Clin Nutr.(1994 Apr)
    255. Nicotine - Harte CB, Meston CMThe inhibitory effects of nicotine on physiological sexual arousal in nonsmoking women: results from a randomized, double-blind, placebo-controlled, cross-over trialJ Sex Med.(2008 May)
    256. Alpha-Lipoic Acid - Wray DW, Uberoi A, Lawrenson L, Bailey DM, Richardson RSOral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcomeClin Sci (Lond).(2009 Mar)
    257. Ginkgo Biloba - Brinkley TE, Lovato JF, Arnold AM, Furberg CD, Kuller LH, Burke GL, Nahin RL, Lopez OL, Yasar S, Williamson JD; Ginkgo Evaluation of Memory (GEM) Study InvestigatorsEffect of Ginkgo biloba on blood pressure and incidence of hypertension in elderly men and womenAm J Hypertens.(2010 May)
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    259. Grape Juice - Park YK, Lee SH, Park E, Kim JS, Kang MHChanges in antioxidant status, blood pressure, and lymphocyte DNA damage from grape juice supplementationAnn N Y Acad Sci.(2009 Aug)
    260. Garlic - Verma SK, Rajeevan V, Jain P, Bordia AEffect of garlic (Allium sativum) oil on exercise tolerance in patients with coronary artery diseaseIndian J Physiol Pharmacol.(2005 Jan)
    261. Pyruvate - Stanko RT, Reynolds HR, Lonchar KD, Arch JEPlasma lipid concentrations in hyperlipidemic patients consuming a high-fat diet supplemented with pyruvate for 6 wkAm J Clin Nutr.(1992 Nov)
    262. Ecklonia Cava - Lee DH, Park MY, Shim BJ, Youn HJ, Hwang HJ, Shin HC, Jeon HKEffects of Ecklonia cava Polyphenol in Individuals with Hypercholesterolemia: A Pilot StudyJ Med Food.(2012 Nov)
    263. Black seed - Dehkordi FR, Kamkhah AFAntihypertensive effect of Nigella sativa seed extract in patients with mild hypertensionFundam Clin Pharmacol.(2008 Aug)
    264. Tetradecyl Thioacetic Acid - Løvås K, Røst TH, Skorve J, Ulvik RJ, Gudbrandsen OA, Bohov P, Wensaas AJ, Rustan AC, Berge RK, Husebye ESTetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidationDiabetes Obes Metab.(2009 Apr)
    265. Panax Ginseng (Korean Ginseng) - Park BJ, Lee YJ, Lee HR, Jung DH, Na HY, Kim HB, Shim JYEffects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled StudyKorean J Fam Med.(2012 Jul)
    266. Coenzyme Q10 - Watts GF, Playford DA, Croft KD, Ward NC, Mori TA, Burke VCoenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitusDiabetologia.(2002 Mar)
    267. Cannabis - Merritt JC, Crawford WJ, Alexander PC, Anduze AL, Gelbart SSEffect of marihuana on intraocular and blood pressure in glaucomaOphthalmology.(1980 Mar)
    268. Citrulline - Powers R, et al[7-OR]: L-Citrulline administration increases the arginine/ADMA ratio, decreases blood pressure and improves vascular function in obese pregnant womenPregnancy Hypertens.()
    269. Cannabis - R J Mathew, W H Wilson, D Humphreys, J V Lowe, K E WietheMiddle cerebral artery velocity during upright posture after marijuana smokingActa Psychiatr Scand.(1992 Aug)
    270. Chromium - Yazaki Y, Faridi Z, Ma Y, Ali A, Northrup V, Njike VY, Liberti L, Katz DLA pilot study of chromium picolinate for weight lossJ Altern Complement Med.(2010 Mar)
    271. Lactobacillus Casei - Leber B, Tripolt NJ, Blattl D, Eder M, Wascher TC, Pieber TR, Stauber R, Sourij H, Oettl K, Stadlbauer VThe influence of probiotic supplementation on gut permeability in patients with metabolic syndrome: an open label, randomized pilot studyEur J Clin Nutr.(2012 Oct)
    272. Arginine - Bode-Böger SM, Böger RH, Galland A, Tsikas D, Frölich JCL-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationshipBr J Clin Pharmacol.(1998 Nov)
    273. Conjugated Linoleic Acid - Maria Pfeuffer, Kerstin Fielitz, Christiane Laue, Petra Winkler, Diana Rubin, Ulf Helwig, Katrin Giller, Julia Kammann, Edzard Schwedhelm, Rainer H Böger, Achim Bub, Doris Bell, Jürgen SchrezenmeirCLA does not impair endothelial function and decreases body weight as compared with safflower oil in overweight and obese male subjectsJ Am Coll Nutr.(2011 Feb)
    274. Ephedrine - Boozer CN, Daly PA, Homel P, Solomon JL, Blanchard D, Nasser JA, Strauss R, Meredith THerbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trialInt J Obes Relat Metab Disord.(2002 May)
    275. Reishi - Chu TT, Benzie IF, Lam CW, Fok BS, Lee KK, Tomlinson BStudy of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trialBr J Nutr.(2012 Apr)
    276. Chia seeds - Vuksan V, Whitham D, Sievenpiper JL, Jenkins AL, Rogovik AL, Bazinet RP, Vidgen E, Hanna ASupplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardiovascular risk factors in type 2 diabetes: results of a randomized controlled trialDiabetes Care.(2007 Nov)
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    282. Coenzyme Q10 - Young JM, Florkowski CM, Molyneux SL, McEwan RG, Frampton CM, Nicholls MG, Scott RS, George PMA randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the metabolic syndromeAm J Hypertens.(2012 Feb)
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    284. Thiamine (Vitamin B1) - Alaei-Shahmiri F, Soares MJ, Zhao Y, Sherriff JThe impact of thiamine supplementation on blood pressure, serum lipids and C-reactive protein in individuals with hyperglycemia: a randomised, double-blind cross-over trialDiabetes Metab Syndr.(2015 Oct-Dec)
    285. Ornithine - Sugino T, Shirai T, Kajimoto Y, Kajimoto OL-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolismNutr Res.(2008 Nov)
    286. Grape Juice - Park YK, Kim JS, Kang MHConcord grape juice supplementation reduces blood pressure in Korean hypertensive men: double-blind, placebo controlled intervention trialBiofactors.(2004)
    287. Spirulina - José J van den Driessche, Jogchum Plat, Maurice C J M Konings, Ronald P MensinkEffects of spirulina and wakame consumption on intestinal cholesterol absorption and serum lipid concentrations in non-hypercholesterolemic adult men and womenEur J Nutr.(2020 Aug)
    288. Astaxanthin - Coombes JS, Sharman JE, Fassett RGAstaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial)Am J Clin Nutr.(2016 Jan)
    289. Bitter orange - Stohs SJ, Preuss HG, Keith SC, Keith PL, Miller H, Kaats GREffects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changesInt J Med Sci.(2011 Apr 28)
    290. Cannabis - Kraft B, Frickey NA, Kaufmann RM, Reif M, Frey R, Gustorff B, Kress HGLack of analgesia by oral standardized cannabis extract on acute inflammatory pain and hyperalgesia in volunteersAnesthesiology.(2008 Jul)
    291. Olive Leaf Extract - Perrinjaquet-Moccetti T, Busjahn A, Schmidlin C, Schmidt A, Bradl B, Aydogan CFood supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twinsPhytother Res.(2008 Sep)
    292. Apple Cider Vinegar - Gheflati A, Bashiri R, Ghadiri-Anari A, Reza JZ, Kord MT, Nadjarzadeh AThe effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized controlled clinical trialClin Nutr ESPEN.(2019 Oct)
    293. L-Tyrosine - M J Sole, C R Benedict, M G Myers, F H Leenen, G H AndersonChronic dietary tyrosine supplements do not affect mild essential hypertensionHypertension.(Jul-Aug 1985)
    294. Lactobacillus Reuteri - Jones ML, Martoni CJ, Di Pietro E, Simon RR, Prakash SEvaluation of clinical safety and tolerance of a Lactobacillus reuteri NCIMB 30242 supplement capsule: a randomized control trialRegul Toxicol Pharmacol.(2012 Jul)
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    296. Ephedrine - Ingerslev J, Svendsen TL, Mørk AIs an ephedrine caffeine treatment contraindicated in hypertensionInt J Obes Relat Metab Disord.(1997 Aug)
    297. L-Tyrosine - C R Benedict, G H Anderson, M J SoleThe influence of oral tyrosine and tryptophan feeding on plasma catecholamines in manAm J Clin Nutr.(1983 Sep)
    298. Arginine - Fahs CA, Heffernan KS, Fernhall BHemodynamic and vascular response to resistance exercise with L-arginineMed Sci Sports Exerc.(2009 Apr)
    299. Nitrate - Kelly J, Fulford J, Vanhatalo A, Blackwell JR, French O, Bailey SJ, Gilchrist M, Winyard PG, Jones AMEffects of short-term dietary nitrate supplementation on blood pressure, O2 uptake kinetics, and muscle and cognitive function in older adultsAm J Physiol Regul Integr Comp Physiol.(2013 Jan 15)
    300. Ketogenic Diet - Partsalaki I, Karvela A, Spiliotis BEMetabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescentsJ Pediatr Endocrinol Metab.(2012)
    301. Red Clover Extract - Nestel PJ, Pomeroy S, Kay S, Komesaroff P, Behrsing J, Cameron JD, West LIsoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal womenJ Clin Endocrinol Metab.(1999 Mar)
    302. Ashwagandha - Sandhu JS, Shah B, Shenoy S, Chauhan S, Lavekar GS, Padhi MMEffects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adultsInt J Ayurveda Res.(2010 Jul)
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    304. L-Carnitine - Aneliya Parvanova, Matias Trillini, Manuel A Podestà, Ilian P Iliev, Carolina Aparicio, Annalisa Perna, Francesco Peraro, Nadia Rubis, Flavio Gaspari, Antonio Cannata, Silvia Ferrari, Antonio C Bossi, Roberto Trevisan, Sreejith Parameswaran, Jonathan S Chávez-Iñiguez, Fahrudin Masnic, Sidy Mohamed Seck, Teerayuth Jiamjariyaporn, Monica Cortinovis, Luca Perico, Kanishka Sharma, Giuseppe Remuzzi, Piero Ruggenenti, David G WarnockBlood Pressure and Metabolic Effects of Acetyl-l-Carnitine in Type 2 Diabetes: DIABASI Randomized Controlled TrialJ Endocr Soc.(2018 Mar 22)
    305. Paleolithic Diet - C Mellberg, S Sandberg, M Ryberg, M Eriksson, S Brage, C Larsson, T Olsson, B LindahlLong-term effects of a Palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trialEur J Clin Nutr.(2014 Mar)
    306. L-Tyrosine - James A Lang, Alex C Krajek, Kelsey S Schwartz, Joel E RandOral L-Tyrosine Supplementation Improves Core Temperature Maintenance in Older AdultsMed Sci Sports Exerc.(2020 Apr)
    307. Coenzyme Q10 - Dai YL, Luk TH, Yiu KH, Wang M, Yip PM, Lee SW, Li SW, Tam S, Fong B, Lau CP, Siu CW, Tse HFReversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trialAtherosclerosis.(2011 Jun)
    308. Maca - Meissner HO, Mscisz A, Reich-Bilinska H, Mrozikiewicz P, Bobkiewicz-Kozlowska T, Kedzia B, Lowicka A, Barchia IHormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (III) Clinical responses of early-postmenopausal women to Maca in double blind, randomized, Placebo-controlled, crossover configuration, outpatient studyInt J Biomed Sci.(2006 Dec)
    309. L-Tyrosine - Deijen JB, Wientjes CJ, Vullinghs HF, Cloin PA, Langefeld JJTyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training courseBrain Res Bull.(1999 Jan 15)
    310. L-Carnitine - Ruggenenti P, Cattaneo D, Loriga G, Ledda F, Motterlini N, Gherardi G, Orisio S, Remuzzi GAmeliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapyHypertension.(2009 Sep)
    311. Anatabine - Jenkins ND, Housh TJ, Johnson GO, Traylor DA, Bergstrom HC, Cochrane KC, Lewis RW Jr, Schmidt RJ, Cramer JTThe effects of anatabine on non-invasive indicators of muscle damage: a randomized, double-blind, placebo-controlled, crossover studyJ Int Soc Sports Nutr.(2013 Jul 22)
    312. Inositol - Santamaria A, Giordano D, Corrado F, Pintaudi B, Interdonato ML, Vieste GD, Benedetto AD, D'Anna ROne-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndromeClimacteric.(2012 Oct)
    313. Tribulus Terrestris - Murthy AR, Dubey SD, Tripathi KAnti-hypertensive effect of Gokshura (Tribulus terrestris Linn.) - A clinical studyAnc Sci Life.(2000 Jan)
    314. Bushman's hat - Blom WA, Abrahamse SL, Bradford R, Duchateau GS, Theis W, Orsi A, Ward CL, Mela DJEffects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trialAm J Clin Nutr.(2011 Nov)
    315. L-Carnitine - Eun Shil Hong, Eun Ky Kim, Seon Mee Kang, Ah Reum Khang, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Soo LimEffect of carnitine-orotate complex on glucose metabolism and fatty liver: a double-blind, placebo-controlled studyJ Gastroenterol Hepatol.(2014)
    316. Theanine - F L Dodd, D O Kennedy, L M Riby, C F Haskell-RamsayA double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and moodPsychopharmacology (Berl).(2015 Jul)
    317. Citrulline - Benjamin Wax, Andreas N Kavazis, Kevin Weldon, Joseph SperlakEffects of supplemental citrulline malate ingestion during repeated bouts of lower-body exercise in advanced weightliftersJ Strength Cond Res.(2015 Mar)
    318. OMAD And 20:4 Intermittent Fasting - Stote KS, Baer DJ, Spears K, Paul DR, Harris GK, Rumpler WV, Strycula P, Najjar SS, Ferrucci L, Ingram DK, Longo DL, Mattson MPA controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adultsAm J Clin Nutr.(2007 Apr)
    319. Vegan Diet - Neal D Barnard, Susan M Levin, Lise Gloede, Rosendo FloresTurning the Waiting Room into a Classroom: Weekly Classes Using a Vegan or a Portion-Controlled Eating Plan Improve Diabetes Control in a Randomized Translational StudyJ Acad Nutr Diet.(2018 Jun)
    320. Caffeine - Astrup A, Toubro S, Cannon S, Hein P, Breum L, Madsen JCaffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteersAm J Clin Nutr.(1990 May)
    321. Bacopa Monnieri - Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken BEffects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trialJ Altern Complement Med.(2008 Jul)
    322. Olive Leaf Extract - de Bock M, Derraik JG, Brennan CM, Biggs JB, Morgan PE, Hodgkinson SC, Hofman PL, Cutfield WSOlive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover TrialPLoS One.(2013)
    323. Cocoa Extract - Davison K, Coates AM, Buckley JD, Howe PREffect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjectsInt J Obes (Lond).(2008 Aug)
    324. Rose Hip - Nagatomo A, Nishida N, Fukuhara I, Noro A, Kozai Y, Sato H, Matsuura YDaily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trialDiabetes Metab Syndr Obes.(2015 Mar 6)
    325. Cocoa Extract - Almoosawi S, Fyfe L, Ho C, Al-Dujaili EThe effect of polyphenol-rich dark chocolate on fasting capillary whole blood glucose, total cholesterol, blood pressure and glucocorticoids in healthy overweight and obese subjectsBr J Nutr.(2010 Mar)
    326. Fish Oil - Ramel A, Martinez JA, Kiely M, Bandarra NM, Thorsdottir IModerate consumption of fatty fish reduces diastolic blood pressure in overweight and obese European young adults during energy restrictionNutrition.(2010 Feb)
    327. Citrulline - Stephen J Bailey, Jamie R Blackwell, Terrence Lord, Anni Vanhatalo, Paul G Winyard, Andrew M Jonesl-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humansJ Appl Physiol (1985).(2015 Aug 15)
    328. Yohimbine - Sommer M, Braumann M, Althoff T, Backhaus J, Kordon A, Junghanns K, Ehrenthal D, Bartmann U, Hohagen F, Broocks APsychological and neuroendocrine responses to social stress and to the administration of the alpha-2-receptor antagonist, yohimbine, in highly trained endurance athletes in comparison to untrained healthy controlsPharmacopsychiatry.(2011 Jun)
    329. Berberine - Pérez-Rubio KG, González-Ortiz M, Martínez-Abundis E, Robles-Cervantes JA, Espinel-Bermúdez MCEffect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretionMetab Syndr Relat Disord.(2013 Oct)
    330. Alpha-Lipoic Acid - Sharman JE, Gunaruwan P, Knez WL, Schmitt M, Marsh SA, Wilson GR, Cockcroft JR, Coombes JSAlpha-lipoic acid does not acutely affect resistance and conduit artery function or oxidative stress in healthy menBr J Clin Pharmacol.(2004 Sep)
    331. Stevia - Chan P, Tomlinson B, Chen YJ, Liu JC, Hsieh MH, Cheng JTA double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertensionBr J Clin Pharmacol.(2000 Sep)
    332. Alpha-Lipoic Acid - Weiss C, Bierhaus A, Nawroth PP, Bärtsch PEffects of supplementation with alpha-lipoic acid on exercise-induced activation of coagulationMetabolism.(2005 Jun)
    333. Vegan Diet - Edelweiss Ramal, Andrea Champlin, Khaled BahjriImpact of a Plant-Based Diet and Support on Mitigating Type 2 Diabetes Mellitus in Latinos Living in Medically Underserved AreasAm J Health Promot.(2018 Mar)
    334. Spirulina - Mazokopakis EE, Starakis IK, Papadomanolaki MG, Mavroeidi NG, Ganotakis ESThe hypolipidemic effects of Spirulina (Arthrospira platensis) supplementation in a Cretan population: a prospective studyJ Sci Food Agric.(2013 Jun 10)
    335. Grape Juice - Neto MM, da Silva TF, de Lima FF, Siqueira TMQ, Toscano LT, de Moura SKMSF, Silva ASWhole Red Grape Juice Reduces Blood Pressure at Rest and Increases Post-exercise HypotensionJ Am Coll Nutr.(2017 Sep-Oct)
    336. Betaine - Schwab U, Törrönen A, Toppinen L, Alfthan G, Saarinen M, Aro A, Uusitupa MBetaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjectsAm J Clin Nutr.(2002 Nov)
    337. Royal Jelly - Morita H, Ikeda T, Kajita K, Fujioka K, Mori I, Okada H, Uno Y, Ishizuka TEffect of royal jelly ingestion for six months on healthy volunteersNutr J.(2012 Sep 21)
    338. Eucommia Bark - Greenway F, Liu Z, Yu Y, Gupta AA clinical trial testing the safety and efficacy of a standardized Eucommia ulmoides Oliver bark extract to treat hypertensionAltern Med Rev.(2011 Dec)
    339. Theanine - Jackson Williams, Andrew J McKune, Ekavi N Georgousopoulou, Jane Kellett, Nathan M D'Cunha, Domenico Sergi, Duane Mellor, Nenad NaumovskiThe Effect of L-Theanine Incorporated in a Functional Food Product (Mango Sorbet) on Physiological Responses in Healthy Males: A Pilot Randomised Controlled TrialFoods.(2020 Mar 23)
    340. Sodium Bicarbonate - Volianitis S, Rasmussen P, Seifert T, Nielsen HB, Secher NHPlasma pH does not influence the cerebral metabolic ratio during maximal whole body exerciseJ Physiol.(2011 Jan 15)
    341. Saffron - Fatemeh Ebrahimi, Naheed Aryaeian, Naseh Pahlavani, Davood Abbasi, Agha Fatemeh Hosseini, Soudabeh Fallah, Nariman Moradi, Iraj HeydariThe effect of saffron ( Crocus sativus L.) supplementation on blood pressure, and renal and liver function in patients with type 2 diabetes mellitus: A double-blinded, randomized clinical trialAvicenna J Phytomed.(Jul-Aug 2019)
    342. Cocoa Extract - Balzer J, Rassaf T, Heiss C, Kleinbongard P, Lauer T, Merx M, Heussen N, Gross HB, Keen CL, Schroeter H, Kelm MSustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trialJ Am Coll Cardiol.(2008 Jun 3)
    343. L-Carnitine - Seyed Mostafa Nachvak, Maryam Shabanpur, Roghayeh Mostafai, Reza Heidari Moghaddam, Jalal MoludiL-Carnitine supplementation reduces biomarkers of inflammatory and oxidative stress in patients with coronary artery disease: a randomised controlled trialArch Physiol Biochem.(2020 Aug 20)
    344. L-Carnitine - Jun-jie Zhang, Zhi-bing Wu, You-jin Cai, Bin Ke, Ying-juan Huang, Chao-ping Qiu, Yu-bing Yang, Lan-ying Shi, Jian QinL-carnitine ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in patients with metabolic syndrome: a randomized controlled studyNutr J.(2014 Nov 26)
    345. Chlorella - Shiro Nakano, Hideo Takekoshi, Masuo NakanoChlorella pyrenoidosa supplementation reduces the risk of anemia, proteinuria and edema in pregnant womenPlant Foods Hum Nutr.(2010 Mar)
    346. Vitamin D - Witham MD, Nadir MA, Struthers ADEffect of vitamin D on blood pressure: a systematic review and meta-analysisJ Hypertens.(2009 Oct)
    347. Chromium - Ali A, Ma Y, Reynolds J, Wise JP Sr, Inzucchi SE, Katz DLChromium effects on glucose tolerance and insulin sensitivity in persons at risk for diabetes mellitusEndocr Pract.(2011 Jan-Feb)
    348. Cannabis - Mathew RJ, Wilson WH, Davis RPostural syncope after marijuana: a transcranial Doppler study of the hemodynamicsPharmacol Biochem Behav.(2003 May)
    349. Grape Seed Extract - Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda TEffect of grape seed extract on blood pressure in subjects with the metabolic syndromeMetabolism.(2009 Dec)
    350. Coenzyme Q10 - Serag H, El Wakeel L, Adly ACoenzyme Q10 administration has no effect on sICAM-1 and metabolic parameters of pediatrics with type 1 diabetes mellitusInt J Vitam Nutr Res.(2020 Jan 16)
    351. Red Clover Extract - Howes JB, Tran D, Brillante D, Howes LGEffects of dietary supplementation with isoflavones from red clover on ambulatory blood pressure and endothelial function in postmenopausal type 2 diabetesDiabetes Obes Metab.(2003 Sep)
    352. Inositol - Costantino D, Minozzi G, Minozzi E, Guaraldi CMetabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trialEur Rev Med Pharmacol Sci.(2009 Mar-Apr)
    353. Resveratrol - Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MK, Kunz I, Schrauwen-Hinderling VB, Blaak EE, Auwerx J, Schrauwen PCalorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humansCell Metab.(2011 Nov 2)
    354. Vitamin C - Mahmoudabadi MM, Djalali M, Djazayery SA, Keshavarz SA, Eshraghian MR, Yaraghi AA, Askari G, Ghiasvand R, Zarei MEffects of eicosapentaenoic acid and vitamin C on glycemic indices, blood pressure, and serum lipids in type 2 diabetic Iranian malesJ Res Med Sci.(2011 Mar)
    355. Psyllium - Bell LP, Hectorn KJ, Reynolds H, Hunninghake DBCholesterol-lowering effects of soluble-fiber cereals as part of a prudent diet for patients with mild to moderate hypercholesterolemiaAm J Clin Nutr.(1990 Dec)
    356. L-Tyrosine - Joanne DiFrancisco-Donoghue, Ely Rabin, Eric M Lamberg, William G WernerEffects of Tyrosine on Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled TrialMov Disord Clin Pract.(2014 Oct 23)
    357. L-Tyrosine - James A Lang, Kevin A SmallerOral l-tyrosine supplementation augments the vasoconstriction response to whole-body cooling in older adultsExp Physiol.(2017 Jul 1)
    358. Arginine - Willoughby DS, Boucher T, Reid J, Skelton G, Clark MEffects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exerciseInt J Sport Nutr Exerc Metab.(2011 Aug)
    359. Vitamin C - Klein F, Juhl B, Christiansen JSUnchanged renal haemodynamics following high dose ascorbic acid administration in normoalbuminuric IDDM patientsScand J Clin Lab Invest.(1995 Feb)
    360. Curcumin - Khajehdehi P, Pakfetrat M, Javidnia K, Azad F, Malekmakan L, Nasab MH, Dehghanzadeh GOral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled studyScand J Urol Nephrol.(2011 Nov)
    361. Creatine - Armentano MJ, Brenner AK, Hedman TL, Solomon ZT, Chavez J, Kemper GB, Salzberg D, Battafarano DF, Christie DSThe effect and safety of short-term creatine supplementation on performance of push-upsMil Med.(2007 Mar)
    362. Magnesium - Guerrero-Romero F, Rodríguez-Morán MThe effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trialJ Hum Hypertens.(2009 Apr)
    363. Creatine - Volek JS, Mazzetti SA, Farquhar WB, Barnes BR, Gómez AL, Kraemer WJPhysiological responses to short-term exercise in the heat after creatine loadingMed Sci Sports Exerc.(2001 Jul)
    364. Roselle - Gurrola-Díaz CM, García-López PM, Sánchez-Enríquez S, Troyo-Sanromán R, Andrade-González I, Gómez-Leyva JFEffects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy)Phytomedicine.(2010 Jun)
    365. L-Tyrosine - Shurtleff D, Thomas JR, Schrot J, Kowalski K, Harford RTyrosine reverses a cold-induced working memory deficit in humansPharmacol Biochem Behav.(1994 Apr)
    366. Vegan Diet - Hope R Ferdowsian, Neal D Barnard, Valerie J Hoover, Heather I Katcher, Susan M Levin, Amber A Green, Joshua L CohenA multicomponent intervention reduces body weight and cardiovascular risk at a GEICO corporate siteAm J Health Promot.(Jul-Aug 2010)
    367. Garlic - Ashraf R, Khan RA, Ashraf I, Qureshi AAEffects of Allium sativum (Garlic) on systolic and diastolic blood pressure in patients with essential hypertensionPak J Pharm Sci.(2013 Sep)
    368. Vegan Diet - Michael Macknin, Tammie Kong, Adam Weier, Sarah Worley, Anne S Tang, Naim Alkhouri, Mladen GolubicPlant-based, no-added-fat or American Heart Association diets: impact on cardiovascular risk in obese children with hypercholesterolemia and their parentsJ Pediatr.(2015 Apr)
    369. Nitrate - Lansley KE, Winyard PG, Fulford J, Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Gilchrist M, Benjamin N, Jones AMDietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled studyJ Appl Physiol.(2011 Mar)
    370. Magnesium - Kawano Y, Matsuoka H, Takishita S, Omae TEffects of magnesium supplementation in hypertensive patients: assessment by office, home, and ambulatory blood pressuresHypertension.(1998 Aug)
    371. Chromium - Kleefstra N, Houweling ST, Jansman FG, Groenier KH, Gans RO, Meyboom-de Jong B, Bakker SJ, Bilo HJChromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trialDiabetes Care.(2006 Mar)
    372. Roselle - Herrera-Arellano A, Flores-Romero S, Chávez-Soto MA, Tortoriello JEffectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trialPhytomedicine.(2004 Jul)
    373. Curcumin - Jazayeri-Tehrani SA, Rezayat SM, Mansouri S, Qorbani M, Alavian SM, Daneshi-Maskooni M, Hosseinzadeh-Attar MJNano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trialNutr Metab (Lond).(2019 Jan 28)
    374. Vanadium - N Cohen, M Halberstam, P Shlimovich, C J Chang, H Shamoon, L RossettiOral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitusJ Clin Invest.(1995 Jun)
    375. Pterostilbene - Riche DM, Riche KD, Blackshear CT, McEwen CL, Sherman JJ, Wofford MR, Griswold MEPterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trialEvid Based Complement Alternat Med.(2014)
    376. Panax Ginseng (Korean Ginseng) - Jovanovski E, Jenkins A, Dias AG, Peeva V, Sievenpiper J, Arnason JT, Rahelic D, Josse RG, Vuksan VEffects of Korean red ginseng (Panax ginseng C.A. Mayer) and its isolated ginsenosides and polysaccharides on arterial stiffness in healthy individualsAm J Hypertens.(2010 May)
    377. Shilajit - Sharma P, Jha J, Shrinivas V, Dwivedi LK, Suresh P, Sinha MShilajit: evalution of its effects on blood chemistry of normal human subjectsAnc Sci Life.(2003 Oct)
    378. Cocoa Extract - Grassi D, Lippi C, Necozione S, Desideri G, Ferri CShort-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy personsAm J Clin Nutr.(2005 Mar)
    379. Bhringaraj - Vasavi Rangineni, D Sharada, Saileshnath SaxenaDiuretic, hypotensive, and hypocholesterolemic effects of Eclipta alba in mild hypertensive subjects: a pilot studyJ Med Food.(2007 Mar)
    380. Ketogenic Diet - Athinarayanan SJ, Adams RN, Hallberg SJ, McKenzie AL, Bhanpuri NH, Campbell WW, Volek JS, Phinney SD, McCarter JPLong-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical TrialFront Endocrinol (Lausanne).(2019 Jun 5)
    381. Policosanol - Castaño G, Más R, Fernández JC, Fernández L, Illnait J, López EEffects of policosanol on older patients with hypertension and type II hypercholesterolaemiaDrugs R D.(2002)
    382. Lactobacillus Reuteri - Wolf BW, Wheeler KB, Ataya DG, Garleb KASafety and tolerance of Lactobacillus reuteri supplementation to a population infected with the human immunodeficiency virusFood Chem Toxicol.(1998 Dec)
    383. Nicotine - Axelsson T, Jansson PA, Smith U, Eliasson BNicotine infusion acutely impairs insulin sensitivity in type 2 diabetic patients but not in healthy subjectsJ Intern Med.(2001 Jun)
    384. Olive Leaf Extract - Susalit E, Agus N, Effendi I, Tjandrawinata RR, Nofiarny D, Perrinjaquet-Moccetti T, Verbruggen MOlive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with CaptoprilPhytomedicine.(2011 Feb 15)
    385. Cannabis - A M Renaud, Y CormierAcute effects of marihuana smoking on maximal exercise performanceMed Sci Sports Exerc.(1986 Dec)
    386. Ketogenic Diet - Foster GD, Wyatt HR, Hill JO, McGuckin BG, Brill C, Mohammed BS, Szapary PO, Rader DJ, Edman JS, Klein SA randomized trial of a low-carbohydrate diet for obesityN Engl J Med.(2003 May 22)
    387. Cocoa Extract - Fraga CG, Actis-Goretta L, Ottaviani JI, Carrasquedo F, Lotito SB, Lazarus S, Schmitz HH, Keen CLRegular consumption of a flavanol-rich chocolate can improve oxidant stress in young soccer playersClin Dev Immunol.(2005 Mar)
    388. Cocoa Extract - Monahan KD, Feehan RP, Kunselman AR, Preston AG, Miller DL, Lott MEDose-dependent increases in flow-mediated dilation following acute cocoa ingestion in healthy older adultsJ Appl Physiol.(2011 Dec)
    389. Roselle - McKay DL, Chen CY, Saltzman E, Blumberg JBHibiscus sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adultsJ Nutr.(2010 Feb)
    390. Alpha-Lipoic Acid - Ziegler D, Low PA, Litchy WJ, Boulton AJ, Vinik AI, Freeman R, Samigullin R, Tritschler H, Munzel U, Maus J, Schütte K, Dyck PJEfficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trialDiabetes Care.(2011 Sep)
    391. Citrulline - Heidi A B Smith, Jeffrey A Canter, Karla G Christian, Davis C Drinkwater, Frank G Scholl, Brian W Christman, Geraldine D Rice, Frederick E Barr, Marshall L SummarNitric oxide precursors and congenital heart surgery: a randomized controlled trial of oral citrullineJ Thorac Cardiovasc Surg.(2006 Jul)
    392. Vegan Diet - S Mishra, J Xu, U Agarwal, J Gonzales, S Levin, N D BarnardA multicenter randomized controlled trial of a plant-based nutrition program to reduce body weight and cardiovascular risk in the corporate setting: the GEICO studyEur J Clin Nutr.(2013 Jul)
    393. Ginkgo Biloba - Gillian Keheyan, Lauren A Dunn, Wendy Louise HallAcute effects of Ginkgo biloba extract on vascular function and blood pressurePlant Foods Hum Nutr.(2011 Sep)
    394. Hesperidin - Morand C, Dubray C, Milenkovic D, Lioger D, Martin JF, Scalbert A, Mazur AHesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteersAm J Clin Nutr.(2011 Jan)
    395. Vegan Diet - Neal D Barnard, Jihad Alwarith, Emilie Rembert, Liz Brandon, Minh Nguyen, Andrea Goergen, Taylor Horne, Gabriel F do Nascimento, Kundanika Lakkadi, Andrea Tura, Richard Holubkov, Hana KahleovaA Mediterranean Diet and Low-Fat Vegan Diet to Improve Body Weight and Cardiometabolic Risk Factors: A Randomized, Cross-over TrialJ Am Coll Nutr.(2021 Feb 5)
    396. Pycnogenol - Saeed Hosseini, Jeongmin Lee, Ramon T. Sepulveda, Peter Rohdewald, Ronald R. WatsonA randomized, double-blind, placebo-controlled, prospective, 16 week crossover study to determine the role of Pycnogenol in modifying blood pressure in mildly hypertensive patientsNutrition Research.()
    397. Vitamin D - Seibert E, Lehmann U, Riedel A, Ulrich C, Hirche F, Brandsch C, Dierkes J, Girndt M, Stangl GIVitamin D3 supplementation does not modify cardiovascular risk profile of adults with inadequate vitamin D statusEur J Nutr.(2015 Nov 30)
    398. Maca - Gonzales-Arimborgo C, Yupanqui I, Montero E, Alarcón-Yaquetto DE, Zevallos-Concha A, Caballero L, Gasco M, Zhao J, Khan IA, Gonzales GFAcceptability, Safety, and Efficacy of Oral Administration of Extracts of Black or Red Maca (Lepidium meyenii) in Adult Human Subjects: A Randomized, Double-Blind, Placebo-Controlled StudyPharmaceuticals (Basel).(2016 Aug 18)
    399. Tart Cherry Juice - Desai T, Roberts M, Bottoms LEffects of short-term continuous Montmorency tart cherry juice supplementation in participants with metabolic syndrome.Eur J Nutr.(2021-Apr)
    400. Tart Cherry Juice - Keane KM, Bailey SJ, Vanhatalo A, Jones AM, Howatson GEffects of montmorency tart cherry (L. Prunus Cerasus) consumption on nitric oxide biomarkers and exercise performance.Scand J Med Sci Sports.(2018-Jul)
    401. Tart Cherry Juice - Rachel Kimble, Karen M Keane, John K Lodge, Glyn HowatsonThe Influence of Tart Cherry ( Prunus cerasus, cv Montmorency) Concentrate Supplementation for 3 Months on Cardiometabolic Risk Factors in Middle-Aged Adults: A Randomised, Placebo-Controlled TrialNutrients.(2021 Apr 23)
    402. Tart Cherry Juice - Keane KM, George TW, Constantinou CL, Brown MA, Clifford T, Howatson GEffects of Montmorency tart cherry (Prunus Cerasus L.) consumption on vascular function in men with early hypertension.Am J Clin Nutr.(2016-Jun)
    403. Tart Cherry Juice - Keane KM, Haskell-Ramsay CF, Veasey RC, Howatson GMontmorency Tart cherries (Prunus cerasus L.) modulate vascular function acutely, in the absence of improvement in cognitive performance.Br J Nutr.(2016-Dec)
    404. Tart Cherry Juice - Kimble R, Murray L, Keane KM, Haggerty K, Howatson G, Lodge JKThe influence of tart cherries () on vascular function and the urinary metabolome: a randomised placebo-controlled pilot study.J Nutr Sci.(2021)
    405. Tart Cherry Juice - Johnson SA, Navaei N, Pourafshar S, Jaime SJ, Akhavan NS, Alvarez-Alvarado S, Proaño GV, Litwin NS, Clark EA, Foley EM, George KS, Elam ML, Payton ME, Arjmandi BH, Figueroa AEffects of Montmorency Tart Cherry Juice Consumption on Cardiometabolic Biomarkers in Adults with Metabolic Syndrome: A Randomized Controlled Pilot Trial.J Med Food.(2020-Dec)
    406. Tart Cherry Juice - Desai T, Bottoms L, Roberts MThe effects of Montmorency tart cherry juice supplementation and FATMAX exercise on fat oxidation rates and cardio-metabolic markers in healthy humans.Eur J Appl Physiol.(2018-Dec)
    407. Tart Cherry Juice - Hillman AR, Trickett O, Brodsky C, Chrismas BMontmorency tart cherry supplementation does not impact sleep, body composition, cellular health, or blood pressure in healthy adults.Nutr Health.(2022-Jul-05)
    408. Tart Cherry Juice - Sinclair J, Bottoms L, Dillon S, Allan R, Shadwell G, Butters BEffects of Montmorency Tart Cherry and Blueberry Juice on Cardiometabolic and Other Health-Related Outcomes: A Three-Arm Placebo Randomized Controlled Trial.Int J Environ Res Public Health.(2022-Apr-27)
    409. Tart Cherry Juice - Keith R Martin, Katie M ColesConsumption of 100% Tart Cherry Juice Reduces Serum Urate in Overweight and Obese AdultsCurr Dev Nutr.(2019 Feb 25)
    410. Tart Cherry Juice - Chai SC, Davis K, Wright RS, Kuczmarski MF, Zhang ZImpact of tart cherry juice on systolic blood pressure and low-density lipoprotein cholesterol in older adults: a randomized controlled trial.Food Funct.(2018-Jun-20)
    411. Tart Cherry Juice - Lynn A, Mathew S, Moore CT, Russell J, Robinson E, Soumpasi V, Barker MEEffect of a tart cherry juice supplement on arterial stiffness and inflammation in healthy adults: a randomised controlled trial.Plant Foods Hum Nutr.(2014-Jun)
    412. Tart Cherry Juice - Eslami O, Khorramrouz F, Ghavami A, Hajebi Khaniki S, Shidfar FEffect of cherry consumption on blood pressure: a systematic review and meta-analysis of randomized controlled trials.Diabetes Metab Syndr.(2022-Feb)
    413. Tart Cherry Juice - Moosavian SP, Maharat M, Chambari M, Moradi F, Rahimlou MEffects of tart cherry juice consumption on cardio-metabolic risk factors: A systematic review and meta-analysis of randomized-controlled trials.Complement Ther Med.(2022-Dec)
    414. Magnesium - Verma H, Garg REffect of magnesium supplementation on type 2 diabetes associated cardiovascular risk factors: a systematic review and meta-analysisJ Hum Nutr Diet.(2017 Oct)
    415. Magnesium - Xi Zhang, Yufeng Li, Liana C Del Gobbo, Andrea Rosanoff, Jiawei Wang, Wen Zhang, Yiqing SongEffects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled TrialsHypertension.(2016 Aug)
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